ID aotvoCD45\(AAM48511)_Fragm\(5') STANDARD;PRT; 433 AA. AC AAM48511; DT 17-MAY-2003 DE CD45 phosphatase [Aotus vociferans]. OS Aotus vociferans. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Aotinae; Aotus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 433) CC GPRFLN| AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. CC GPRFLN| TITLE Partial characterization of the CD45 phosphatase cDNA in the owl CC GPRFLN| monkey Aotus vociferans CC GPRFLN| JOURNAL Unpublished CC GPRFLN|REFERENCE 2 (residues 1 to 433) CC GPRFLN| AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (26-MAR-2001) Fisiologia Molecular, FIDIC, Avenida El CC GPRFLN| Dorado, Carrera 50. INEA, Bogota, DC, Colombia CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301970215| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 433 VNTIFKEY:269 FT PROTEIN 1 433 VNTIFKEY:270 SQ SEQUENCE 433 AA; RMMQRNGGAA MCHFTTKSAP PSQVWNMTVS MTSDNSMHVK CRPPRDRNGP HERYHLEVEA 60 GNTLVRNESH KNCDFRVKDL QYSTDYTFKA YFHNGDYPGE PFILHHSTSY NSKALIAFLA 120 FLIIVTSIAL LVVLYKIYDL HKKRSCNLDE QQELVERDDE KQLMNVEPIH ADILLETYKR 180 KIADEGRLFL AEFQSIPRVF SKFPIKEARK PFNQNKNRYV DILPYDYNRV ELSEINGDAG 240 SNYINASYID GFKEPRKYIA AQGPRDETVD DFWRMIWEQK ATVIVMVTRC EEGNRNKCAE 300 YWPSVEEGTR AFGDVVVKIN QHKRCPDYII QKLNIINKKE KTAGREVTHI QFTSWPDHGV 360 PEDPHLLLKL RRRVNAFSNF FXGPIVVHCS AGVGRTGTYI GIDAMLEGLE AENKVDVYGY 420 VDKLRRQRCL MVQ 433 // ID aotvoCD45\(AAM48512)_Fragm\(3') STANDARD;PRT; 365 AA. AC AAM48512; DT 17-MAY-2003 DE CD45 phosphatase [Aotus vociferans]. OS Aotus vociferans. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Platyrrhini; Cebidae; Aotinae; Aotus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 365) CC GPRFLN| AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. CC GPRFLN| TITLE Partial characterization of the CD45 phosphatase cDNA in the owl CC GPRFLN| monkey Aotus vociferans CC GPRFLN| JOURNAL Unpublished CC GPRFLN|REFERENCE 2 (residues 1 to 365) CC GPRFLN| AUTHORS Montoya,G.E., Vernot,J.P. and Patarroyo,M.E. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (26-MAR-2001) Fisiologia Molecular, FIDIC, Avenida El CC GPRFLN| Dorado, Carrera 50. INEA, Bogota, DC, Colombia CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301969998| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 365 VNTIFKEY:269 FT PROTEIN 1 365 VNTIFKEY:270 SQ SEQUENCE 365 AA; NMKKRDPPSE PSPLEAEFQR LPSYRSWRTQ HIGNQEENKS KNRNSNVIPY DFNRVPLKHE 60 LEMSKESEHD SDESSDDDSD SEEXSKYINA SFIMXXWKPE VMIAAQGPLX ETIGDFWQMI 120 FQRKVKVIVM LTELKHGDQE ICAQYWGEGK QTYGDIEVDL KDTDKSSTYT LRVFELRHSK 180 RKDSRTVYQY QYTNWSVXXL PAXPKELISM IQVXKQKLPQ KNSSEGNKXH KSXPLLIHCR 240 DGSQQTGIFC ALLNLLESAE TEEVVDXFQV VKALRKARPG MXSTFEQXQF LYDXIASTYP 300 AQNGQVKKNN HQEDKIEFDN EVDKVKQDAN CVNPLGAPEK LPEANEQAAG SEPTSGTEGP 360 EHCVT 365 // ID bIA2\(P56722)\PTPRN STANDARD; PRT; 979 AA. AC P56722; DT 17-MAY-2003 DE Protein-tyrosine phosphatase-like N precursor (R-PTP-N) (Islet cell autoantigen 512) (ICA512). KW Receptor; Glycoprotein; Signal; Transmembrane. OS Bos taurus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos. CC ------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a CC collaboration between the Swiss Institute of Bioinformatics and CC the EMBL outstation - the European Bioinformatics Institute. CC The original entry is available from http://www.expasy.ch/sprot CC and http://www.ebi.ac.uk/sprot CC ------------------------------------------------------------------. CC [FUNCTION] Implicated in neuroendocrine secretory processes. May be CC involved in processes specific for neurosecretory granules, such as CC their biogenesis, trafficking or regulated exocytosis or may have a CC general role in neuroendocrine functions. Lacks intrinsic enzyme CC activity. May play a role in the regulation of secretory granules CC via its interaction with SNTB2 (By similarity). CC [SUBUNIT] Interacts with phosphorylated SNTB2, protecting it from CC protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin CC stimulation disrupts the interaction and results in its cleavage CC (By similarity). CC [SUBCELLULAR LOCATION] Type I membrane protein. Neuroendocrine CC secretory granules. CC [PTM] N-glycosylated. CC [SIMILARITY] CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN. CC GPRFLN|REFERENCE 1 (residues 1 to 979) CC GPRFLN| AUTHORS Hermel,J.-M., Dirkx,R. and Solimena,M. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (~JUN-1999) CC GPRFLN| REMARK SEQUENCE FROM N.A. CC GPRFLN|REFERENCE 2 (residues 1 to 979) CC GPRFLN| AUTHORS Hermel,J.M., Dirkx,R. Jr. and Solimena,M. CC GPRFLN| TITLE Post-translational modifications of ICA512, a receptor tyrosine CC GPRFLN| phosphatase-like protein of secretory granules CC GPRFLN| JOURNAL Eur. J. Neurosci. 11 (8), 2609-2620 (1999) CC GPRFLN| MEDLINE 99388259 CC GPRFLN| REMARK SEQUENCE OF N-TERMINUS, AND CHARACTERIZATION. CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 979 VNTIFKEY:269 FT PROTEIN 1 979 VNTIFKEY:270 FT SIGNAL 1 34 VNTIFKEY:200; VNTINAME:PTPRN FT CHAIN 35 979 PROTEIN-TYROSINE PHOSPHATASE-LIKE N. FT VNTIFKEY:203; VNTINAME:PTPRN FT DOMAIN 35 575 EXTRACELLULAR (POTENTIAL). FT VNTIFKEY:1001; VNTINAME:PTPRN FT SITE 448 449 CLEAVAGE SITE. FT VNTIFKEY:221; VNTINAME:PTPRN FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRN FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRN FT TRANSMEM 576 600 POTENTIAL. FT VNTIFKEY:210; VNTINAME:PTPRN FT DOMAIN 601 979 CYTOPLASMIC (POTENTIAL). FT VNTIFKEY:1004; VNTINAME:PTPRN FT DOMAIN 696 979 PROTEIN-TYROSINE PHOSPHATASE-LIKE. FT VNTIFKEY:1000; VNTINAME:PTPRN FT ACT_SITE ? ? BY SIMILARITY. FT VNTIFKEY:220; VNTINAME:PTPRN SQ SEQUENCE 979 AA; MRLPGRPGGP GGSGGLRVLL CLLLLGSRPG GCNAISAHGC LFDRRLCSHL EVCIQDGLFG 60 QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE 120 PHPRDRSGLV PRRPGPAGEL LLQGIPTGSA PALQHRLPRP SVGGGRAGAG SPLSPLQAEL 180 LPPLLEHLLL PPQPPHPALS YEPALLQPYL FHQFGSRDGS RGSESSPGMV SVDPLPKAEA 240 PAFLSRAGSK GMFGAHPGHS YGDPPGPPPA QLFQESELFY LAQESQVPSR TRAPRLPEPG 300 GSSRAGDSSE GYEEEGLEGR EEKPPAPAEQ PDVTLQRVAA VLAGYGVELH QLTPEQLSTL 360 STLLQLLPKG SRQNPGGAVN VGADIKKTME EQVQGEDPAE PPPPMPSLPG SPTGSSTSNK 420 AQKELSTGAS EPPKAAGPPA TPVLVEKKSP LGQNQPTMAG QPSTRPSAEE YGYIVTDQKP 480 LSLAAGVRLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE 540 LEAQTGLQIL QTGVGQREEA AAILPRPAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV 600 RQHARQRDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ 660 FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ 720 AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY 780 IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGSS LYHVYEVNLV 840 SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG 900 RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE 960 FALTAVAEEV NAILKALPQ 979 // ID bPTPBA14\(NP_777015)\PTPN13 STANDARD;PRT; 2484 AA. AC NP_777015; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 13 [APO-1/CD95 (Fas)-associated phosphatase] [Bos taurus]. OS Bos taurus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; Bovinae; Bos. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from U20807.1. CC GPRFLN|REFERENCE 1 (residues 1 to 2484) CC GPRFLN| AUTHORS Vega,Q.C., Walton,K.M. and Dixon,J.E. CC GPRFLN| TITLE Tyrosine Phosphatases and the Cytoskeleton CC GPRFLN| JOURNAL Unpublished CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301945150| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 2484 VNTIFKEY:269 FT PROTEIN 1 2484 VNTIFKEY:270 FT REGION 572 781 B41 FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 1090 1179 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 1366 1452 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 1496 1587 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 1787 1866 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 1882 1965 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT REGION 2213 2467 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 2484 AA; MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS IADPAALGFI ISPWSLLLRS 60 GSVSFTDENI SNQDLRAFTA PEVLQSQSLT SLSDVEKIHI YSLGMTLYWG ADHEVPQSQP 120 IKLGDHLNSI LLGMCEDVVY ARVSVRTVLD ACSAHIRNSN CAPSFSYVKQ LVKLVLGSLS 180 GTDQLSRSSE QKPDRSQAIR DRLRGKGLPT GRSSTSDVLD TYKSPSCHQA FLNKGLSKSM 240 GFLSIKDTRD EEDYFKDLSS DNNSGQEDSE SSCSPYPFKS SGPEKKAVPG LDVLPKKKIW 300 ASSMDLLCTG DRDFSSGETD RYQRRLPEAV TVRTSTTPRK KEARYSDGSL ALDIFGPQKM 360 DPAFHTRDLP TSSAISSALD RIRERQKKLR VLREAMNVEE PVQRYKTYHS DLFSTSSESP 420 SIISSESDFR QVRKSETSKR FESNSGLPGV DETPSQGQSQ RPRQYETPLE GNLINQEIML 480 KRQEEEMMQL QARMALRQSR LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG 540 PEFVKMTIEP FISLDLPRSI LTKKGKSEDN RRKVNIMLLS GQRLELTCDT KTICKDVFDM 600 VVAHIGLVEH HLFALATLKD NEYFFVDSDL KLTKVAPEGW KEEPKKKSKA SINFTLFFRI 660 KFFMDDVSLI QHTLTCHQYY LQLRKDTLEE RIHCDDETSL LLASLALQAE YGDYQPEVHG 720 VSYFRLEHYL PPRVMEKLDL SYIKEELPKL HNTYMGASEK ETELEFLKVC QRLTEYGVHF 780 HRVHPEKKSQ TGILLGVCSK GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD 840 GIKHAFQTDN SKICQYLLHL CSSQHKFQLQ MRARQSNQDA QDIERASFRS LNFQAESVRG 900 FNMGRAVSTG SLASSTLNKL AVRPLSVQAE ILKRLSCSEL SLCQPLQNSA KEKNGKTAWE 960 EKPRGMSKSY HDLSQACLYP HRKNVNVNME PPPQTIAELV GKTLHQMARS DTESLAGVTK 1020 LNNSKSVASL NRSPERRKHE SDSSSFEDLG QAYVLGMTLH SSGNSSSQVP LKENDVLHKR 1080 WSIASSPERE ITLVNLKKDA QYGLGFQIIG GEKMGRLDLG VFISSVTPGG PADLDGCLKP 1140 GDRLISVNSV SLEGVSHHAA VEILQNAPED VTLVISQPKE KLSKVPSTPV HMANGTKNYM 1200 KKPSHLQDGT VNSSEDHCWP RGTPRHISES SFGLSGGLRE GSLSSQDSRT ESASLSQSQV 1260 NGFFASHAAD RSWQDSQRGS PSPSVISKAT EKKWTSTDSN RSKAKNTGIS DAPDYSDRGD 1320 SDMDEATYSS SQDHHIPKKE SSSSMNTSNK MNFKTFPSSP PKPGDIFEVE LAKNDNSLGI 1380 SVTGGVNTSV RHGGIYVKAV IPKGAAESDG RIHKGDRVLA VNGVSLEGAT HKQAVETLRN 1440 TGQVVHLLLE KGQSPASKEH VLQCTVSDPD TQGQAPEKMM TKMTHVKDYS FVTEENTFEV 1500 KLLKNSSGLG FSFSREDNVI PEQMNTSIVR VKKLFPGQPA AESGQIDVGD VILKVNGASL 1560 KGLSQQEVIS ALRGTSPEVS LLLCRPPPGV LPEIDPALST PLHSPAQVPL NNSKDPPQTA 1620 CAEQGTSSDE NEMSDKNRRP CTSPSRRDSY SDSSESGEDD LAKAPAKIPN MSWSSALQQT 1680 LSNMMSQAQS HHDTLRSQED PICTMFYYPQ KVPNKPEHEG SNPLPPRPLD VTPGQSCQSQ 1740 SESVPINAMD KYHTHHTSEP TRQESLTSLK NDLENHLEDF ELEVELLITL HKSEKGSLGF 1800 TVTKGNQSIG CYVHDVIQDP AKSDGRLRPG DRLIKVNDTD VTNMTHTDAV NLLRRAPRTV 1860 RLVLGRVLEL PRMPVLPHLL PDITFTCNRE ELGFSLSGGR DSLHQVVYVS DINPRSIAAT 1920 EGNLQLLDVI HYVNGVSTQG MTLEEAKRTL DMSLPSVVLK ATRDGHPVVP SSKGSALSAS 1980 KSAKANGPHI VEPCGKPSLT PNNSFSKVNG EEIIEILYPE GKCSTYQMKE SANLILYKES 2040 DGQEDENYDD PQEAEVIQSL LDVVDEEAQN LLNQNNVAGD ACVPGALKAN EKLSEERAQD 2100 TYCDGSPLPE DFTESTKMNG CEEHCEEKGK SESLIQKSEE KKTEDDEITW GSDELPIETT 2160 DHEDSNKEHP FLTNEELTTL PIIKVLPSGK YTGAKLKSVI RMLRGLLDQG IPSKELENLQ 2220 ELKPLDQCLI GQTKENRRKN RYKNILPYDA TRVPLGDEGG YINASFIKIP VGREEFVYIA 2280 CQGPLPTTVG DFWQMIWEQN SSVIAMMTQE VEGEKIKCQR YWPNVLGKST MVSNRLRLAL 2340 VRVQQLKGFV VRAMTLEDIQ TGEVRHVSHL NFTAWPDHDT PSQPDDLLTF ISYMRHVHRS 2400 GPIITHCSAG IGRSGTLICI DVVLGLISQD LEFDISDLVR CMRLQRHGMV QTEDQYIFCY 2460 QVILYVLTRL QAEEEQKEQP QPLK 2484 // ID cCD45\(A54080) STANDARD; PRT; 1237 AA. AC A54080; DT 17-MAY-2003 DE protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta precursor - chicken. KW phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC GPRFLN|REFERENCE 1 (residues 1 to 1237) CC GPRFLN| AUTHORS Fang,K.S., Barker,K., Sudol,M. and Hanafusa,H. CC GPRFLN| TITLE A transmembrane protein-tyrosine phosphatase contains spectrin-like CC GPRFLN| repeats in its extracellular domain CC GPRFLN| JOURNAL J. Biol. Chem. 269 (19), 14056-14063 (1994) CC GPRFLN| MEDLINE 94245724 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301941064| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1237 VNTIFKEY:269 FT PROTEIN 1 1237 VNTIFKEY:270 FT DOMAIN 528 1170 leukocyte common antigen cytosolic domain homology #label LAC FT VNTIFKEY:1000; VNTINAME:LAC FT DOMAIN 610 834 protein-tyrosine-phosphatase homology #label PTP FT VNTIFKEY:1000; VNTINAME:PTP FT ACT_SITE ? ? Cys (phosphocysteine intermediate) FT VNTIFKEY:220; VNTINAME:Active_Site_1 FT BINDING ? ? substrate phosphate (Arg) FT VNTIFKEY:1007; VNTINAME:Binding_1 SQ SEQUENCE 1237 AA; MFLCLKLLAF GVAFLCQDAF AQAGNDNLTS ASSLSSTLPT PTRSTSFSPP STTAGVQPAS 60 TGASPTASTH LSTHSGSGPT TGLGHLQHSS PAALTTRTLT AFHQTVSDYY SSTSLHNTTS 120 PVITPASTET IPTSTIESAT TTEEPCDNSI DYGNIEEKNN SAEVTLKNLK ENRIYDILLE 180 DGKSLSVNAS NNIVMLNWCR RYTVQSRSCK VMYLTIPPDE KRYTFGAKSI GNDNATLRLN 240 SLCIDCEDVC SNVTVSCKTN SINSGGTGNL TGSYELMKHD INADNITILS LSSDSEYLCR 300 VTVRFFEKNF TKEVNITTDY DAPKAPENLT VHPTDRNVTV TWMKPTGTLE KHIDGYTVEC 360 NNTSQNVNRN ETSFTCGDLE PYSTGSVSVR AFKKSKYKNK NFEGEKVNGS FQTKPAKPEN 420 VTDFKLTLLA DNTVKVACRS QKVYGNETKF KLSWNSSSNS GENQRKNECN FTVRDLSYLT 480 KYTFKISVFN GVYTGDSVCE EIYTRYNSRA LIIFLVFLIV VTSIALLLVL YKIYDLHQKK 540 LSNSSEVISL VAVKDDERQL LNIEPIPSEK LLETYKRKIA DEGRLFLDEF QSIPRIFTKF 600 PMKEAKRSHN QNKNRYIDIL PYDHNRVELS EIPGDPGSDY INASYIDGFK EPRKYIAAQG 660 PKDETTDDFW RMIWEQKATI IVMVTRCEEG NRNKCAQYGP SMENGSATYG DITVKINESK 720 ICPDYIIQKL HITNGRERTS GRDVTHIQFT SWPDHGVPED PHLLLKLRRR VNALSNFFSG 780 PIVVHCSAGV GRTGTYIGID AMLEGLDAEG RVDVYGYVVK LRRQRCLMVQ VESQYILIHQ 840 ALVEYHQYGE TEVSLSELHS YLNNLKRKDP PSEPSLLEAK FQRLPSYKGW RTQNTGNREE 900 NKNKNRSANT IPYDFNRVPI RSEEEQSKEG EHDSEDSSDE DSDCEESSRY INASFITGYW 960 GPKAMIATQG PLQETISDFW QMVFQRKVKV IVMLTELKEG DQELCAQYWG EGRQTYDDIE 1020 VQVTDVNCCP SYTIRAFDVT HLKRKETQKV YQYQYHKWNG LDVPEDPKDL VDMILSLKQK 1080 VPSRPASEDS RNSRSVPFVI HCCDGSQQTW CVLCLMTLLE SAETEEVIDV FQVVKALRRS 1140 RLGVVSTFEQ YQFLYDTIAR TYPAQNGQIK NIHQEDKVEF CNEVEKKDQE SDLITIDLTP 1200 STPEENDAPE CCDDFKAADT NKGTESSTNG PTTPVLT 1237 // ID cDEP1\(CAB41885) STANDARD; PRT; 1406 AA. AC CAB41885; DT 17-MAY-2003 DE supporting-cell antigen [Gallus gallus]. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC On Jun 28, 2001 this sequence version replaced gi:4741401. CC GPRFLN|REFERENCE 1 CC GPRFLN| AUTHORS Kruger,R.P., Goodyear,R.J., Legan,P.K., Warchol,M.E., Raphael,Y., CC GPRFLN| Cotanche,D.A. and Richardson,G.P. CC GPRFLN| TITLE The supporting-cell antigen: a receptor-like protein tyrosine CC GPRFLN| phosphatase expressed in the sensory epithelia of the avian inner CC GPRFLN| ear CC GPRFLN| JOURNAL J. Neurosci. 19 (12), 4815-4827 (1999) CC GPRFLN| MEDLINE 99296852 CC GPRFLN|REFERENCE 2 CC GPRFLN| AUTHORS Legan,P.K. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (26-APR-1999) Legan P.K., School of Biological Sciences, CC GPRFLN| University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM CC GPRFLN| REMARK Revised by [3] CC GPRFLN|REFERENCE 3 (residues 1 to 1406) CC GPRFLN| AUTHORS Legan,P.K. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (27-JUN-2001) Legan P.K., School of Biological Sciences, CC GPRFLN| University of Sussex, Falmer, Brighton, BN1 9QG, UNITED KINGDOM CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1406 VNTIFKEY:269 FT PROTEIN 1 1406 VNTIFKEY:270 FT SIGNAL 1 24 VNTIFKEY:200; VNTINAME:Signal_1 SQ SEQUENCE 1406 AA; MRRLPLLPPC PLLLLLLLPA EVRCTTACTD DCSLKNVTEE MGTSSNDELS VNATSGNRRL 60 SEDVSLPGRA MSDQNSVAQP RAVLDLKTEY VGVTSVNLTW TVNDTASDSY TYRIEVRNGS 120 SINNKTSDIT DAEITGLIPG TLYTFTVFAV AADGQTAGEG ASISLYTKPS PVLDLKAEYV 180 GVTSVNLTWT VNDTASASYT YRIEVTSDSS IDSLTSSVTM AEITGLIPGT LYSFKVFAVA 240 ADNRTEADGA SISLYTKPSP VLDLKAEYVG VTSVNLTWTV NGTALTAYTY RIEVRNATSI 300 RNETSNINKI EITGLIPGTS YNFKVFATPV NNTTEEEGLS LNLYTKPSPV LRVVTEYVGV 360 TSVNLTWMVD DTASDSYTYR IEVRNGSSIN NKTSDITDAE ITGLIPGTLY TFTVFAVAAD 420 GQTAGEGASI SLYTKPSPVL DLKAEYVGVT SVNLTWTVND TASASYTYRI EVTSDSSIDS 480 LTSNVTMAEI TGLIPGTLYN FTVFAVAADN RTEADGAFTS LYTKPTPVTD LKAEHGVTSV 540 SLNWMVNDTA SDSYTYRIEV RNGHSVNNKT SNIPETEITG LNPGTLYTFT VFAVAADGET 600 EGEGASISVY TKPRAVLHLK TEYVGVTSVN LTWTVNDTDS ASYTYRIEVR NGSSINNKTS 660 DITDAEITGL DPGTLYIFTV FAVAADGQTA GEGASISLYT KPSMVLNLKA EYVTMTSVNL 720 TWMVNDAESA SYTYRIEVAH ESLINETMSN VTKSIVTYLI PGTSYNFTVF AIAADNQTEG 780 EGASISQNTV PSSVNAFQCE AVANMSYLTL KWNCPYGGYS GFDIEIFNGT WTKKQQSQFC 840 GREGSEEIFK TEPLDYYKTY TVSVTTVSDG LTSLPVQKIC KTSITDPPVP NKAPLVKAVS 900 HNSLSVEFPD FESVNGPLKA YAVMIVTEAE GCLPSKSDLD YTYNDFKQKM TATYVTYVID 960 VEEISSSSHS QNGHNIVDVG KGNTMYGYEN GPLIPLHSYR ASVAGFTNIN FTVANKIMGE 1020 QSYVSFSPCS EVVSLPQDPG VIAGAVIGCL LAILAVVAIG GYIFWRRRRK DKRNTEVSFS 1080 PIKIKKSKMI KVENFESYFK KQQADSNCGF AEEYEELKSA GVHQPKFAAE IAENRGKNRY 1140 NNVLPYDISR VKLSNPSCTT DDYINANYMP GYSSKKAFIA AQGPLPNTIE DFWRMIWEKN 1200 IYSIVMLTKC VEQARTKCEQ YWPDKQSKSY GDIIVTMVSE VVLPEWTIRD FNVENADTME 1260 SHTVRQFHFT SWPDHGVPET TDLLINFRHL VHEYSSQNPI DSPILVHCSA GVGRTGTFIA 1320 IDRLIQQIEM ENTVDVYGVV YDLRMHRPLM VQTEDQYVFL NQCVMDIIRS QKEKKTDLIY 1380 QNTTAMAIYE NFTPGPAFGK ANGYHA 1406 // ID cGLEPP1\(AAB17968) STANDARD; PRT; 1267 AA. AC AAB17968; DT 17-MAY-2003 DE protein tyrosine phosphatase CRYP-2 [Gallus gallus]. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 1267) CC GPRFLN| AUTHORS Bodden,K. and Bixby,J.L. CC GPRFLN| TITLE CRYP-2: a receptor-type tyrosine phosphatase selectively expressed CC GPRFLN| by developing vertebrate neurons CC GPRFLN| JOURNAL J. Neurobiol. 31 (3), 309-324 (1996) CC GPRFLN| MEDLINE 97067376 CC GPRFLN|REFERENCE 2 (residues 1 to 1267) CC GPRFLN| AUTHORS Bodden,K. and Bixby,J.L. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (01-AUG-1996) Pharmacology, University of Miami, 1600 NW CC GPRFLN| 10 Ave, Miami, FL 33136, USA CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1267 VNTIFKEY:269 FT PROTEIN 1 1267 VNTIFKEY:270 SQ SEQUENCE 1267 AA; MLPQFAIAGH ASEPGGGRRG AAARGRGAEE PQPPPPGRSR GRGRRAPRCP TAAGGARGGP 60 GARSCLLWLF VLLKNAEPFQ VTVQEDNCIV VSLEASDVVS SSSVYVVKIA GESKNYFFQF 120 EEFNSTLPAP VIFNAKYHGL YYIVTLLVVN SNMVSKSARS ITVLTKPLPV SSVSIYDYKP 180 SPETGVLFEI QYPEKYNVFT RVNISYWEGK DYRTMLYKDF FKGKTVFNHW LPGICYSNIT 240 FQLVSEATFN KSTLVEYSGV RHEPKQHRTV PYPPRNISVQ IVPINRNNWE EHSGNFAEES 300 FMGQQEIISK EKLSRFPSDP PEIPVVNTTA AWPDYRSNST EYETTSQPYW WSNEAESSEG 360 EEEFVNAVPR DYGASEANAS GKLTAEPAPF LPVQMVLTWL PPKPPTAFDG FHINIEREEN 420 STELLTVSED THKFVAELKE PGKYKLSVTT FSSSGSCEVR GSQSAKTLSF YISPTGEWIE 480 ELTEKPQHVT VTVLSSTTAL TSWTASHESG SNGTIVSVVS LTCQKQKESQ RLEKHYCTEV 540 NSSSSLIENL VPGAQYQVVV YLRKGPLVGP PSDPVTFSIV PTGIKDLTLY PLGPTAVVLS 600 WNRPFLGVFR KYVVEMFYFN PSTMTSEWTT YYEIAATISL TASVRIANLL PAWYYNFRVT 660 MVTWGDPELS CCDSSTISFI TAPVAPEITS IEYYNHLLYV TWTYGGDGTD LSHSRMLHWM 720 VIAEGKKKIK KSVTRSVMTA VLSLPPGDIY NLSVTACTER GSNTSLPQLV KLEPAPPKSL 780 FAVNKTQTSV TLLWVEEGVA DFFEVYCQQA GSNQEVKVQE PVTVSSHVVT ISSLTPATSY 840 NCSVTTFSHN SPSVPTYIAV STMVTEMNPN IVVISVLAIL SILLIGLLLV TLVVLRRKHL 900 QMARECGAGT FVNFASLERD GKLPYNWRRS VFAFLTLLPS CLWTDYLLAF YINPWSKNGL 960 KKRKLTNPVQ LDDFDGYIKD MAKDSDYKFS LQFEELKLIG LDIPHFAADL PMNRCKNRYT 1020 NILPYDFSRV RLVSMNEEEG SDYINANYIP GYNSPQEYIA TQGPLPETRN DFWKMVLQQK 1080 SQIIVMLTQC NEKRRVKCDH YWPFTEDPIA YGDITVEMLS EEEHTDWVYR NFRISYADEV 1140 QDVMHFNYTA WPDHGVPTAN AAESILQFVQ MVRQKSVKSK GPMIIHCSAG VGRTGTFIAL 1200 DWLLQHIRDH EFVDILGLVS DMRSYRMSMV QTEEQYIFIH QCVQLMWQKK KQQFCISDVI 1260 YENVSKS 1267 // ID cMG-PTP1\(AAB33980)_Fragm STANDARD;PRT; 81 AA. AC AAB33980; DT 17-MAY-2003 DE Muller glia protein tyrosine phosphatase 1, MG-PTP1 [chickens, retinas, Muller glia cells, Peptide Partial, 81 aa]. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation supplied by author. CC GPRFLN|REFERENCE 1 (residues 1 to 81) CC GPRFLN| AUTHORS Shock,L.P., Bare,D.J., Klinz,S.G. and Maness,P.F. CC GPRFLN| TITLE Protein tyrosine phosphatases expressed in developing brain and CC GPRFLN| retinal Muller glia CC GPRFLN| JOURNAL Brain Res. Mol. Brain Res. 28 (1), 110-116 (1995) CC GPRFLN| MEDLINE 95223107 CC GPRFLN| REMARK GenBank staff at the National Library of Medicine created this CC GPRFLN| entry [NCBI gibbsq 165661] from the original journal article. CC GPRFLN| This sequence comes from Fig. 2C. CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 81 VNTIFKEY:269 FT PROTEIN 1 81 MG-PTP1 FT VNTIFKEY:270 SQ SEQUENCE 81 AA; GRGTDTYGMI QVTLLDTIEL ATFCVRTFSL HKNGSSKKRE VRQFQFTAWP DHGVPEYPTP 60 FLAFLRRVKT CNPPDAGPIV V 81 // ID cMG-PTP2\(AAB33981)_Fragm STANDARD;PRT; 87 AA. AC AAB33981; DT 17-MAY-2003 DE Muller glia protein tyrosine phosphatase 2, MG-PTP2 {MG-PTP2 catalytic domain} [chickens, retinas, Muller glia cells, Peptide Partial, 87 aa]. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation supplied by author. CC GPRFLN|REFERENCE 1 (residues 1 to 87) CC GPRFLN| AUTHORS Shock,L.P., Bare,D.J., Klinz,S.G. and Maness,P.F. CC GPRFLN| TITLE Protein tyrosine phosphatases expressed in developing brain and CC GPRFLN| retinal Muller glia CC GPRFLN| JOURNAL Brain Res. Mol. Brain Res. 28 (1), 110-116 (1995) CC GPRFLN| MEDLINE 95223107 CC GPRFLN| REMARK GenBank staff at the National Library of Medicine created this CC GPRFLN| entry [NCBI gibbsq 165663] from the original journal article. CC GPRFLN| This sequence comes from Fig. 2D. CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 87 VNTIFKEY:269 FT PROTEIN 1 87 MG-PTP2 FT VNTIFKEY:270 SQ SEQUENCE 87 AA; TRGEEVMVFS ETGFRVRLVS EDIKSYYTVH LLQLENINSG ESRMISHFHY TTWPDFGVPE 60 SPASFLNFLF KVRESGCLSP EHGPAVD 87 // ID cPTP-NT1subtype\(AAA49018)\Fragm STANDARD;PRT; 62 AA. AC AAA49018; DT 28-JUN-2003 DE phosphoprotein phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 62) CC GPRFLN| AUTHORS Potts,J.D. CC GPRFLN| TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens CC GPRFLN| epithelium CC GPRFLN| JOURNAL Unpublished (1993) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|306551667| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 62 VNTIFKEY:269 FT PROTEIN 1 62 VNTIFKEY:270 SQ SEQUENCE 62 AA; GSDYINASLI KMEEAQRSYI LTQGPLPNTC GHFWEMVWEQ KSRGVVMLNR VMEKGSIKCD 60 QY 62 // ID cPTP-NT1subtype\(AAA49019)_Fragm STANDARD;PRT; 63 AA. AC AAA49019; DT 17-MAY-2003 DE phosphoprotein phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 63) CC GPRFLN| AUTHORS Potts,J.D. CC GPRFLN| TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens CC GPRFLN| epithelium CC GPRFLN| JOURNAL Unpublished (1993) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 63 VNTIFKEY:269 FT PROTEIN 1 63 VNTIFKEY:270 SQ SEQUENCE 63 AA; GSDYINASLV VIEEAQRYYI LTQGPLPNTC CHFWLMVWQQ QTKAVVMLNR IVEKDSVKCA 60 QYW 63 // ID cPTP-R2Asubtype\(AAA49017)_Fragm STANDARD;PRT; 63 AA. AC AAA49017; DT 17-MAY-2003 DE phosphoprotein phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 63) CC GPRFLN| AUTHORS Potts,J.D. CC GPRFLN| TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens CC GPRFLN| epithelium CC GPRFLN| JOURNAL Unpublished (1993) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 63 VNTIFKEY:269 FT PROTEIN 1 63 VNTIFKEY:270 SQ SEQUENCE 63 AA; GSDYINASSI DGYRQQKAYI ATQGPLAETT EDFWWMLWEN NSTIVVMLTK LREMGREKCA 60 QYW 63 // ID cPTP-R2Bsubtype\(AAA49016)_Fragm STANDARD;PRT; 63 AA. AC AAA49016; DT 17-MAY-2003 DE phosphoprotein phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 63) CC GPRFLN| AUTHORS Potts,J.D. CC GPRFLN| TITLE Protein tyrosine phosphatases isolated from embryonic chicken lens CC GPRFLN| epithelium CC GPRFLN| JOURNAL Unpublished (1993) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 63 VNTIFKEY:269 FT PROTEIN 1 63 VNTIFKEY:270 SQ SEQUENCE 63 AA; GSDYMNANYI DGYHRSNHFI ATQGPKQEMV YDFWRMVWQE HCSSIVMITK LVEVGRVKCA 60 QYW 63 // ID cPTP1B\(O13016) STANDARD; PRT; 434 AA. AC O13016; DT 17-MAY-2003 DE Protein-tyrosine phosphatase, non-receptor type 1 (Protein-tyrosine phosphatase 1B) (PTP-1B) (CPTP1). KW Hydrolase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC ------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a CC collaboration between the Swiss Institute of Bioinformatics and CC the EMBL outstation - the European Bioinformatics Institute. CC The original entry is available from http://www.expasy.ch/sprot CC and http://www.ebi.ac.uk/sprot CC ------------------------------------------------------------------. CC [CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN CC TYROSINE + ORTHOPHOSPHATE. CC [SUBCELLULAR LOCATION] ASSOCIATED TO THE ENDOPLASMIC RETICULUM VIA CC ITS C-TERMINAL DOMAIN WITH ITS PHOSPHATASE DOMAIN ORIENTED TOWARDS CC THE CYTOPLASM (BY SIMILARITY). CC [SIMILARITY] BELONGS TO THE NON-RECEPTOR CLASS OF THE CC PROTEIN-TYROSINE PHOSPHATASE FAMILY. CC GPRFLN|REFERENCE 1 (residues 1 to 434) CC GPRFLN| AUTHORS Balsamo,J., Leung,T., Ernst,H., Zanin,M.K., Hoffman,S. and CC GPRFLN| Lilien,J. CC GPRFLN| TITLE Regulated binding of PTP1B-like phosphatase to N-cadherin: control CC GPRFLN| of cadherin-mediated adhesion by dephosphorylation of beta-catenin CC GPRFLN| JOURNAL J. Cell Biol. 134 (3), 801-813 (1996) CC GPRFLN| MEDLINE 96326683 CC GPRFLN| REMARK SEQUENCE FROM N.A. CC GPRFLN| TISSUE=Retina CC GPRFLN|REFERENCE 2 (residues 1 to 434) CC GPRFLN| AUTHORS Kim,C.W., Jung,E.J. and Kang,Y.-S. CC GPRFLN| TITLE Cloning and characterization of a chicken protein tyrosine CC GPRFLN| phosphatase, CPTP1 CC GPRFLN| JOURNAL Exp. Mol. Med. 28, 207-213 (1996) CC GPRFLN| REMARK SEQUENCE OF 14-369 FROM N.A. CC GPRFLN| TISSUE=Intestine CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 434 VNTIFKEY:269 FT PROTEIN 1 434 VNTIFKEY:270 FT CONFLICT ? ? A -> R (IN REF. 2). FT VNTIFKEY:240; VNTINAME:PTPN1 FT DOMAIN 40 288 PROTEIN-TYROSINE PHOSPHATASE. FT VNTIFKEY:1000; VNTINAME:PTPN1 FT CONFLICT 62 63 GD -> RC (IN REF. 2). FT VNTIFKEY:240; VNTINAME:PTPN1 FT ACT_SITE ? ? VNTIFKEY:220; VNTINAME:PTPN1 SQ SEQUENCE 434 AA; MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS PFDHSRIKLN 60 QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSIK 120 CAQYWPRKEE KEMFFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP 180 DFGVPESPAS FLNFLFKVRE SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD 240 PSSVDVKQVL LEMRKYRMGL IQTADQLRFS YLAVIEGAKF IMGDASVQEQ WKELSNEDLD 300 PPPEHTPPPP RPPKRTSEMH NGRMHEHAEF FPKHQVVEEE IRCSVSTAEE TVSDGRVFSS 360 VPLITDSTSQ DTEIRRRTVG ENLHVTAHKE ESKSESVEED DENMMTTWKP FLVNICMFTF 420 LTAGAYLCYR VCFH 434 // ID cPTPalpha\(AAB04150) STANDARD;PRT; 807 AA. AC AAB04150; DT 17-MAY-2003 DE protein tyrosine phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 807) CC GPRFLN| AUTHORS Fang,K.S. CC GPRFLN| TITLE Structural and functional characterization of two chicken tyrosine CC GPRFLN| phosphatases CC GPRFLN| JOURNAL Thesis (1993) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 807 VNTIFKEY:269 FT PROTEIN 1 807 VNTIFKEY:270 FT SIGNAL 1 20 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 21 807 VNTIFKEY:203; VNTINAME:Chain_1 SQ SEQUENCE 807 AA; MDLWFFVLLL GSGLISVGAT NVTTEPPTTV PTSTRIPTKA PTAAPDGGTT PRVSSLNVSS 60 PMTTSAPASE PPTTTATSIS PNATTASLNA STPGTSVPTS APVAISLPPS ATPSALLTAL 120 PSTEAEMTER NVSATVTTQE TSSASHNGNS DRRDETPIIA VMVALSSLLV IVFIIIVLYM 180 LRFKKYKQAG SHSNSFRLPN GRTDDAEPQS MPLLARSPST NRKYPPLPVD KLEEEINRRI 240 GDDNKLFREE FNALPACPIQ ATCEAASKEE NKEKNRYVNI LPYDHSRVHL TPVEGVPDSH 300 YINTSFINSY QEKNKFIAAQ GPKEETVNDF WRMIWEQNTA TIVMVTNLKE RKECKCAQYW 360 PDQGCWTYGN IRVSVEDVTV LVDYTVRKFC IQQVGDVTNK KPQRLVTQFH FTSWPDFGVP 420 FTPIGMLKFL KKVKTCNPQY AGAIVVHCSA GVGRTGTFIV IDAMLDMMHA ERKVDVYGFV 480 SRIRAQRCQM VQTDMQYVFI YQALLEHYLY GDTELEVTSL EIHLQKIYNK VPGTSSNGLE 540 EEFKKLTSIK IQNDKMRTGN LPANMKKNRV LQIIPYEFNR VIIPVKRGEE NTDYVNASFI 600 DGYRRRTPTC QPRPVQHTIE DFWRMIWEWK SCSIVMLTEL EERGQEKCAQ YWPSDGSVSY 660 GDINVELKKE EECESYTVRD LLVTNTRENK SRQIRQFHFH GWPEVGIPSD GKGMINIIAA 720 VQKQQQQSGN HPMHCHCSAG AGRTGTFCAL STVLERVKAE GILDVFQTVK SLRLQRPHMV 780 QTLEQYEFCY KVVQEYIDAF SDYANFK 807 // ID cPTPgamma\(Q98936) STANDARD; PRT; 1422 AA. AC Q98936; DT 17-MAY-2003 DE Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma). KW Glycoprotein; Transmembrane; Hydrolase; Repeat; Signal. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC ------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a CC collaboration between the Swiss Institute of Bioinformatics and CC the EMBL outstation - the European Bioinformatics Institute. CC The original entry is available from http://www.expasy.ch/sprot CC and http://www.ebi.ac.uk/sprot CC ------------------------------------------------------------------. CC [CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC [SUBCELLULAR LOCATION] Type I membrane protein (Probable). CC [SIMILARITY] IN THE N-TERMINAL SECTION; BELONGS TO THE CC EUKARYOTIC-TYPE CARBONIC ANHYDRASE FAMILY. CC [SIMILARITY] CONTAINS 2 PROTEIN-TYROSINE PHOSPHATASE DOMAINS. CC [SIMILARITY] CONTAINS 1 FIBRONECTIN TYPE III-LIKE DOMAIN. CC GPRFLN|REFERENCE 1 (residues 1 to 1422) CC GPRFLN| AUTHORS Qinghua,X., Xiaojun,G., Cong,S., Zong,S.M., Jong,Y.J., Chan,J. and CC GPRFLN| Wang,L.-H. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (~OCT-1995) CC GPRFLN| REMARK SEQUENCE FROM N.A. CC GPRFLN| TISSUE=Brain, and Kidney CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1422 VNTIFKEY:269 FT PROTEIN 1 1422 VNTIFKEY:270 FT SIGNAL 1 19 BY SIMILARITY. FT VNTIFKEY:200; VNTINAME:PTPRG FT CHAIN 20 1422 PROTEIN-TYROSINE PHOSPHATASE GAMMA. FT VNTIFKEY:203; VNTINAME:PTPRG FT DOMAIN 20 742 EXTRACELLULAR (POTENTIAL). FT VNTIFKEY:1001; VNTINAME:PTPRG FT DOMAIN 56 322 CARBONIC-ANHYDRASE LIKE. FT VNTIFKEY:1000; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT DOMAIN 347 441 FIBRONECTIN TYPE-III. FT VNTIFKEY:1018; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRG FT TRANSMEM 743 768 POTENTIAL. FT VNTIFKEY:210; VNTINAME:PTPRG FT DOMAIN 769 1422 CYTOPLASMIC (POTENTIAL). FT VNTIFKEY:1004; VNTINAME:PTPRG FT DOMAIN 846 1102 PROTEIN-TYROSINE PHOSPHATASE 1. FT VNTIFKEY:1000; VNTINAME:PTPRG FT ACT_SITE ? ? BY SIMILARITY. FT VNTIFKEY:220; VNTINAME:PTPRG FT DOMAIN 1103 1422 PROTEIN-TYROSINE PHOSPHATASE 2. FT VNTIFKEY:1000; VNTINAME:PTPRG FT SITE ? ? ANCESTRAL ACTIVE SITE. FT VNTIFKEY:265; VNTINAME:PTPRG SQ SEQUENCE 1422 AA; MRRLLQPCWW IFFLKITSSV LHDVVCFPAL TEGYVGSLHE SRHGSSVQIR RRKASGDPYW 60 GYSGTYGPEH WVTSSEKCGG SHQSPIDIVD HQAHVLYEYQ ELQLDGFDNE SSNKTWMKNT 120 GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGQSNGSAG SEHSINGKRF PVEMQIYFYN 180 PDDFDSFGTA VLENREVGAM AVFFQVSQRD NSALDPIIRG LKGVVHHEKE TFLDPFVLRD 240 LLPTSLGSYY RYTGSLTTPP CSEIVEWIIF RKPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300 YLRNNFRPQQ RLNNRKVSKS AVKDAWSQDM TDILENPLGT EASKACSTPP VNMKVQPVNR 360 TALLVTWNQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKAII SHVSPDILYL 420 FRVQAVCRNE MRSDFSQTML FQANTTRIFE GTRIVKTGVP TASPASSADM APISSGSSTW 480 TSSGLPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FSGSSISSFP SSVWPTRLPT 540 AAAPTKQAGR PVVATTEPAA ASPGPERDSA LTKDGEGAEE GEKDEKSESE DGEREHEEED 600 EKEAEKKEKS RATAAAEARN STEPSVATAS PNWTAEEEGN KTVSGEEPNQ NVVPKAGRPE 660 EESFTDADTQ PQPLPSTQVP PAFTDELYLE KIPRRPETTR KPLPKDNRFL EEYPSDNKFI 720 TINPADKNSS SMATRPSPGK MEWIIPLIVV SALTFVCLIL LIAVLVYWRK CFQTAHFYVE 780 DSSSPRVVPN ESIPIIPIPD DMEAIPVKQF VKHISELYSN NQHGFSEDFE EVQRCTADMN 840 ITAEHSNHPD NKHKNRYINI LAYDHSRVKL RPLPGKDSKH SDYINANYVS GYNKAKAYIA 900 TQGPLKSTFE DFWRMIWAQH TGIIVMITNL VEKGRRKCDQ YWPTENSEEY GNIIVTLKST 960 NIHACYTVRP LHGQEHKDEK GSERKPKGRQ NERTVIQYHY TQWPDMGVPE YALPVLTFVR 1020 RSSAARTPHM GPVVVHCSAG VGRTGTYIVI DSMLQQIKDK STVNVLGFLK HIRTQRNYLV 1080 QTEEQYIFIH DALLEAILGK ETEVSANQLH SYVNSILIPG IGGKTRLEKQ FKLVTQCNAK 1140 YVECFSAQKD CNKEKNRNSS VVPSERARVG LAPLPGMKGT DYINASYIMG YYRSNENVIT 1200 QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW PSREESMNCE AFTVTLISKD 1260 RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD APISSTFELI NVIKEEALTR 1320 DGPTIVHDEY GAVSAGTLCA LTTLSQQLEN ENAVDVFQVA KMINLMRPGV FTDIEQYQFL 1380 YKAMLSLVST KENGNGPMTL DKNGAVMASD ESDPAESMES LV 1422 // ID cPTPsigma\(I50212) STANDARD; PRT; 1499 AA. AC I50212; DT 17-MAY-2003 DE protein-tyrosine-phosphatase (EC 3.1.3.48) - chicken. KW phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC GPRFLN|REFERENCE 1 (residues 1 to 1499) CC GPRFLN| AUTHORS Stoker,A.W. CC GPRFLN| TITLE Isoforms of a novel cell adhesion molecule-like protein tyrosine CC GPRFLN| phosphatase are implicated in neural development CC GPRFLN| JOURNAL Mech. Dev. 46 (3), 201-217 (1994) CC GPRFLN| MEDLINE 95001563 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301941142| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1499 VNTIFKEY:269 FT PROTEIN 1 1499 VNTIFKEY:270 FT DOMAIN 148 208 immunoglobulin homology #label IMM1 FT VNTIFKEY:1000; VNTINAME:IMM1 FT DOMAIN 245 299 immunoglobulin homology #label IMM2 FT VNTIFKEY:1000; VNTINAME:IMM2 FT DOMAIN 317 399 fibronectin type III repeat homology #label 3FR FT VNTIFKEY:1018; VNTINAME:3FR FT DOMAIN 881 1499 leukocyte common antigen cytosolic domain homology #label LAC FT VNTIFKEY:1000; VNTINAME:LAC FT ACT_SITE ? ? Cys (phosphocysteine intermediate) FT VNTIFKEY:220; VNTINAME:Active_Site_1 FT BINDING ? ? substrate phosphate (Arg) FT VNTIFKEY:1007; VNTINAME:Binding_1 FT DOMAIN 1257 1479 protein-tyrosine-phosphatase homology #label PTP2 FT VNTIFKEY:1000; VNTINAME:PTP2 FT ACT_SITE ? ? Cys (phosphocysteine intermediate) FT VNTIFKEY:220; VNTINAME:Active_Site_2 FT BINDING ? ? substrate phosphate (Arg) FT VNTIFKEY:1007; VNTINAME:Binding_2 SQ SEQUENCE 1499 AA; MRILPSPGMP ALLSLVSLLS VLLMGCVAES PPVFIKKPVD QIGVSGGVAS FVCQATGDPK 60 PRVTWNKKGK KVNSQRFETI EFDESAGAVL RIQPLRTPRD ENIYECVAQN PHGEVTVHAK 120 LTVLREDQLP PGFPNIDMGP QLKVVERTRT ATMLCAASGN PDPEITWFKD FLPVDPSTSN 180 GRIKQLRSGG LQIESSEETD QGKYECVASN SAGVRYSSPA NLYVRVRRVA PRFSILPVSH 240 EIMPGGNVNI TCVAVGSPMP YVKWMQGAED LTPEDDMPVG RNVLELTDVK DSANYTCVAM 300 SSLGVIEAVA QITVKSLPKA PGTPVVTETT ATSITITWDS GNPDPVSYYV IEYKSKSQDG 360 PYQIKEDITT TRYSIGGLSP NSEYEIWVSA VNSIGQGPPS ESVVTRTGEQ APASAPRNVQ 420 GRMLSSTTMI IQWEEPVEPN GQIRGYRVYY TMEPDQPVSN WQKHNVDDSL LTTVGSLLED 480 ETYTVRVLAF TSVGDGPLSD PIQVKTQQGV PGQPMNFRAE AKTETSIVLS WSPPRQEIIV 540 KYELLFKEGD HGREVPRNFE PTTSFTVEGL KPNTEYVFRL AARSALGLGA FTPEVRERTL 600 QSILPKNFKV KMVTKTSVLL SWEFPENYNS PTPYKIQYNG LNVDVDGRTT KKLITNLKPH 660 TFYNFVLMNR GNSMGGLQQN VAAWTAANML SRKPEVTHKP DADGNVVVIL PDVKSSVAVQ 720 AYYIVVVPLR KSRGGQFLNP LGSPEEMDLE ELIQDIARLR RRSLRHSRQL DFPKPYIAAR 780 FRSLPNHFVL GDMKHYDNFE NRALEPGQRY VIFILAVLQE PEATFAASPF SDPIQLDNPD 840 PQPIIDGEEG LIWVIGPVLA VVFIICIVIA ILLYKNKPDS KRKDSEPRTK CLLNNAEITP 900 HHPKDPVEMR RINFQTPGML SHPPIPVSEL AEHTEHLKAN DNLKLSQEYE SIDPGQQFTW 960 EHSNLEVNKP KNRYANVIAY DHSRVILLPI EGIVGSDYIN ANYIDGYRKQ NAYIATQGPL 1020 PETFGDFWRM VWEQRSATIV MMTKLEEKSR IKCDQYWPGR GTDTYGMIQV TLLDTIELAT 1080 FCVRTFSLHK NGSSEKREVR QFQFTAWPDH GVPEYPTPFL AFLRRVKTCN PPDAGPIVVH 1140 CSAGVGRTGC FIVIDAMLER IKHEKTVDIY GHVTLMRSQR NYMVQTEDQY SFIHDALLEA 1200 VACGNTEVPA RNLYTYIQKL AQIEVGEHVT GMELEFKRLA NSKAHTSRFI SANLPCNKFK 1260 NRLVNIMPYE TTRVCLQPIR GVEGSDYINA SFIDGYRQQK AYIATQGPLA ETTEDFWRML 1320 WENNSTIVVM LTKLREMGRE KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA 1380 RDGQSRTVRQ FQFTDWPEQG VPKSGEGFID FIGQVHKTKE QFGQDGPISV HCSAGVGRTG 1440 VFITLSIVLE RMRYEGVVDI FQTVKMLRTQ PAMVQTEDEY QFCYQAALEY LGSFDHYAT 1499 // ID cPTPzeta\(AAA49015) STANDARD; PRT; 832 AA. AC AAA49015; DT 17-MAY-2003 DE phosphotyrosyl phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 832) CC GPRFLN| AUTHORS Rowley,R.B., Lee,J.M., Corbeil,H.B., Charbonneau,R., Jue,K., CC GPRFLN| Dankort,D.L. and Branton,P.E. CC GPRFLN| TITLE Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and CC GPRFLN| identification of a brain-specific species related to human PTP CC GPRFLN| zeta CC GPRFLN| JOURNAL Cell. Mol. Biol. Res. 39 (3), 209-219 (1993) CC GPRFLN| MEDLINE 94122757 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 832 VNTIFKEY:269 FT PROTEIN 1 832 VNTIFKEY:270 SQ SEQUENCE 832 AA; MQDVLYQGSV THVSEGAAPP SSDKPPKHTS STDGNLWFRN ATELTSQPVG TMDSSHLSQT 60 SYTEDYVEGL KPATVPYSGS PVVSQDTSDV DLELPHYSTF AFSSAELPPH SLSSSSGEYG 120 SASAASEVLS QTTQPIYNEA SNSSHESRIG LAESLESEKK TVIPLVVVSA LTFICLVILV 180 GILIYWRKCF QTAHFYLEDN TSPRVISAPP APVFPVSDDV GAIPIKHFPK HVADLHASNG 240 FSEEFEEIQS CTVDLGITSD SSNHPDNKNK NRYINIVAYD HTRVKLAQLA EKDGKLTDYI 300 NANYVDGYNK PKAYIAAQGP LKSTAEDFWR MIWEHNVEVI VMITNLLEKG RRKCDQYWPA 360 EGSEEYGNFL VTQKSVHVLA YYTVRNFTLR NTKIKKGSQK GRSSGRVVTQ YHYTQWPDMG 420 VPEYTLPVLT FVRKASHAKR HAVGPIVVHC SAGVGRTGTY VVLDSMLQQI QHEGTVNIFG 480 FLKHIRTQRN YLVQTEEQYI FIHDALVEAI LSKETEVLET HIHAYVNALL IPGPTGKTRL 540 EKQFKLLSQS NTQQCDYSTA LKQCNREKNR TSSIIPVERS RVGISSLSGE GTDYINASYI 600 MGYYQSNEFI ITQHPLLHTI KDFWRMIWDH NAQLIVMLPD SQNMAEDEFV YWPNKDEPIN 660 CETFKVTMIA EEHKCLSKEE KLIIQDFILE ATQDDYVLEV RHFQCPKWPN PDSPISKTFE 720 LISIIKEETS NRDGPMIVHD EHGGVTAGTF CALTTLMHQL ENENSVDVYQ VAKMINLMRP 780 GVFTDIEQYQ FLYKAILSLV STRQEENPSA SMDSNGSALP DGNAAESLES LV 832 // ID cSHP2\(JC5167) STANDARD; PRT; 593 AA. AC JC5167; DT 17-MAY-2003 DE protein-tyrosine-phosphatase (EC 3.1.3.48), nonreceptor type 11 - chicken. KW phosphoprotein; phosphoric monoester hydrolase; tyrosine-specific phosphatase. OS Gallus gallus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. CC This enzyme plays positive roles in mitogenic signaling and early CC development. CC GPRFLN|REFERENCE 1 (residues 1 to 593) CC GPRFLN| AUTHORS Park,C.Y., LaMontagne,K.R., Tonks,N.K. and Hayman,M.J. CC GPRFLN| TITLE Cloning and expression of the chicken protein tyrosine phosphatase CC GPRFLN| SH-PTP2 CC GPRFLN| JOURNAL Gene 177 (1-2), 93-97 (1996) CC GPRFLN| MEDLINE 97080506 CC GPRFLN| REMARK erythroblast CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301941188| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 593 VNTIFKEY:269 FT PROTEIN 1 593 phosphotyrosine phosphatase; PTP1D; PTP2c; SH-PTP2; SyP FT VNTIFKEY:270 FT DOMAIN 6 105 SH2 FT VNTIFKEY:1026; VNTINAME:SH2_1 FT DOMAIN 6 100 SH2 homology #label SH2A FT VNTIFKEY:1026; VNTINAME:SH2A FT DOMAIN 112 214 SH2 homology #label SH2B FT VNTIFKEY:1026; VNTINAME:SH2B FT DOMAIN 112 193 SH2 FT VNTIFKEY:1026; VNTINAME:SH2_4 FT DOMAIN 273 510 protein-tyrosine-phosphatase homology #label PTP FT VNTIFKEY:1000; VNTINAME:PTP FT ACT_SITE ? ? Cys (phosphocysteine intermediate) FT VNTIFKEY:220; VNTINAME:Active_Site_1 FT BINDING ? ? substrate phosphate (Arg) FT VNTIFKEY:1007; VNTINAME:Binding_1 FT BINDING ? ? phosphate (Tyr) (covalent) FT VNTIFKEY:1007; VNTINAME:Binding_2 FT BINDING ? ? phosphate (Tyr) (covalent) FT VNTIFKEY:1007; VNTINAME:Binding_3 FT REGION 559 570 proline-rich FT VNTIFKEY:266; VNTINAME:Region_1 FT BINDING ? ? phosphate (Tyr) (covalent) FT VNTIFKEY:1007; VNTINAME:Binding_4 SQ SEQUENCE 593 AA; MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA VTHIKIQNTG 60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGR 120 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIHCQDLKYD 180 VGGGEKFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360 ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 420 RTWPDHGVPS DPGGVLDFLE EVHHKQESIS DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 480 EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH 540 EYTNIKYSLS DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR 593 // ID cypcaCD45\(BAA92179) STANDARD;PRT; 1216 AA. AC BAA92179; DT 17-MAY-2003 DE CD45 [Cyprinus carpio]. OS Cyprinus carpio. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Cyprinus. CC GPRFLN|REFERENCE 1 CC GPRFLN| AUTHORS Fujiki,K., Shin,D.H., Nakao,M. and Yano,T. CC GPRFLN| TITLE Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived CC GPRFLN| chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by CC GPRFLN| use of suppression subtractive hybridisation CC GPRFLN| JOURNAL Fish Shellfish Immunol. 10 (7), 643-650 (2000) CC GPRFLN| MEDLINE 20531692 CC GPRFLN|REFERENCE 2 (residues 1 to 1216) CC GPRFLN| AUTHORS Fujiki,K., Nakao,M., Shin,D. and Yano,T. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (24-AUG-1999) Kazuhiro Fujiki, Kyushu University, CC GPRFLN| Laboratory of Marine Biochemistry, Faculty of Agriculture; Hakozaki CC GPRFLN| 6-10-1, Higashi-ku, Fukuoka, Fukuoka 812-8581, Japan CC GPRFLN| (E-mail:fujikik@agr.kyushu-u.ac.jp, Tel:81-92-642-2896, CC GPRFLN| Fax:81-92-642-2894) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301944007| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1216 VNTIFKEY:269 FT PROTEIN 1 1216 VNTIFKEY:270 SQ SEQUENCE 1216 AA; MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT PALPTGSVKG 60 VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT IRIKDKKSEK KIPVSIVSDT 120 TTIDILFEWL KPCTNYSVNI DNCNVVGENH FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL 180 TKCVNITTED SCVQKPIQIN LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN 240 VTSQCKDTFK VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI 300 NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND TTAECVFSEL 360 KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE DHDNVKVKET SHNSFNVNCK 420 NLKPDEWNGP KGIYIAKLLS NRPPVTKENP KSCSFTFENL YYHTEYTIEI IAINGNKNES 480 SAKATHSTRY NDKALIGFLV FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV 540 EPIYAGGLVE AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD 600 YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ KSSIIVMVTR 660 CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV IRHLILNNKR EKGSEREVTH 720 IQFISWPDHG VPGDPSLLLK LRRRVNSFKN FFSGPVVVHC SAGVGRTGTY MSIDAMIESL 780 EAEGRVDIYG FVAKLRRQRC LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR 840 QKNGSDPSLL EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN 900 QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE FLLMLYQQQT 960 KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET FPTYVRRHLE IQSLKKKEVL 1020 KVDQYQFLKW RGRELPENAQ ELVEMASIIR ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF 1080 CALWNLLDSA YTEKLVDVLQ EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP 1140 PAKDAAQVIN ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK 1200 ATSEGPTNGP TATVEV 1216 // ID fuCD45\(CAB96211) STANDARD; PRT; 1246 AA. AC CAB96211; DT 17-MAY-2003 DE CD45 [Takifugu rubripes]. OS Takifugu rubripes. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu. CC GPRFLN|REFERENCE 1 CC GPRFLN| AUTHORS Diaz del Pozo,E.M., Beverley,P.C. and Timon,M. CC GPRFLN| TITLE Genomic structure and sequence of the leukocyte common antigen CC GPRFLN| (CD45) from the pufferfish Fugu rubripes and comparison with its CC GPRFLN| mammalian homologue CC GPRFLN| JOURNAL Unpublished CC GPRFLN|REFERENCE 2 (residues 1 to 1246) CC GPRFLN| AUTHORS Diaz del Pozo,E.M. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (25-JUN-1999) Diaz del Pozo E.M., CD45 Group, The Edward CC GPRFLN| Jenner Institute for Vaccine Research, High Street, Compton, CC GPRFLN| Newbury, Berkshire, RG20 7NN, UNITED KINGDOM CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301950228| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1246 VNTIFKEY:269 FT PROTEIN 1 1246 VNTIFKEY:270 FT SIGNAL 1 19 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 20 1246 VNTIFKEY:203; VNTINAME:Chain_1 SQ SEQUENCE 1246 AA; MAGYFGLNIL LWAGIVTLAS SSTTSPALTT HASTVTEANV TLLVAPLTST HNSSSNLSTN 60 LSLSSTTPAA ASETTVSLTT PTTPMALTNI SAITSSTNAT SDAPTQPPAA PQCSYTLKPI 120 PFGFRLTISN FTTAGLYNLT LQEQDDMTET TYSPDKTSLD ILDLKPCTSY RHWLSLTLQH 180 SAIDCNQTVN TTATLQPKME DFQNVKSSPG SICYQSKWNI RSLLTQPNNM QLRDDDTFCI 240 RYDSKDICTN FTKNVSTSCG SFPFTKFIDL VPSHITMRRL GVYPEKIETT FPPNCKNWTV 300 EHVCSEKGSP HQNKSLTELE PYTDYSCAAV VTRGTVSMWT EDIDIRINCN LLIYECSKSN 360 VLTNTSMNLH WNLTSSVCKD LFTRFNFSYN CYCDNPVKGS KDVPLKSQQV SCSFSALDAF 420 EDYTCGINVK YKKFSVLDRV FLYRTEPGIP ERPPQLHLDV HEHNQITVKV DKISRFNGPS 480 KFYIVRLYEG KTHKETRNGT KPSFVFKDLS YSTEYTVQAS TFNGHFESSP HTRTTSTFYN 540 EPALINFLIF LIIVTSVALI LVAYKIYVLK RKRSRDTSES MILIPKTNDE EKLIFVEPLT 600 SETLLDAYKR KIADEGRLFL AEFQSIPRIF SKYTVKEAKK SHNVPKNRYV DILPYDYNRV 660 QLTTGNGSAG CDYINASFID GFKELKKYIA AQGPKEETVS NFWRMIWEQQ TSIIVMVSRC 720 EEGNRIKCAQ YWPSEDRDTE IFEEFIVKLT SEDHYPDYII RHLSLTNKKD KGSEREVTHI 780 QFMSWPDHGV PEEAQLLLKL RRRVNSFKNF FSGPIVVHCS AGVGRTGTYI GIDAMMESLE 840 AEGRVDIYGY VVMLRRQRCL MVQVEAQYIL IHQALLEHTQ FGETENTLQE LHSTLNTLKQ 900 RSSDNEPTLL EDEFERLPNF KNWRTFNTGV TEENKKKNRT SSVIPYDYNR VLLKLDEEKS 960 HESDPDPDDD YDTSSYDDIE DSAKYINASL LSGYWGPHTF ISAQTPLPDT VADFWSMILQ 1020 KRVSIVVMLS DCSQGDEDCV YWGEDKKTVE DIEVETESTD NSPNFILRNM MIHHLKTDAH 1080 QQVKHFQFLK WGDKEVPEKP QDLADLIKEI KHRCGYTWPR STPIIVHCND GSSRSGAFCA 1140 LWNLLDNAEK EKMVDVFQVV KTLRKERQGM CPSLEQYQFL YDALEVVYPV QNGDVKAAQN 1200 SVQIVNETAE QQASTTRTDH QEAEEGADGD VSTATGEKSS TVTVEV 1246 // ID hBDP1\(NP_055184)\PTPN18 STANDARD;PRT; 460 AA. AC NP_055184; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from X79568.1 and BI261717.1. CC On Jan 25, 2002 this sequence version replaced gi:7657484. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains a PEST motif, which CC often serves as a protein-protein interaction domain, and may be CC related to protein intracellular half-live. This gene was found to CC be expressed in brain, colon tissues, and several different CC tumor-derived cell lines. The bilogical function of this PTP has CC not yet been determined. CC GPRFLN|REFERENCE 1 (residues 1 to 460) CC GPRFLN| AUTHORS Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and CC GPRFLN| Ullrich,A. CC GPRFLN| TITLE Characterization of the PEST family protein tyrosine phosphatase CC GPRFLN| BDP1 CC GPRFLN| JOURNAL Oncogene 13 (10), 2275-2279 (1996) CC GPRFLN| MEDLINE 97108674 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 460 VNTIFKEY:269 FT PROTEIN 1 460 brain-derived phosphatase FT VNTIFKEY:270 FT REGION 26 292 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 460 AA; MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA GSRPENVRKN 60 RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA YIATQGPLPH TLLDFWRLVW 120 EFGVKVILMA CREIENGRKR CERYWAQEQE PLQTGLFCIT LIKEKWLNED IMLRTLKVTF 180 QKESRSVYQL QYMSWPDRGV PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC 240 TVDYVRQLLL TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS 300 PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM ADTYAVVQKR 360 GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG AHAEDARGTL PGRVPADQSP 420 AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP RDPPAEWTRV 460 // ID hCD45\(NP_002829)\PTPRC STANDARD;PRT; 1304 AA. AC NP_002829; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from Y00638.1 and Y00062.1. CC On Feb 8, 2002 this sequence version replaced gi:4506307. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an extracellular CC domain, a single transmembrane segment and two tandem CC intracytoplasmic catalytic domains, and thus belongs to receptor CC type PTP. This gene is specifically expressed in hematopoietic CC cells. This PTP has been shown to be an essential regulator of T- CC and B-cell antigen receptor signaling. It functions through either CC direct interaction with components of the antigen receptor CC complexes, or by activating various Src family kinases required for CC the antigen receptor signaling. This PTP also suppresses JAK CC kinases, and thus functions as a regulator of cytokine receptor CC signaling. Four alternatively spliced transcripts variants of this CC gene, which encode distinct isoforms, have been reported. CC CC Transcript Variant: This variant (1) encodes the longest isoform CC (1). CC GPRFLN|REFERENCE 1 (residues 1 to 1304) CC GPRFLN| AUTHORS Baldwin,T.A. and Ostergaard,H.L. CC GPRFLN| TITLE The protein-tyrosine phosphatase CD45 reaches the cell surface via CC GPRFLN| golgi-dependent and -independent pathways CC GPRFLN| JOURNAL J. Biol. Chem. 277 (52), 50333-50340 (2002) CC GPRFLN| MEDLINE 22384317 CC GPRFLN| REMARK GeneRIF: reaches the cell surface via Golgi-dependent and CC GPRFLN| -independent pathways CC GPRFLN|REFERENCE 2 (residues 1 to 1304) CC GPRFLN| AUTHORS Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y., CC GPRFLN| Motoda,R., Yoshioka,T. and Orita,K. CC GPRFLN| TITLE CD45 tyrosine phosphatase inhibits erythroid differentiation of CC GPRFLN| umbilical cord blood CD34+ cells associated with selective CC GPRFLN| inactivation of Lyn CC GPRFLN| JOURNAL Blood 100 (13), 4440-4445 (2002) CC GPRFLN| MEDLINE 22340750 CC GPRFLN| REMARK GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45 CC GPRFLN| tyrosine phosphatase inhibits erythroid differentiation of CC GPRFLN| umbilical cord blood CD34+ cells associated with selective CC GPRFLN| inactivation of Lyn. CC GPRFLN|REFERENCE 3 (residues 1 to 1304) CC GPRFLN| AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. CC GPRFLN| TITLE Intra- and intermolecular interactions between intracellular CC GPRFLN| domains of receptor protein-tyrosine phosphatases CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) CC GPRFLN| MEDLINE 22344739 CC GPRFLN| REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are CC GPRFLN| a common but specific mechanism that is likely to be regulated- CC GPRFLN| domain2s and the wedge structures are crucial determinants of CC GPRFLN| binding specificity, thus regulating cross-talk between RPTPs CC GPRFLN|REFERENCE 4 (residues 1 to 1304) CC GPRFLN| AUTHORS Pradhan,D. and Morrow,J. CC GPRFLN| TITLE The spectrin-ankyrin skeleton controls CD45 surface display and CC GPRFLN| interleukin-2 production CC GPRFLN| JOURNAL Immunity 17 (3), 303-315 (2002) CC GPRFLN| MEDLINE 22241694 CC GPRFLN| REMARK GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface CC GPRFLN| display and interleukin-2 production. CC GPRFLN|REFERENCE 5 (residues 1 to 1304) CC GPRFLN| AUTHORS Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S., CC GPRFLN| Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M. CC GPRFLN| TITLE Protein tyrosine phosphatase receptor-type C exon 4 gene mutation CC GPRFLN| distribution in an Italian multiple sclerosis population CC GPRFLN| JOURNAL Neurosci. Lett. 328 (3), 325-327 (2002) CC GPRFLN| MEDLINE 22142931 CC GPRFLN| REMARK GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the CC GPRFLN| protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding CC GPRFLN| for the CD45 molecule, for the development of multiple sclerosis CC GPRFLN| (MS) in Italy. CC GPRFLN|REFERENCE 6 (residues 1 to 1304) CC GPRFLN| AUTHORS Yamada,T., Zhu,D., Saxon,A. and Zhang,K. CC GPRFLN| TITLE CD45 controls interleukin-4-mediated IgE class switch recombination CC GPRFLN| in human B cells through its function as a Janus kinase phosphatase CC GPRFLN| JOURNAL J. Biol. Chem. 277 (32), 28830-28835 (2002) CC GPRFLN| MEDLINE 22151051 CC GPRFLN| REMARK GeneRIF: CD45 controls interleukin-4-mediated IgE class switch CC GPRFLN| recombination in human B cells CC GPRFLN|REFERENCE 7 (residues 1 to 1304) CC GPRFLN| AUTHORS Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y. CC GPRFLN| TITLE Anti-CD45 isoform antibodies enhance phagocytosis and gene CC GPRFLN| expression of IL-8 and TNF-alpha in human neutrophils by CC GPRFLN| differential suppression on protein tyrosine phosphorylation and CC GPRFLN| p56lck tyrosine kinase CC GPRFLN| JOURNAL Clin. Exp. Immunol. 129 (1), 78-85 (2002) CC GPRFLN| MEDLINE 22095000 CC GPRFLN| REMARK GeneRIF: Biological functions of membrane expressed CD45 isoforms CC GPRFLN| on PMNs were studied. Cross-linking of CD45 isoforms by specific CC GPRFLN| MAbs stimulated different PMN activities by differential CC GPRFLN| suppression on protein tyrosine phosphorylation and p56lck. CC GPRFLN|REFERENCE 8 (residues 1 to 1304) CC GPRFLN| AUTHORS Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N. CC GPRFLN| and Hemmer,B. CC GPRFLN| TITLE A novel mutation in PTPRC interferes with splicing and alters the CC GPRFLN| structure of the human CD45 molecule CC GPRFLN| JOURNAL Immunogenetics 54 (3), 158-163 (2002) CC GPRFLN| MEDLINE 22067726 CC GPRFLN| REMARK GeneRIF: a mutation in PTPRC interferes with splicing and alters CC GPRFLN| the structure of the CD45 molecule CC GPRFLN|REFERENCE 9 (residues 1 to 1304) CC GPRFLN| AUTHORS Tchilian,E.Z. and Beverley,P.C. CC GPRFLN| TITLE CD45 in memory and disease CC GPRFLN| JOURNAL Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002) CC GPRFLN| MEDLINE 22017393 CC GPRFLN| REMARK GeneRIF: Role of high and low molecular weight isoforms of CD45 in CC GPRFLN| the function of na##ve and memory T lymphocytes. Review. CC GPRFLN|REFERENCE 10 (residues 1 to 1304) CC GPRFLN| AUTHORS Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and CC GPRFLN| Monostori,E. CC GPRFLN| TITLE Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not CC GPRFLN| mediate its apoptotic signal in T cell lines CC GPRFLN| JOURNAL Immunol. Lett. 82 (1-2), 149-154 (2002) CC GPRFLN| MEDLINE 22003829 CC GPRFLN| REMARK GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but CC GPRFLN| does not mediate its apoptotic signal in Jurkat cells CC GPRFLN|REFERENCE 11 (residues 1 to 1304) CC GPRFLN| AUTHORS Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S. CC GPRFLN| and Matsuda,H. CC GPRFLN| TITLE A study on CD45 isoform expression during T-cell development and CC GPRFLN| selection events in the human thymus CC GPRFLN| JOURNAL Hum. Immunol. 63 (5), 394-404 (2002) CC GPRFLN| MEDLINE 21972715 CC GPRFLN| REMARK GeneRIF: analysis of CD45 isoform expression during T-cell CC GPRFLN| development and selection in the human thymus CC GPRFLN|REFERENCE 12 (residues 1 to 1304) CC GPRFLN| AUTHORS Wu,L., Fu,J. and Shen,S.H. CC GPRFLN| TITLE SKAP55 coupled with CD45 positively regulates T-cell CC GPRFLN| receptor-mediated gene transcription CC GPRFLN| JOURNAL Mol. Cell. Biol. 22 (8), 2673-2686 (2002) CC GPRFLN| MEDLINE 21907230 CC GPRFLN| REMARK GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell CC GPRFLN| receptor-mediated gene transcription. CC GPRFLN|REFERENCE 13 (residues 1 to 1304) CC GPRFLN| AUTHORS Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O. CC GPRFLN| and Kawano,M.M. CC GPRFLN| TITLE Requirements of src family kinase activity associated with CD45 for CC GPRFLN| myeloma cell proliferation by interleukin-6 CC GPRFLN| JOURNAL Blood 99 (6), 2172-2178 (2002) CC GPRFLN| MEDLINE 21866149 CC GPRFLN| REMARK GeneRIF: Requirements of src family kinase activity associated with CC GPRFLN| CD45 for myeloma cell proliferation by interleukin-6 CC GPRFLN|REFERENCE 14 (residues 1 to 1304) CC GPRFLN| AUTHORS Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A., CC GPRFLN| Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F., CC GPRFLN| Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V., CC GPRFLN| Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C. CC GPRFLN| TITLE A CD45 polymorphism associated with abnormal splicing is absent in CC GPRFLN| African populations CC GPRFLN| JOURNAL Immunogenetics 53 (10-11), 980-983 (2002) CC GPRFLN| MEDLINE 21850514 CC GPRFLN| REMARK GeneRIF: we examined the frequency of the C77G allele in African CC GPRFLN| and Asian populations from countries with high or low prevalence of CC GPRFLN| HIV infection; Here we report that the variant CD45 C77G allele is CC GPRFLN| absent in African populations CC GPRFLN|REFERENCE 15 (residues 1 to 1304) CC GPRFLN| AUTHORS Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H. CC GPRFLN| and Badenhoop,K. CC GPRFLN| TITLE CD45 exon 4 point mutation does not confer susceptibility to type 1 CC GPRFLN| diabetes mellitus or Graves' disease CC GPRFLN| JOURNAL Eur. J. Immunogenet. 29 (1), 73-74 (2002) CC GPRFLN| MEDLINE 21830605 CC GPRFLN| REMARK GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility CC GPRFLN| to either IDDM or Graves' disease CC GPRFLN|REFERENCE 16 (residues 1 to 1304) CC GPRFLN| AUTHORS Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M., CC GPRFLN| Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M. CC GPRFLN| TITLE Interleukin-2-dependent but not independent T-cell lines infected CC GPRFLN| with human T-cell leukemia virus type 1 selectively express CD45RO, CC GPRFLN| a marker for persistent infection in vivo CC GPRFLN| JOURNAL Virus Genes 23 (3), 263-271 (2001) CC GPRFLN| MEDLINE 21636965 CC GPRFLN| REMARK GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo CC GPRFLN|REFERENCE 17 (residues 1 to 1304) CC GPRFLN| AUTHORS Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M., CC GPRFLN| Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K., CC GPRFLN| Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and CC GPRFLN| Penninger,J.M. CC GPRFLN| TITLE CD45 is a JAK phosphatase and negatively regulates cytokine CC GPRFLN| receptor signalling CC GPRFLN| JOURNAL Nature 409 (6818), 349-354 (2001) CC GPRFLN| MEDLINE 21069057 CC GPRFLN|REFERENCE 18 (residues 1 to 1304) CC GPRFLN| AUTHORS Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C. CC GPRFLN| TITLE Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on CC GPRFLN| human chromosome band 1q31-->q32 localizes with marker D1S413(1) on CC GPRFLN| a 610-kb yeast artificial chromosome CC GPRFLN| JOURNAL Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999) CC GPRFLN| MEDLINE 20169194 CC GPRFLN|REFERENCE 19 (residues 1 to 1304) CC GPRFLN| AUTHORS Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F., CC GPRFLN| Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J., CC GPRFLN| Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C. CC GPRFLN| TITLE Antiproliferative action of interferon-alpha requires components of CC GPRFLN| T-cell-receptor signalling CC GPRFLN| JOURNAL Nature 390 (6660), 629-632 (1997) CC GPRFLN| MEDLINE 98065953 CC GPRFLN|REFERENCE 20 (residues 1 to 1304) CC GPRFLN| AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M., CC GPRFLN| Ricca,G., Jaye,M. and Schlessinger,J. CC GPRFLN| TITLE Cloning of three human tyrosine phosphatases reveals a multigene CC GPRFLN| family of receptor-linked protein-tyrosine-phosphatases expressed CC GPRFLN| in brain CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990) CC GPRFLN| MEDLINE 90384936 CC GPRFLN|REFERENCE 21 (residues 1 to 1304) CC GPRFLN| AUTHORS Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C. CC GPRFLN| TITLE Association of CD2 and CD45 on human T lymphocytes CC GPRFLN| JOURNAL Nature 345 (6270), 71-74 (1990) CC GPRFLN| MEDLINE 90231464 CC GPRFLN|REFERENCE 22 (residues 1 to 1304) CC GPRFLN| AUTHORS Pingel,J.T. and Thomas,M.L. CC GPRFLN| TITLE Evidence that the leukocyte-common antigen is required for CC GPRFLN| antigen-induced T lymphocyte proliferation CC GPRFLN| JOURNAL Cell 58 (6), 1055-1065 (1989) CC GPRFLN| MEDLINE 89376557 CC GPRFLN|REFERENCE 23 (residues 1 to 1304) CC GPRFLN| AUTHORS Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H. CC GPRFLN| TITLE The leukocyte common antigen (CD45): a putative receptor-linked CC GPRFLN| protein tyrosine phosphatase CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988) CC GPRFLN| MEDLINE 89017162 CC GPRFLN|REFERENCE 24 (residues 1 to 1304) CC GPRFLN| AUTHORS Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H. CC GPRFLN| TITLE Differential usage of three exons generates at least five different CC GPRFLN| mRNAs encoding human leukocyte common antigens CC GPRFLN| JOURNAL J. Exp. Med. 166 (5), 1548-1566 (1987) CC GPRFLN| MEDLINE 88061067 CC GPRFLN|REFERENCE 25 (residues 1 to 1304) CC GPRFLN| AUTHORS Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S. CC GPRFLN| TITLE Structural variants of human T200 glycoprotein (leukocyte-common CC GPRFLN| antigen) CC GPRFLN| JOURNAL EMBO J. 6 (5), 1251-1257 (1987) CC GPRFLN| MEDLINE 87275816 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1304 VNTIFKEY:269 FT PROTEIN 1 1304 protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen FT VNTIFKEY:270 FT SIGNAL 1 23 VNTIFKEY:200; VNTINAME:Signal_1 FT REGION 21 135 HRD1 FT VNTIFKEY:266; VNTINAME:Region_1 FT CHAIN 24 1304 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 390 460 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 486 563 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT REGION 650 910 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 942 1227 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1304 AA; MYLWLKLLAF GFAFLDTEVF VTGQSPTPSP TGLTTAKMPS VPLSSDPLPT HTTAFSPAST 60 FERENDFSET TTSLSPDNTS TQVSPDSLDN ASAFNTTGVS SVQTPHLPTH ADSQTPSAGT 120 DTQTFSGSAA NAKLNPTPGS NAISDVPGER STASTFPTDP VSPLTTTLSL AHHSSAALPA 180 RTSNTTITAN TSDAYLNASE TTTLSPSGSA VISTTTIATT PSKPTCDEKY ANITVDYLYN 240 KETKLFTAKL NVNENVECGN NTCTNNEVHN LTECKNASVS ISHNSCTAPD KTLILDVPPG 300 VEKFQLHDCT QVEKADTTIC LKWKNIETFT CDTQNITYRF QCGNMIFDNK EIKLENLEPE 360 HEYKCDSEIL YNNHKFTNAS KIIKTDFGSP GEPQIIFCRS EAAHQGVITW NPPQRSFHNF 420 TLCYIKETEK DCLNLDKNLI KYDLQNLKPY TKYVLSLHAY IIAKVQRNGS AAMCHFTTKS 480 APPSQVWNMT VSMTSDNSMH VKCRPPRDRN GPHERYHLEV EAGNTLVRNE SHKNCDFRVK 540 DLQYSTDYTF KAYFHNGDYP GEPFILHHST SYNSKALIAF LAFLIIVTSI ALLVVLYKIY 600 DLHKKRSCNL DEQQELVERD DEKQLMNVEP IHADILLETY KRKIADEGRL FLAEFQSIPR 660 VFSKFPIKEA RKPFNQNKNR YVDILPYDYN RVELSEINGD AGSNYINASY IDGFKEPRKY 720 IAAQGPRDET VDDFWRMIWE QKATVIVMVT RCEEGNRNKC AEYWPSMEEG TRAFGDVVVK 780 INQHKRCPDY IIQKLNIVNK KEKATGREVT HIQFTSWPDH GVPEDPHLLL KLRRRVNAFS 840 NFFSGPIVVH CSAGVGRTGT YIGIDAMLEG LEAENKVDVY GYVVKLRRQR CLMVQVEAQY 900 ILIHQALVEY NQFGETEVNL SELHPYLHNM KKRDPPSEPS PLEAEFQRLP SYRSWRTQHI 960 GNQEENKSKN RNSNVIPYDY NRVPLKHELE MSKESEHDSD ESSDDDSDSE EPSKYINASF 1020 IMSYWKPEVM IAAQGPLKET IGDFWQMIFQ RKVKVIVMLT ELKHGDQEIC AQYWGEGKQT 1080 YGDIEVDLKD TDKSSTYTLR VFELRHSKRK DSRTVYQYQY TNWSVEQLPA EPKELISMIQ 1140 VVKQKLPQKN SSEGNKHHKS TPLLIHCRDG SQQTGIFCAL LNLLESAETE EVVDIFQVVK 1200 ALRKARPGMV STFEQYQFLY DVIASTYPAQ NGQVKKNNHQ EDKIEFDNEV DKVKQDANCV 1260 NPLGAPEKLP EAKEQAEGSE PTSGTEGPEH SVNGPASPAL NQGS 1304 // ID hDEP1\(NP_002834)\PTPRJ STANDARD;PRT; 1337 AA. AC NP_002834; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, J precursor; protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from U10886.1. CC On Feb 22, 2002 this sequence version replaced gi:4506315. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region containing five fibronectin type III repeats, a single CC transmembrane region, and a single intracytoplasmic catalytic CC domain, and thus represents a receptor-type PTP. This PTP is CC present in all hematopoietic lineages, and was shown to negatively CC regulate T cell receptor signaling possibly through interfering CC with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and CC Linker for Activation of T Cells (LAT). This PTP was also found to CC dephosphorylate PDGF beta receptor, and may be involved in CC UV-induced signal transduction. CC GPRFLN|REFERENCE 1 (residues 1 to 1337) CC GPRFLN| AUTHORS Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C., CC GPRFLN| Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L., CC GPRFLN| Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G., CC GPRFLN| Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and CC GPRFLN| Demant,P. CC GPRFLN| TITLE Ptprj is a candidate for the mouse colon-cancer susceptibility CC GPRFLN| locus Scc1 and is frequently deleted in human cancers CC GPRFLN| JOURNAL Nat. Genet. 31 (3), 295-300 (2002) CC GPRFLN| MEDLINE 22084388 CC GPRFLN| REMARK GeneRIF: This protein is frequently deleted in human breast CC GPRFLN| cancers. CC GPRFLN|REFERENCE 2 (residues 1 to 1337) CC GPRFLN| AUTHORS Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A. CC GPRFLN| TITLE Protein tyrosine phosphatase CD148-mediated inhibition of T-cell CC GPRFLN| receptor signal transduction is associated with reduced LAT and CC GPRFLN| phospholipase Cgamma1 phosphorylation CC GPRFLN| JOURNAL Mol. Cell. Biol. 21 (7), 2393-2403 (2001) CC GPRFLN| MEDLINE 21160271 CC GPRFLN|REFERENCE 3 (residues 1 to 1337) CC GPRFLN| AUTHORS Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S., CC GPRFLN| Jandt,E., Vilella,R., Bohmer,F. and Ostman,A. CC GPRFLN| TITLE Site-selective dephosphorylation of the platelet-derived growth CC GPRFLN| factor beta-receptor by the receptor-like protein-tyrosine CC GPRFLN| phosphatase DEP-1 CC GPRFLN| JOURNAL J. Biol. Chem. 275 (21), 16219-16226 (2000) CC GPRFLN| MEDLINE 20283660 CC GPRFLN|REFERENCE 4 (residues 1 to 1337) CC GPRFLN| AUTHORS Gross,S., Knebel,A., Tenev,T., Neininger,A., Gaestel,M., CC GPRFLN| Herrlich,P. and Bohmer,F.D. CC GPRFLN| TITLE Inactivation of protein-tyrosine phosphatases as mechanism of CC GPRFLN| UV-induced signal transduction CC GPRFLN| JOURNAL J. Biol. Chem. 274 (37), 26378-26386 (1999) CC GPRFLN| MEDLINE 99403084 CC GPRFLN|REFERENCE 5 (residues 1 to 1337) CC GPRFLN| AUTHORS Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and CC GPRFLN| Aversa,G. CC GPRFLN| TITLE CD148: a receptor-type protein tyrosine phosphatase involved in the CC GPRFLN| regulation of human T cell activation CC GPRFLN| JOURNAL J. Immunol. 161 (7), 3249-3255 (1998) CC GPRFLN| MEDLINE 98430639 CC GPRFLN|REFERENCE 6 (residues 1 to 1337) CC GPRFLN| AUTHORS de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E., CC GPRFLN| Thomas,A.P., Vilella,R., Vives,J. and Gaya,A. CC GPRFLN| TITLE CD148 is a membrane protein tyrosine phosphatase present in all CC GPRFLN| hematopoietic lineages and is involved in signal transduction on CC GPRFLN| lymphocytes CC GPRFLN| JOURNAL Blood 91 (8), 2800-2809 (1998) CC GPRFLN| MEDLINE 98200586 CC GPRFLN|REFERENCE 7 (residues 1 to 1337) CC GPRFLN| AUTHORS Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H. CC GPRFLN| TITLE Molecular cloning, characterization, and chromosomal localization CC GPRFLN| of a novel protein-tyrosine phosphatase, HPTP eta CC GPRFLN| JOURNAL Blood 84 (12), 4186-4194 (1994) CC GPRFLN| MEDLINE 95086212 CC GPRFLN|REFERENCE 8 (residues 1 to 1337) CC GPRFLN| AUTHORS Ostman,A., Yang,Q. and Tonks,N.K. CC GPRFLN| TITLE Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, CC GPRFLN| is enhanced with increasing cell density CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994) CC GPRFLN| MEDLINE 95024024 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1337 VNTIFKEY:269 FT PROTEIN 1 1337 protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen FT VNTIFKEY:270 FT SIGNAL 1 36 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 37 1337 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 119 187 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 369 445 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 540 615 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 626 705 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT REGION 1040 1300 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 1337 AA; MKPAAREARL PPRSPGLRWA LPLLLLLLRL GQILCAGGTP SPIPDPSVAT VATGENGITQ 60 ISSTAESFHK QNGTGTPQVE TNTSEDGESS GANDSLRTPE QGSNGTDGAS QKTPSSTGPS 120 PVFDIKAVSI SPTNVILTWK SNDTAASEYK YVVKHKMENE KTITVVHQPW CNITGLRPAT 180 SYVFSITPGI GNETWGDPRV IKVITEPIPV SDLRVALTGV RKAALSWSNG NGTASCRVLL 240 ESIGSHEELT QDSRLQVNIS GLKPGVQYNI NPYLLQSNKT KGDPLGTEGG LDASNTERSR 300 AGSPTAPVHD ESLVGPVDPS SGQQSRDTEV LLVGLEPGTR YNATVYSQAA NGTEGQPQAI 360 EFRTNAIQVF DVTAVNISAT SLTLIWKVSD NESSSNYTYK IHVAGETDSS NLNVSEPRAV 420 IPGLRSSTFY NITVCPVLGD IEGTPGFLQV HTPPVPVSDF RVTVVSTTEI GLAWSSHDAE 480 SFQMHITQEG AGNSRVEITT NQSIIIGGLF PGTKYCFEIV PKGPNGTEGA SRTVCNRTVP 540 SAVFDIHVVY VTTTEMWLDW KSPDGASEYV YHLVIESKHG SNHTSTYDKA ITLQGLIPGT 600 LYNITISPEV DHVWGDPNST AQYTRPSNVS NIDVSTNTTA ATLSWQNFDD ASPTYSYCLL 660 IEKAGNSSNA TQVVTDIGIT DATVTELIPG SSYTVEIFAQ VGDGIKSLEP GRKSFCTDPA 720 SMASFDCEVV PKEPALVLKW TCPPGANAGF ELEVSSGAWN NATHLESCSS ENGTEYRTEV 780 TYLNFSTSYN ISITTVSCGK MAAPTRNTCT TGITDPPPPD GSPNITSVSH NSVKVKFSGF 840 EASHGPIKAY AVILTTGEAG HPSADVLKYT YDDFKKGASD TYVTYLIRTE EKGRSQSLSE 900 VLKYEIDVGN ESTTLGYYNG KLEPLGSYRA CVAGFTNITF HPQNKGLIDG AESYVSFSRY 960 SDAVSLPQDP GVICGAVFGC IFGALVIVTV GGFIFWRKKR KDAKNNEVSF SQIKPKKSKL 1020 IRVENFEAYF KKQQADSNCG FAEEYEDLKL VGISQPKYAA ELAENRGKNR YNNVLPYDIS 1080 RVKLSVQTHS TDDYINANYM PGYHSKKDFI ATQGPLPNTL KDFWRMVWEK NVYAIIMLTK 1140 CVEQGRTKCE EYWPSKQAQD YGDITVAMTS EIVLPEWTIR DFTVKNIQTS ESHPLRQFHF 1200 TSWPDHGVPD TTDLLINFRY LVRDYMKQSP PESPILVHCS AGVGRTGTFI AIDRLIYQIE 1260 NENTVDVYGI VYDLRMHRPL MVQTEDQYVF LNQCVLDIVR SQKDSKVDLI YQNTTAMTIY 1320 ENLAPVTTFG KTNGYIA 1337 // ID hGLEPP1\(NP_109592)\PTPRO STANDARD;PRT; 1216 AA. AC NP_109592; DT 17-MAY-2003 DE receptor-type protein tyrosine phosphatase O isoform a precursor; glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from Z48541.1 and U20489.1. CC CC Summary: This gene encodes a receptor-type protein tyrosine CC phosphatase containing a single intracellular catalytic domain with CC a characteristic signature motif. The gene product, which has a CC transmembrane domain, is an integral membrane protein. Several CC alternatively spliced transcript variants, some of which encode CC different isoforms of the protein, have been described. These CC variants exhibit tissue-specific expression. CC CC Transcript Variant: This variant (1) encodes the longest isoform CC (a) known to date. The encoded protein has a large extracellular CC domain containing 8 repeats of a fibronectin type III-like motif. CC This variant is expressed in the glomerulus of kidney and in brain. CC In kidney, it may play a role in regulating glomerular epithelial CC cell (podocyte) structure and/or function. CC GPRFLN|REFERENCE 1 (residues 1 to 1216) CC GPRFLN| AUTHORS Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J. CC GPRFLN| and Shipp,M.A. CC GPRFLN| TITLE PTPROt: an alternatively spliced and developmentally regulated CC GPRFLN| B-lymphoid phosphatase that promotes G0/G1 arrest CC GPRFLN| JOURNAL Blood 94 (7), 2403-2413 (1999) CC GPRFLN| MEDLINE 99428326 CC GPRFLN|REFERENCE 2 (residues 1 to 1216) CC GPRFLN| AUTHORS Seimiya,H., Sawabe,T., Inazawa,J. and Tsuruo,T. CC GPRFLN| TITLE Cloning, expression and chromosomal localization of a novel gene CC GPRFLN| for protein tyrosine phosphatase (PTP-U2) induced by various CC GPRFLN| differentiation-inducing agents CC GPRFLN| JOURNAL Oncogene 10 (9), 1731-1738 (1995) CC GPRFLN| MEDLINE 95273089 CC GPRFLN|REFERENCE 3 (residues 1 to 1216) CC GPRFLN| AUTHORS Wiggins,R.C., Wiggins,J.E., Goyal,M., Wharram,B.L. and Thomas,P.E. CC GPRFLN| TITLE Molecular cloning of cDNAs encoding human GLEPP1, a membrane CC GPRFLN| protein tyrosine phosphatase: characterization of the GLEPP1 CC GPRFLN| protein distribution in human kidney and assignment of the GLEPP1 CC GPRFLN| gene to human chromosome 12p12-p13 CC GPRFLN| JOURNAL Genomics 27 (1), 174-181 (1995) CC GPRFLN| MEDLINE 95394455 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1216 VNTIFKEY:269 FT PROTEIN 1 1216 glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt FT VNTIFKEY:270 FT SIGNAL 1 29 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 30 1216 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 50 813 VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 436 521 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 726 805 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT TRANSMEM 820 844 VNTIFKEY:210; VNTINAME:Transmem_1 FT REGION 937 1192 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT DOMAIN 1134 1144 VNTIFKEY:1000; VNTINAME:Dom_Misc_3 SQ SEQUENCE 1216 AA; MGHLPTGIHG ARRLLPLLWL FVLFKNATAF HVTVQDDNNI VVSLEASDVI SPASVYVVKI 60 TGESKNYFFE FEEFNSTLPP PVIFKASYHG LYYIITLVVV NGNVVTKPSR SITVLTKPLP 120 VTSVSIYDYK PSPETGVLFE IHYPEKYNVF TRVNISYWEG KDFRTMLYKD FFKGKTVFNH 180 WLPGMCYSNI TFQLVSEATF NKSTLVEYSG VSHEPKQHRT APYPPQNISV RIVNLNKNNW 240 EEQSGNFPEE SFMRSQDTIG KEKLFHFTEE TPEIPSGNIS SGWPDFNSSD YETTSQPYWW 300 DSASAAPESE DEFVSVLPME YENNSTLSET EKSTSGSFSF FPVQMILTWL PPKPPTAFDG 360 FHIHIEREEN FTEYLMVDEE AHEFVAELKE PGKYKLSVTT FSSSGSCETR KSQSAKSLSF 420 YISPSGEWIE ELTEKPQHVS VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR 480 LEKQYCTQVN SSKPIIENLV PGAQYQVVIY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP 540 LGPTAVVLSW TRPYLGVFRK YVVEMFYFNP ATMTSEWTTY YEIAATVSLT ASVRIANLLP 600 AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS WTYGDDTTDL 660 SHSRMLHWMV VAEGKKKIKK SVTRNVMTAI LSLPPGDIYN LSVTACTERG SNTSMLRLVK 720 LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD FFEVFCQQVG SSQKTKLQEP VAVSSHVVTI 780 SSLLPATAYN CSVTSFSHDS PSVPTFIAVS TMVTEMNPNV VVISVLAILS TLLIGLLLVT 840 LIILRKKHLQ MARECGAGTF VNFASLERDG KLPYNWRRSI FAFLTLLPSC LWTDYLLAFY 900 INPWSKNGLK KRKLTNPVQL DDFDAYIKDM AKDSDYKFSL QFEELKLIGL DIPHFAADLP 960 LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG YNSPQEYIAT QGPLPETRND 1020 FWKMVLQQKS QIIVMLTQCN EKRRVKCDHY WPFTEEPIAY GDITVEMISE EEQDDWACRH 1080 FRINYADEMQ DVMHFNYTAW PDHGVPTANA AESILQFVHM VRQQATKSKG PMIIHCSAGV 1140 GRTGTFIALD RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWMKKK 1200 QQFCISDVIY ENVSKS 1216 // ID hHDPTP\(NP_056281)\PTPN23 STANDARD;PRT; 1636 AA. AC NP_056281; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 23; His-domain protein tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC PREDICTED REFSEQ: The mRNA record is supported by experimental CC evidence; however, the coding sequence is predicted. The reference CC sequence was derived from AF290614.1. CC GPRFLN|REFERENCE 1 (residues 1 to 1636) CC GPRFLN| AUTHORS Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Lu,C., Wang,M. and He,F. CC GPRFLN| TITLE Cloning, chromosomal assignment and tissue expression of a novel CC GPRFLN| human protein tyrosine phosphatase (PTP-TD14) gene CC GPRFLN| JOURNAL I Chuan 23 (6), 1-9 (2001) CC GPRFLN|REFERENCE 2 (residues 1 to 1636) CC GPRFLN| AUTHORS Toyooka,S., Ouchida,M., Jitsumori,Y., Tsukuda,K., Sakai,A., CC GPRFLN| Nakamura,A., Shimizu,N. and Shimizu,K. CC GPRFLN| TITLE HD-PTP: A novel protein tyrosine phosphatase gene on human CC GPRFLN| chromosome 3p21.3 CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 278 (3), 671-678 (2000) CC GPRFLN| MEDLINE 20549011 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1636 VNTIFKEY:269 FT PROTEIN 1 1636 His-domain protein tyrosine phosphatase FT VNTIFKEY:270 FT DOMAIN 8 161 BRO1 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 550 711 Smc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 1191 1454 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 1636 AA; MEAVPRMPMI WLDLKEAGDF HFQPAVKKFV LKNYGENPEA YNEELKKLEL LRQNAVRVPR 60 DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVPVTWTEIF SGKSVAHEDI KYEQACILYN 120 LGALHSMLGA MDKRVSEEGM KVSCTHFQCA AGAFAYLREH FPQAYSVDMS RQILTLNVNL 180 MLGQAQECLL EKSMLDNRKS FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL 240 VQMKIYYFAA VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF 300 TMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA VTGPDIFAKL 360 VPMAAHEASS LYSEEKAKLL REMMAKIEDK NEVLDQFMDS MQLDPETVDN LDAYSHIPPQ 420 LMEKCAALSV RPDTVRNLVQ SMQVLSGVFT DVEASLKDIR DLLEEDELLE QKFQEAVGQA 480 GAISITSKAE LAEVRREWAK YMEVHEKASF TNSELHRAMN LHVGNLRLLS GPLDQVRAAL 540 PTPALSPEDK AVLQNLKRIL AKVQEMRDQR VSLEQQLREL IQKDDITASL VTTDHSEMKK 600 LFEEQLKKYD QLKVYLEQNL AAQDRVLCAL TEANVQYAAV RRVLSDLDQK WNSTLQTLVA 660 SYEAYEDLMK KSQEGRDFYA DLESKVAALL ERTQSTCQAR EAARQQLLDR ELKKKPPPRP 720 TAPKPLLPRR EESEAVEAGD PPEELRSLPP DMVAGPRLPD TFLGSATPLH FPPSPFPSST 780 GPGPHYLSGP LPPGTYSGPT QLIQPRAPGP HAMPVAPGPA LYPAPAYTPE LGLVPRSSPQ 840 HGVVSSPYVG VGPAPPVAGL PSAPPPQFSG PELAMAVRPA TTTVDSIQAP IPSHTAPRPN 900 PTPAPPPPCF PVPPPQPLPT PYTYPAGAKQ PIPAQHHFSS GIPAGFPAPR IGPQPQPHPQ 960 PHPSQAFGPQ PPQQPLPLQH PHLFPPQAPG LLPPQSPYPY APQPGVLGQP PPPLHTQLYP 1020 GPAQDPLPAH SGALPFPSPG PPQPPHPPLA YGPAPSTRPM GPQAAPLTIR GPSSAGQSTP 1080 SPHLVPSPAP SPGPGPVPPR PPAAEPPPCL RRGAAAADLL SSSPESQHGG TQSPGGGQPL 1140 LQPTKVDAAE GRRPQALRLI ERDPYEHPER LRQLQQELEA FRGQLGDVGA LDTVWRELQD 1200 AQEHDARGRS IAIARCYSLK NRHQDVMPYD SNRVVLRSGK DDYINASCVE GLSPYCPPLV 1260 ATQAPLPGTA ADFWLMVHEQ KVSVIVMLVS EAEMEKQKVA RYFPTERGQP MVHGALSLAL 1320 SSVRSTETHV ERVLSLQFRD QSLKRSLVHL HFPTWPELGL PDSPSNLLRF IQEVHAHYLH 1380 QRPLHTPIIV HCSSGVGRTG AFALLYAAVQ EVEAGNGIPE LPQLVRRMRQ QRKHMLQEKL 1440 HLRFCYEAVV RHVEQVLQRH GVPPPCKPLA SASISQKNHL PQDSQDLVLG GDVPISSIQA 1500 TIAKLSIRPP GGLESPVASL PGPAEPPGLP PASLPESTPI PSSSPPPLSS PLPEAPQPKE 1560 EPPVPEAPSS GPPSSSLELL ASLTPEAFSL DSSLRGKQRM SKHNFLQAHN GQGLRATRPS 1620 DDPLSLLDPL WTLNKT 1636 // ID hHePTP\(NP_002823)\PTPN7 STANDARD;PRT; 360 AA. AC NP_002823; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 7 isoform 1; protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from BC001746.1, BG340453.1, CC D11327.1 and M64322.1. CC On Jan 25, 2002 this sequence version replaced gi:4506299. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This gene is preferentially expressed in CC a variety of hematopoietic cells, and is an early response gene in CC lymphokine stimulated cells. The noncatalytic N-terminus of this CC PTP can interact with MAP kinases and suppress the MAP kinase CC activities. This PTP was shown to be involved in the regulation of CC T cell antigen receptor (TCR) signaling, which was thought to CC function through dephosphorylating the molecules related to MAP CC kinase pathway. Three alternatively spliced transcript variants of CC this gene, which encode two distinct isoforms, are reported. CC CC Transcript Variant: This variant (1) contains a different 5' CC region, which includes a part of the coding sequence when compared CC to variant 2. It thus encodes a protein that has a shorter CC N-terminus, as compared to isoform 2. CC GPRFLN|REFERENCE 1 (residues 1 to 360) CC GPRFLN| AUTHORS Oh-hora,M., Ogata,M., Mori,Y., Adachi,M., Imai,K., Kosugi,A. and CC GPRFLN| Hamaoka,T. CC GPRFLN| TITLE Direct suppression of TCR-mediated activation of extracellular CC GPRFLN| signal-regulated kinase by leukocyte protein tyrosine phosphatase, CC GPRFLN| a tyrosine-specific phosphatase CC GPRFLN| JOURNAL J. Immunol. 163 (3), 1282-1288 (1999) CC GPRFLN| MEDLINE 99343735 CC GPRFLN|REFERENCE 2 (residues 1 to 360) CC GPRFLN| AUTHORS Saxena,M., Williams,S., Brockdorff,J., Gilman,J. and Mustelin,T. CC GPRFLN| TITLE Inhibition of T cell signaling by mitogen-activated protein CC GPRFLN| kinase-targeted hematopoietic tyrosine phosphatase (HePTP) CC GPRFLN| JOURNAL J. Biol. Chem. 274 (17), 11693-11700 (1999) CC GPRFLN| MEDLINE 99223488 CC GPRFLN|REFERENCE 3 (residues 1 to 360) CC GPRFLN| AUTHORS Saxena,M., Williams,S., Gilman,J. and Mustelin,T. CC GPRFLN| TITLE Negative regulation of T cell antigen receptor signal transduction CC GPRFLN| by hematopoietic tyrosine phosphatase (HePTP) CC GPRFLN| JOURNAL J. Biol. Chem. 273 (25), 15340-15344 (1998) CC GPRFLN| MEDLINE 98288260 CC GPRFLN|REFERENCE 4 (residues 1 to 360) CC GPRFLN| AUTHORS Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P. CC GPRFLN| TITLE Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells CC GPRFLN| induces tyrosine phosphorylation of the cytosolic protein-tyrosine CC GPRFLN| phosphatase HePTP CC GPRFLN| JOURNAL J. Biol. Chem. 270 (37), 21902-21906 (1995) CC GPRFLN| MEDLINE 95394959 CC GPRFLN|REFERENCE 5 (residues 1 to 360) CC GPRFLN| AUTHORS Adachi,M., Sekiya,M., Isobe,M., Kumura,Y., Ogita,Z., Hinoda,Y., CC GPRFLN| Imai,K. and Yachi,A. CC GPRFLN| TITLE Molecular cloning and chromosomal mapping of a human CC GPRFLN| protein-tyrosine phosphatase LC-PTP CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 186 (3), 1607-1615 (1992) CC GPRFLN| MEDLINE 92378634 CC GPRFLN|REFERENCE 6 (residues 1 to 360) CC GPRFLN| AUTHORS Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., CC GPRFLN| Imai,K. and Yachi,A. CC GPRFLN| TITLE Protein-tyrosine phosphatase expression in pre-B cell NALM-6 CC GPRFLN| JOURNAL Cancer Res. 52 (3), 737-740 (1992) CC GPRFLN| MEDLINE 92119637 CC GPRFLN|REFERENCE 7 (sites) CC GPRFLN| AUTHORS Zanke,B., Suzuki,H., Kishihara,K., Mizzen,L., Minden,M., Pawson,A. CC GPRFLN| and Mak,T.W. CC GPRFLN| TITLE Cloning and expression of an inducible lymphoid-specific, protein CC GPRFLN| tyrosine phosphatase (HePTPase) CC GPRFLN| JOURNAL Eur. J. Immunol. 22 (1), 235-239 (1992) CC GPRFLN| MEDLINE 92111631 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 360 VNTIFKEY:269 FT PROTEIN 1 360 protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase FT VNTIFKEY:270 FT REGION 96 350 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 360 AA; MVQAHGGRSR AQPLTLSLGA AMTQPPPEKT PAKKHVRLQE RRGSNVALML DVRSLGAVEP 60 ICSVNTPREV TLHFLRTAGH PLTRWALQRQ PPSPKQLEEE FLKIPSNFVS PEDLDIPGHA 120 SKDRYKTILP NPQSRVCLGR AQSQEDGDYI NANYIRGYDG KEKVYIATQG PMPNTVSDFW 180 EMVWQEEVSL IVMLTQLREG KEKCVHYWPT EEETYGPFQI RIQDMKECPE YTVRQLTIQY 240 QEERRSVKHI LFSAWPDHQT PESAGPLLRL VAEVEESPET AAHPGPIVVH CSAGIGRTGC 300 FIATRIGCQQ LKARGEVDIL GIVCQLRLDR GGMIQTAEQY QFLHHTLALY AGQLPEEPSP 360 // ID hIA2\(NP_002837)\PTPRN STANDARD;PRT; 979 AA. AC NP_002837; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, N precursor; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from L18983.1, AF042285.4 and CC BC007713.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and a single catalytic CC domain, and thus represents a receptor-type PTP. This PTP was found CC to be an autoantigen that is reactive with insulin-dependent CC diabetes mellitus (IDDM) patient sera, and thus may be a potential CC target of autoimmunity in diabetes mellitus. CC GPRFLN|REFERENCE 1 (residues 1 to 979) CC GPRFLN| AUTHORS Sanjeevi,C.B., Das,A.K. and Shtauvere-Brameus,A. CC GPRFLN| TITLE BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune CC GPRFLN| diabetes in southern India CC GPRFLN| JOURNAL Ann. N. Y. Acad. Sci. 958, 293-296 (2002) CC GPRFLN| MEDLINE 22015049 CC GPRFLN| REMARK GeneRIF: BCG vaccination and GAD65 and IA-2 autoantibodies in CC GPRFLN| autoimmune diabetes in southern India. CC GPRFLN|REFERENCE 2 (residues 1 to 979) CC GPRFLN| AUTHORS Kawasaki,E., Yamaguchi,H., Hattori,H., Egashira,T. and Eguchi,K. CC GPRFLN| TITLE Autoantibodies to IA-2 in type 1 diabetes: measurements with a new CC GPRFLN| enzyme-linked immunosorbent assay CC GPRFLN| JOURNAL Ann. N. Y. Acad. Sci. 958, 241-246 (2002) CC GPRFLN| MEDLINE 22015037 CC GPRFLN| REMARK GeneRIF: Autoantibodies to IA-2 in type 1 diabetes: measurements CC GPRFLN| with a new enzyme-linked immunosorbent assay. CC GPRFLN|REFERENCE 3 (residues 1 to 979) CC GPRFLN| AUTHORS Miao,D., Yu,L., Tiberti,C., Cuthbertson,D.D., Rewers,M., di CC GPRFLN| Mario,U., Eisenbarth,G.S. and Dotta,F. CC GPRFLN| TITLE ICA512(IA-2) epitope specific assays distinguish transient from CC GPRFLN| diabetes associated autoantibodies CC GPRFLN| JOURNAL J. Autoimmun. 18 (2), 191-196 (2002) CC GPRFLN| MEDLINE 21906940 CC GPRFLN| REMARK GeneRIF: ICA512(IA-2) epitope specific assays distinguish transient CC GPRFLN| from diabetes associated autoantibodies. CC GPRFLN|REFERENCE 4 (residues 1 to 979) CC GPRFLN| AUTHORS Mikulecky,M. and Michalkova,D. CC GPRFLN| TITLE Secular and seasonal cycling of IA2-ab autoantibody in Slovak CC GPRFLN| diabetic children CC GPRFLN| JOURNAL Biomed. Pharmacother. 55 Suppl 1, 106S-109S (2001) CC GPRFLN| MEDLINE 21630621 CC GPRFLN|REFERENCE 5 (residues 1 to 979) CC GPRFLN| AUTHORS Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J. CC GPRFLN| TITLE Cloning and characterization of islet cell antigen-related CC GPRFLN| protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and CC GPRFLN| autoantigen in insulin-dependent diabetes CC GPRFLN| JOURNAL J. Biol. Chem. 271 (40), 24817-24823 (1996) CC GPRFLN| MEDLINE 96394649 CC GPRFLN|REFERENCE 6 (residues 1 to 979) CC GPRFLN| AUTHORS van den Maagdenberg,A.M., Olde Weghuis,D., Rijss,J., van de CC GPRFLN| Wetering,R.A., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J. CC GPRFLN| TITLE Assignment of the human gene for receptor-type protein tyrosine CC GPRFLN| phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and CC GPRFLN| identification of an intragenic genetic marker CC GPRFLN| JOURNAL Cytogenet. Cell Genet. 73 (1-2), 145-148 (1996) CC GPRFLN| MEDLINE 96244610 CC GPRFLN|REFERENCE 7 (residues 1 to 979) CC GPRFLN| AUTHORS Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L. CC GPRFLN| TITLE Molecular cloning and identification of a receptor-type protein CC GPRFLN| tyrosine phosphatase, IA-2, from human insulinoma CC GPRFLN| JOURNAL DNA Cell Biol. 13 (5), 505-514 (1994) CC GPRFLN| MEDLINE 94296553 CC GPRFLN|REFERENCE 8 (residues 1 to 979) CC GPRFLN| AUTHORS Rabin,D.U., Pleasic,S.M., Shapiro,J.A., Yoo-Warren,H., Oles,J., CC GPRFLN| Hicks,J.M., Goldstein,D.E. and Rae,P.M. CC GPRFLN| TITLE Islet cell antigen 512 is a diabetes-specific islet autoantigen CC GPRFLN| related to protein tyrosine phosphatases CC GPRFLN| JOURNAL J. Immunol. 152 (6), 3183-3188 (1994) CC GPRFLN| MEDLINE 94194080 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 979 VNTIFKEY:269 FT PROTEIN 1 979 islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor FT VNTIFKEY:270 FT SIGNAL 1 25 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 26 979 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 709 970 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 979 AA; MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG 60 QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE 120 PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL 180 LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA 240 PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG 300 SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL 360 LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE 420 VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP 480 LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE 540 LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV 600 RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ 660 FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ 720 AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY 780 IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV 840 SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG 900 RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE 960 FALTAVAEEV NAILKALPQ 979 // ID hIA2beta\(NP_002838)\PTPRN2 STANDARD;PRT; 1015 AA. AC NP_002838; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor; protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from U66702.1 and AF007555.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and a single intracellular CC catalytic domain, and thus represents a receptor-type PTP. The CC catalytic domain of this PTP is most closely related to CC PTPRN/IA-2beta. This PTP and PTPRN are both found to be major CC autoantigens associated with insulin-dependent diabetes mellitus. CC Three alternatively spliced transcript variants of this gene, which CC encode distinct proteins, have been reported. CC CC Transcript Variant: This variant (1) encodes the longest isoform CC (1). CC GPRFLN|REFERENCE 1 (residues 1 to 1015) CC GPRFLN| AUTHORS van den Maagdenberg,A.M., Schepens,J.T., Schepens,M.T., Pepers,B., CC GPRFLN| Wieringa,B., van Kessel,A.G. and Hendriks,W.J. CC GPRFLN| TITLE Assignment of Ptprn2, the gene encoding receptor-type protein CC GPRFLN| tyrosine phosphatase IA-2beta, a major autoantigen in CC GPRFLN| insulin-dependent diabetes mellitus, to mouse chromosome region 12F CC GPRFLN| JOURNAL Cytogenet. Cell Genet. 82 (3-4), 153-155 (1998) CC GPRFLN| MEDLINE 99077744 CC GPRFLN|REFERENCE 2 (residues 1 to 1015) CC GPRFLN| AUTHORS Schmidli,R.S., Colman,P.G., Cui,L., Yu,W.P., Kewming,K., CC GPRFLN| Jankulovski,C., Harrison,L.C., Pallen,C.J. and DeAizpurua,H.J. CC GPRFLN| TITLE Antibodies to the protein tyrosine phosphatases IAR and IA-2 are CC GPRFLN| associated with progression to insulin-dependent diabetes (IDDM) in CC GPRFLN| first-degree relatives at-risk for IDDM CC GPRFLN| JOURNAL Autoimmunity 28 (1), 15-23 (1998) CC GPRFLN| MEDLINE 98425805 CC GPRFLN|REFERENCE 3 (residues 1 to 1015) CC GPRFLN| AUTHORS Li,Q., Borovitskaya,A.E., DeSilva,M.G., Wasserfall,C., CC GPRFLN| Maclaren,N.K., Notkins,A.L. and Lan,M.S. CC GPRFLN| TITLE Autoantigens in insulin-dependent diabetes mellitus: molecular CC GPRFLN| cloning and characterization of human IA-2 beta CC GPRFLN| JOURNAL Proc. Assoc. Am. Physicians 109 (4), 429-439 (1997) CC GPRFLN| MEDLINE 97364262 CC GPRFLN|REFERENCE 4 (residues 1 to 1015) CC GPRFLN| AUTHORS Smith,P.D., Barker,K.T., Wang,J., Lu,Y.J., Shipley,J. and CC GPRFLN| Crompton,M.R. CC GPRFLN| TITLE ICAAR, a novel member of a new family of transmembrane, tyrosine CC GPRFLN| phosphatase-like proteins CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 229 (2), 402-411 (1996) CC GPRFLN| MEDLINE 97127415 CC GPRFLN|REFERENCE 5 (residues 1 to 1015) CC GPRFLN| AUTHORS Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S. CC GPRFLN| TITLE Molecular cloning and characterization of the human transmembrane CC GPRFLN| protein tyrosine phosphatase homologue, phogrin, an autoantigen of CC GPRFLN| type 1 diabetes CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 227 (2), 440-447 (1996) CC GPRFLN| MEDLINE 97032784 CC GPRFLN|REFERENCE 6 (residues 1 to 1015) CC GPRFLN| AUTHORS Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J. CC GPRFLN| TITLE Cloning and characterization of islet cell antigen-related CC GPRFLN| protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and CC GPRFLN| autoantigen in insulin-dependent diabetes CC GPRFLN| JOURNAL J. Biol. Chem. 271 (40), 24817-24823 (1996) CC GPRFLN| MEDLINE 96394649 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1015 VNTIFKEY:269 FT PROTEIN 1 1015 protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase FT VNTIFKEY:270 FT SIGNAL 1 21 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 22 1015 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 745 1006 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 1015 AA; MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNDGVFGR 60 CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY TQYVMDQELA DLPKTYLRRP 120 EASSPARPSK HSVGSERRYS REGGAALANA LRRHLPFLEA LSQAPASDVL ARTHTAQDRP 180 PAEGDDRFSE SILTYVAHTS ALTYPPGPRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH 240 HLMAALSAYA AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS 300 TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG SPGRAALGES 360 GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG GLLQDHGSRL LPGALPFARP 420 LDMERKKSEH PESSLSSEEE TAGVENVKSQ TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP 480 SKEEQSLPAG AQEALSDGLQ LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP 540 SSAFADVEVL GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL 600 KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK LSGLGGDPGA 660 DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG PIPSPSARSS ASSWSEEPVQ 720 SNMDISTGHM ILSYMEDHLK NKNRLEKEWE ALCAYQAEPN SSFVAQREEN VPKNRSLAVL 780 TYDHSRVLLK AENSHSHSDY INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV 840 VIVMLTPLAE NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET 900 RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG RSGTYVLIDM 960 VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT AVAEEVNAIL KALPQ 1015 // ID hLAR\(NP_002831)\PTPRF STANDARD;PRT; 1897 AA. AC NP_002831; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, F isoform 1 precursor; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from Y00815.1 and BI711143.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and two tandem CC intracytoplasmic catalytic domains, and thus represents a CC receptor-type PTP. The extracellular region contains three Ig-like CC domains, and nine non-Ig like domains similar to that of CC neural-cell adhesion molecule. This PTP was shown to function in CC the regulation of epithelial cell-cell contacts at adherents CC junctions, as well as in the control of beta-catenin signaling. An CC increased expression level of this protein was found in the CC insulin-responsive tissue of obese, insulin-resistant individuals, CC and may contribute to the pathogenesis of insulin resistance. Two CC alternatively spliced transcript variants of this gene, which CC encode distinct proteins, have been reported. CC CC Transcript Variant: This variant (1) contains an extra internal CC fragment within the coding region when compared to variant 2. It CC thus encodes a protein that has a 9 aa internal fragment absent in CC isoform 2. CC GPRFLN|REFERENCE 1 (residues 1 to 1897) CC GPRFLN| AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. CC GPRFLN| TITLE Intra- and intermolecular interactions between intracellular CC GPRFLN| domains of receptor protein-tyrosine phosphatases CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) CC GPRFLN| MEDLINE 22344739 CC GPRFLN| REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are CC GPRFLN| a common but specific mechanism that is likely to be regulated- CC GPRFLN| domain2s and the wedge structures are crucial determinants of CC GPRFLN| binding specificity, thus regulating cross-talk between RPTPs CC GPRFLN|REFERENCE 2 (residues 1 to 1897) CC GPRFLN| AUTHORS Symons,J.R., LeVea,C.M. and Mooney,R.A. CC GPRFLN| TITLE Expression of the leucocyte common antigen-related (LAR) tyrosine CC GPRFLN| phosphatase is regulated by cell density through functional CC GPRFLN| E-cadherin complexes CC GPRFLN| JOURNAL Biochem. J. 365 (Pt 2), 513-519 (2002) CC GPRFLN| MEDLINE 22090243 CC GPRFLN| REMARK GeneRIF: regulation of expression by cell density through CC GPRFLN| functional E-cadherin complexes CC GPRFLN|REFERENCE 3 (residues 1 to 1897) CC GPRFLN| AUTHORS Zabolotny,J.M., Kim,Y.B., Peroni,O.D., Kim,J.K., Pani,M.A., CC GPRFLN| Boss,O., Klaman,L.D., Kamatkar,S., Shulman,G.I., Kahn,B.B. and CC GPRFLN| Neel,B.G. CC GPRFLN| TITLE Overexpression of the LAR (leukocyte antigen-related) CC GPRFLN| protein-tyrosine phosphatase in muscle causes insulin resistance CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (9), 5187-5192 (2001) CC GPRFLN| MEDLINE 21221100 CC GPRFLN|REFERENCE 4 (residues 1 to 1897) CC GPRFLN| AUTHORS Muller,T., Choidas,A., Reichmann,E. and Ullrich,A. CC GPRFLN| TITLE Phosphorylation and free pool of beta-catenin are regulated by CC GPRFLN| tyrosine kinases and tyrosine phosphatases during epithelial cell CC GPRFLN| migration CC GPRFLN| JOURNAL J. Biol. Chem. 274 (15), 10173-10183 (1999) CC GPRFLN| MEDLINE 99214576 CC GPRFLN|REFERENCE 5 (residues 1 to 1897) CC GPRFLN| AUTHORS Ahmad,F. and Goldstein,B.J. CC GPRFLN| TITLE Functional association between the insulin receptor and the CC GPRFLN| transmembrane protein-tyrosine phosphatase LAR in intact cells CC GPRFLN| JOURNAL J. Biol. Chem. 272 (1), 448-457 (1997) CC GPRFLN| MEDLINE 97150746 CC GPRFLN|REFERENCE 6 (residues 1 to 1897) CC GPRFLN| AUTHORS Harder,K.W., Saw,J., Miki,N. and Jirik,F. CC GPRFLN| TITLE Coexisting amplifications of the chromosome 1p32 genes (PTPRF and CC GPRFLN| MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a CC GPRFLN| small cell lung cancer line CC GPRFLN| JOURNAL Genomics 27 (3), 552-553 (1995) CC GPRFLN| MEDLINE 96047346 CC GPRFLN|REFERENCE 7 (residues 1 to 1897) CC GPRFLN| AUTHORS Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T., CC GPRFLN| Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J. CC GPRFLN| TITLE The mouse gene Ptprf encoding the leukocyte common antigen-related CC GPRFLN| molecule LAR: cloning, characterization, and chromosomal CC GPRFLN| localization CC GPRFLN| JOURNAL Genomics 27 (1), 124-130 (1995) CC GPRFLN| MEDLINE 95394448 CC GPRFLN|REFERENCE 8 (residues 1 to 1897) CC GPRFLN| AUTHORS O'Grady,P., Krueger,N.X., Streuli,M. and Saito,H. CC GPRFLN| TITLE Genomic organization of the human LAR protein tyrosine phosphatase CC GPRFLN| gene and alternative splicing in the extracellular fibronectin CC GPRFLN| type-III domains CC GPRFLN| JOURNAL J. Biol. Chem. 269 (40), 25193-25199 (1994) CC GPRFLN| MEDLINE 95014301 CC GPRFLN|REFERENCE 9 (residues 1 to 1897) CC GPRFLN| AUTHORS Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H. CC GPRFLN| TITLE A new member of the immunoglobulin superfamily that has a CC GPRFLN| cytoplasmic region homologous to the leukocyte common antigen CC GPRFLN| JOURNAL J. Exp. Med. 168 (5), 1523-1530 (1988) CC GPRFLN| MEDLINE 89035978 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1897 VNTIFKEY:269 FT PROTEIN 1 1897 protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog FT VNTIFKEY:270 FT SIGNAL 1 16 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 17 1897 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 29 115 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 140 204 IGc2 FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 228 306 IG FT VNTIFKEY:266; VNTINAME:Region_3 FT DOMAIN 333 391 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 407 490 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 502 581 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 600 686 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 824 893 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT DOMAIN 909 990 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_6 FT REGION 1341 1596 PTPc FT VNTIFKEY:266; VNTINAME:Region_4 FT REGION 1632 1889 PTPc FT VNTIFKEY:266; VNTINAME:Region_5 SQ SEQUENCE 1897 AA; MVPLVPALVM LGLVAGAHGD SKPVFIKVPE DQTGLSGGVA SFVCQATGEP KPRITWMKKG 60 KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA KLSVLEEEQL 120 PPGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPATS NGRIKQLRSG 180 ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGSVN 240 LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA ISSLGMIEAT 300 AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVTYY GIQYRAAGTE GPFQEVDGVA 360 TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV QARMLSASTM 420 LVQWEPPEEP NGLVRGYRVY YTPDSRRPPN AWHKHNTDAG LLTTVGSLLP GITYSLRVLA 480 FTAVGDGPPS PTIQVKTQQG VPAQPADFQA EVESDTRIQL SWLLPPQERI IMYELVYWAA 540 EDEDQQHKVT FDPTSSYTLE DLKPDTLYRF QLAARSDMGV GVFTPTIEAR TAQSTPSAPP 600 QKVMCVSMGS TTVRVSWVPP PADSRNGVIT QYSVAHEAVD GEDRGRHVVD GISREHSSWD 660 LVGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL NSTAVHVYWK 720 LPVPSKQHGQ IRGYQVTYVR LENGEPRGLP IIQDVMLAEA QWRPEESEDY ETTISGLTPE 780 TTYSVTVAAY TTKGDGARSK PKIVTTTGAV PGRPTMMIST TAMNTALLQW HPPKELPGEL 840 LGYRLQYCRA DEARPNTIDF GKDDQHFTVT GLHKGTTYIF RLAAKNRAGL GEEFEKEIRT 900 PEDLPSGFPQ NLHVTGLTTS TTELAWDPPV LAERNGRIIS YTVVFRDINS QQELQNITTD 960 TRFTLTGLKP DTTYDIKVRA WTSKGSGPLS PSIQSRTMPV EQVFAKNFRV AAAMKTSVLL 1020 SWEVPDSYKS AVPFKILYNG QSVEVDGHSM RKLIADLQPN TEYSFVLMNR GSSAGGLQHL 1080 VSIRTAPDLL PHKPLPASAY IEDGRFDLSM PHVQDPSLVR WFYIVVVPID RVGGSMLTPR 1140 WSTPEELELD ELLEAIEQGG EEQRRRRRQA ERLKPYVAAQ LDVLPETFTL GDKKNYRGFY 1200 NRPLSPDLSY QCFVLASLKE PMDQKRYASS PYSDEIVVQV TPAQQQEEPE MLWVTGPVLA 1260 VILIILIVIA ILLFKRKRTH SPSSKDEQSI GLKDSLLAHS SDPVEMRRLN YQTPGMRDHP 1320 PIPITDLADN IERLKANDGL KFSQEYESID PGQQFTWENS NLEVNKPKNR YANVIAYDHS 1380 RVILTSIDGV PGSDYINANY IDGYRKQNAY IATQGPLPET MGDFWRMVWE QRTATVVMMT 1440 RLEEKSRVKC DQYWPARGTE TCGLIQVTLL DTVELATYTV RTFALHKSGS SEKRELRQFQ 1500 FMAWPDHGVP EYPTPILAFL RRVKACNPLD AGPMVVHCSA GVGRTGCFIV IDAMLERMKH 1560 EKTVDIYGHV TCMRSQRNYM VQTEDQYVFI HEALLEAATC GHTEVPARNL YAHIQKLGQV 1620 PPGESVTAME LEFKLLASSK AHTSRFISAN LPCNKFKNRL VNIMPYELTR VCLQPIRGVE 1680 GSDYINASFL DGYRQQKAYI ATQGPLAEST EDFWRMLWEH NSTIIVMLTK LREMGREKCH 1740 QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTIRQFQF TDWPEQGVPK 1800 TGEGFIDFIG QVHKTKEQFG QDGPITVHCS AGVGRTGVFI TLSIVLERMR YEGVVDMFQT 1860 VKTLRTQRPA MVQTEDQYQL CYRAALEYLG SFDHYAT 1897 // ID hLyPTP\(NP_057051)\PTPN22 STANDARD;PRT; 807 AA. AC NP_057051; DT 17-MAY-2003 DE lymphoid-specific protein tyrosine phosphatase isoform 1; lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from AF077031.1 and AF001846.1. CC CC Summary: This gene encodes a protein tyrosine phosphatase which is CC expressed primarily in lymphoid tissues. This enzyme associates CC with the molecular adapter protein CBL and may be involved in CC regulating CBL function in the T-cell receptor signaling pathway. CC Alternative splicing of this gene results in two transcript CC variants encoding distinct isoforms. CC CC Transcript Variant: This variant (1) encodes the longer isoform (1) CC which is 116 aa longer than isoform 2 and has a distinct CC C-terminus. CC GPRFLN|REFERENCE 1 (residues 1 to 807) CC GPRFLN| AUTHORS Hill,R.J., Zozulya,S., Lu,Y.L., Ward,K., Gishizky,M. and Jallal,B. CC GPRFLN| TITLE The lymphoid protein tyrosine phosphatase Lyp interacts with the CC GPRFLN| adaptor molecule Grb2 and functions as a negative regulator of CC GPRFLN| T-cell activation CC GPRFLN| JOURNAL Exp. Hematol. 30 (3), 237-244 (2002) CC GPRFLN| MEDLINE 21876996 CC GPRFLN| REMARK GeneRIF: data demonstrate a novel interaction between Lyp and the CC GPRFLN| adaptor Grb2 and are consistent with a negative regulatory role for CC GPRFLN| Lyp in T-cell signaling. CC GPRFLN|REFERENCE 2 (residues 1 to 807) CC GPRFLN| AUTHORS Cohen,S., Dadi,H., Shaoul,E., Sharfe,N. and Roifman,C.M. CC GPRFLN| TITLE Cloning and characterization of a lymphoid-specific, inducible CC GPRFLN| human protein tyrosine phosphatase, Lyp CC GPRFLN| JOURNAL Blood 93 (6), 2013-2024 (1999) CC GPRFLN| MEDLINE 99168989 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 807 VNTIFKEY:269 FT PROTEIN 1 807 lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog FT VNTIFKEY:270 FT REGION 24 291 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 807 AA; MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY 60 KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY 120 SVLIIGMACM EYEMGKKKCE RYWAEPVEMQ LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS 180 ETRTIYQFHY KNWPDHDVPS SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI 240 DYTWMLLKDG IIPENFSVFS LIREMRTQRP SLVQTQEQYE LVYNAVLELF KRQMDVIRDK 300 HSGTESQAKH CIPEKNHTLQ ADSYSPNLPK STTKAAKMMN QQRTKMEIKE SSSFDFRTSE 360 ISAKEELVLH PAKSSTSFDF LELNYSFDKN ADTTMKWQTK AFPIVGEPLQ KHQSLDLGSP 420 LFEGCSNSKP VNAAGRYFNS KVPITRTKST PFELIQQRET KEVDSKENFS YLESQPHDSC 480 FVEMQAQKVM HVSSAELNYS LPYDSKHQIR NASNVKHHDS SALGVYSYIP LVENPYFSSW 540 PPSGTSSKMS LDLPEKQDGT VFPSSLLPTS STSLFSYYNS HDSLSLNSPT NISSLLNQES 600 AVLATAPRID DEIPPPLPVW TPESFIVVEE AGEFSPNVPK SLSSAVKVKI GTSLEWGGTS 660 EPKKFDDSVI LRPSKSVKLR SPKSELHQDR SSPPPPLPER TLESFFLADE DCMQAQSIET 720 YSTSYPDTME NSTSSKQTLK TSGKSFTRSK SLKILRNMKK SICNSCPPNK PAESVQSNNS 780 SSFLNFGFAN RFSKPKGPRN PPPTWNI 807 // ID hMEG1\(NP_002821)\PTPN4 STANDARD;PRT; 926 AA. AC NP_002821; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 4; megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M68941.1 and BC010674.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This protein contains a C-terminal PTP CC domain and an N-terminal domain homologous to the band 4.1 CC superfamily of cytoskeletal-associated proteins. This PTP has been CC shown to interact with glutamate receptor delta 2 and epsilon CC subunits, and is thought to play a role in signalling downstream of CC the glutamate receptors through tyrosine dephosphorylation. CC GPRFLN|REFERENCE 1 (residues 1 to 926) CC GPRFLN| AUTHORS Hironaka,K., Umemori,H., Tezuka,T., Mishina,M. and Yamamoto,T. CC GPRFLN| TITLE The protein-tyrosine phosphatase PTPMEG interacts with glutamate CC GPRFLN| receptor delta 2 and epsilon subunits CC GPRFLN| JOURNAL J. Biol. Chem. 275 (21), 16167-16173 (2000) CC GPRFLN| MEDLINE 20283654 CC GPRFLN|REFERENCE 2 (residues 1 to 926) CC GPRFLN| AUTHORS Gu,M., Meng,K. and Majerus,P.W. CC GPRFLN| TITLE The effect of overexpression of the protein tyrosine phosphatase CC GPRFLN| PTPMEG on cell growth and on colony formation in soft agar in COS-7 CC GPRFLN| cells CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (23), 12980-12985 (1996) CC GPRFLN| MEDLINE 97075104 CC GPRFLN|REFERENCE 3 (residues 1 to 926) CC GPRFLN| AUTHORS Gu,M. and Majerus,P.W. CC GPRFLN| TITLE The properties of the protein tyrosine phosphatase PTPMEG CC GPRFLN| JOURNAL J. Biol. Chem. 271 (44), 27751-27759 (1996) CC GPRFLN| MEDLINE 97066967 CC GPRFLN|REFERENCE 4 (residues 1 to 926) CC GPRFLN| AUTHORS Gu,M.X., York,J.D., Warshawsky,I. and Majerus,P.W. CC GPRFLN| TITLE Identification, cloning, and expression of a cytosolic CC GPRFLN| megakaryocyte protein-tyrosine-phosphatase with sequence homology CC GPRFLN| to cytoskeletal protein 4.1 CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (13), 5867-5871 (1991) CC GPRFLN| MEDLINE 91288564 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 926 VNTIFKEY:269 FT PROTEIN 1 926 megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase FT VNTIFKEY:270 FT DOMAIN 31 222 Band_41 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 517 604 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT REGION 655 913 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 926 AA; MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ GQVLLDVVFK 60 HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE 120 YTRYQYFLQI KQDILTGRLP CPSNTAALLA SFAVQSELGD YDQSENLSGY LSDYSFIPNQ 180 PQDFEKEIAK LHQQHIGLSP AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG 240 ILIYKNRVRM NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA 300 CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS 360 KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR NSTFTQEGTR LRPSSVGHLV 420 DHMVHTSPSE VFVNQRSPSS TQANSIVLES SPSQETPGDG KPPALPPKQS KKNSWNQIHY 480 SHSQQDLESH INETFDIPSS PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM 540 PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL 600 VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLTQFD 660 QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG NEDYINANYI NMEIPSSSII 720 NQYIACQGPL PHTCTDFWQM TWEQGSSMVV MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ 780 VTCHSEEGNT AYIFRKMTLF NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK 840 RAGKEEPVVV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ 900 YRFVCEAILK VYEEGFVKPL TTSTNK 926 // ID hMEG2\(NP_002824)\PTPN9 STANDARD;PRT; 593 AA. AC NP_002824; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 9; protein-tyrosine phosphatase MEG2; PTPase-MEG2 [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M83738.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an N-terminal domain CC that shares a significant similarity with yeast SEC14, which is a CC protein that has phosphatidylinositol transfer activity and is CC required for protein secretion through the Golgi complex in yeast. CC This PTP was found to be activated by polyphosphoinositide, and is CC thought to be involved in signaling events regulating phagocytosis. CC GPRFLN|REFERENCE 1 (residues 1 to 593) CC GPRFLN| AUTHORS Qi,Y., Zhao,R., Cao,H., Sui,X., Krantz,S.B. and Zhao,Z.J. CC GPRFLN| TITLE Purification and characterization of protein tyrosine phosphatase CC GPRFLN| PTP-MEG2 CC GPRFLN| JOURNAL J. Cell. Biochem. 86 (1), 79-89 (2002) CC GPRFLN| MEDLINE 22106294 CC GPRFLN| REMARK GeneRIF: Purification and characterization of protein tyrosine CC GPRFLN| phosphatase PTP-MEG2 CC GPRFLN|REFERENCE 2 (residues 1 to 593) CC GPRFLN| AUTHORS Kruger,J.M., Fukushima,T., Cherepanov,V., Borregaard,N., Loeve,C., CC GPRFLN| Shek,C., Sharma,K., Tanswell,A.K., Chow,C.W. and Downey,G.P. CC GPRFLN| TITLE Protein-tyrosine phosphatase MEG2 is expressed by human CC GPRFLN| neutrophils. Localization to the phagosome and activation by CC GPRFLN| polyphosphoinositides CC GPRFLN| JOURNAL J. Biol. Chem. 277 (4), 2620-2628 (2002) CC GPRFLN| MEDLINE 21659736 CC GPRFLN|REFERENCE 3 (residues 1 to 593) CC GPRFLN| AUTHORS Gu,M., Warshawsky,I. and Majerus,P.W. CC GPRFLN| TITLE Cloning and expression of a cytosolic megakaryocyte CC GPRFLN| protein-tyrosine-phosphatase with sequence homology to CC GPRFLN| retinaldehyde-binding protein and yeast SEC14p CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2980-2984 (1992) CC GPRFLN| MEDLINE 92212952 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 593 VNTIFKEY:269 FT PROTEIN 1 593 protein-tyrosine phosphatase MEG2; PTPase-MEG2 FT VNTIFKEY:270 FT DOMAIN 10 80 CRAL_TRIO_N FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 84 266 CRAL_TRIO FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT REGION 302 576 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 593 AA; MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR 60 AIELFHSYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH 120 KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP 180 ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK 240 IDLATWNFQF LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNARQK 300 QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA 360 SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK 420 DSRIRFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL 480 IDFLRVVRNQ QSLAVSNMGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT 540 LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEKEGM VSSGQNLLAV ESQ 593 // ID hPCPTP1\(NP_002840)\PTPRR STANDARD;PRT; 657 AA. AC NP_002840; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, R isoform 1 precursor; protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from D64053.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and a single intracellular CC catalytic domains, and thus represents a receptor-type PTP. The CC similar gene predominately expressed in mouse brain was found to CC associate with, and thus regulate the activity and cellular CC localization of MAP kinases. The rat counterpart of this gene was CC reported to be regulated by the nerve growth factor, which CC suggested the function of this gene in neuronal growth and CC differentiation. CC CC Transcript Variant: This variant (1) contains a different 5' end CC region when compared to variant 2. It thus encodes a protein that CC has a longer N-terminus, as compared to isoform 2. CC GPRFLN|REFERENCE 1 (residues 1 to 657) CC GPRFLN| AUTHORS Blanco-Aparicio,C., Torres,J. and Pulido,R. CC GPRFLN| TITLE A novel regulatory mechanism of MAP kinases activation and nuclear CC GPRFLN| translocation mediated by PKA and the PTP-SL tyrosine phosphatase CC GPRFLN| JOURNAL J. Cell Biol. 147 (6), 1129-1136 (1999) CC GPRFLN| MEDLINE 20069779 CC GPRFLN|REFERENCE 2 (residues 1 to 657) CC GPRFLN| AUTHORS Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H. CC GPRFLN| TITLE Cloning and expression of PCPTP1 encoding protein tyrosine CC GPRFLN| phosphatase CC GPRFLN| JOURNAL Gene 162 (2), 279-284 (1995) CC GPRFLN| MEDLINE 96032358 CC GPRFLN| REMARK founctional study of the rat homolog CC GPRFLN|REFERENCE 3 (residues 1 to 657) CC GPRFLN| AUTHORS Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T. CC GPRFLN| TITLE cDNA cloning and characterization of a novel receptor-type protein CC GPRFLN| tyrosine phosphatase expressed predominantly in the brain CC GPRFLN| JOURNAL J. Biol. Chem. 270 (5), 2337-2343 (1995) CC GPRFLN| MEDLINE 95138207 CC GPRFLN| REMARK functional study of the mouse homolog CC GPRFLN|REFERENCE 4 (residues 1 to 657) CC GPRFLN| AUTHORS Sharma,E. and Lombroso,P.J. CC GPRFLN| TITLE A neuronal protein tyrosine phosphatase induced by nerve growth CC GPRFLN| factor CC GPRFLN| JOURNAL J. Biol. Chem. 270 (1), 49-53 (1995) CC GPRFLN| MEDLINE 95113874 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 657 VNTIFKEY:269 FT PROTEIN 1 657 protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase FT VNTIFKEY:270 FT SIGNAL 1 23 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 24 657 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 392 647 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 657 AA; MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI EKSLDIAPQK 60 IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD GQDLEVENLP IPAANVIVVT 120 LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ VHINRLIGKK NSIELFVSPI NRKTGISDAL 180 PSEEVLRSLN INVLHQSLSQ FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI 240 IVTCLMILYR LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN 300 VVVDPQGRGA PEIRATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL GNIEPFVSIP 360 TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI PMNFVDPKEI DIPRHGTKNR 420 YKTILPNPLS RVCLRPKNVT DSLSTYINAN YIRGYSGKEK AFIATQGPMI NTVDDFWQMV 480 WQEDSPVIVM ITKLKEKNEK CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH 540 TQHVKHYWYT SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA 600 TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR LSAETVQ 657 // ID hPEST\(NP_002826)\PTPN12 STANDARD;PRT; 780 AA. AC NP_002826; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 12; protein-tyrosine phosphatase G1 [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M93425.1. CC On Jan 25, 2002 this sequence version replaced gi:4506287. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains a C-terminal PEST CC motif, which serves as a protein-protein interaction domain, and CC may be related to protein intracellular half-life. This PTP was CC found to bind and dephosphorylate the product of oncogene c-ABL, CC thus may play a role in oncogenesis. This PTP was shown to interact CC with, and dephosphorylate, various of cytoskeleton and cell CC adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and CC paxillin, which suggested its regulatory roles in controlling cell CC shape and mobility. CC GPRFLN|REFERENCE 1 (residues 1 to 780) CC GPRFLN| AUTHORS Lyons,P.D., Dunty,J.M., Schaefer,E.M. and Schaller,M.D. CC GPRFLN| TITLE Inhibition of the catalytic activity of cell adhesion kinase beta CC GPRFLN| by protein-tyrosine phosphatase-PEST-mediated dephosphorylation CC GPRFLN| JOURNAL J. Biol. Chem. 276 (26), 24422-24431 (2001) CC GPRFLN| MEDLINE 21316574 CC GPRFLN|REFERENCE 2 (residues 1 to 780) CC GPRFLN| AUTHORS Cong,F., Spencer,S., Cote,J.F., Wu,Y., Tremblay,M.L., Lasky,L.A. CC GPRFLN| and Goff,S.P. CC GPRFLN| TITLE Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine CC GPRFLN| phosphatase to the c-Abl kinase to mediate Abl dephosphorylation CC GPRFLN| JOURNAL Mol. Cell 6 (6), 1413-1423 (2000) CC GPRFLN| MEDLINE 21111050 CC GPRFLN|REFERENCE 3 (residues 1 to 780) CC GPRFLN| AUTHORS Shen,Y., Lyons,P., Cooley,M., Davidson,D., Veillette,A., Salgia,R., CC GPRFLN| Griffin,J.D. and Schaller,M.D. CC GPRFLN| TITLE The noncatalytic domain of protein-tyrosine phosphatase-PEST CC GPRFLN| targets paxillin for dephosphorylation in vivo CC GPRFLN| JOURNAL J. Biol. Chem. 275 (2), 1405-1413 (2000) CC GPRFLN| MEDLINE 20092920 CC GPRFLN|REFERENCE 4 (residues 1 to 780) CC GPRFLN| AUTHORS Nishiya,N., Iwabuchi,Y., Shibanuma,M., Cote,J.F., Tremblay,M.L. and CC GPRFLN| Nose,K. CC GPRFLN| TITLE Hic-5, a paxillin homologue, binds to the protein-tyrosine CC GPRFLN| phosphatase PEST (PTP-PEST) through its LIM 3 domain CC GPRFLN| JOURNAL J. Biol. Chem. 274 (14), 9847-9853 (1999) CC GPRFLN| MEDLINE 99194842 CC GPRFLN|REFERENCE 5 (residues 1 to 780) CC GPRFLN| AUTHORS Garton,A.J. and Tonks,N.K. CC GPRFLN| TITLE Regulation of fibroblast motility by the protein tyrosine CC GPRFLN| phosphatase PTP-PEST CC GPRFLN| JOURNAL J. Biol. Chem. 274 (6), 3811-3818 (1999) CC GPRFLN| MEDLINE 99121127 CC GPRFLN|REFERENCE 6 (residues 1 to 780) CC GPRFLN| AUTHORS Takekawa,M., Itoh,F., Hinoda,Y., Adachi,M., Ariyama,T., Inazawa,J., CC GPRFLN| Imai,K. and Yachi,A. CC GPRFLN| TITLE Chromosomal localization of the protein tyrosine phosphatase G1 CC GPRFLN| gene and characterization of the aberrant transcripts in human CC GPRFLN| colon cancer cells CC GPRFLN| JOURNAL FEBS Lett. 339 (3), 222-228 (1994) CC GPRFLN| MEDLINE 94156037 CC GPRFLN|REFERENCE 7 (residues 1 to 780) CC GPRFLN| AUTHORS Yang,Q., Co,D., Sommercorn,J. and Tonks,N.K. CC GPRFLN| TITLE Cloning and expression of PTP-PEST. A novel, human, CC GPRFLN| nontransmembrane protein tyrosine phosphatase CC GPRFLN| JOURNAL J. Biol. Chem. 268 (9), 6622-6628 (1993) CC GPRFLN| MEDLINE 93203262 CC GPRFLN|REFERENCE 8 (residues 1 to 780) CC GPRFLN| AUTHORS Takekawa,M., Itoh,F., Hinoda,Y., Arimura,Y., Toyota,M., Sekiya,M., CC GPRFLN| Adachi,M., Imai,K. and Yachi,A. CC GPRFLN| TITLE Cloning and characterization of a human cDNA encoding a novel CC GPRFLN| putative cytoplasmic protein-tyrosine-phosphatase CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 189 (2), 1223-1230 (1992) CC GPRFLN| MEDLINE 93112015 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 780 VNTIFKEY:269 FT PROTEIN 1 780 protein-tyrosine phosphatase G1 FT VNTIFKEY:270 FT REGION 28 295 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 780 AA; MEQVEILRKF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT ATGEKEENVK 60 KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP KAYVATQGPL ANTVIDFWRM 120 IWEYNVVIIV MACREFEMGR KKCERYWPLY GEDPITFAPF KISCEDEQAR TDYFIRTLLL 180 EFQNESRRLY QFHYVNWPDH DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA 240 ICAIDYTWNL LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL 300 YEIHGAQKIA DGVNEINTEN MISSIEPEKQ DSPPPKPPRT RSCLVEGDAK EEILQPPEPH 360 PVPPILTPSP PSAFPTVTTV WQDNDRYHPK PVLHMVSSEQ HSADLNRNYS KSTELPGKNE 420 STIEQIDKKL ERNLSFEIKK VPLQEGPKSF DGNTLLNRGH AIKIKSASPC IADKISKPQE 480 LSSDLNVGDT SQNSCVDCSV TQSNKVSVTP PEESQNSDTP PRPDRLPLDE KGHVTWSFHG 540 PENAIPIPDL SEGNSSDINY QTRKTVSLTP SPTTQVETPD LVDHDNTSPL FRTPLSFTNP 600 LHSDDSDSDE RNSDGAVTQN KTNISTASAT VSAATSTESI STRKVLPMSI ARHNIAGTTH 660 SGAEKDVDVS EDSPPPLPER TPESFVLASE HNTPVRSEWS ELQSQERSEQ KKSEGLITSE 720 NEKCDHPAGG IHYEMCIECP PTFSDKREQI SENPTEATDI GFGNRCGKPK GPRDPPSEWT 780 // ID hPTP1B\(NP_002818)\PTPN1 STANDARD;PRT; 435 AA. AC NP_002818; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 1; non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M33689.1 and AU117677.1. CC CC Summary: The protein encoded by this gene is the founding member of CC the protein tyrosine phosphatase (PTP) family, which was isolated CC and identified based on its enzymatic activity and amino acid CC sequence. PTPs catalyze the hydrolysis of the phosphate monoesters CC specifically on tyrosine residues. Members of the PTP family share CC a highly conserved catalytic motif, which is essential for the CC catalytic activity. PTPs are known to be signaling molecules that CC regulate a variety of cellular processes including cell growth, CC differentiation, mitotic cycle, and oncogenic transformation. This CC PTP has been shown to act as a negative regulator of insulin CC signaling by dephosphorylating the phosphotryosine residues of CC insulin receptor kinase. This PTP was also reported to CC dephosphorylate epidermal growth factor receptor kinase, as well as CC JAK2 and TYK2 kinases, which implicated the role of this PTP in CC cell growth control, and cell response to interferon stimulation. CC GPRFLN|REFERENCE 1 (residues 1 to 435) CC GPRFLN| AUTHORS Li,S. and Whorton,A.R. CC GPRFLN| TITLE Regulation of protein tyrosine phosphatase 1B in intact cells by CC GPRFLN| S-nitrosothiols CC GPRFLN| JOURNAL Arch. Biochem. Biophys. 410 (2), 269-279 (2003) CC GPRFLN| MEDLINE 22461115 CC GPRFLN| REMARK GeneRIF: PTP1B inhibition by S-nitrosylation is caused by formation CC GPRFLN| of a mixed disulfide CC GPRFLN|REFERENCE 2 (residues 1 to 435) CC GPRFLN| AUTHORS Fukada,T. and Tonks,N.K. CC GPRFLN| TITLE Identification of YB-1 as a regulator of PTP1B expression: CC GPRFLN| implications for regulation of insulin and cytokine signaling CC GPRFLN| JOURNAL EMBO J. 22 (3), 479-493 (2003) CC GPRFLN| MEDLINE 22441887 CC GPRFLN| REMARK GeneRIF: Data show that Y box-binding protein-1 (YB-1) is a CC GPRFLN| regulator of protein tyrosine phosphatase 1B (PTP1B) expression, CC GPRFLN| and highlight PTP1B as a critical regulator of insulin- and CC GPRFLN| cytokine-mediated signal transduction. CC GPRFLN|REFERENCE 3 (residues 1 to 435) CC GPRFLN| AUTHORS Yigzaw,Y., Poppleton,H.M., Sreejayan,N., Hassid,A. and Patel,T.B. CC GPRFLN| TITLE Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory CC GPRFLN| actions of Sprouty CC GPRFLN| JOURNAL J. Biol. Chem. 278 (1), 284-288 (2003) CC GPRFLN| MEDLINE 22393490 CC GPRFLN| REMARK GeneRIF: Data show that an increase in soluble protein-tyrosine CC GPRFLN| phosphatase 1B activity contributes to the anti-migratory, but not CC GPRFLN| anti-mitogenic, actions of human Sprouty 2. CC GPRFLN|REFERENCE 4 (residues 1 to 435) CC GPRFLN| AUTHORS Di Paola,R., Frittitta,L., Miscio,G., Bozzali,M., Baratta,R., CC GPRFLN| Centra,M., Spampinato,D., Santagati,M.G., Ercolino,T., CC GPRFLN| Cisternino,C., Soccio,T., Mastroianno,S., Tassi,V., Almgren,P., CC GPRFLN| Pizzuti,A., Vigneri,R. and Trischitta,V. CC GPRFLN| TITLE A variation in 3' UTR of hPTP1B increases specific gene expression CC GPRFLN| and associates with insulin resistance CC GPRFLN| JOURNAL Am. J. Hum. Genet. 70 (3), 806-812 (2002) CC GPRFLN| MEDLINE 21832513 CC GPRFLN| REMARK GeneRIF: variation in 3' UTR of hPTP1B increases specific gene CC GPRFLN| expression and associates with insulin resistance CC GPRFLN|REFERENCE 5 (residues 1 to 435) CC GPRFLN| AUTHORS Myers,M.P., Andersen,J.N., Cheng,A., Tremblay,M.L., Horvath,C.M., CC GPRFLN| Parisien,J.P., Salmeen,A., Barford,D. and Tonks,N.K. CC GPRFLN| TITLE TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B CC GPRFLN| JOURNAL J. Biol. Chem. 276 (51), 47771-47774 (2001) CC GPRFLN| MEDLINE 21611285 CC GPRFLN|REFERENCE 6 (residues 1 to 435) CC GPRFLN| AUTHORS Wang,J., Cheung,A.T., Kolls,J.K., Starks,W.W., CC GPRFLN| Martinez-Hernandez,A., Dietzen,D. and Bryer-Ash,M. CC GPRFLN| TITLE Effects of adenovirus-mediated liver-selective overexpression of CC GPRFLN| protein tyrosine phosphatase-1b on insulin sensitivity in vivo CC GPRFLN| JOURNAL Diabetes Obes Metab 3 (5), 367-380 (2001) CC GPRFLN| MEDLINE 21560532 CC GPRFLN| REMARK GeneRIF: Moderate overabundance of PTP-1B in liver tissue does not CC GPRFLN| alter insulin action on glucose metabolism, and the site of action CC GPRFLN| of PTP-1B is presumably at insulin-responsive target tissue or CC GPRFLN| tissues other than the liver. CC GPRFLN|REFERENCE 7 (residues 1 to 435) CC GPRFLN| AUTHORS Dadke,S., Kusari,A. and Kusari,J. CC GPRFLN| TITLE Phosphorylation and activation of protein tyrosine phosphatase CC GPRFLN| (PTP) 1B by insulin receptor CC GPRFLN| JOURNAL Mol. Cell. Biochem. 221 (1-2), 147-154 (2001) CC GPRFLN| MEDLINE 21396990 CC GPRFLN|REFERENCE 8 (residues 1 to 435) CC GPRFLN| AUTHORS Egawa,K., Maegawa,H., Shimizu,S., Morino,K., Nishio,Y., CC GPRFLN| Bryer-Ash,M., Cheung,A.T., Kolls,J.K., Kikkawa,R. and Kashiwagi,A. CC GPRFLN| TITLE Protein-tyrosine phosphatase-1B negatively regulates insulin CC GPRFLN| signaling in l6 myocytes and Fao hepatoma cells CC GPRFLN| JOURNAL J. Biol. Chem. 276 (13), 10207-10211 (2001) CC GPRFLN| MEDLINE 21167830 CC GPRFLN|REFERENCE 9 (residues 1 to 435) CC GPRFLN| AUTHORS Salmeen,A., Andersen,J.N., Myers,M.P., Tonks,N.K. and Barford,D. CC GPRFLN| TITLE Molecular basis for the dephosphorylation of the activation segment CC GPRFLN| of the insulin receptor by protein tyrosine phosphatase 1B CC GPRFLN| JOURNAL Mol. Cell 6 (6), 1401-1412 (2000) CC GPRFLN| MEDLINE 21111049 CC GPRFLN|REFERENCE 10 (residues 1 to 435) CC GPRFLN| AUTHORS Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S., CC GPRFLN| Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P. CC GPRFLN| TITLE Residue 259 is a key determinant of substrate specificity of CC GPRFLN| protein-tyrosine phosphatases 1B and alpha CC GPRFLN| JOURNAL J. Biol. Chem. 275 (24), 18201-18209 (2000) CC GPRFLN| MEDLINE 20309769 CC GPRFLN|REFERENCE 11 (residues 1 to 435) CC GPRFLN| AUTHORS Ahmad,F., Li,P.M., Meyerovitch,J. and Goldstein,B.J. CC GPRFLN| TITLE Osmotic loading of neutralizing antibodies demonstrates a role for CC GPRFLN| protein-tyrosine phosphatase 1B in negative regulation of the CC GPRFLN| insulin action pathway CC GPRFLN| JOURNAL J. Biol. Chem. 270 (35), 20503-20508 (1995) CC GPRFLN| MEDLINE 95386495 CC GPRFLN|REFERENCE 12 (residues 1 to 435) CC GPRFLN| AUTHORS Milarski,K.L., Zhu,G., Pearl,C.G., McNamara,D.J., Dobrusin,E.M., CC GPRFLN| MacLean,D., Thieme-Sefler,A., Zhang,Z.Y., Sawyer,T., Decker,S.J. et CC GPRFLN| al. CC GPRFLN| TITLE Sequence specificity in recognition of the epidermal growth factor CC GPRFLN| receptor by protein tyrosine phosphatase 1B CC GPRFLN| JOURNAL J. Biol. Chem. 268 (31), 23634-23639 (1993) CC GPRFLN| MEDLINE 94043167 CC GPRFLN|REFERENCE 13 (residues 1 to 435) CC GPRFLN| AUTHORS Brown-Shimer,S., Johnson,K.A., Lawrence,J.B., Johnson,C., CC GPRFLN| Bruskin,A., Green,N.R. and Hill,D.E. CC GPRFLN| TITLE Molecular cloning and chromosome mapping of the human gene encoding CC GPRFLN| protein phosphotyrosyl phosphatase 1B CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5148-5152 (1990) CC GPRFLN| MEDLINE 90311360 CC GPRFLN|REFERENCE 14 (residues 1 to 435) CC GPRFLN| AUTHORS Chernoff,J., Schievella,A.R., Jost,C.A., Erikson,R.L. and Neel,B.G. CC GPRFLN| TITLE Cloning of a cDNA for a major human protein-tyrosine-phosphatase CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (7), 2735-2739 (1990) CC GPRFLN| MEDLINE 90207272 CC GPRFLN|REFERENCE 15 (residues 1 to 435) CC GPRFLN| AUTHORS Charbonneau,H., Tonks,N.K., Kumar,S., Diltz,C.D., Harrylock,M., CC GPRFLN| Cool,D.E., Krebs,E.G., Fischer,E.H. and Walsh,K.A. CC GPRFLN| TITLE Human placenta protein-tyrosine-phosphatase: amino acid sequence CC GPRFLN| and relationship to a family of receptor-like proteins CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5252-5256 (1989) CC GPRFLN| MEDLINE 89315775 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 435 VNTIFKEY:269 FT PROTEIN 1 435 non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental FT VNTIFKEY:270 FT REGION 3 279 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 435 AA; MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH 60 QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK 120 CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP 180 DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD 240 PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE 300 PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK GSPLNAAPYG 360 IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED HALSYWKPFL VNMCVATVLT 420 AGAYLCYRFL FNSNT 435 // ID hPTPalpha\(NP_002827)\PTPRA STANDARD;PRT; 802 AA. AC NP_002827; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, A isoform 1 precursor; protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M34668.1 and AI284972.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an extracellular CC domain, a single transmembrane segment and two tandem CC intracytoplasmic catalytic domains, and thus represents a CC receptor-type PTP. This PTP has been shown to dephosphorylate and CC activate Src family tyrosine kinases, and is implicated in the CC regulation of integrin signaling, cell adhesion and proliferation. CC Three alternatively spliced variants of this gene, which encode two CC distinct isoforms, have been reported. CC CC Transcript Variant: This variant (1) contains a unique 5' UTR CC region when compared to other variants. The genomic exons forming CC the 5' end region of this transcript are also used to form an CC internal coding region in the transcripts of VPS16, a distinct gene CC located at the locus immediately upstream of this gene on CC chromosome 20. This variant encodes the longest isoform (1). CC GPRFLN|REFERENCE 1 (residues 1 to 802) CC GPRFLN| AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. CC GPRFLN| TITLE Intra- and intermolecular interactions between intracellular CC GPRFLN| domains of receptor protein-tyrosine phosphatases CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) CC GPRFLN| MEDLINE 22344739 CC GPRFLN| REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are CC GPRFLN| a common but specific mechanism that is likely to be regulated- CC GPRFLN| domain2s and the wedge structures are crucial determinants of CC GPRFLN| binding specificity, thus regulating cross-talk between RPTPs CC GPRFLN|REFERENCE 2 (residues 1 to 802) CC GPRFLN| AUTHORS Mustelin,T. and Hunter,T. CC GPRFLN| TITLE Meeting at mitosis: cell cycle-specific regulation of c-Src by CC GPRFLN| RPTPalpha CC GPRFLN| JOURNAL Sci STKE 2002 (115), PE3 (2002) CC GPRFLN| MEDLINE 21655780 CC GPRFLN| REMARK GeneRIF: In entering mitosis the cell cycle-specific regulation of CC GPRFLN| c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527 CC GPRFLN| that activates c-Src in a reaction catalyzed by the transmembrane CC GPRFLN| receptor-like protein tyrosine phosphatase RPTPalpha. CC GPRFLN|REFERENCE 3 (residues 1 to 802) CC GPRFLN| AUTHORS Ardini,E., Agresti,R., Tagliabue,E., Greco,M., Aiello,P., CC GPRFLN| Yang,L.T., Menard,S. and Sap,J. CC GPRFLN| TITLE Expression of protein tyrosine phosphatase alpha (RPTPalpha) in CC GPRFLN| human breast cancer correlates with low tumor grade, and inhibits CC GPRFLN| tumor cell growth in vitro and in vivo CC GPRFLN| JOURNAL Oncogene 19 (43), 4979-4987 (2000) CC GPRFLN| MEDLINE 20499263 CC GPRFLN|REFERENCE 4 (residues 1 to 802) CC GPRFLN| AUTHORS Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S., CC GPRFLN| Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P. CC GPRFLN| TITLE Residue 259 is a key determinant of substrate specificity of CC GPRFLN| protein-tyrosine phosphatases 1B and alpha CC GPRFLN| JOURNAL J. Biol. Chem. 275 (24), 18201-18209 (2000) CC GPRFLN| MEDLINE 20309769 CC GPRFLN|REFERENCE 5 (residues 1 to 802) CC GPRFLN| AUTHORS Harder,K.W., Moller,N.P., Peacock,J.W. and Jirik,F.R. CC GPRFLN| TITLE Protein-tyrosine phosphatase alpha regulates Src family kinases and CC GPRFLN| alters cell-substratum adhesion CC GPRFLN| JOURNAL J. Biol. Chem. 273 (48), 31890-31900 (1998) CC GPRFLN| MEDLINE 99041953 CC GPRFLN|REFERENCE 6 (residues 1 to 802) CC GPRFLN| AUTHORS Zheng,X.M., Wang,Y. and Pallen,C.J. CC GPRFLN| TITLE Cell transformation and activation of pp60c-src by overexpression CC GPRFLN| of a protein tyrosine phosphatase CC GPRFLN| JOURNAL Nature 359 (6393), 336-339 (1992) CC GPRFLN| MEDLINE 93024881 CC GPRFLN|REFERENCE 7 (residues 1 to 802) CC GPRFLN| AUTHORS Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I. CC GPRFLN| TITLE The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is CC GPRFLN| assigned to human chromosome 20p12-pter by in situ hybridization CC GPRFLN| (ISH and FISH) CC GPRFLN| JOURNAL Genomics 13 (3), 906-907 (1992) CC GPRFLN| MEDLINE 92347910 CC GPRFLN|REFERENCE 8 (residues 1 to 802) CC GPRFLN| AUTHORS Ohagi,S., Nishi,M. and Steiner,D.F. CC GPRFLN| TITLE Sequence of a cDNA encoding human LRP (leukocyte common CC GPRFLN| antigen-related peptide) CC GPRFLN| JOURNAL Nucleic Acids Res. 18 (23), 7159 (1990) CC GPRFLN| MEDLINE 91088320 CC GPRFLN|REFERENCE 9 (residues 1 to 802) CC GPRFLN| AUTHORS Jirik,F.R., Janzen,N.M., Melhado,I.G. and Harder,K.W. CC GPRFLN| TITLE Cloning and chromosomal assignment of a widely expressed human CC GPRFLN| receptor-like protein-tyrosine phosphatase CC GPRFLN| JOURNAL FEBS Lett. 273 (1-2), 239-242 (1990) CC GPRFLN| MEDLINE 91032191 CC GPRFLN|REFERENCE 10 (residues 1 to 802) CC GPRFLN| AUTHORS Krueger,N.X., Streuli,M. and Saito,H. CC GPRFLN| TITLE Structural diversity and evolution of human receptor-like protein CC GPRFLN| tyrosine phosphatases CC GPRFLN| JOURNAL EMBO J. 9 (10), 3241-3252 (1990) CC GPRFLN| MEDLINE 91006018 CC GPRFLN|REFERENCE 11 (residues 1 to 802) CC GPRFLN| AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M., CC GPRFLN| Ricca,G., Jaye,M. and Schlessinger,J. CC GPRFLN| TITLE Cloning of three human tyrosine phosphatases reveals a multigene CC GPRFLN| family of receptor-linked protein-tyrosine-phosphatases expressed CC GPRFLN| in brain CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990) CC GPRFLN| MEDLINE 90384936 CC GPRFLN|REFERENCE 12 (residues 1 to 802) CC GPRFLN| AUTHORS Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J. CC GPRFLN| TITLE Cloning and expression of a widely expressed receptor tyrosine CC GPRFLN| phosphatase CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6112-6116 (1990) CC GPRFLN| MEDLINE 90349565 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 802 VNTIFKEY:269 FT PROTEIN 1 802 protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase FT VNTIFKEY:270 FT SIGNAL 1 18 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 19 802 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 240 503 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 532 792 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 802 AA; MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS 60 VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP 120 WEGNSSTAAT TPETFPPSGN SDSKDRRDET PIIAVMVALS SLLVIVFIII VLYMLRFKKY 180 KQAGSHSNSF RLSNGRTEDV EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL 240 FREEFNALPA CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF 300 INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC AQYWPDQGCW 360 TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI TQFHFTSWPD FGVPFTPIGM 420 LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ 480 RCQMVQTDMQ YVFIYQALLE HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL 540 TSIKIQNDKM RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK 600 DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD GLVSYGDITV 660 ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV GIPSDGKGMI SIIAAVQKQQ 720 QQSGNHPITV HCSAGAGRTG TFCALSTVLE RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ 780 YEFCYKVVQE YIDAFSDYAN FK 802 // ID hPTPBAS\(NP_006255)\PTPN13 STANDARD;PRT; 2466 AA. AC NP_006255; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 13 isoform 2; protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from D21210.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP is a large protein that CC possesses a PTP domain at C-terminus, and multiple noncatalytic CC domains, which include a domain with similarity to band 4.1 CC superfamily of cytoskeletal-associated proteins, a region CC consisting of five PDZ domains, and a leucine zipper motif. This CC PTP was found to interact with, and dephosphorylate Fas receptor, CC as well as IkappaBalpha through the PDZ domains, which suggested CC its role in Fas mediated programmed cell death. This PTP was also CC shown to interact with GTPase-activating protein, and thus may CC function as a regulator of Rho signaling pathway. Four CC alternatively spliced transcript variants, which encode distinct CC proteins, have been reported. CC CC Transcript Variant: This variant (2) lacks an internal fragment CC within the coding region when compared to variant 4. The CC translation remains in frame, and the encoded protein lacks CC internal 19 aa, as compared to isoform 4. CC GPRFLN|REFERENCE 1 (residues 1 to 2466) CC GPRFLN| AUTHORS Yoshida,S., Harada,H., Nagai,H., Fukino,K., Teramoto,A. and Emi,M. CC GPRFLN| TITLE Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) CC GPRFLN| and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and CC GPRFLN| seven polymorphisms of the FAP-1 gene CC GPRFLN| JOURNAL J. Hum. Genet. 47 (11), 614-619 (2002) CC GPRFLN| MEDLINE 22323362 CC GPRFLN| REMARK GeneRIF: Shares a promoter region with the tightly linked gene CC GPRFLN| encoding stress-activated protein kinase JNK3. CC GPRFLN|REFERENCE 2 (residues 1 to 2466) CC GPRFLN| AUTHORS Bompard,G., Puech,C., Prebois,C., Vignon,F. and Freiss,G. CC GPRFLN| TITLE Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in CC GPRFLN| human breast cancer cells CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47861-47869 (2002) CC GPRFLN| MEDLINE 22344658 CC GPRFLN| REMARK GeneRIF: PTPL1/FAP-1 has a key role in the apoptotic process in CC GPRFLN| human breast cancer cells independent of Fas but associated with an CC GPRFLN| early inhibition of the insulin receptor CC GPRFLN| substrate-1/phosphatidylinositol 3-kinase pathway CC GPRFLN|REFERENCE 3 (residues 1 to 2466) CC GPRFLN| AUTHORS Kozlov,G., Banville,D., Gehring,K. and Ekiel,I. CC GPRFLN| TITLE Solution structure of the PDZ2 domain from cytosolic human CC GPRFLN| phosphatase hPTP1E complexed with a peptide reveals contribution of CC GPRFLN| the beta2-beta3 loop to PDZ domain-ligand interactions CC GPRFLN| JOURNAL J. Mol. Biol. 320 (4), 813-820 (2002) CC GPRFLN| MEDLINE 22090786 CC GPRFLN| REMARK GeneRIF: PDZ2 domain from cytosolic human phosphatase hPTP1E CC GPRFLN| complexed with peptide, RA-GEF-2, reveals contribution of the CC GPRFLN| beta2-beta3 loop to PDZ domain-ligand interactions CC GPRFLN|REFERENCE 4 (residues 1 to 2466) CC GPRFLN| AUTHORS Walma,T., Spronk,C.A., Tessari,M., Aelen,J., Schepens,J., CC GPRFLN| Hendriks,W. and Vuister,G.W. CC GPRFLN| TITLE Structure, dynamics and binding characteristics of the second PDZ CC GPRFLN| domain of PTP-BL CC GPRFLN| JOURNAL J. Mol. Biol. 316 (5), 1101-1110 (2002) CC GPRFLN| MEDLINE 21881810 CC GPRFLN| REMARK GeneRIF: Structure, dynamics and binding characteristics of the CC GPRFLN| second PDZ domain of PTP-BL CC GPRFLN|REFERENCE 5 (residues 1 to 2466) CC GPRFLN| AUTHORS Marin,L., Minguela,A., Moya-Quiles,M.R., Torio,A., Muro,M., CC GPRFLN| Garcia-Alonso,A.M., Sanchez-Bueno,F., Bru,M., Parrilla,P. and CC GPRFLN| Alvarez-Lopez,M.R. CC GPRFLN| TITLE Expression of CD95 and apoptosis induction in peripheral blood CC GPRFLN| cells from liver graft recipients CC GPRFLN| JOURNAL Transplant. Proc. 34 (1), 280-282 (2002) CC GPRFLN| MEDLINE 21957524 CC GPRFLN| REMARK GeneRIF: expression and apoptosis induction in peripheral blood CC GPRFLN| cells from liver graft CC GPRFLN|REFERENCE 6 (residues 1 to 2466) CC GPRFLN| AUTHORS Nakai,Y., Irie,S. and Sato,T.A. CC GPRFLN| TITLE Identification of IkappaBalpha as a substrate of Fas-associated CC GPRFLN| phosphatase-1 CC GPRFLN| JOURNAL Eur. J. Biochem. 267 (24), 7170-7175 (2000) CC GPRFLN| MEDLINE 20558254 CC GPRFLN|REFERENCE 7 (residues 1 to 2466) CC GPRFLN| AUTHORS Irie,S., Hachiya,T., Rabizadeh,S., Maruyama,W., Mukai,J., Li,Y., CC GPRFLN| Reed,J.C., Bredesen,D.E. and Sato,T.A. CC GPRFLN| TITLE Functional interaction of Fas-associated phosphatase-1 (FAP-1) with CC GPRFLN| p75(NTR) and their effect on NF-kappaB activation CC GPRFLN| JOURNAL FEBS Lett. 460 (2), 191-198 (1999) CC GPRFLN| MEDLINE 20012928 CC GPRFLN|REFERENCE 8 (residues 1 to 2466) CC GPRFLN| AUTHORS Maekawa,K., Imagawa,N., Naito,A., Harada,S., Yoshie,O. and CC GPRFLN| Takagi,S. CC GPRFLN| TITLE Association of protein-tyrosine phosphatase PTP-BAS with the CC GPRFLN| transcription-factor-inhibitory protein IkappaBalpha through CC GPRFLN| interaction between the PDZ1 domain and ankyrin repeats CC GPRFLN| JOURNAL Biochem. J. 337 (Pt 2), 179-184 (1999) CC GPRFLN| MEDLINE 99102074 CC GPRFLN|REFERENCE 9 (residues 1 to 2466) CC GPRFLN| AUTHORS Saras,J., Franzen,P., Aspenstrom,P., Hellman,U., Gonez,L.J. and CC GPRFLN| Heldin,C.H. CC GPRFLN| TITLE A novel GTPase-activating protein for Rho interacts with a PDZ CC GPRFLN| domain of the protein-tyrosine phosphatase PTPL1 CC GPRFLN| JOURNAL J. Biol. Chem. 272 (39), 24333-24338 (1997) CC GPRFLN| MEDLINE 97450957 CC GPRFLN|REFERENCE 10 (residues 1 to 2466) CC GPRFLN| AUTHORS Saras,J., Engstrom,U., Gonez,L.J. and Heldin,C.H. CC GPRFLN| TITLE Characterization of the interactions between PDZ domains of the CC GPRFLN| protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail CC GPRFLN| of Fas CC GPRFLN| JOURNAL J. Biol. Chem. 272 (34), 20979-20981 (1997) CC GPRFLN| MEDLINE 97407871 CC GPRFLN|REFERENCE 11 (residues 1 to 2466) CC GPRFLN| AUTHORS Yanagisawa,J., Takahashi,M., Kanki,H., Yano-Yanagisawa,H., CC GPRFLN| Tazunoki,T., Sawa,E., Nishitoba,T., Kamishohara,M., Kobayashi,E., CC GPRFLN| Kataoka,S. and Sato,T. CC GPRFLN| TITLE The molecular interaction of Fas and FAP-1. A tripeptide blocker of CC GPRFLN| human Fas interaction with FAP-1 promotes Fas-induced apoptosis CC GPRFLN| JOURNAL J. Biol. Chem. 272 (13), 8539-8545 (1997) CC GPRFLN| MEDLINE 97236811 CC GPRFLN|REFERENCE 12 (residues 1 to 2466) CC GPRFLN| AUTHORS Inazawa,J., Ariyama,T., Abe,T., Druck,T., Ohta,M., Huebner,K., CC GPRFLN| Yanagisawa,J., Reed,J.C. and Sato,T. CC GPRFLN| TITLE PTPN13, a fas-associated protein tyrosine phosphatase, is located CC GPRFLN| on the long arm of chromosome 4 at band q21.3 CC GPRFLN| JOURNAL Genomics 31 (2), 240-242 (1996) CC GPRFLN| MEDLINE 96422192 CC GPRFLN|REFERENCE 13 (residues 1 to 2466) CC GPRFLN| AUTHORS Sato,T., Irie,S., Kitada,S. and Reed,J.C. CC GPRFLN| TITLE FAP-1: a protein tyrosine phosphatase that associates with Fas CC GPRFLN| JOURNAL Science 268 (5209), 411-415 (1995) CC GPRFLN| MEDLINE 95232528 CC GPRFLN|REFERENCE 14 (residues 1 to 2466) CC GPRFLN| AUTHORS Saras,J., Claesson-Welsh,L., Heldin,C.H. and Gonez,L.J. CC GPRFLN| TITLE Cloning and characterization of PTPL1, a protein tyrosine CC GPRFLN| phosphatase with similarities to cytoskeletal-associated proteins CC GPRFLN| JOURNAL J. Biol. Chem. 269 (39), 24082-24089 (1994) CC GPRFLN| MEDLINE 95014139 CC GPRFLN|REFERENCE 15 (residues 1 to 2466) CC GPRFLN| AUTHORS Banville,D., Ahmad,S., Stocco,R. and Shen,S.H. CC GPRFLN| TITLE A novel protein-tyrosine phosphatase with homology to both the CC GPRFLN| cytoskeletal proteins of the band 4.1 family and CC GPRFLN| junction-associated guanylate kinases CC GPRFLN| JOURNAL J. Biol. Chem. 269 (35), 22320-22327 (1994) CC GPRFLN| MEDLINE 94350988 CC GPRFLN|REFERENCE 16 (residues 1 to 2466) CC GPRFLN| AUTHORS Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S. CC GPRFLN| TITLE Molecular cloning of a novel protein-tyrosine phosphatase CC GPRFLN| containing a membrane-binding domain and GLGF repeats CC GPRFLN| JOURNAL FEBS Lett. 337 (2), 200-206 (1994) CC GPRFLN| MEDLINE 94116679 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 2466 VNTIFKEY:269 FT PROTEIN 1 2466 protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase FT VNTIFKEY:270 FT REGION 572 781 B41 FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 1071 1160 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 1347 1433 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 1479 1570 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 1769 1848 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 1864 1947 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT REGION 2195 2449 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 2466 AA; MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS LADPAALGFI ISPWSLLLLP 60 SGSVSFTDEN ISNQDLRAFT APEVLQNQSL TSLSDVEKIH IYSLGMTLYW GADYEVPQSQ 120 PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSYVK HLVKLVLGNL 180 SGTDQLSCNS EQKPDRSQAI RDRLRGKGLP TGRSSTSDVL DIQKPPLSHQ TFLNKGLSKS 240 MGFLSIKDTQ DENYFKDILS DNSGREDSEN TFSPYQFKTS GPEKKPIPGI DVLSKKKIWA 300 SSMDLLCTAD RDFSSGETAT YRRCHPEAVT VRTSTTPRKK EARYSDGSIA LDIFGPQKMD 360 PIYHTRELPT SSAISSALDR IRERQKKLQV LREAMNVEEP VRRYKTYHGD VFSTSSESPS 420 IISSESDFRQ VRRSEASKRF ESSSGLPGVD ETLSQGQSQR PSRQYETPFE GNLINQEIML 480 KRQEEELMQL QAKMALRQSR LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG 540 PEFVKMTIEP FISLDLPRSI LTKKGKNEDN RRKVNIMLLN GQRLELTCDT KTICKDVFDM 600 VVAHIGLVEH HLFALATLKD NEYFFVDPDL KLTKVAPEGW KEEPKKKTKA TVNFTLFFRI 660 KFFMDDVSLI QHTLTCHQYY LQLRKDILEE RMHCDDETSL LLASLALQAE YGDYQPEVHG 720 VSYFRMEHYL PARVMEKLDL SYIKEELPKL HNTYVGASEK ETELEFLKVC QRLTEYGVHF 780 HRVHPEKKSQ TGILLGVCSK GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD 840 GIKHGFQTDN SKICQYLLHL CSYQHKFQLQ MRARQSNQDA QDIERASFRS LNLQAESVRG 900 FNMGRAISTG SLASSTLNKL AVRPLSVQAE ILKRLSCSEL SLYQPLQNSS KEKNDKASWE 960 EKPREMSKSY HDLSQASLYP HRKNVIVNME PPPQTVAELV GKPSHQMSRS DAESLAGVTK 1020 LNNSKSVASL NRSPERRKHE SDSSSIEDPG QAYVLDVLHK RWSIVSSPER EITLVNLKKD 1080 AKYGLGFQII GGEKMGRLDL GIFISSVAPG GPADLDGCLK PGDRLISVNS VSLEGVSHHA 1140 AIEILQNAPE DVTLVISQPK EKISKVPSTP VHLTNEMKNY MKKSSYMQDS AIDSSSKDHH 1200 WSRGTLRHIS ENSFGPSGGL REGSLSSQDS RTESASLSQS QVNGFFASHL GDQTWQESQH 1260 GSPSPSVISK ATEKETFTDS NQSKTKKPGI SDVTDYSDRG DSDMDEATYS SSQDHQTPKQ 1320 ESSSSVNTSN KMNFKTFSSS PPKPGDIFEV ELAKNDNSLG ISVTGGVNTS VRHGGIYVKA 1380 VIPQGAAESD GRIHKGDRVL AVNGVSLEGA THKQAVETLR NTGQVVHLLL EKGQSPTSKE 1440 HVPVTPQCTL SDQNAQGQGP EKVKKTTQVK DYSFVTEENT FEVKLFKNSS GLGFSFSRED 1500 NLIPEQINAS IVRVKKLFPG QPAAESGKID VGDVILKVNG ASLKGLSQQE VISALRGTAP 1560 EVFLLLCRPP PGVLPEIDTA LLTPLQSPAQ VLPNSSKDSS QPSCVEQSTS SDENEMSDKS 1620 KKQCKSPSRR DSYSDSSGSG EDDLVTAPAN ISNSTWSSAL HQTLSNMVSQ AQSHHEAPKS 1680 QEDTICTMFY YPQKIPNKPE FEDSNPSPLP PDMAPGQSYQ PQSESASSSS MDKYHIHHIS 1740 EPTRQENWTP LKNDLENHLE DFELEVELLI TLIKSEKGSL GFTVTKGNQR IGCYVHDVIQ 1800 DPAKSDGRLK PGDRLIKVND TDVTNMTHTD AVNLLRAASK TVRLVIGRVL ELPRIPMLPH 1860 LLPDITLTCN KEELGFSLCG GHDSLYQVVY ISDINPRSVA AIEGNLQLLD VIHYVNGVST 1920 QGMTLEEVNR ALDMSLPSLV LKATRNDLPV VPSSKRSAVS APKSTKGNGS YSVGSCSQPA 1980 LTPNDSFSTV AGEEINEISY PKGKCSTYQI KGSPNLTLPK ESYIQEDDIY DDSQEAEVIQ 2040 SLLDVVDEEA QNLLNENNAA GYSCGPGTLK MNGKLSEERT EDTDCDGSPL PEYFTEATKM 2100 NGCEEYCEEK VKSESLIQKP QEKKTDDDEI TWGNDELPIE RTNHEDSDKD HSFLTNDELA 2160 VLPVVKVLPS GKYTGANLKS VIRVLRGLLD QGIPSKELEN LQELKPLDQC LIGQTKENRR 2220 KNRYKNILPY DATRVPLGDE GGYINASFIK IPVGKEEFVY IACQGPLPTT VGDFWQMIWE 2280 QKSTVIAMMT QEVEGEKIKC QRYWPNILGK TTMVSNRLRL ALVRMQQLKG FVVRAMTLED 2340 IQTREVRHIS HLNFTAWPDH DTPSQPDDLL TFISYMRHIH RSGPIITHCS AGIGRSGTLI 2400 CIDVVLGLIS QDLDFDISDL VRCMRLQRHG MVQTEDQYIF CYQVILYVLT RLQAEEEQKQ 2460 QPQLLK 2466 // ID hPTPbeta\(NP_002828)\PTPRB STANDARD;PRT; 1997 AA. AC NP_002828; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, B precursor; protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from X54131.1 and BE042873.1. CC On Feb 4, 2002 this sequence version replaced gi:4506305. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an extracellular CC domain, a single transmembrane segment and one intracytoplasmic CC catalytic domain, thus belongs to receptor type PTP. The CC extracellular region of this PTP is composed of multiple CC fibronectin type_III repeats, which was shown to interact with CC neuronal receptor and cell adhesion molecules, such as contactin CC and tenascin C. This protein was also found to interact with sodium CC channels, and thus may regulate sodium channels by altering CC tyrosine phosphorylation status. The functions of the interaction CC partners of this protein implicate the roles of this PTP in cell CC adhesion, neurite growth, and neuronal differentiation. CC GPRFLN|REFERENCE 1 (residues 1 to 1997) CC GPRFLN| AUTHORS Adamsky,K., Schilling,J., Garwood,J., Faissner,A. and Peles,E. CC GPRFLN| TITLE Glial tumor cell adhesion is mediated by binding of the FNIII CC GPRFLN| domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to CC GPRFLN| tenascin C CC GPRFLN| JOURNAL Oncogene 20 (5), 609-618 (2001) CC GPRFLN| MEDLINE 21214455 CC GPRFLN|REFERENCE 2 (residues 1 to 1997) CC GPRFLN| AUTHORS Ratcliffe,C.F., Qu,Y., McCormick,K.A., Tibbs,V.C., Dixon,J.E., CC GPRFLN| Scheuer,T. and Catterall,W.A. CC GPRFLN| TITLE A sodium channel signaling complex: modulation by associated CC GPRFLN| receptor protein tyrosine phosphatase beta CC GPRFLN| JOURNAL Nat. Neurosci. 3 (5), 437-444 (2000) CC GPRFLN| MEDLINE 20233995 CC GPRFLN|REFERENCE 3 (residues 1 to 1997) CC GPRFLN| AUTHORS Sakurai,T., Lustig,M., Nativ,M., Hemperly,J.J., Schlessinger,J., CC GPRFLN| Peles,E. and Grumet,M. CC GPRFLN| TITLE Induction of neurite outgrowth through contactin and Nr-CAM by CC GPRFLN| extracellular regions of glial receptor tyrosine phosphatase beta CC GPRFLN| JOURNAL J. Cell Biol. 136 (4), 907-918 (1997) CC GPRFLN| MEDLINE 97201469 CC GPRFLN|REFERENCE 4 (residues 1 to 1997) CC GPRFLN| AUTHORS Peles,E., Nativ,M., Campbell,P.L., Sakurai,T., Martinez,R., Lev,S., CC GPRFLN| Clary,D.O., Schilling,J., Barnea,G., Plowman,G.D. et al. CC GPRFLN| TITLE The carbonic anhydrase domain of receptor tyrosine phosphatase beta CC GPRFLN| is a functional ligand for the axonal cell recognition molecule CC GPRFLN| contactin CC GPRFLN| JOURNAL Cell 82 (2), 251-260 (1995) CC GPRFLN| MEDLINE 95354206 CC GPRFLN|REFERENCE 5 (residues 1 to 1997) CC GPRFLN| AUTHORS Harder,K.W., Anderson,L.L., Duncan,A.M. and Jirik,F.R. CC GPRFLN| TITLE The gene for receptor-like protein tyrosine phosphatase (PTPRB) is CC GPRFLN| assigned to chromosome 12q15-->q21 CC GPRFLN| JOURNAL Cytogenet. Cell Genet. 61 (4), 269-270 (1992) CC GPRFLN| MEDLINE 93137605 CC GPRFLN|REFERENCE 6 (residues 1 to 1997) CC GPRFLN| AUTHORS Krueger,N.X., Streuli,M. and Saito,H. CC GPRFLN| TITLE Structural diversity and evolution of human receptor-like protein CC GPRFLN| tyrosine phosphatases CC GPRFLN| JOURNAL EMBO J. 9 (10), 3241-3252 (1990) CC GPRFLN| MEDLINE 91006018 CC GPRFLN|REFERENCE 7 (residues 1 to 1997) CC GPRFLN| AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M., CC GPRFLN| Ricca,G., Jaye,M. and Schlessinger,J. CC GPRFLN| TITLE Cloning of three human tyrosine phosphatases reveals a multigene CC GPRFLN| family of receptor-linked protein-tyrosine-phosphatases expressed CC GPRFLN| in brain CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990) CC GPRFLN| MEDLINE 90384936 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1997 VNTIFKEY:269 FT PROTEIN 1 1997 protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta FT VNTIFKEY:270 FT SIGNAL 1 22 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 23 1997 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 117 192 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 289 363 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 392 454 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 472 547 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 658 722 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT DOMAIN 734 811 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_6 FT DOMAIN 822 894 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_7 FT DOMAIN 910 981 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_8 FT DOMAIN 1008 1076 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_9 FT DOMAIN 1088 1160 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_10 FT DOMAIN 1176 1248 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_11 FT DOMAIN 1264 1344 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_12 FT DOMAIN 1359 1435 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_13 FT SITE 1622 1642 VNTIFKEY:265; VNTINAME:Site_1 FT REGION 1702 1965 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 1997 AA; MLSHGAGLAL WITLSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS PCNFSLIYSS 60 DTLGAALCPT FRIDNTTYGC NLQDLQAGTI YNFKIISLDE ERTVVLQTDP LPPARFGVSK 120 EKTTSTGLHV WWTPSSGKVT SYEVQLFDEN NQKIQGVQIQ ESTSWNEYTF FNLTAGSKYN 180 IAITAVSGGK RSFSVYTNGS TVPSPVKDIG ISTKANSLLI SWSHGSGNVE RYRLMLMDKG 240 ILVHGGVVDK HATSYAFHGL SPGYLYNLTV MTEAAGLQNY RWKLVRTAPM EVSNLKVTND 300 GSLTSLKVKW QRPPGNVDSY NITLSHKGTI KESRVLAPWI TETHFKELVP GRLYQVTVSC 360 VSGELSAQKM AVGRTFPDKV ANLEANNNGR MRSLVVSWSP PAGDWEQYRI LLFNDSVVLL 420 NITVGKEETQ YVMDDTGLVP GRQYEVEVIV ESGNLKNSER CQGRTVPLAV LQLRVKHANE 480 TSLSIMWQTP VAEWEKYIIS LADRDLLLIH KSLSKDAKEF TFTDLVPGRK YMATVTSISG 540 DLKNSSSVKG RTVPAQVTDL HVANQGMTSS LFTNWTQAQG DVEFYQVLLI HENVVIKNES 600 ISSETSRYSF HSLKSGSLYS VVVTTVSGGI SSRQVVVEGR TVPSSVSGVT VNNSGRNDYL 660 SVSWLLAPGD VDNYEVTLSH DGKVVQSLVI AKSVRECSFS SLTPGRLYTV TITTRSGKYE 720 NHSFSQERTV PDKVQGVSVS NSARSDYLRV SWVHATGDFD HYEVTIKNKN NFIQTKSIPK 780 SENECVFVQL VPGRLYSVTV TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR STEDLHVTWS 840 GANGDVDQYE IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGDVQQSAF 900 IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD SQTIPKHVFE 960 HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG VIADNAYSSY SLIVSWQKAA 1020 GVAERYDILL LTENGILLRN TSEPATTKQH KFEDLTPGKK YKIQILTVSG GLFSKEAQTE 1080 GRTVPAAVTD LRITENSTRH LSFRWTASEG ELSWYNIFLY NPDGNLQERA QVDPLVQSFS 1140 FQNLLQGRMY KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL WFNWSPASGD 1200 FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS NKVTAESRTA 1260 PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR DALTVFNPYN NRKSEGRIVY 1320 GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS VRTKPDKIQN LHCRPQNSTA IACSWIPPDS 1380 DFDGYSIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS 1440 TITMIDRPPP PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV VVREADGSDE 1500 LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA EMESLGGKRD 1560 PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT TESEPLFGAI 1620 EGVSAGLFLI GMLVAVVALL ICRQKVSHGR ERPSARLSIR RDRPLSVHLN LGQKGNRKTS 1680 CPIKINQFEG HFMKLQADSN YLLSKEYEEL KDVGRNQSCD IALLPENRGK NRYNNILPYD 1740 ATRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV WEQNVHNIVM 1800 VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG EEQLDAHRLI 1860 RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT VVHCSAGVGR TGTFIALDRI 1920 LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR SEQENPLFPI 1980 YENVNPEYHR DPVYSRH 1997 // ID hPTPD1\(NP_008970)\PTPN21 STANDARD;PRT; 1174 AA. AC NP_008970; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 21; protein tyrosine phosphatase D1 [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from X79510.1 and AI800682.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an N-terminal domain, CC similar to cytoskeletal- associated proteins including band 4.1, CC ezrin, merlin, and radixin. This PTP was shown to specially CC interact with BMX/ETK, a member of Tec tyrosine kinase family CC characterized by a multimodular structures including PH, SH3, and CC SH2 domains. The interaction of this PTP with BMX kinase was found CC to increase the activation of STAT3, but not STAT2 kinase. Studies CC of the similar gene in mice suggested the possible roles of this CC PTP in liver regeneration and spermatogenesis. CC GPRFLN|REFERENCE 1 (residues 1 to 1174) CC GPRFLN| AUTHORS Jui,H.Y., Tseng,R.J., Wen,X., Fang,H.I., Huang,L.M., Chen,K.Y., CC GPRFLN| Kung,H.J., Ann,D.K. and Shih,H.M. CC GPRFLN| TITLE Protein-tyrosine phosphatase D1, a potential regulator and effector CC GPRFLN| for Tec family kinases CC GPRFLN| JOURNAL J. Biol. Chem. 275 (52), 41124-41132 (2000) CC GPRFLN| MEDLINE 20576274 CC GPRFLN|REFERENCE 2 (residues 1 to 1174) CC GPRFLN| AUTHORS Tokuchi,H., Higashitsuji,H., Nishiyama,H., Nonoguchi,K., Nagao,T., CC GPRFLN| Xue,J.H., Itoh,K., Ogawa,O. and Fujita,J. CC GPRFLN| TITLE Expression of protein tyrosine phosphatase PTP-RL10 and its isoform CC GPRFLN| in the mouse testis CC GPRFLN| JOURNAL Int J Urol 6 (11), 572-577 (1999) CC GPRFLN| MEDLINE 20049818 CC GPRFLN|REFERENCE 3 (residues 1 to 1174) CC GPRFLN| AUTHORS Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y., CC GPRFLN| Takenawa,J., Nakayama,H. and Fujita,J. CC GPRFLN| TITLE Enhanced expression of multiple protein tyrosine phosphatases in CC GPRFLN| the regenerating mouse liver: isolation of PTP-RL10, a novel CC GPRFLN| cytoplasmic-type phosphatase with sequence homology to cytoskeletal CC GPRFLN| protein 4.1 CC GPRFLN| JOURNAL Oncogene 10 (2), 407-414 (1995) CC GPRFLN| MEDLINE 95140431 CC GPRFLN|REFERENCE 4 (residues 1 to 1174) CC GPRFLN| AUTHORS Moller,N.P., Moller,K.B., Lammers,R., Kharitonenkov,A., Sures,I. CC GPRFLN| and Ullrich,A. CC GPRFLN| TITLE Src kinase associates with a member of a distinct subfamily of CC GPRFLN| protein-tyrosine phosphatases containing an ezrin-like domain CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (16), 7477-7481 (1994) CC GPRFLN| MEDLINE 94329538 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1174 VNTIFKEY:269 FT PROTEIN 1 1174 protein tyrosine phosphatase D1 FT VNTIFKEY:270 FT REGION 19 222 B41 FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 895 1169 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 1174 AA; MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE 60 VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK YALEPTVYFG VVFYVPSVSQ LQQEITRYQY 120 YLQLKKDILE GSIPCTLEQA IQLAGLAVQA DFGDFDQYES QDFLQKFALF PVGWLQDEKV 180 LEEATQKVAL LHQKYRGLTA PDAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLEG 240 IFVKHKNGRH PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYIWRLCVAR 300 HKFYRLNQCN LQTQTVTVNP IRRRSSSRMS LPKPQPYVMP PPPQLHYNGH YTEPYASSQD 360 NLFVPNQNGY YCHSQTSLDR AQIDFNGRIR NGSVYSAHST NSLNNPQPYL QPSPMSSNPS 420 ITGSDVMRPD YLPSHRHSAV IPPSYRPTPD YETVMKQLNR GLVHAERQSH SLRNLNIGSS 480 YAYSRPAALV YSQPEIREHA QLPSPAAAHC PFSLSYSFHS PSPYPYPAER RPVVGAVSVP 540 ELTNAQLQAQ DYPSPNIMRT QVYRPPPPYP PPRPANSTPD LSRHLYISSS NPDLITRRVH 600 HSVQTFQEDS LPVAHSLQEV SEPLTAARHA QLHKRNSIEV AGLSHGLEGL RLKERTLSAS 660 AAEVAPRAVS VGSQPSVFTE RTQREGPEEA EGLRYGHKKS LSDATMLIHS SEEEEDEDFE 720 EESGARAPPA RAREPRPGLA QDPPGCPRVL LAGPLHILEP KAHVPDAEKR MMDSSPVRTT 780 AEAQRPWRDG LLMPSMSESD LTTSGRYRAR RDSLKKRPVS DLLSGKKNIV EGLPPLGGMK 840 KTRVDAKKIG PLKLAALNGL SLSRVPLPDE GKEVATRATN DERCKILEQR LEQGMVFTEY 900 ERILKKRLVD GECSTARLPE NAERNRFQDV LPYDDARVEL VPTKENNTGY INASHIKVSV 960 SGIEWDYIAT QGPLQNTCQD FWQMVWEQGI AIIAMVTAEE EGGREKSFRY WPRLGSRHNT 1020 VTYGRFKITT RFRTDSGCYA TTGLKMKHLL TGQERTVWHL QYTDWPEHGC PEDLKGFLSY 1080 LEEIQSVRRH TNSTSDPQSP NPPLLVHCSA GVGRTGVVIL SEIMIACLEH NEVLDIPRVL 1140 DMLRQQRMML VQTLCQYTFV YRVLIQFLKS SRLI 1174 // ID hPTPD2\(NP_005392)\PTPN14 STANDARD;PRT; 1187 AA. AC NP_005392; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 14; cytoskeletal-associated protein tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from X82676.1 and BC017300.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an N-terminal CC noncatalytic domain similar to that of band 4.1 superfamily CC cytoskeleton-associated proteins, which suggested the membrane or CC cytoskeleton localization of this protein. The specific function of CC this PTP has not yet been determined. CC GPRFLN|REFERENCE 1 (residues 1 to 1187) CC GPRFLN| AUTHORS Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y. CC GPRFLN| TITLE Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to CC GPRFLN| the nucleus is associated with induction of cell proliferation CC GPRFLN| JOURNAL J. Cell. Sci. 113 (Pt 17), 3117-3123 (2000) CC GPRFLN| MEDLINE 20394014 CC GPRFLN|REFERENCE 2 (residues 1 to 1187) CC GPRFLN| AUTHORS Aoyama,K., Matsuda,T. and Aoki,N. CC GPRFLN| TITLE Characterization of newly identified four isoforms for a putative CC GPRFLN| cytosolic protein tyrosine phosphatase PTP36 CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999) CC GPRFLN| MEDLINE 20068798 CC GPRFLN|REFERENCE 3 (residues 1 to 1187) CC GPRFLN| AUTHORS Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A., CC GPRFLN| Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T. CC GPRFLN| TITLE Regulation of phosphorylation level and distribution of PTP36, a CC GPRFLN| putative protein tyrosine phosphatase, by cell-substrate adhesion CC GPRFLN| JOURNAL J. Biol. Chem. 274 (29), 20717-20724 (1999) CC GPRFLN| MEDLINE 99329094 CC GPRFLN|REFERENCE 4 (residues 1 to 1187) CC GPRFLN| AUTHORS Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A., CC GPRFLN| Miyake,K. and Hamaoka,T. CC GPRFLN| TITLE Effects of overexpression of PTP36, a putative protein tyrosine CC GPRFLN| phosphatase, on cell adhesion, cell growth, and cytoskeletons in CC GPRFLN| HeLa cells CC GPRFLN| JOURNAL J. Biol. Chem. 274 (18), 12905-12909 (1999) CC GPRFLN| MEDLINE 99230323 CC GPRFLN|REFERENCE 5 (residues 1 to 1187) CC GPRFLN| AUTHORS Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V. CC GPRFLN| and Crompton,M.R. CC GPRFLN| TITLE Pez: a novel human cDNA encoding protein tyrosine phosphatase- and CC GPRFLN| ezrin-like domains CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 209 (3), 959-965 (1995) CC GPRFLN| MEDLINE 95251727 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1187 VNTIFKEY:269 FT PROTEIN 1 1187 cytoskeletal-associated protein tyrosine phosphatase FT VNTIFKEY:270 FT REGION 17 220 B41 FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 908 1182 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 1187 AA; MPFGLKLRRT RRYNVLSKNC FVTRIRLLDS NVIECTLSVE STGQECLEAV AQRLELRETH 60 YFGLWFLSKS QQARWVELEK PLKKHLDKFA NEPLLFFGVM FYVPNVSWLQ QEATRYQYYL 120 QVKKDVLEGR LRCTLDQVIR LAGLAVQADF GDYNQFDSQD FLREYVLFPM DLALEEAVLE 180 ELTQKVAQEH KAHSGILPAE AELMYINEVE RLDGFGQEIF PVKDNHGNCV HLGIFFMGIF 240 VRNRIGRQAV IYRWNDMGNI THNKSTILVE LINKEETALF HTDDIENAKY ISRLFATRHK 300 FYKQNKICTE QSNSPPPIRR QPTWSRSSLP RQQPYILPPV HVQCGEHYSE THTSQDSIFH 360 GNEEALYCNS HNSLDLNYLN GTVTNGSVCS VDSVNSLNCS QSFIQASPVS SNLSIPGSDI 420 MRADYIPSHR HSAIIVPSYR PTPDYETVMR QMKRGILHTD SQSQSLRNLN IINTHAYNQP 480 EDLVYSQPEM RERHPYTVPY GPQGVYSNKL VSPSDQRNPK NNVVPSKPGA SAISHTVSTP 540 ELANMQLQGS HNYSTAHMLK NYLFRPPPPY PRPRPATSTP DLASHRHKYV SGSSPDLVTR 600 KVQLSVKTFQ EDSSPVVHQS LQEVSEPLTA TKHHGTVNKR HSLEVMNSMV RGMEAMTLKS 660 LHLPMARRNT LREQGPPEEG SGSHEVPQLP QYHHKKTFSD ATMLIHSSES EEEEEEAPES 720 VPQIPMLREK MEYSAQLQAA LARIPNKPPP EYPGPRKSVS NGALRQDQAS LPPAMARARV 780 LRHGPAKAIS MSRTDPPAVN GASLGPSISE PDLTSVKERV KKEPVKERPV SEMFSLEDSI 840 IEREMMIRNL EKQKMAGLEA QKRPLMLAAL NGLSVARVSG REENRVDATR VPMDERFRTL 900 KKKLEEGMVF TEYEQIPKKK ANGIFSTAAL PENAERSRIR EVVPYEENRV ELIPTKENNT 960 GYINASHIKV VVGGAEWHYI ATQGPLPHTC HDFWQMVWEQ GVNVIAMVTA EEEGGRTKSH 1020 RYWPKLGSKH SSATYGKFKV TTKFRTDSVC YATTGLKVKH LLSGQERTVW HLQYTDWPDH 1080 GCPEDVQGFL SYLEEIQSVR RHTNSMLEGT KNRHPPIVVH CSAGVGRTGV LILSELMIYC 1140 LEHNEKVEVP MMLRLLREQR MFMIQTIAQY KFVYQVLIQF LQNSRLI 1187 // ID hPTPdelta\(NP_002830)\PTPRD STANDARD;PRT; 1912 AA. AC NP_002830; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, D isoform 1 precursor; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from L38929.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an extracellular CC region, a single transmembrane segment and two tandem CC intracytoplasmic catalytic domains, thus represents a receptor-type CC PTP. The extracellular region of this protein is composed of three CC Ig-like and eight fibronectin type III-like domains. Studies of the CC similar genes in chick and fly suggest the role of this PTP is in CC promoting neurite growth, and regulating neurons axon guidance. CC Multiple tissue specific alternatively spliced transcript variants CC of this gene have been reported. CC CC Transcript Variant: This variant (1) encodes the longest isoform CC (1). CC GPRFLN|REFERENCE 1 (residues 1 to 1912) CC GPRFLN| AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. CC GPRFLN| TITLE Intra- and intermolecular interactions between intracellular CC GPRFLN| domains of receptor protein-tyrosine phosphatases CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) CC GPRFLN| MEDLINE 22344739 CC GPRFLN| REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are CC GPRFLN| a common but specific mechanism that is likely to be regulated- CC GPRFLN| domain2s and the wedge structures are crucial determinants of CC GPRFLN| binding specificity, thus regulating cross-talk between RPTPs CC GPRFLN|REFERENCE 2 (residues 1 to 1912) CC GPRFLN| AUTHORS Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M. CC GPRFLN| TITLE The LAR/PTP delta/PTP sigma subfamily of transmembrane CC GPRFLN| protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and CC GPRFLN| PTP sigma isoforms are expressed in a tissue-specific manner and CC GPRFLN| associate with the LAR-interacting protein LIP.1 CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995) CC GPRFLN| MEDLINE 96102179 CC GPRFLN|REFERENCE 3 (residues 1 to 1912) CC GPRFLN| AUTHORS Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M. CC GPRFLN| TITLE Molecular characterization of the human transmembrane CC GPRFLN| protein-tyrosine phosphatase delta. Evidence for tissue-specific CC GPRFLN| expression of alternative human transmembrane protein-tyrosine CC GPRFLN| phosphatase delta isoforms CC GPRFLN| JOURNAL J. Biol. Chem. 270 (12), 6722-6728 (1995) CC GPRFLN| MEDLINE 95204468 CC GPRFLN|REFERENCE 4 (residues 1 to 1912) CC GPRFLN| AUTHORS Krueger,N.X., Streuli,M. and Saito,H. CC GPRFLN| TITLE Structural diversity and evolution of human receptor-like protein CC GPRFLN| tyrosine phosphatases CC GPRFLN| JOURNAL EMBO J. 9 (10), 3241-3252 (1990) CC GPRFLN| MEDLINE 91006018 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1912 VNTIFKEY:269 FT PROTEIN 1 1912 protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta FT VNTIFKEY:270 FT SIGNAL 1 20 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 21 1912 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 30 116 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 141 214 IGc2 FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 242 320 IG FT VNTIFKEY:266; VNTINAME:Region_3 FT DOMAIN 326 405 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 421 504 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 516 594 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 613 699 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 715 812 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT DOMAIN 824 904 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_6 FT DOMAIN 922 1006 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_7 FT REGION 1356 1613 PTPc FT VNTIFKEY:266; VNTINAME:Region_4 FT REGION 1643 1904 PTPc FT VNTIFKEY:266; VNTINAME:Region_5 SQ SEQUENCE 1912 AA; MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK 60 GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ 120 IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS 180 ESIGGTPIRG ALQIEQSEES DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI 240 PPTNHEIMPG GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY 300 TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP VSYYIIQHKP 360 KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG RGPPSEPVLT QTSEQAPSSA 420 PRDVQARMLS STTILVQWKE PEEPNGQIQG YRVYYTMDPT QHVNNWMKHN VADSQITTIG 480 NLVPQKTYSV KVLAFTSIGD GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR 540 SDTIANYELV YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI 600 SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT AVDGEDDKPH 660 EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL SVLIRTNEDV PSGPPRKVEV 720 EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH YVRMENGEPK GQPMLKDVML ADAQWEFDDT 780 TEHDMIISGL QPETSYSLTV TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL 840 IQWHPPVDTF GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK 900 VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI ITKYTLLYRD 960 INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK GPGPYSPSVQ FRTLPVDQVF 1020 AKNFHVKAVM KTSVLLSWEI PENYNSAMPF KILYDDGKMV EEVDGRATQK LIVNLKPEKS 1080 YSFVLTNRGN SAGGLQHRVT AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY 1140 YIIIVPLKKS RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP 1200 TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV VSMDLDPQPI 1260 TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR KSSIPNNKEI PSHHPTDPVE 1320 LRRLNFQTPG MASHPPIPIL ELADHIERLK ANDNLKFSQE YESIDPGQQF TWEHSNLEVN 1380 KPKNRYANVI AYDHSRVLLS AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW 1440 RMIWEQRSAT VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL 1500 YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV VHCSAGVGRT 1560 GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED QYIFIHDALL EAVTCGNTEV 1620 PARNLYAYIQ KLTQIETGEN VTGMELEFKR LASSKAHTSR FISANLPCNK FKNRLVNIMP 1680 YESTRVCLQP IRGVEGSDYI NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV 1740 VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV 1800 RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR TGVFITLSIV 1860 LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA LEYLGSFDHY AT 1912 // ID hPTPepsilon\(NP_006495)\PTPRE STANDARD;PRT; 700 AA. AC NP_006495; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, E isoform 1 precursor; protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from X54134.1, AJ315969.1 and CC BI559814.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. Two alternatively spliced transcript CC variants of this gene have been reported, one of which encodes a CC receptor-type PTP that possesses a short extracellular domain, a CC single transmembrane region, and two tandem intracytoplasmic CC catalytic domains; Another one encodes a PTP that contains a CC distinct hydrophilic N-terminus, and thus represents a CC nonreceptor-type isoform of this PTP. Studies of the similar gene CC in mice suggested the regulatory roles of this PTP in RAS related CC signal transduction pathways, cytokines induced SATA signaling, as CC well as the activation of voltage-gated K+ channels. CC CC Transcript Variant: This variant (1) contains a different 5' end CC region that includes a part of the coding region, when compared to CC variant 2. It thus encodes a protein that has a distinct CC N-terminus, as compared to isoform 2. The encoded protein is a CC receptor type isoform of this PTP. CC GPRFLN|REFERENCE 1 (residues 1 to 700) CC GPRFLN| AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. CC GPRFLN| TITLE Intra- and intermolecular interactions between intracellular CC GPRFLN| domains of receptor protein-tyrosine phosphatases CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) CC GPRFLN| MEDLINE 22344739 CC GPRFLN| REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are CC GPRFLN| a common but specific mechanism that is likely to be regulated- CC GPRFLN| domain2s and the wedge structures are crucial determinants of CC GPRFLN| binding specificity, thus regulating cross-talk between RPTPs CC GPRFLN|REFERENCE 2 (residues 1 to 700) CC GPRFLN| AUTHORS Wabakken,T., Hauge,H., Funderud,S. and Aasheim,H.C. CC GPRFLN| TITLE Characterization, expression and functional aspects of a novel CC GPRFLN| protein tyrosine phosphatase epsilon isoform CC GPRFLN| JOURNAL Scand. J. Immunol. 56 (3), 276-285 (2002) CC GPRFLN| MEDLINE 22181756 CC GPRFLN| REMARK GeneRIF: Characterization, expression and functional aspects of an CC GPRFLN| alternative spliced isoform of protein tyrosine phosphatase epsilon CC GPRFLN|REFERENCE 3 (residues 1 to 700) CC GPRFLN| AUTHORS Wabakken,T., Hauge,H., Finne,E.F., Wiedlocha,A. and Aasheim,H. CC GPRFLN| TITLE Expression of human protein tyrosine phosphatase epsilon in CC GPRFLN| leucocytes: a potential ERK pathway-regulating phosphatase CC GPRFLN| JOURNAL Scand. J. Immunol. 56 (2), 195-203 (2002) CC GPRFLN| MEDLINE 22118122 CC GPRFLN| REMARK GeneRIF: Transfection of cells with different PTPepsilon constructs CC GPRFLN| and activator protein-1 reporter gene indicates that the catalytic CC GPRFLN| activity of PTPepsilon is involved in the regulation of the CC GPRFLN| mitogen-activated protein kinase cascade. CC GPRFLN|REFERENCE 4 (residues 1 to 700) CC GPRFLN| AUTHORS Tanuma,N., Nakamura,K., Shima,H. and Kikuchi,K. CC GPRFLN| TITLE Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT CC GPRFLN| signaling and differentiation induced by interleukin-6 and leukemia CC GPRFLN| inhibitory factor in M1 leukemia cells CC GPRFLN| JOURNAL J. Biol. Chem. 275 (36), 28216-28221 (2000) CC GPRFLN| MEDLINE 20428741 CC GPRFLN| REMARK functional study of the mouse homolog CC GPRFLN|REFERENCE 5 (residues 1 to 700) CC GPRFLN| AUTHORS Peretz,A., Gil-Henn,H., Sobko,A., Shinder,V., Attali,B. and CC GPRFLN| Elson,A. CC GPRFLN| TITLE Hypomyelination and increased activity of voltage-gated K(+) CC GPRFLN| channels in mice lacking protein tyrosine phosphatase epsilon CC GPRFLN| JOURNAL EMBO J. 19 (15), 4036-4045 (2000) CC GPRFLN| MEDLINE 20380937 CC GPRFLN| REMARK functional study of the mouse homolog CC GPRFLN|REFERENCE 6 (residues 1 to 700) CC GPRFLN| AUTHORS Toledano-Katchalski,H. and Elson,A. CC GPRFLN| TITLE The transmembranal and cytoplasmic forms of protein tyrosine CC GPRFLN| phosphatase epsilon physically associate with the adaptor molecule CC GPRFLN| Grb2 CC GPRFLN| JOURNAL Oncogene 18 (36), 5024-5031 (1999) CC GPRFLN| MEDLINE 99422037 CC GPRFLN| REMARK functional study of the mouse homolog CC GPRFLN|REFERENCE 7 (residues 1 to 700) CC GPRFLN| AUTHORS Elson,A. and Leder,P. CC GPRFLN| TITLE Identification of a cytoplasmic, phorbol ester-inducible isoform of CC GPRFLN| protein tyrosine phosphatase epsilon CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12235-12239 (1995) CC GPRFLN| MEDLINE 96109240 CC GPRFLN|REFERENCE 8 (residues 1 to 700) CC GPRFLN| AUTHORS van den Maagdenberg,A.M., van den Hurk,H.H., Weghuis,D., CC GPRFLN| Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J. CC GPRFLN| TITLE Assignment of the human protein tyrosine phosphatase epsilon CC GPRFLN| (PTPRE) gene to chromosome 10q26 by fluorescence in situ CC GPRFLN| hybridization CC GPRFLN| JOURNAL Genomics 30 (1), 128-129 (1995) CC GPRFLN| MEDLINE 96129319 CC GPRFLN|REFERENCE 9 (residues 1 to 700) CC GPRFLN| AUTHORS Krueger,N.X., Streuli,M. and Saito,H. CC GPRFLN| TITLE Structural diversity and evolution of human receptor-like protein CC GPRFLN| tyrosine phosphatases CC GPRFLN| JOURNAL EMBO J. 9 (10), 3241-3252 (1990) CC GPRFLN| MEDLINE 91006018 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 700 VNTIFKEY:269 FT PROTEIN 1 700 protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon FT VNTIFKEY:270 FT SIGNAL 1 19 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 20 700 VNTIFKEY:203; VNTINAME:Chain_1 FT SITE 47 69 VNTIFKEY:265; VNTINAME:Site_1 FT REGION 134 396 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 425 690 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 700 AA; MEPLCPLLLV GFSLPLARAL RGNETTADSN ETTTTSGPPD PGASQPLLAW LLLPLLLLLL 60 VLLLAAYFFR FRKQRKAVVS TSDKKMPNGI LEEQEQQRVM LLSRSPSGPK KYFPIPVEHL 120 EEEIRIRSAD DCKQFREEFN SLPSGHIQGT FELANKEENR EKNRYPNILP NDHSRVILSQ 180 LDGIPCSDYI NASYIDGYKE KNKFIAAQGP KQETVNDFWR MVWEQKSATI VMLTNLKERK 240 EEKCHQYWPD QGCWTYGNIR VCVEDCVVLV DYTIRKFCIQ PQLPDGCKAP RLVSQLHFTS 300 WPDFGVPFTP IGMLKFLKKV KTLNPVHAGP IVVHCSAGVG RTGTFIVIDA MMAMMHAEQK 360 VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT ELDVSSLEKH LQTMHGTTTH 420 FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA NMKKARVIQI IPYDFNRVIL SMKRGQEYTD 480 YINASFIDGY RQKDYFIATQ GPLAHTVEDF WRMIWEWKSH TIVMLTEVQE REQDKCYQYW 540 PTEGSVTHGE ITIEIKNDTL SEAISIRDFL VTLNQPQARQ EEQVRVVRQF HFHGWPEIGI 600 PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV KAEGLLDVFQ 660 AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK 700 // ID hPTPgamma\(NP_002832)\PTPRG STANDARD;PRT; 1445 AA. AC NP_002832; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, G precursor; protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from L09247.1, AI872451.1 and CC U46089.1. CC On Feb 22, 2002 this sequence version replaced gi:11386169. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and two tandem CC intracytoplasmic catalytic domains, and thus represents a CC receptor-type PTP. The extracellular region of this PTP contains a CC carbonic anhydrase-like (CAH) domain, which is also found in the CC extracellular region of PTPRBETA/ZETA. This gene is located in a CC chromosomal region that is frequently deleted in renal cell CC carcinoma and lung carcinoma, thus is thought to be a candidate CC tumor suppressor gene. CC GPRFLN|REFERENCE 1 (residues 1 to 1445) CC GPRFLN| AUTHORS Liu,S., Sugimoto,Y., Kulp,S.K., Jiang,J., Chang,H.L., Park,K.Y., CC GPRFLN| Kashida,Y. and Lin,Y.C. CC GPRFLN| TITLE Estrogenic down-regulation of protein tyrosine phosphatase gamma CC GPRFLN| (PTP gamma) in human breast is associated with estrogen receptor CC GPRFLN| alpha CC GPRFLN| JOURNAL Anticancer Res. 22 (6C), 3917-3923 (2002) CC GPRFLN| MEDLINE 22441179 CC GPRFLN| REMARK GeneRIF: Estrogenic down-regulation of protein tyrosine phosphatase CC GPRFLN| gamma (PTP gamma) in human breast is associated with estrogen CC GPRFLN| receptor alpha. CC GPRFLN|REFERENCE 2 (residues 1 to 1445) CC GPRFLN| AUTHORS Liu,S., Kulp,S.K., Sugimoto,Y., Jiang,J., Chang,H.L. and Lin,Y.C. CC GPRFLN| TITLE Involvement of breast epithelial-stromal interactions in the CC GPRFLN| regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA CC GPRFLN| expression by estrogenically active agents CC GPRFLN| JOURNAL Breast Cancer Res. Treat. 71 (1), 21-35 (2002) CC GPRFLN| MEDLINE 21848634 CC GPRFLN| REMARK GeneRIF: both estradiol-17beta and zeranol regulate PTPgamma CC GPRFLN| expression in human breast; epithelial-stromal cell interaction is CC GPRFLN| important in regulation of PTPgamma expression by estrogenically CC GPRFLN| active agents CC GPRFLN|REFERENCE 3 (residues 1 to 1445) CC GPRFLN| AUTHORS Kastury,K., Ohta,M., Lasota,J., Moir,D., Dorman,T., LaForgia,S., CC GPRFLN| Druck,T. and Huebner,K. CC GPRFLN| TITLE Structure of the human receptor tyrosine phosphatase gamma gene CC GPRFLN| (PTPRG) and relation to the familial RCC t(3;8) chromosome CC GPRFLN| translocation CC GPRFLN| JOURNAL Genomics 32 (2), 225-235 (1996) CC GPRFLN| MEDLINE 96429999 CC GPRFLN|REFERENCE 4 (residues 1 to 1445) CC GPRFLN| AUTHORS Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D., CC GPRFLN| D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al. CC GPRFLN| TITLE Identification of a carbonic anhydrase-like domain in the CC GPRFLN| extracellular region of RPTP gamma defines a new subfamily of CC GPRFLN| receptor tyrosine phosphatases CC GPRFLN| JOURNAL Mol. Cell. Biol. 13 (3), 1497-1506 (1993) CC GPRFLN| MEDLINE 93180796 CC GPRFLN|REFERENCE 5 (residues 1 to 1445) CC GPRFLN| AUTHORS LaForgia,S., Morse,B., Levy,J., Barnea,G., Cannizzaro,L.A., Li,F., CC GPRFLN| Nowell,P.C., Boghosian-Sell,L., Glick,J., Weston,A. et al. CC GPRFLN| TITLE Receptor protein-tyrosine phosphatase gamma is a candidate tumor CC GPRFLN| suppressor gene at human chromosome region 3p21 CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (11), 5036-5040 (1991) CC GPRFLN| MEDLINE 91271326 CC GPRFLN|REFERENCE 6 (residues 1 to 1445) CC GPRFLN| AUTHORS Krueger,N.X., Streuli,M. and Saito,H. CC GPRFLN| TITLE Structural diversity and evolution of human receptor-like protein CC GPRFLN| tyrosine phosphatases CC GPRFLN| JOURNAL EMBO J. 9 (10), 3241-3252 (1990) CC GPRFLN| MEDLINE 91006018 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1445 VNTIFKEY:269 FT PROTEIN 1 1445 protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma FT VNTIFKEY:270 FT SIGNAL 1 19 G00-127-351 FT VNTIFKEY:200; VNTINAME:PTPRG FT CHAIN 20 1445 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 60 320 carb_anhydrase FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 348 426 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 847 1121 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1150 1412 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1445 AA; MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW 60 AYSGAYGPEH WVTSSVSCGS RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT 120 GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN 180 PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD 240 LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300 YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ 360 TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 420 FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 480 TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 540 AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE 600 KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR 660 DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE 720 KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRGCNKIKS KGFPRRFREV 780 PSSGERGEKG SRKCFQTAHF YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL 840 YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD 900 SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI TNLVEKGRRK 960 CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK VKKGQKGNPK GRQNERVVIQ 1020 YHYTQWPDMG VPEYALPVLT FVRRSSAARM PETGPVLVHC SAGVGRTGTY IVIDSMLQQI 1080 KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL 1140 IPGVGGKTRL EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM 1200 KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP DNQSLAEDEF 1260 VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL EATQDDYVLE VRHFQCPKWP 1320 NPDAPISSTF ELINVIKEEA LTRDGPTIVH DEYGAVSAGM LCALTTLSQQ LENENAVDVF 1380 QVAKMINLMR PGVFTDIEQY QFIYKARLSL VSTKENGNGP MTVDKNGAVL IADESDPAES 1440 MESLV 1445 // ID hPTPH1\(NP_002820)\PTPN3 STANDARD;PRT; 913 AA. AC NP_002820; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 3; protein tyrosin phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M64572.1 and W15441.1. CC On Jan 10, 2002 this sequence version replaced gi:4506293. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This protein contains a C-terminal PTP CC domain and an N-terminal domain homologous to the band 4.1 CC superfamily of cytoskeletal-associated proteins. P97, a cell cycle CC regulator involved in a variety of membrane related functions, has CC been shown to be a substrate of this PTP. This PTP was also found CC to interact with, and be regulated by adaptor protein 14-3-3 beta. CC GPRFLN|REFERENCE 1 (residues 1 to 913) CC GPRFLN| AUTHORS Zheng,Y., Schlondorff,J. and Blobel,C.P. CC GPRFLN| TITLE Evidence for regulation of the tumor necrosis factor CC GPRFLN| alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1 CC GPRFLN| JOURNAL J. Biol. Chem. 277 (45), 42463-42470 (2002) CC GPRFLN| MEDLINE 22301977 CC GPRFLN| REMARK GeneRIF: regulates TACE (tnf-alpha convertase} CC GPRFLN|REFERENCE 2 (residues 1 to 913) CC GPRFLN| AUTHORS Zhang,S.H., Liu,J., Kobayashi,R. and Tonks,N.K. CC GPRFLN| TITLE Identification of the cell cycle regulator VCP (p97/CDC48) as a CC GPRFLN| substrate of the band 4.1-related protein-tyrosine phosphatase CC GPRFLN| PTPH1 CC GPRFLN| JOURNAL J. Biol. Chem. 274 (25), 17806-17812 (1999) CC GPRFLN| MEDLINE 99292748 CC GPRFLN|REFERENCE 3 (residues 1 to 913) CC GPRFLN| AUTHORS Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and CC GPRFLN| Tonks,N.K. CC GPRFLN| TITLE Serine phosphorylation-dependent association of the band CC GPRFLN| 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta CC GPRFLN| protein CC GPRFLN| JOURNAL J. Biol. Chem. 272 (43), 27281-27287 (1997) CC GPRFLN| MEDLINE 98001710 CC GPRFLN|REFERENCE 4 (residues 1 to 913) CC GPRFLN| AUTHORS Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and CC GPRFLN| Yachi,A. CC GPRFLN| TITLE Expression of cytoskeletal-associated protein tyrosine phosphatase CC GPRFLN| PTPH1 mRNA in human hepatocellular carcinoma CC GPRFLN| JOURNAL J. Gastroenterol. 29 (6), 727-732 (1994) CC GPRFLN| MEDLINE 95179278 CC GPRFLN|REFERENCE 5 (residues 1 to 913) CC GPRFLN| AUTHORS Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M., CC GPRFLN| Ariyama,T., Inazawa,J., Imai,K. and Yachi,A. CC GPRFLN| TITLE Expression and chromosomal assignment of PTPH1 gene encoding a CC GPRFLN| cytosolic protein tyrosine phosphatase homologous to CC GPRFLN| cytoskeletal-associated proteins CC GPRFLN| JOURNAL Int. J. Cancer 55 (6), 947-951 (1993) CC GPRFLN| MEDLINE 94075060 CC GPRFLN|REFERENCE 6 (residues 1 to 913) CC GPRFLN| AUTHORS Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M., CC GPRFLN| Adachi,M., Imai,K. and Yachi,A. CC GPRFLN| TITLE cDNA cloning of new protein tyrosine phosphatases in the human CC GPRFLN| colon CC GPRFLN| JOURNAL Tumour Biol. 13 (3), 180-186 (1992) CC GPRFLN| MEDLINE 92327504 CC GPRFLN|REFERENCE 7 (residues 1 to 913) CC GPRFLN| AUTHORS Yang,Q. and Tonks,N.K. CC GPRFLN| TITLE Isolation of a cDNA clone encoding a human protein-tyrosine CC GPRFLN| phosphatase with homology to the cytoskeletal-associated proteins CC GPRFLN| band 4.1, ezrin, and talin CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (14), 5949-5953 (1991) CC GPRFLN| MEDLINE 91296738 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 913 VNTIFKEY:269 FT PROTEIN 1 913 protein tyrosin phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase FT VNTIFKEY:270 FT DOMAIN 31 222 Band_41 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 510 597 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT REGION 649 903 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 913 AA; MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT GQVLLDMVHN 60 HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP CTLHFRVRFF IPDPNTLQQE 120 QTRHLYFLQL KMDICEGRLT CPLNSAVVLA SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ 180 NEDFLTKVES LHEQHSGLKQ SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG 240 VAVYRKYICT SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 300 CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW NPAMRRSLSV 360 EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA NEMTYITETE DVFYTYKGSL 420 APQDSDSEVS QNRSPHQESL SENNPAQSYL TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD 480 FHRVTKGGST EDASQYYCDK NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI 540 NPESPADTCI PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR 600 SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF EQLYRKKPGL 660 AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY VNMEIPAANL VNKYIATQGP 720 LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT 780 IAYVSREMLV TNTQTGEEHT VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPLLV 840 HCSAGIGRTG VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 900 VYEEGLVQML DPS 913 // ID hPTPkappa\(NP_002835)\PTPRK STANDARD;PRT; 1440 AA. AC NP_002835; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, K precursor; protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from L77886.1 and BI755683.1. CC On Feb 22, 2002 this sequence version replaced gi:4506317. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and two tandem catalytic CC domains, and thus represents a receptor-type PTP. The extracellular CC region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like CC domain and four fibronectin type III-like repeats. This PTP was CC shown to mediate homophilic intercellular interaction, possibly CC through the interaction with beta- and gamma-catenin at adherens CC junctions. Expression of this gene was found to be stimulated by CC TGF-beta 1, which may be important for the inhibition of CC keratinocyte proliferation. CC GPRFLN|REFERENCE 1 (residues 1 to 1440) CC GPRFLN| AUTHORS Yang,Y., Gil,M.C., Choi,E.Y., Park,S.H., Pyun,K.H. and Ha,H. CC GPRFLN| TITLE Molecular cloning and chromosomal localization of a human gene CC GPRFLN| homologous to the murine R-PTP-kappa, a receptor-type protein CC GPRFLN| tyrosine phosphatase CC GPRFLN| JOURNAL Gene 186 (1), 77-82 (1997) CC GPRFLN| MEDLINE 97199372 CC GPRFLN|REFERENCE 2 (residues 1 to 1440) CC GPRFLN| AUTHORS Yang,Y., Gil,M., Byun,S.M., Choi,I., Pyun,K.H. and Ha,H. CC GPRFLN| TITLE Transforming growth factor-beta1 inhibits human keratinocyte CC GPRFLN| proliferation by upregulation of a receptor-type tyrosine CC GPRFLN| phosphatase R-PTP-kappa gene expression CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 228 (3), 807-812 (1996) CC GPRFLN| MEDLINE 97096334 CC GPRFLN|REFERENCE 3 (residues 1 to 1440) CC GPRFLN| AUTHORS Fuchs,M., Muller,T., Lerch,M.M. and Ullrich,A. CC GPRFLN| TITLE Association of human protein-tyrosine phosphatase kappa with CC GPRFLN| members of the armadillo family CC GPRFLN| JOURNAL J. Biol. Chem. 271 (28), 16712-16719 (1996) CC GPRFLN| MEDLINE 96279245 CC GPRFLN|REFERENCE 4 (residues 1 to 1440) CC GPRFLN| AUTHORS Zondag,G.C., Koningstein,G.M., Jiang,Y.P., Sap,J., Moolenaar,W.H. CC GPRFLN| and Gebbink,M.F. CC GPRFLN| TITLE Homophilic interactions mediated by receptor tyrosine phosphatases CC GPRFLN| mu and kappa. A critical role for the novel extracellular MAM CC GPRFLN| domain CC GPRFLN| JOURNAL J. Biol. Chem. 270 (24), 14247-14250 (1995) CC GPRFLN| MEDLINE 95301498 CC GPRFLN|REFERENCE 5 (residues 1 to 1440) CC GPRFLN| AUTHORS Sap,J., Jiang,Y.P., Friedlander,D., Grumet,M. and Schlessinger,J. CC GPRFLN| TITLE Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic CC GPRFLN| binding CC GPRFLN| JOURNAL Mol. Cell. Biol. 14 (1), 1-9 (1994) CC GPRFLN| MEDLINE 94088505 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1440 VNTIFKEY:269 FT PROTEIN 1 1440 protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor FT VNTIFKEY:270 FT SIGNAL 1 26 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 27 1440 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 32 194 MAM FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 202 289 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 292 363 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 490 583 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT REGION 887 1144 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1174 1438 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1440 AA; MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV 60 SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP 120 GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI 180 AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV 240 AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL 300 LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE 360 IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC 420 HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE 480 TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV 540 AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE 600 GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN 660 AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE 720 TKTQCVRIAT KAAATEEPEV IPDPAKQTDR VVKIAGISAG ILVFILLLLV VILIVKKSKL 780 AKKRKDAMGN TRQEMTHMVN AMDRSYADQS TLHAEDPLSI TFMDQHNFSP RYENHSATAE 840 SSRLLDVPRY LCEGTESPYQ TGQLHPAIRV ADLLQHINLM KTSDSYGFKE EYESFFEGQS 900 ASWDVAKKDQ NRAKNRYGNI IAYDHSRVIL QPVEDDPSSD YINANYIDGY QRPSHYIATQ 960 GPVHETVYDF WRMIWQEQSA CIVMVTNLVE VGRVKCYKYW PDDTEVYGDF KVTCVEMEPL 1020 AEYVVRTFTL ERRGYNEIRE VKQFHFTGWP DHGVPYHATG LLSFIRRVKL SNPPSAGPIV 1080 VHCSAGAGRT GCYIVIDIML DMAEREGVVD IYNCVKALRS RRINMVQTEE QYIFIHDAIL 1140 EACLCGETAI PVCEFKAAYF DMIRIDSQTN SSHLKDEFQT LNSVTPRLQA EDCSIACLPR 1200 NHDKNRFMDM LPPDRCLPFL ITIDGESSNY INAALMDSYR QPAAFIVTQY PLPNTVKDFW 1260 RLVYDYGCTS IVMLNEVDLS QGCPQYWPEE GMLRYGPIQV ECMSCSMDCD VINRIFRICN 1320 LTRPQEGYLM VQQFQYLGWA SHREVPGSKR SFLKLILQVE KWQEECEEGE GRTIIHCLNG 1380 GGRSGMFCAI GIVVEMVKRQ NVVDVFHAVK TLRNSKPNMV EAPEQYRFCY DVALEYLESS 1440 // ID hPTPlamda\(NP_005695)\PTPRU STANDARD;PRT; 1446 AA. AC NP_005695; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, U isoform 3 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from X97198.1 and X95712.1. CC On Mar 26, 2002 this sequence version replaced gi:5032003. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and two tandem intracellular CC catalytic domains, and thus represents a receptor-type PTP. The CC extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, CC Ig-like and fibronectin type III-like repeats. This PTP was thought CC to play roles in cell-cell recognition and adhesion. Studies of the CC similar gene in mice suggested the role of this PTP in early neural CC development. The expression of this gene was reported to be CC regulated by phorbol myristate acetate (PMA) or calcium ionophore CC in Jurkat T lymphoma cells. Three alternatively spliced transcript CC variants, which encode distinct proteins, have been reported. CC CC Transcript Variant: This variant (3) encodes the longest isoform CC (3). CC GPRFLN|REFERENCE 1 (residues 1 to 1446) CC GPRFLN| AUTHORS Yan,H.X., He,Y.Q., Dong,H., Zhang,P., Zeng,J.Z., Cao,H.F., Wu,M.C. CC GPRFLN| and Wang,H.Y. CC GPRFLN| TITLE Physical and functional interaction between receptor-like protein CC GPRFLN| tyrosine phosphatase PCP-2 and beta-catenin CC GPRFLN| JOURNAL Biochemistry 41 (52), 15854-15860 (2002) CC GPRFLN| MEDLINE 22389441 CC GPRFLN| REMARK GeneRIF: Expressed in a cell density-dependent fashion, PCP-2 CC GPRFLN| interacts directly with its substrate beta-catenin, independent of CC GPRFLN| the tyrosine phosphorylation state of beta-catenin. CC GPRFLN|REFERENCE 2 (residues 1 to 1446) CC GPRFLN| AUTHORS Wang,B., Kishihara,K., Zhang,D., Sakamoto,T. and Nomoto,K. CC GPRFLN| TITLE Transcriptional regulation of a receptor protein tyrosine CC GPRFLN| phosphatase gene hPTP-J by PKC-mediated signaling pathways in CC GPRFLN| Jurkat and Molt-4 T lymphoma cells CC GPRFLN| JOURNAL Biochim. Biophys. Acta 1450 (3), 331-340 (1999) CC GPRFLN| MEDLINE 99326162 CC GPRFLN|REFERENCE 3 (residues 1 to 1446) CC GPRFLN| AUTHORS Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S., CC GPRFLN| White,R.A., Painter,C., Steinberger,A.A. and Avraham,H. CC GPRFLN| TITLE Characterization and chromosomal localization of PTPRO, a novel CC GPRFLN| receptor protein tyrosine phosphatase, expressed in hematopoietic CC GPRFLN| stem cells CC GPRFLN| JOURNAL Gene 204 (1-2), 5-16 (1997) CC GPRFLN| MEDLINE 98094249 CC GPRFLN|REFERENCE 4 (residues 1 to 1446) CC GPRFLN| AUTHORS Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K. CC GPRFLN| TITLE Molecular cloning and characterization of a novel human receptor CC GPRFLN| protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene CC GPRFLN| expression by PMA and calcium ionophore in Jurkat T lymphoma cells CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 231 (1), 77-81 (1997) CC GPRFLN| MEDLINE 97223402 CC GPRFLN|REFERENCE 5 (residues 1 to 1446) CC GPRFLN| AUTHORS Crossland,S., Smith,P.D. and Crompton,M.R. CC GPRFLN| TITLE Molecular cloning and characterization of PTP pi, a novel CC GPRFLN| receptor-like protein-tyrosine phosphatase CC GPRFLN| JOURNAL Biochem. J. 319 (Pt 1), 249-254 (1996) CC GPRFLN| MEDLINE 97024447 CC GPRFLN|REFERENCE 6 (residues 1 to 1446) CC GPRFLN| AUTHORS Wang,H., Lian,Z., Lerch,M.M., Chen,Z., Xie,W. and Ullrich,A. CC GPRFLN| TITLE Characterization of PCP-2, a novel receptor protein tyrosine CC GPRFLN| phosphatase of the MAM domain family CC GPRFLN| JOURNAL Oncogene 12 (12), 2555-2562 (1996) CC GPRFLN| MEDLINE 96293401 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1446 VNTIFKEY:269 FT PROTEIN 1 1446 protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron FT VNTIFKEY:270 FT SIGNAL 1 18 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 19 1446 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 22 188 MAM FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 196 283 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 286 357 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 386 471 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 486 578 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT REGION 893 1146 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1175 1441 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1446 AA; MARAQALVLA LTFQLCAPET ETPAAGCTFE EASDPAVPCE YSQAQYDDFQ WEQVRIHPGT 60 RAPADLPHGS YLMVNTSQHA PGQRAHVIFQ SLSENDTHCV QFSYFLYSRD GHRPGTLGVY 120 VRVNGGPLGS AVWNMTGSHG RQWHQAELAV STFWPNEYQV LFEALISPDR RGYMGLDDIL 180 LLSYPCAKAP HFSRLGDVEV NAGQNASFQC MAAGRAAMRQ RFLLQRQSGA LVPAAGVRHI 240 SHRRFLATFP LAAVSRAEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT 300 YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVSLQ TYKLWHLDPD TEYEISVLLT 360 RPGDGGTGRP GPPLISRTKC AEPMRAPKGL AFAEIQARQL TLQWEPLGYN VTRCHTYTVS 420 LCYHYTLGSS HNQTIRECVK TEQGVSRYTI KNLLPYRNVH VRLVLTNPEG RKEGKEVTFQ 480 TDEDVPSGIA AESLTFTPLE DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR 540 RTISKLRNET YHVFSNLHPG TTYLFSVRAR TGKGFGQAAL TEITTNISAP SFDYADMPSP 600 LGESENTITV LLRPAQGRGA PISVYQVIVE EERARRLRRE RGGQDCFPVP LTFEAALARG 660 LVHYFGAELA ASSLPEAMPF TVGDNQTYRG FWNPPLEPRK AYLIYFQAAS HLKGETRLNC 720 IRIARKAACK ESKRPLEVSQ RSEEMGLILG ICAGGLAVLI LLLGAIIVII RKGRDHYAYS 780 YYPKPVNMTK ATVNYRQEKT HMMSAVDRSF TDQSTLQEDE RLGLSFMDTH GYSTRGDQRS 840 GGVTEASSLL GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES 900 FFEGWDATKK KDKVKGSRQE PMPAYDRHRV KLHPMLGDPN ADYINANYID GYHRSNHFIA 960 TQGPKPEMVY DFWRMVWQEH CSSIVMITKL VEVGRVKCSR YWPEDSDTYG DIKIMLVKTE 1020 TLAEYVVRTF ALERRGYSAR HEVRQFHFTA WPEHGVPYHA TGLLAFIRRV KASTPPDAGP 1080 IVIHCSAGTG RTGCYIVLDV MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA 1140 ILEACLCGET TIPVSEFKAT YKEMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL 1200 PRNRDKNRSM DVLPPDRCLP FLISTDGDSN NYINAALTDS YTRSAAFIVT LHPLQSTTPD 1260 FWRLVYDYGC TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY GLMEVEFMSG TADEDLVARV 1320 FRVQNISRLQ EGHLLVRHFQ FLRWSAYRDT PDSKKAFLHL LAEVDKWQAE SGDGRTIVHC 1380 LNGGGRSGTF CACATVLEMI RCHNLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL 1440 EGLESR 1446 // ID hPTPmu\(NP_002836)\PTPRM STANDARD;PRT; 1452 AA. AC NP_002836; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, M precursor; protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from X58288.1 and AA281524.1. CC On Feb 22, 2002 this sequence version replaced gi:4506319. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and two tandem catalytic CC domains, and thus represents a receptor-type PTP. The extracellular CC region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like CC domain and four fibronectin type III-like repeats. This PTP has CC been shown to mediate cell-cell aggregation through the interaction CC with another molecule of this PTP on an adjacent cell. This PTP can CC interact with scaffolding protein RACK1/GNB2L1, which may be CC necessary for the downstream signaling in response to cell-cell CC adhesion. CC GPRFLN|REFERENCE 1 (residues 1 to 1452) CC GPRFLN| AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. CC GPRFLN| TITLE Intra- and intermolecular interactions between intracellular CC GPRFLN| domains of receptor protein-tyrosine phosphatases CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) CC GPRFLN| MEDLINE 22344739 CC GPRFLN| REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are CC GPRFLN| a common but specific mechanism that is likely to be regulated- CC GPRFLN| domain2s and the wedge structures are crucial determinants of CC GPRFLN| binding specificity, thus regulating cross-talk between RPTPs CC GPRFLN|REFERENCE 2 (residues 1 to 1452) CC GPRFLN| AUTHORS Mourton,T., Hellberg,C.B., Burden-Gulley,S.M., Hinman,J., Rhee,A. CC GPRFLN| and Brady-Kalnay,S.M. CC GPRFLN| TITLE The PTPmu protein-tyrosine phosphatase binds and recruits the CC GPRFLN| scaffolding protein RACK1 to cell-cell contacts CC GPRFLN| JOURNAL J. Biol. Chem. 276 (18), 14896-14901 (2001) CC GPRFLN| MEDLINE 21226727 CC GPRFLN|REFERENCE 3 (residues 1 to 1452) CC GPRFLN| AUTHORS Feiken,E., van Etten,I., Gebbink,M.F., Moolenaar,W.H. and CC GPRFLN| Zondag,G.C. CC GPRFLN| TITLE Intramolecular interactions between the juxtamembrane domain and CC GPRFLN| phosphatase domains of receptor protein-tyrosine phosphatase CC GPRFLN| RPTPmu. Regulation of catalytic activity CC GPRFLN| JOURNAL J. Biol. Chem. 275 (20), 15350-15356 (2000) CC GPRFLN| MEDLINE 20270248 CC GPRFLN|REFERENCE 4 (residues 1 to 1452) CC GPRFLN| AUTHORS Brady-Kalnay,S.M. and Tonks,N.K. CC GPRFLN| TITLE Identification of the homophilic binding site of the receptor CC GPRFLN| protein tyrosine phosphatase PTP mu CC GPRFLN| JOURNAL J. Biol. Chem. 269 (45), 28472-28477 (1994) CC GPRFLN| MEDLINE 95050637 CC GPRFLN|REFERENCE 5 (residues 1 to 1452) CC GPRFLN| AUTHORS Suijkerbuijk,R.F., Gebbink,M.F., Moolenaar,W.H. and Geurts van CC GPRFLN| Kessel,A. CC GPRFLN| TITLE Fine mapping of the human receptor-like protein tyrosine CC GPRFLN| phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ CC GPRFLN| hybridization CC GPRFLN| JOURNAL Cytogenet. Cell Genet. 64 (3-4), 245-246 (1993) CC GPRFLN| MEDLINE 94007972 CC GPRFLN|REFERENCE 6 (residues 1 to 1452) CC GPRFLN| AUTHORS Brady-Kalnay,S.M., Flint,A.J. and Tonks,N.K. CC GPRFLN| TITLE Homophilic binding of PTP mu, a receptor-type protein tyrosine CC GPRFLN| phosphatase, can mediate cell-cell aggregation CC GPRFLN| JOURNAL J. Cell Biol. 122 (4), 961-972 (1993) CC GPRFLN| MEDLINE 93352709 CC GPRFLN|REFERENCE 7 (residues 1 to 1452) CC GPRFLN| AUTHORS Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R., CC GPRFLN| Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H. CC GPRFLN| TITLE Cloning, expression and chromosomal localization of a new putative CC GPRFLN| receptor-like protein tyrosine phosphatase CC GPRFLN| JOURNAL FEBS Lett. 290 (1-2), 123-130 (1991) CC GPRFLN| MEDLINE 92008644 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1452 VNTIFKEY:269 FT PROTEIN 1 1452 protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor FT VNTIFKEY:270 FT SIGNAL 1 20 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 21 1452 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 23 182 MAM FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 192 279 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 282 361 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 383 467 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 499 574 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT REGION 899 1156 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1185 1449 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1452 AA; MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ VNTLTKPTSD 60 PWMPSGSLML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNSP PGLLNVYVKV 120 NNGPLGNPIW NISGDPTRTW NRAELAISTF WPNFYQVIFE VITSGHQGYL AIDEVKVLGH 180 PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR 240 FIASFNVVNT TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI 300 QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE 360 GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW EPFGYNVTRC HSYNLTVHYC 420 YQVGGQEQVR EEVSWDTENS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELIVQTDED 480 LPGAVPTESI QGSTFEEKIF LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS 540 KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT 600 DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ NASLLNSQYY 660 FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI YFQAASRANG ETKIDCVQVA 720 TKGAATPKPV PEPEKQTDHT VKIAGVIAGI LLFVIIFLGV VLVMKKRKLA KKRKETMSST 780 RQEMTVMVNS MDKSYAEQGT NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY 840 YPDETHTMAS DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900 KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN SDYINGNYID 960 GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL VEVGRVKCCK YWPDDTEIYK 1020 DIKVTLIETE LLAEYVIRTF AVEKRGVHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV 1080 KSKSPPSAGP LVVHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT 1140 EEQYVFIHDA ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200 RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT 1260 QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE 1320 EDIISRIFRI YNAARPQDGY RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG 1380 GEGPTVVHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF 1440 CYEVALEYLN SG 1452 // ID hPTPrho\(NP_573400)\PTPRT STANDARD;PRT; 1463 AA. AC NP_573400; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, T isoform 1 precursor; receptor protein tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from AF043644.4 and R50970.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and two tandem intracellular CC catalytic domains, and thus represents a receptor-type PTP. The CC extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, CC Ig-like and fibronectin type III-like repeats. The protein domain CC structure and the expression pattern of the mouse counterpart of CC this PTP suggest its roles in both signal transduction and cellular CC adhesion in the central nervous system. Two alternatively spliced CC transcript variants of this gene, which encode distinct proteins, CC have been reported. CC CC Transcript Variant: This variant (1) contains an additional CC fragment within the coding region when compared to variant 2, and CC thus encodes a protein that contains an extra internal segment, as CC compared to isoform 2. CC GPRFLN|REFERENCE 1 (residues 1 to 1463) CC GPRFLN| AUTHORS Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A. CC GPRFLN| TITLE Genomic organization and alternative splicing of the human and CC GPRFLN| mouse RPTPrho genes CC GPRFLN| JOURNAL BMC Genomics 2 (1), 1 (2001) CC GPRFLN|REFERENCE 2 (residues 1 to 1463) CC GPRFLN| AUTHORS McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H. CC GPRFLN| TITLE Identification and characterization of RPTP rho, a novel RPTP CC GPRFLN| mu/kappa-like receptor protein tyrosine phosphatase whose CC GPRFLN| expression is restricted to the central nervous system CC GPRFLN| JOURNAL Brain Res. Mol. Brain Res. 56 (1-2), 9-21 (1998) CC GPRFLN| MEDLINE 98267260 CC GPRFLN|REFERENCE 3 (residues 1 to 1463) CC GPRFLN| AUTHORS McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D., CC GPRFLN| Chiu,I.M., Burghes,A.H. and Rotter,A. CC GPRFLN| TITLE Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic CC GPRFLN| fibroblast growth factor (FGF-1) transcripts delineate a CC GPRFLN| rostrocaudal boundary in the granule cell layer of the murine CC GPRFLN| cerebellar cortex CC GPRFLN| JOURNAL J. Comp. Neurol. 391 (4), 444-455 (1998) CC GPRFLN| MEDLINE 98146229 CC GPRFLN|REFERENCE 4 (residues 1 to 1463) CC GPRFLN| AUTHORS Hillier,L.D., Lennon,G., Becker,M., Bonaldo,M.F., Chiapelli,B., CC GPRFLN| Chissoe,S., Dietrich,N., DuBuque,T., Favello,A., Gish,W., CC GPRFLN| Hawkins,M., Hultman,M., Kucaba,T., Lacy,M., Le,M., Le,N., CC GPRFLN| Mardis,E., Moore,B., Morris,M., Parsons,J., Prange,C., Rifkin,L., CC GPRFLN| Rohlfing,T., Schellenberg,K., Marra,M. et al. CC GPRFLN| TITLE Generation and analysis of 280,000 human expressed sequence tags CC GPRFLN| JOURNAL Genome Res. 6 (9), 807-828 (1996) CC GPRFLN| MEDLINE 97044478 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1463 VNTIFKEY:269 FT PROTEIN 1 1463 receptor protein tyrosine phosphatase FT VNTIFKEY:270 FT SIGNAL 1 25 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 26 1463 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 27 191 MAM FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 289 360 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 502 577 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT REGION 910 1167 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 1196 1461 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 1463 AA; MASLAALALS LLLRLQLPPL PGARAQSAPG GCSFDEHYSN CGYSVALGTN GFTWEQINTT 60 EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT HCIDFHYYFS SRDRSSPGAL 120 NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE LAISTFWPHF YQVIFESVSL KGHPGYIAVD 180 EVRVLAHPCR KAPHFLRLQN VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT 240 RVVNHRRFSA TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 300 GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL DPDVEYEIRV 360 LLTRPGEGGT GPPGAPLTTR TKCADPVHGP QNVEIVDIRA RQLTLQWEPF GYAVTRCHSY 420 NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR GLRPFMTIRL RLLLSNPEGR MESEELVVQT 480 EEDVPGAVPL ESIQGGPFEE KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG 540 KVFKLRNETH HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 600 NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV SYRNASSLDS 660 LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS YSIYFQALSK ANGETKINCV 720 RLATKAPMGS AQVTPGTPLC LLTTGASTQN SNTVEPEKQV DNTVKMAGVI AGLLMFIIIL 780 LGVMLTIKRR RNAYSYSYYL SQRKLAKKQK ETQSGAQREM GPVASADKPT TKLSASRNDE 840 GFSSSSQDVN GFTDGSRGEL SQPTLTIQTH PYRTCDPVEM SYPRDQFQLA IRVADLLQHI 900 TQMKRGQGYG FKEEYEALPE GQTASWDTAK EDENRNKNRY GNIISYDHSR VRLLVLDGDP 960 HSDYINANYI DGYHRPRHYI ATQGPMQETV KDFWRMIWQE NSASIVMVTN LVEVGRVKCV 1020 RYWPDDTEVY GDIKVTLIET EPLAEYVIRT FTVQKKGYHE IRELRLFHFT SWPDHGVPCY 1080 ATGLLGFVRQ VKFLNPPEAG PIVVHCSAGA GRTGCFIAID TMLDMAENEG VVDIFNCVRE 1140 LRAQRVNLVQ TEEQYVFVHD AILEACLCGN TAIPVCEFRS LYYNISRLDP QTNSSQIKDE 1200 FQTLNIVTPR VRPEDCSIGL LPRNHDKNRS MDVLPLDRCL PFLISVDGES SNYINAALMD 1260 SHKQPAAFVV TQHPLPNTVA DFWRLVFDYN CSSVVMLNEM DTAQFCMQYW PEKTSGCYGP 1320 IQVEFVSADI DEDIIHRIFR ICNMARPQDG YRIVQHLQYI GWPAYRDTPP SKRSLLKVVR 1380 RLEKWQEQYD GREGRTVVHC LNGGGRSGTF CAICSVCEMI QQQNIIDVFH IVKTLRNNKS 1440 NMVETLEQYK FVYEVALEYL SSF 1463 // ID hPTPS31\(AR073855)\PTPGMC1 STANDARD;PRT; 898 AA. DT 17-MAY-2003 DE Translation of a fragment of delete. KW TRANSLATED. CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| SQ SEQUENCE 898 AA; GRSGSQYPVD TKVPSVPTNI AFSDVQSTSA TLTWIRPDTI LGYFQNYKIT TQLRAQKCKE 60 WESEECVEYQ KIQYLYEAHL TEETVYGLKK FRWYRFQVAA STNAGYGNAS NWISTKTLPG 120 PPDGPPENVH VVATSPFSIS ISWSEPAVIT GPTCYLIDVK SVDNDEFNIS FIKSNEENKT 180 IEIKDLEIFT RYSVVITAFT GNISAAYVEG KSSAEMIVTT LESAPKDPPN NMTFQKIPDE 240 VTKFQLTFLP PSQPNGNIQV YQALVYREDD PTAVQIHNLS IIQKTNTFVI AMLEGLKGGH 300 TYNISVYAVN SAGAGPKVPM RITMDIKAPA RPKTKPTPIY DATGKLLVTS TTITIRMPIC 360 YYSDDHGPIK NVQVLVTETG AQHDGNVTKW YDAYFNKARP YFTNEGFPNP PCTEGKTKFS 420 GNEEIYIIGA DNACMIPGNE DKICNGPLKP KKQYLFKFRA TNIMGQFTDS DYSDPVKTLG 480 EGLSERTVEI ILSVTLCILS IILLGTAIFA FARIRQKQKE GGTYSPQDAE IIDTKLKLDQ 540 LITVADLELK DERLTRYSSF FFRRKEIFVI QLLSYRKSIK PISKKSFLQH VEELCTNNNL 600 KFQEEFSELP KFLQDLSSTD ADLPWNRAKN RFPNIKPYNN NRVKLIADAS VPGSDYINAS 660 YISGYLCPNE FIATQGPLPG TVGDFWRMVW ETRAKTLVML TQCFEKGRIR CHQYWPEDNK 720 PVTVFGDIVI TKLMEDVQID WTIRDLKIER HGDCMTVRQC NFTAWPEHGV PENSAPLIHF 780 VKLVRASRAH DTTPMIVHCS AGVGRTGVFI ALDHLTQHIN DHDFVDIYGL VAELRSERMC 840 MVQNLAQYIF LHQCILDLLS NKGSNQPICF VNYSALQKMD SLDAMEGDVE LEWEETTM 898 // ID hPTPsigma\(NP_002841)\PTPRS STANDARD;PRT; 1948 AA. AC NP_002841; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, sigma isoform 1 precursor; protein tyrosine phosphatase PTPsigma [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from U35234.1 and BI461316.1. CC On Mar 26, 2002 this sequence version replaced gi:4506327. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains an extracellular CC region, a single transmembrane segment and two tandem CC intracytoplasmic catalytic domains, and thus represents a CC receptor-type PTP. The extracellular region of this protein is CC composed of multiple Ig-like and fibronectin type III-like domains. CC Studies of the similar gene in mice suggested that this PTP may be CC involved in cell-cell interaction, primary axonogenesis, and axon CC guidance during embryogenesis. This PTP has been also implicated in CC the molecular control of adult nerve repair. Four alternatively CC spliced transcript variants, which encode distinct proteins, have CC been reported. CC CC Transcript Variant: This variant (1) encodes the longest isoform CC (1). CC GPRFLN|REFERENCE 1 (residues 1 to 1948) CC GPRFLN| AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J. CC GPRFLN| TITLE Intra- and intermolecular interactions between intracellular CC GPRFLN| domains of receptor protein-tyrosine phosphatases CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002) CC GPRFLN| MEDLINE 22344739 CC GPRFLN| REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are CC GPRFLN| a common but specific mechanism that is likely to be regulated- CC GPRFLN| domain2s and the wedge structures are crucial determinants of CC GPRFLN| binding specificity, thus regulating cross-talk between RPTPs CC GPRFLN|REFERENCE 2 (residues 1 to 1948) CC GPRFLN| AUTHORS Wallace,M.J., Batt,J., Fladd,C.A., Henderson,J.T., Skarnes,W. and CC GPRFLN| Rotin,D. CC GPRFLN| TITLE Neuronal defects and posterior pituitary hypoplasia in mice lacking CC GPRFLN| the receptor tyrosine phosphatase PTPsigma CC GPRFLN| JOURNAL Nat. Genet. 21 (3), 334-338 (1999) CC GPRFLN| MEDLINE 99178277 CC GPRFLN| REMARK functional study of the mouse homolog CC GPRFLN|REFERENCE 3 (residues 1 to 1948) CC GPRFLN| AUTHORS Elchebly,M., Wagner,J., Kennedy,T.E., Lanctot,C., Michaliszyn,E., CC GPRFLN| Itie,A., Drouin,J. and Tremblay,M.L. CC GPRFLN| TITLE Neuroendocrine dysplasia in mice lacking protein tyrosine CC GPRFLN| phosphatase sigma CC GPRFLN| JOURNAL Nat. Genet. 21 (3), 330-333 (1999) CC GPRFLN| MEDLINE 99178276 CC GPRFLN| REMARK functional study of the mouse homolog CC GPRFLN|REFERENCE 4 (residues 1 to 1948) CC GPRFLN| AUTHORS Haworth,K., Shu,K.K., Stokes,A., Morris,R. and Stoker,A. CC GPRFLN| TITLE The expression of receptor tyrosine phosphatases is responsive to CC GPRFLN| sciatic nerve crush CC GPRFLN| JOURNAL Mol. Cell. Neurosci. 12 (3), 93-104 (1998) CC GPRFLN| MEDLINE 99009170 CC GPRFLN| REMARK functional study of the rat homolog CC GPRFLN|REFERENCE 5 (residues 1 to 1948) CC GPRFLN| AUTHORS Wagner,J., Gordon,L.A., Heng,H.H., Tremblay,M.L. and Olsen,A.S. CC GPRFLN| TITLE Physical mapping of receptor type protein tyrosine phosphatase CC GPRFLN| sigma (PTPRS) to human chromosome 19p13.3 CC GPRFLN| JOURNAL Genomics 38 (1), 76-78 (1996) CC GPRFLN| MEDLINE 97124849 CC GPRFLN|REFERENCE 6 (residues 1 to 1948) CC GPRFLN| AUTHORS Endo,N., Rutledge,S.J., Opas,E.E., Vogel,R., Rodan,G.A. and CC GPRFLN| Schmidt,A. CC GPRFLN| TITLE Human protein tyrosine phosphatase-sigma: alternative splicing and CC GPRFLN| inhibition by bisphosphonates CC GPRFLN| JOURNAL J. Bone Miner. Res. 11 (4), 535-543 (1996) CC GPRFLN| MEDLINE 96255038 CC GPRFLN|REFERENCE 7 (residues 1 to 1948) CC GPRFLN| AUTHORS Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M. CC GPRFLN| TITLE The LAR/PTP delta/PTP sigma subfamily of transmembrane CC GPRFLN| protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and CC GPRFLN| PTP sigma isoforms are expressed in a tissue-specific manner and CC GPRFLN| associate with the LAR-interacting protein LIP.1 CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995) CC GPRFLN| MEDLINE 96102179 CC GPRFLN|REFERENCE 8 (residues 1 to 1948) CC GPRFLN| AUTHORS Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., CC GPRFLN| Imai,K. and Yachi,A. CC GPRFLN| TITLE Protein-tyrosine phosphatase expression in pre-B cell NALM-6 CC GPRFLN| JOURNAL Cancer Res. 52 (3), 737-740 (1992) CC GPRFLN| MEDLINE 92119637 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1948 VNTIFKEY:269 FT PROTEIN 1 1948 protein tyrosine phosphatase PTPsigma FT VNTIFKEY:270 FT SIGNAL 1 29 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 30 1948 VNTIFKEY:203; VNTINAME:Chain_1 FT REGION 39 125 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 150 223 IGc2 FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 251 329 IG FT VNTIFKEY:266; VNTINAME:Region_3 FT DOMAIN 332 411 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 428 510 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 525 603 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 622 700 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 724 821 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT DOMAIN 836 914 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_6 FT DOMAIN 932 1022 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_7 FT DOMAIN 1037 1097 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_8 FT REGION 1392 1649 PTPc FT VNTIFKEY:266; VNTINAME:Region_4 FT REGION 1679 1940 PTPc FT VNTIFKEY:266; VNTINAME:Region_5 SQ SEQUENCE 1948 AA; MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP 60 KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 120 KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 180 NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV 240 RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL 300 TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV 360 SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR 420 TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV 480 DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS 540 ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ 600 GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA LVGYSVRYRP 660 LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT EVGPGPESSP VVVRTDEDVP 720 SAPPRKVEAE ALNATAIRVL WRSPAPGRQH GQIRGYQVHY VRMEGAEARG PPRIKDVMLA 780 DAQWETDDTA EYEMVITNLQ PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV 840 QQTPEGSLLA RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT 900 YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW LPPVPAERNG 960 AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL KPDTAYDLQV RAHTRRGPGP 1020 FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR 1080 TTKKLITHLK PHTFYNFVLT NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV 1140 YLPDGQSPVP VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR 1200 QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL QKSEPTFAAS 1260 PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV IAILLYKNKP DSKRKDSEPR 1320 TKCLLNNADL APHHPKDPVE MRRINFQTPD SGLRSPLREP GFHFESMLSH PPIPIADMAE 1380 HTERLKANDS LKLSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG 1440 IMGSDYINAN YVDGYRRQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK 1500 CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF QFTAWPDHGV 1560 PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI VIDAMLERIK PEKTVDVYGH 1620 VTLMRSQRNY MVQTEDQYSF IHEALLEAVG CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM 1680 ELEFKRLANS KAHTSRFISA NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF 1740 IDGYRQQKAY IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA 1800 RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP KSGEGFIDFI 1860 GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP 1920 AMVQTEDEYQ FCYQAALEYL GSFDHYAT 1948 // ID hPTPTyp\(AL050040)\PTPN20 STANDARD;PRT; 339 AA. DT 17-MAY-2003 DE Translation of a fragment of hPTPTyp (AL050040). KW TRANSLATED. CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| SQ SEQUENCE 339 AA; MWTARGPFRR DRWSSEDEEA AGPSQALSPL LSDTRKIVSE GELDQLAQIR PLIFNFHEQT 60 AIKDCLKILE EKTAAYDIMQ EFMALELKNL PGEFYSGNQP SNREKNRYRD ILPYDSTRVP 120 LGKSKDYINA SYIRIVNCGE EYFYIATQGP LLSTIDDFWQ MVLENNSNVI AMITREMEGG 180 IIKCYHYWPI SLKKPLELKH FRVFLENYQI LQYFIIRMFQ VVEKSTGTSH SVKQLQFTKW 240 PDHGTPASAD SFIKYIRYAR KSHLTGPMVV HCSAGIGRTG VFLCVDVVFC AIVKDCSFNI 300 MDIVAQMREQ RSGMVQTKEQ YHFCYDIVLE VLRKLLTLD 339 // ID hPTPzeta\(NP_002842)\PTPRZ1 STANDARD;PRT; 2314 AA. AC NP_002842; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from M93426.1. CC GPRFLN|REFERENCE 1 (residues 1 to 2314) CC GPRFLN| AUTHORS Harroch,S., Furtado,G.C., Brueck,W., Rosenbluth,J., Lafaille,J., CC GPRFLN| Chao,M., Buxbaum,J.D. and Schlessinger,J. CC GPRFLN| TITLE A critical role for the protein tyrosine phosphatase receptor type CC GPRFLN| Z in functional recovery from demyelinating lesions CC GPRFLN| JOURNAL Nat. Genet. 32 (3), 411-414 (2002) CC GPRFLN| MEDLINE 22297719 CC GPRFLN| REMARK GeneRIF: PTPRZ1 has a role in oligodendrocyte survival and in CC GPRFLN| recovery from demyelinating disease CC GPRFLN|REFERENCE 2 (residues 1 to 2314) CC GPRFLN| AUTHORS Thomaidou,D., Coquillat,D., Meintanis,S., Noda,M., Rougon,G. and CC GPRFLN| Matsas,R. CC GPRFLN| TITLE Soluble forms of NCAM and F3 neuronal cell adhesion molecules CC GPRFLN| promote Schwann cell migration: identification of protein tyrosine CC GPRFLN| phosphatases zeta/beta as the putative F3 receptors on Schwann CC GPRFLN| cells CC GPRFLN| JOURNAL J. Neurochem. 78 (4), 767-778 (2001) CC GPRFLN| MEDLINE 21412137 CC GPRFLN|REFERENCE 3 (residues 1 to 2314) CC GPRFLN| AUTHORS Kawachi,H., Fujikawa,A., Maeda,N. and Noda,M. CC GPRFLN| TITLE Identification of GIT1/Cat-1 as a substrate molecule of protein CC GPRFLN| tyrosine phosphatase zeta /beta by the yeast substrate-trapping CC GPRFLN| system CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (12), 6593-6598 (2001) CC GPRFLN| MEDLINE 21287250 CC GPRFLN|REFERENCE 4 (residues 1 to 2314) CC GPRFLN| AUTHORS Meng,K., Rodriguez-Pena,A., Dimitrov,T., Chen,W., Yamin,M., Noda,M. CC GPRFLN| and Deuel,T.F. CC GPRFLN| TITLE Pleiotrophin signals increased tyrosine phosphorylation of beta CC GPRFLN| beta-catenin through inactivation of the intrinsic catalytic CC GPRFLN| activity of the receptor-type protein tyrosine phosphatase CC GPRFLN| beta/zeta CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (6), 2603-2608 (2000) CC GPRFLN| MEDLINE 20183934 CC GPRFLN|REFERENCE 5 (residues 1 to 2314) CC GPRFLN| AUTHORS Kawachi,H., Tamura,H., Watakabe,I., Shintani,T., Maeda,N. and CC GPRFLN| Noda,M. CC GPRFLN| TITLE Protein tyrosine phosphatase zeta/RPTPbeta interacts with CC GPRFLN| PSD-95/SAP90 family CC GPRFLN| JOURNAL Brain Res. Mol. Brain Res. 72 (1), 47-54 (1999) CC GPRFLN| MEDLINE 99453345 CC GPRFLN|REFERENCE 6 (residues 1 to 2314) CC GPRFLN| AUTHORS Onyango,P., Lubyova,B., Gardellin,P., Kurzbauer,R. and Weith,A. CC GPRFLN| TITLE Molecular cloning and expression analysis of five novel genes in CC GPRFLN| chromosome 1p36 CC GPRFLN| JOURNAL Genomics 50 (2), 187-198 (1998) CC GPRFLN| MEDLINE 98317532 CC GPRFLN|REFERENCE 7 (residues 1 to 2314) CC GPRFLN| AUTHORS Ariyama,T., Hasegawa,K., Inazawa,J., Mizuno,K., Ogimoto,M., CC GPRFLN| Katagiri,T. and Yakura,H. CC GPRFLN| TITLE Assignment of the human protein tyrosine phosphatase, CC GPRFLN| receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3 CC GPRFLN| JOURNAL Cytogenet. Cell Genet. 70 (1-2), 52-54 (1995) CC GPRFLN| MEDLINE 95254878 CC GPRFLN|REFERENCE 8 (residues 1 to 2314) CC GPRFLN| AUTHORS Levy,J.B., Canoll,P.D., Silvennoinen,O., Barnea,G., Morse,B., CC GPRFLN| Honegger,A.M., Huang,J.T., Cannizzaro,L.A., Park,S.H., Druck,T. et CC GPRFLN| al. CC GPRFLN| TITLE The cloning of a receptor-type protein tyrosine phosphatase CC GPRFLN| expressed in the central nervous system CC GPRFLN| JOURNAL J. Biol. Chem. 268 (14), 10573-10581 (1993) CC GPRFLN| MEDLINE 93252948 CC GPRFLN|REFERENCE 9 (residues 1 to 2314) CC GPRFLN| AUTHORS Krueger,N.X. and Saito,H. CC GPRFLN| TITLE A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is CC GPRFLN| expressed in brain and has an N-terminal receptor domain homologous CC GPRFLN| to carbonic anhydrases CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7417-7421 (1992) CC GPRFLN| MEDLINE 92366472 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 2314 VNTIFKEY:269 FT PROTEIN 1 2314 protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta FT VNTIFKEY:270 FT REGION 38 299 carb_anhydrase FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 315 395 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 1715 1993 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 2021 2283 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 2314 AA; MRILKRFLAC IQLLCVCRLD WANGYYRQQR KLVEEIGWSY TGALNQKNWG KKYPTCNSPK 60 QSPINIDEDL TQVNVNLKKL KFQGWDKTSL ENTFIHNTGK TVEINLTNDY RVSGGVSEMV 120 FKASKITFHW GKCNMSSDGS EHSLEGQKFP LEMQIYCFDA DRFSSFEEAV KGKGKLRALS 180 ILFEVGTEEN LDFKAIIDGV ESVSRFGKQA ALDPFILLNL LPNSTDKYYI YNGSLTSPPC 240 TDTVDWIVFK DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 300 TGKEEIHEAV CSSEPENVQA DPENYTSLLV TWERPRVVYD TMIEKFAVLY QQLDGEDQTK 360 HEFLTDGYQD LGAILNNLLP NMSYVLQIVA ICTNGLYGKY SDQLIVDMPT DNPELDLFPE 420 LIGTEEIIKE EEEGKDIEEG AIVNPGRDSA TNQIRKKEPQ ISTTTHYNRI GTKYNEAKTN 480 RSPTRGSEFS GKGDVPNTSL NSTSQPVTKL ATEKDISLTS QTVTELPPHT VEGTSASLND 540 GSKTVLRSPH MNLSGTAESL NTVSITEYEE ESLLTSFKLD TGAEDSSGSS PATSAIPFIS 600 ENISQGYIFS SENPETITYD VLIPESARNA SEDSTSSGSE ESLKDPSMEG NVWFPSSTDI 660 TAQPDVGSGR ESFLQTNYTE IRVDESEKTT KSFSAGPVMS QGPSVTDLEM PHYSTFAYFP 720 TEVTPHAFTP SSRQQDLVST VNVVYSQTTQ PVYNGETPLQ PSYSSEVFPL VTPLLLDNQI 780 LNTTPAASSS DSALHATPVF PSVDVSFESI LSSYDGAPLL PFSSASFSSE LFRHLHTVSQ 840 ILPQVTSATE SDKVPLHASL PVAGGDLLLE PSLAQYSDVL STTHAASETL EFGSESGVLY 900 KTLMFSQVEP PSSDAMMHAR SSGPEPSYAL SDNEGSQHIF TVSYSSAIPV HDSVGVTYQG 960 SLFSGPSHIP IPKSSLITPT ASLLQPTHAL SGDGEWSGAS SDSEFLLPDT DGLTALNISS 1020 PVSVAEFTYT TSVFGDDNKA LSKSEIIYGN ETELQIPSFN EMVYPSESTV MPNMYDNVNK 1080 LNASLQETSV SISSTKGMFP GSLAHTTTKV FDHEISQVPE NNFSVQPTHT VSQASGDTSL 1140 KPVLSANSEP ASSDPASSEM LSPSTQLLFY ETSASFSTEV LLQPSFQASD VDTLLKTVLP 1200 AVPSDPILVE TPKVDKISST MLHLIVSNSA SSENMLHSTS VPVFDVSPTS HMHSASLQGL 1260 TISYASEKYE PVLLKSESSH QVVPSLYSND ELFQTANLEI NQAHPPKGRH VFATPVLSID 1320 EPLNTLINKL IHSDEILTST KSSVTGKVFA GIPTVASDTF VSTDHSVPIG NGHVAITAVS 1380 PHRDGSVTST KLLFPSKATS ELSHSAKSDA GLVGGGEDGD TDDDGDDDDD RDSDGLSIHK 1440 CMSCSSYRES QEKVMNDSDT HENSLMDQNN PISYSLSENS EEDNRVTSVS SDSQTGMDRS 1500 PGKSPSANGL SQKHNDGKEE NDIQTGSALL PLSPESKAWA VLTSDEESGS GQGTSDSLNE 1560 NETSTDFSFA DTNEKDADGI LAAGDSEITP GFPQSPTSSV TSENSEVFHV SEAEASNSSH 1620 ESRIGLAEGL ESEKKAVIPL VIVSALTFIC LVVLVGILIY WRKCFQTAHF YLEDSTSPRV 1680 ISTPPTPIFP ISDDVGAIPI KHFPKHVADL HASSGFTEEF ETLKEFYQEV QSCTVDLGIT 1740 ADSSNHPDNK HKNRYINIVA YDHSRVKLAQ LAEKDGKLTD YINANYVDGY NRPKAYIAAQ 1800 GPLKSTAEDF WRMIWEHNVE VIVMITNLVE KGRRKCDQYW PADGSEEYGN FLVTQKSVQV 1860 LAYYTVRNFT LRNTKIKKGS QKGRPSGRVV TQYHYTQWPD MGVPEYSLPV LTFVRKAAYA 1920 KRHAVGPVVV HCSAGVGRTG TYIVLDSMLQ QIQHEGTVNI FGFLKHIRSQ RNYLVQTEEQ 1980 YVFIHDTLVE AILSKETEVL DSHIHAYVNA LLIPGPAGKT KLEKQFQLLS QSNIQQSDYS 2040 AALKQCNREK NRTSSIIPVE RSRVGISSLS GEGTDYINAS YIMGYYQSNE FIITQHPLLH 2100 TIKDFWRMIW DHNAQLVVMI PDGQNMAEDE FVYWPNKDEP INCESFKVTL MAEEHKCLSN 2160 EEKLIIQDFI LEATQDDYVL EVRHFQCPKW PNPDSPISKT FELISVIKEE AANRDGPMIV 2220 HDEHGGVTAG TFCALTTLMH QLEKENSVDV YQVAKMINLM RPGVFADIEQ YQFLYKVILS 2280 LVSTRQEENP STSLDSNGAA LPDGNIAESL ESLV 2314 // ID hSAP1\(NP_002833)\PTPRH STANDARD;PRT; 1118 AA. AC NP_002833; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, H precursor [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from D15049.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP possesses an extracellular CC region, a single transmembrane region, and a single CC intracytoplasmic catalytic domain, and thus represents a CC receptor-type PTP. The extracellular region contains eight CC fibronectin type III-like repeats and multiple N-glycosylation CC sites. The gene was shown to be expressed primarily in brain and CC liver, and at a lower level in heart and stomach. It was also found CC to be expressed in several cancer cell lines, but not in the CC corresponding normal tissues. CC GPRFLN|REFERENCE 1 (residues 1 to 1118) CC GPRFLN| AUTHORS Takada,T., Noguchi,T., Inagaki,K., Hosooka,T., Fukunaga,K., CC GPRFLN| Yamao,T., Ogawa,W., Matozaki,T. and Kasuga,M. CC GPRFLN| TITLE Induction of apoptosis by stomach cancer-associated CC GPRFLN| protein-tyrosine phosphatase-1 CC GPRFLN| JOURNAL J. Biol. Chem. 277 (37), 34359-34366 (2002) CC GPRFLN| MEDLINE 22206505 CC GPRFLN| REMARK GeneRIF: SAP-1 induces apoptotic cell death by inhibition of cell CC GPRFLN| survival signaling mediated by PI 3-kinase, Akt, and ILK and CC GPRFLN| activation of a caspase-dependent proapoptotic pathway. CC GPRFLN|REFERENCE 2 (residues 1 to 1118) CC GPRFLN| AUTHORS Marneros,A.G., Mehenni,H., Reichenberger,E., Antonarakis,S.E., CC GPRFLN| Krieg,T. and Olsen,B.R. CC GPRFLN| TITLE Gene for the human transmembrane-type protein tyrosine phosphatase CC GPRFLN| H (PTPRH): genomic structure, fine-mapping and its exclusion as a CC GPRFLN| candidate for Peutz-Jeghers syndrome CC GPRFLN| JOURNAL Cytogenet. Cell Genet. 92 (3-4), 213-216 (2001) CC GPRFLN| MEDLINE 21328879 CC GPRFLN|REFERENCE 3 (residues 1 to 1118) CC GPRFLN| AUTHORS Matozaki,T., Suzuki,T., Uchida,T., Inazawa,J., Ariyama,T., CC GPRFLN| Matsuda,K., Horita,K., Noguchi,H., Mizuno,H., Sakamoto,C. et al. CC GPRFLN| TITLE Molecular cloning of a human transmembrane-type protein tyrosine CC GPRFLN| phosphatase and its expression in gastrointestinal cancers CC GPRFLN| JOURNAL J. Biol. Chem. 269 (3), 2075-2081 (1994) CC GPRFLN| MEDLINE 94124561 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1118 VNTIFKEY:269 FT PROTEIN 1 1118 VNTIFKEY:270 FT SIGNAL 1 25 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 26 1118 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 119 190 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 299 370 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 567 650 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT REGION 821 1078 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 1118 AA; MAGAGGGLGV WGNLVLLGLC SWTGARAPAP NPGRNLTVET QTTSSISLSW EVPDGLDSQN 60 SNYWVQCTGD GGTTETRNTT ATNVTVDGLG PGSLYTCSVW VEKDGVNSSV GTVTTATAPN 120 PVRNLRVEAQ TNSSIALTWE VPDGPDPQNS TYGVEYTGDG GRAGTRSTAH TNITVDGLEP 180 GCLYAFSMWV GKNGINSSRE TRNATTAHNP VRKPESGGSD HQLHLPELGG PRWHRPTELD 240 LLRTSALEMV AEQRLETQQT PESPVDGLGP GSLYTCSVWV EKDGVNSSSW RLVTSTTAPN 300 PVRNLTVEAQ TNSSIALTWE VPDGPDPQNS TYGVEYTGDG GRAGTRSTAH TNITVDRLEP 360 GCLYVFSVWV GKNGINSSRE TRNATTAPNP VRNLHMETQT NSSIALCWEV PDGPYPQDYT 420 YWVGYTGDGG GTETRNTTNT SVTAERLEPG TLYTFSVWAE KNGARGSRQN VSISTVPNAV 480 TSLSKQDWTN STIALRWTAP QGPGQSSYSY WVSWVREGMT DPRTQSTSGT DITLKELEAG 540 SLYHLTVWAE RNEVRGYNST LTAATAPNEV TDLQNETQTK NSVMLWWKAP GDPHSQLYVY 600 WVQWASKGHP RRGQDPQANW VNQTSRTNET WYKVEALEPG TLYNFTVWAE RNDVASSTQS 660 LCASTYPDTV TITSCVSTSA GYGVNLIWSC PQGGYEAFEL EVGGQRGSQD RSSCGEAVSV 720 LGLGPARSYP ATITTIWDGM KVVSHSVVCH TESAGVIAGA FVGILLFLIL VGLLIFFLKR 780 RNKKKQQKPE LRDLVFSSPG DIPAEDFADH VRKNERDSNC GFADEYQQLS LVGHSQSQMV 840 ASASENNAKN RYRNVLPYDW SRVPLKPIHE EPGSDYINAS FMPGLWSPQE FIATQGPLPQ 900 TVGDFWRLVW EQQSHTLVML TNCMEAGRVK CEHYWPLDSQ PCTHGHLRVT LVGEEVMENW 960 TVRELLLLQV EEQKTLSVRQ FHYQAWPDHG VPSSPDTLLA FWRMLRQWLD QTMEGGPPIV 1020 HCSAGVGRTG TLIALDVLLR QLQSEGLLGP FSFVRKMRES RPLMVQTEAQ YVFLHQCICG 1080 SSNSQPRPQP RRKSRMRMSK TSSTRTWPPS RPTSWRSK 1118 // ID hSHP1\(NP_002822)\PTPN6 STANDARD;PRT; 595 AA. AC NP_002822; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 6 isoform 1; protein-tyrosine phosphatase 1C; hematopoietic cell phophatase; hematopoietic cell protein-tyrosine phosphatase; 70 kda SHP-1L protein [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M77273.1, BC002523.1 and CC U15536.1. CC On Jan 10, 2002 this sequence version replaced gi:4506297. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. N-terminal part of this PTP contains two CC tandem Src homolog (SH2) domains, which act as protein CC phospho-tyrosine binding domains, and mediate the interaction of CC this PTP with its substrates. This PTP is expressed primarily in CC hematopoietic cells, and functions as an important regulator of CC multiple signaling pathways in hematopoietic cells. This PTP has CC been shown to interact with, and dephosphorylate a wide spectrum of CC phospho-proteins involved in hematopoietic cell signaling. Three CC alternatively spliced variants of this gene, which encode distinct CC isoforms, have been reported. CC CC Transcript Variant: This variant (1) lacks an internal fragment CC within the coding region, which leads to a translation frame change CC when compared to variant 3. It encodes a protein that has an CC identical N-terminus and a different C-terminus, as compared to CC isoform 3. CC GPRFLN|REFERENCE 1 (residues 1 to 595) CC GPRFLN| AUTHORS Hanson,E.M., Dickensheets,H., Qu,C.K., Donnelly,R.P. and CC GPRFLN| Keegan,A.D. CC GPRFLN| TITLE Regulation of the dephosphorylation of Stat6. Participation of CC GPRFLN| Tyr-713 in the interleukin-4 receptor alpha, the tyrosine CC GPRFLN| phosphatase SHP-1, and the proteasome CC GPRFLN| JOURNAL J. Biol. Chem. 278 (6), 3903-3911 (2003) CC GPRFLN| MEDLINE 22450671 CC GPRFLN| REMARK GeneRIF: participation in regulation of Stat6 dephosphorylation CC GPRFLN|REFERENCE 2 (residues 1 to 595) CC GPRFLN| AUTHORS Oka,T., Ouchida,M., Koyama,M., Ogama,Y., Takada,S., Nakatani,Y., CC GPRFLN| Tanaka,T., Yoshino,T., Hayashi,K., Ohara,N., Kondo,E., CC GPRFLN| Takahashi,K., Tsuchiyama,J., Tanimoto,M., Shimizu,K. and Akagi,T. CC GPRFLN| TITLE Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant CC GPRFLN| methylation in leukemias/lymphomas CC GPRFLN| JOURNAL Cancer Res. 62 (22), 6390-6394 (2002) CC GPRFLN| MEDLINE 22325693 CC GPRFLN| REMARK GeneRIF: Functional loss of SHP1 is associated with the CC GPRFLN| pathogenesis of leukemias/lymphomas. CC GPRFLN|REFERENCE 3 (residues 1 to 595) CC GPRFLN| AUTHORS Leon,F., Cespon,C., Franco,A., Lombardia,M., Roldan,E., CC GPRFLN| Escribano,L., Harto,A., Gonzalez-Porque,P. and Roy,G. CC GPRFLN| TITLE SHP-1 expression in peripheral T cells from patients with Sezary CC GPRFLN| syndrome and in the T cell line HUT-78: implications in CC GPRFLN| JAK3-mediated signaling CC GPRFLN| JOURNAL Leukemia 16 (8), 1470-1477 (2002) CC GPRFLN| MEDLINE 22140504 CC GPRFLN| REMARK GeneRIF: In the T cell line HUT-78, JAK3 was found to be highly CC GPRFLN| phosphorylated. These results suggest that SHP-1 might be involved CC GPRFLN| in maintaining the IL-2R/JAK3 signaling pathway under control and CC GPRFLN| point towards a role of SHP-1 in the pathogenesis of the disease. CC GPRFLN|REFERENCE 4 (residues 1 to 595) CC GPRFLN| AUTHORS Nikolova,M., Musette,P., Bagot,M., Boumsell,L. and Bensussan,A. CC GPRFLN| TITLE Engagement of ILT2/CD85j in Sezary syndrome cells inhibits their CC GPRFLN| CD3/TCR signaling CC GPRFLN| JOURNAL Blood 100 (3), 1019-1025 (2002) CC GPRFLN| MEDLINE 22122461 CC GPRFLN| REMARK GeneRIF: ILT2 triggering on cutaneous T-cell lymphoma (CTCL) cells CC GPRFLN| leads to the recruitment of SHP-1 and to the specific inhibition of CC GPRFLN| CTCL malignant cell proliferation in S##zary syndrome induced by CC GPRFLN| CD3/T-cell receptor. (TCR) stimulation. CC GPRFLN|REFERENCE 5 (residues 1 to 595) CC GPRFLN| AUTHORS Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and CC GPRFLN| Varki,A. CC GPRFLN| TITLE Cloning and characterization of human Siglec-11. A recently evolved CC GPRFLN| signaling that can interact with SHP-1 and SHP-2 and is expressed CC GPRFLN| by tissue macrophages, including brain microglia CC GPRFLN| JOURNAL J. Biol. Chem. 277 (27), 24466-24474 (2002) CC GPRFLN| MEDLINE 22086217 CC GPRFLN| REMARK GeneRIF: interacts with siglec-11 CC GPRFLN|REFERENCE 6 (residues 1 to 595) CC GPRFLN| AUTHORS Vyas,Y.M., Maniar,H. and Dupont,B. CC GPRFLN| TITLE Cutting edge: differential segregation of the SRC homology CC GPRFLN| 2-containing protein tyrosine phosphatase-1 within the early NK CC GPRFLN| cell immune synapse distinguishes noncytolytic from cytolytic CC GPRFLN| interactions CC GPRFLN| JOURNAL J. Immunol. 168 (7), 3150-3154 (2002) CC GPRFLN| MEDLINE 21904490 CC GPRFLN| REMARK GeneRIF: SHP-1 is recruited to the NK cell immune synapse within 1 CC GPRFLN| min in both cytolytic and noncytolytic conjugates, allowing clear CC GPRFLN| distinction between noncytolytic and cytolytic interactions at this CC GPRFLN| early time. CC GPRFLN|REFERENCE 7 (residues 1 to 595) CC GPRFLN| AUTHORS Kurita-Taniguchi,M., Hazeki,K., Murabayashi,N., Fukui,A., Tsuji,S., CC GPRFLN| Matsumoto,M., Toyoshima,K. and Seya,T. CC GPRFLN| TITLE Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and CC GPRFLN| protein tyrosine phosphatase SHP-1 in human macrophages through CC GPRFLN| differentiation by GM-CSF CC GPRFLN| JOURNAL Mol. Immunol. 38 (9), 689-700 (2002) CC GPRFLN| MEDLINE 21848359 CC GPRFLN| REMARK GeneRIF: peripheral blood monocytes treated for 5--8 days with CC GPRFLN| GM-CSF (i.e. mature Mphi) acquired the capacity to assemble CC GPRFLN| tyrosine phosphatase SHP-1 with CD9, alpha3-beta1 integrin and CC GPRFLN| their CD46. CC GPRFLN|REFERENCE 8 (residues 1 to 595) CC GPRFLN| AUTHORS Blasioli,J. and Goodnow,C.C. CC GPRFLN| TITLE Lyn/CD22/SHP-1 and their importance in autoimmunity CC GPRFLN| JOURNAL Curr. Dir. Autoimmun. 5, 151-160 (2002) CC GPRFLN| MEDLINE 21685428 CC GPRFLN| REMARK GeneRIF: The Lyn/CD22/SHP-1 pathway is important in autoimmunity. CC GPRFLN| Naive and tolerant B-cells differ in their calcium signaling in CC GPRFLN| response to antigenic stimulation. CC GPRFLN|REFERENCE 9 (residues 1 to 595) CC GPRFLN| AUTHORS Jin,Y.J., Yu,C.L. and Burakoff,S.J. CC GPRFLN| TITLE Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal CC GPRFLN| structure and catalytic activity CC GPRFLN| JOURNAL J. Biol. Chem. 274 (40), 28301-28307 (1999) CC GPRFLN| MEDLINE 99428497 CC GPRFLN|REFERENCE 10 (residues 1 to 595) CC GPRFLN| AUTHORS Bousquet,C., Delesque,N., Lopez,F., Saint-Laurent,N., Esteve,J.P., CC GPRFLN| Bedecs,K., Buscail,L., Vaysse,N. and Susini,C. CC GPRFLN| TITLE sst2 somatostatin receptor mediates negative regulation of insulin CC GPRFLN| receptor signaling through the tyrosine phosphatase SHP-1 CC GPRFLN| JOURNAL J. Biol. Chem. 273 (12), 7099-7106 (1998) CC GPRFLN| MEDLINE 98175983 CC GPRFLN|REFERENCE 11 (residues 1 to 595) CC GPRFLN| AUTHORS Blery,M., Kubagawa,H., Chen,C.C., Vely,F., Cooper,M.D. and CC GPRFLN| Vivier,E. CC GPRFLN| TITLE The paired Ig-like receptor PIR-B is an inhibitory receptor that CC GPRFLN| recruits the protein-tyrosine phosphatase SHP-1 CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (5), 2446-2451 (1998) CC GPRFLN| MEDLINE 98151532 CC GPRFLN|REFERENCE 12 (residues 1 to 595) CC GPRFLN| AUTHORS Ono,M., Okada,H., Bolland,S., Yanagi,S., Kurosaki,T. and CC GPRFLN| Ravetch,J.V. CC GPRFLN| TITLE Deletion of SHIP or SHP-1 reveals two distinct pathways for CC GPRFLN| inhibitory signaling CC GPRFLN| JOURNAL Cell 90 (2), 293-301 (1997) CC GPRFLN| MEDLINE 97386454 CC GPRFLN|REFERENCE 13 (residues 1 to 595) CC GPRFLN| AUTHORS Li,R.Y., Gaits,F., Ragab,A., Ragab-Thomas,J.M. and Chap,H. CC GPRFLN| TITLE Tyrosine phosphorylation of an SH2-containing protein tyrosine CC GPRFLN| phosphatase is coupled to platelet thrombin receptor via a CC GPRFLN| pertussis toxin-sensitive heterotrimeric G-protein CC GPRFLN| JOURNAL EMBO J. 14 (11), 2519-2526 (1995) CC GPRFLN| MEDLINE 95300784 CC GPRFLN|REFERENCE 14 (residues 1 to 595) CC GPRFLN| AUTHORS Banville,D., Stocco,R. and Shen,S.H. CC GPRFLN| TITLE Human protein tyrosine phosphatase 1C (PTPN6) gene structure: CC GPRFLN| alternate promoter usage and exon skipping generate multiple CC GPRFLN| transcripts CC GPRFLN| JOURNAL Genomics 27 (1), 165-173 (1995) CC GPRFLN| MEDLINE 95394454 CC GPRFLN|REFERENCE 15 (residues 1 to 595) CC GPRFLN| AUTHORS Plutzky,J., Neel,B.G., Rosenberg,R.D., Eddy,R.L., Byers,M.G., CC GPRFLN| Jani-Sait,S. and Shows,T.B. CC GPRFLN| TITLE Chromosomal localization of an SH2-containing tyrosine phosphatase CC GPRFLN| (PTPN6) CC GPRFLN| JOURNAL Genomics 13 (3), 869-872 (1992) CC GPRFLN| MEDLINE 92347896 CC GPRFLN|REFERENCE 16 (residues 1 to 595) CC GPRFLN| AUTHORS Plutzky,J., Neel,B.G. and Rosenberg,R.D. CC GPRFLN| TITLE Isolation of a src homology 2-containing tyrosine phosphatase CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (3), 1123-1127 (1992) CC GPRFLN| MEDLINE 92141214 CC GPRFLN|REFERENCE 17 (residues 1 to 595) CC GPRFLN| AUTHORS Yi,T.L., Cleveland,J.L. and Ihle,J.N. CC GPRFLN| TITLE Protein tyrosine phosphatase containing SH2 domains: CC GPRFLN| characterization, preferential expression in hematopoietic cells, CC GPRFLN| and localization to human chromosome 12p12-p13 CC GPRFLN| JOURNAL Mol. Cell. Biol. 12 (2), 836-846 (1992) CC GPRFLN| MEDLINE 92123209 CC GPRFLN|REFERENCE 18 (residues 1 to 595) CC GPRFLN| AUTHORS Shen,S.H., Bastien,L., Posner,B.I. and Chretien,P. CC GPRFLN| TITLE A protein-tyrosine phosphatase with sequence similarity to the SH2 CC GPRFLN| domain of the protein-tyrosine kinases CC GPRFLN| JOURNAL Nature 352 (6337), 736-739 (1991) CC GPRFLN| MEDLINE 91343005 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 595 VNTIFKEY:269 FT PROTEIN 1 595 protein-tyrosine phosphatase 1C; hematopoietic cell phophatase; hematopoietic cell protein-tyrosine phosphatase; 70 kda SHP-1L protein FT VNTIFKEY:270 FT DOMAIN 4 79 SH2 FT VNTIFKEY:1026; VNTINAME:SH2_1 FT DOMAIN 110 194 SH2 FT VNTIFKEY:1026; VNTINAME:SH2_2 FT REGION 243 517 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 595 AA; MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRVGDQVT HIRIQNSGDF 60 YDLYGGEKFA TLTELVEYYT QQQGVLQDRD GTIIHLKYPL NCSDPTSERW YHGHMSGGQA 120 ETLLQAKGEP WTFLVRESLS QPGDFVLSVL SDQPKAGPGS PLRVTHIKVM CEGGRYTVGG 180 LETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA 240 KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KGKNRYKNIL PFDHSRVILQ GRDSNIPGSD 300 YINANYIKNQ LLGPDENAKT YIASQGCLEA TVNDFWQMAW QENSRVIVMT TREVEKGRNK 360 CVPYWPEVGM QRAYGPYSVT NCGEHDTTEY KLRTLQVSPL DNGDLIREIW HYQYLSWPDH 420 GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ENISTKGLDC 480 DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEVLQSQK GQESEYGNIT 540 YPPAMKNAHA KASRTSSKHK EDVYENLHTK NKREEKVKKQ RSADKEKSKG SLKRK 595 // ID hSHP2\(NP_002825)\PTPN11 STANDARD;PRT; 593 AA. AC NP_002825; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 11 isoform 1; protein-tyrosine phosphatase 2C; Noonan syndrome 1; protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from D13540.1 and BF515187.1. CC On Jan 25, 2002 this sequence version replaced gi:13430846. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. PTPs are known to be CC signaling molecules that regulate a variety of cellular processes CC including cell growth, differentiation, mitotic cycle, and CC oncogenic transformation. This PTP contains two tandem Src CC homology-2 domains, which function as phospho-tyrosine binding CC domains and mediate the interaction of this PTP with its CC substrates. This PTP is widely expressed in most tissues and plays CC a regulatory role in various cell signaling events that are CC important for a diversity of cell functions, such as mitogenic CC activation, metabolic control, transcription regulation, and cell CC migration. Two alternatively spliced transcript variants of this CC gene, which encode distinct isoforms, have been described. CC CC Transcript Variant: This variant (1) contains a different 3' end CC region, and encodes a longer isoform (1), as compared to variant 2. CC GPRFLN|REFERENCE 1 (residues 1 to 593) CC GPRFLN| AUTHORS Yamazaki,S., Yamakawa,A., Ito,Y., Ohtani,M., Higashi,H., CC GPRFLN| Hatakeyama,M. and Azuma,T. CC GPRFLN| TITLE The CagA protein of Helicobacter pylori is translocated into CC GPRFLN| epithelial cells and binds to SHP-2 in human gastric mucosa CC GPRFLN| JOURNAL J. Infect. Dis. 187 (2), 334-337 (2003) CC GPRFLN| MEDLINE 22439942 CC GPRFLN| REMARK GeneRIF: The CagA protein of Helicobacter pylori is translocated CC GPRFLN| into epithelial cells and binds to SHP-2 in human gastric mucosa CC GPRFLN|REFERENCE 2 (residues 1 to 593) CC GPRFLN| AUTHORS Lehmann,U., Schmitz,J., Weissenbach,M., Sobota,R.M., Hortner,M., CC GPRFLN| Friederichs,K., Behrmann,I., Tsiaris,W., Sasaki,A., CC GPRFLN| Schneider-Mergener,J., Yoshimura,A., Neel,B.G., Heinrich,P.C. and CC GPRFLN| Schaper,F. CC GPRFLN| TITLE SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of CC GPRFLN| interleukin-6 signaling through gp130 CC GPRFLN| JOURNAL J. Biol. Chem. 278 (1), 661-671 (2003) CC GPRFLN| MEDLINE 22393451 CC GPRFLN| REMARK GeneRIF: These data suggest, that there are two, largely distinct CC GPRFLN| modes of negative regulation of gp130 activity, despite the fact CC GPRFLN| that both SOCS3 and SHP2 are recruited to the same site within CC GPRFLN| gp130. CC GPRFLN|REFERENCE 3 (residues 1 to 593) CC GPRFLN| AUTHORS Wu,T.R., Hong,Y.K., Wang,X.D., Ling,M.Y., Dragoi,A.M., Chung,A.S., CC GPRFLN| Campbell,A.G., Han,Z.Y., Feng,G.S. and Chin,Y.E. CC GPRFLN| TITLE SHP-2 is a dual-specificity phosphatase involved in Stat1 CC GPRFLN| dephosphorylation at both tyrosine and serine residues in nuclei CC GPRFLN| JOURNAL J. Biol. Chem. 277 (49), 47572-47580 (2002) CC GPRFLN| MEDLINE 22344627 CC GPRFLN| REMARK GeneRIF: SHP-2 is a dual-specificity protein phosphatase involved CC GPRFLN| in Stat1 dephosphorylation at both tyrosine and serine residues and CC GPRFLN| plays an important role in modulating STAT function in gene CC GPRFLN| regulation CC GPRFLN|REFERENCE 4 (residues 1 to 593) CC GPRFLN| AUTHORS Maile,L.A. and Clemmons,D.R. CC GPRFLN| TITLE The alphaVbeta3 integrin regulates insulin-like growth factor I CC GPRFLN| (IGF-I) receptor phosphorylation by altering the rate of CC GPRFLN| recruitment of the Src-homology 2-containing phosphotyrosine CC GPRFLN| phosphatase-2 to the activated IGF-I receptor CC GPRFLN| JOURNAL Endocrinology 143 (11), 4259-4264 (2002) CC GPRFLN| MEDLINE 22286240 CC GPRFLN| REMARK GeneRIF: activation state of alphaVbeta3 integrin is an important CC GPRFLN| regulator of the duration of insulin-like growth factor I receptor CC GPRFLN| phosphorylation and this regulation is mediated through changes in CC GPRFLN| the subcellular localization of SHP-2 CC GPRFLN|REFERENCE 5 (residues 1 to 593) CC GPRFLN| AUTHORS Ion,A., Tartaglia,M., Song,X., Kalidas,K., van der Burgt,I., CC GPRFLN| Shaw,A.C., Ming,J.E., Zampino,G., Zackai,E.H., Dean,J.C., Somer,M., CC GPRFLN| Parenti,G., Crosby,A.H., Patton,M.A., Gelb,B.D. and Jeffery,S. CC GPRFLN| TITLE Absence of PTPN11 mutations in 28 cases of cardiofaciocutaneous CC GPRFLN| (CFC) syndrome CC GPRFLN| JOURNAL Hum. Genet. 111 (4-5), 421-427 (2002) CC GPRFLN| MEDLINE 22271640 CC GPRFLN| REMARK GeneRIF: absence of mutation in cases of cardiofaciocutaneous CC GPRFLN| syndrome CC GPRFLN|REFERENCE 6 (residues 1 to 593) CC GPRFLN| AUTHORS Cai,T., Nishida,K., Hirano,T. and Khavari,P.A. CC GPRFLN| TITLE Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and CC GPRFLN| differentiation CC GPRFLN| JOURNAL J. Cell Biol. 159 (1), 103-112 (2002) CC GPRFLN| MEDLINE 22267353 CC GPRFLN| REMARK GeneRIF: Results indicate that Gab1 and SHP-2 promote the CC GPRFLN| undifferentiated epidermal cell state by facilitating Ras/MAPK CC GPRFLN| signaling. CC GPRFLN|REFERENCE 7 (residues 1 to 593) CC GPRFLN| AUTHORS Maheshwari,M., Belmont,J., Fernbach,S., Ho,T., Molinari,L., CC GPRFLN| Yakub,I., Yu,F., Combes,A., Towbin,J., Craigen,W.J. and Gibbs,R. CC GPRFLN| TITLE PTPN11 mutations in Noonan syndrome type I: detection of recurrent CC GPRFLN| mutations in exons 3 and 13 CC GPRFLN| JOURNAL Hum. Mutat. 20 (4), 298-304 (2002) CC GPRFLN| MEDLINE 22236043 CC GPRFLN| REMARK GeneRIF: Mutations in PTPN11/SHP2 underlie a common form of Noonan CC GPRFLN| syndrome and confirm that the disease exhibits both allelic and CC GPRFLN| locus heterogeneity. CC GPRFLN|REFERENCE 8 (residues 1 to 593) CC GPRFLN| AUTHORS Legius,E., Schrander-Stumpel,C., Schollen,E., CC GPRFLN| Pulles-Heintzberger,C., Gewillig,M. and Fryns,J.P. CC GPRFLN| TITLE PTPN11 mutations in LEOPARD syndrome CC GPRFLN| JOURNAL J. Med. Genet. 39 (8), 571-574 (2002) CC GPRFLN| MEDLINE 22151430 CC GPRFLN| REMARK GeneRIF: Some PTPN11 mutations (e.g., Y279C) are associated with CC GPRFLN| both the Noonan syndrome phenotype and with skin pigmentation CC GPRFLN| anomalies, such as multiple lentigines or caf## au lait spots CC GPRFLN| (LEOPARD syndrome). CC GPRFLN|REFERENCE 9 (residues 1 to 593) CC GPRFLN| AUTHORS Kosaki,K., Suzuki,T., Muroya,K., Hasegawa,T., Sato,S., Matsuo,N., CC GPRFLN| Kosaki,R., Nagai,T., Hasegawa,Y. and Ogata,T. CC GPRFLN| TITLE PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) CC GPRFLN| mutations in seven Japanese patients with Noonan syndrome CC GPRFLN| JOURNAL J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002) CC GPRFLN| MEDLINE 22151235 CC GPRFLN| REMARK GeneRIF: PTPN11 mutations are responsible for Noonan syndrome in a CC GPRFLN| substantial fraction of patients and that relatively infrequent CC GPRFLN| features of Noonan syndrome, such as sensory deafness and bleeding CC GPRFLN| diathesis, can also result from mutations of PTPN11. CC GPRFLN|REFERENCE 10 (residues 1 to 593) CC GPRFLN| AUTHORS Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and CC GPRFLN| Varki,A. CC GPRFLN| TITLE Cloning and characterization of human Siglec-11. A recently evolved CC GPRFLN| signaling that can interact with SHP-1 and SHP-2 and is expressed CC GPRFLN| by tissue macrophages, including brain microglia CC GPRFLN| JOURNAL J. Biol. Chem. 277 (27), 24466-24474 (2002) CC GPRFLN| MEDLINE 22086217 CC GPRFLN| REMARK GeneRIF: interacts with siglec-11 CC GPRFLN|REFERENCE 11 (residues 1 to 593) CC GPRFLN| AUTHORS Bordin,L., Brunati,A.M., Donella-Deana,A., Baggio,B., Toninello,A. CC GPRFLN| and Clari,G. CC GPRFLN| TITLE Band 3 is an anchor protein and a target for SHP-2 tyrosine CC GPRFLN| phosphatase in human erythrocytes CC GPRFLN| JOURNAL Blood 100 (1), 276-282 (2002) CC GPRFLN| MEDLINE 22065093 CC GPRFLN| REMARK GeneRIF: Band 3 is an anchor protein for and a target for SHP-2 CC GPRFLN| tyrosine phosphatase in human erythrocytes. CC GPRFLN|REFERENCE 12 (residues 1 to 593) CC GPRFLN| AUTHORS Tartaglia,M., Kalidas,K., Shaw,A., Song,X., Musat,D.L., van der CC GPRFLN| Burgt,I., Brunner,H.G., Bertola,D.R., Crosby,A., Ion,A., CC GPRFLN| Kucherlapati,R.S., Jeffery,S., Patton,M.A. and Gelb,B.D. CC GPRFLN| TITLE PTPN11 mutations in Noonan syndrome: molecular spectrum, CC GPRFLN| genotype-phenotype correlation, and phenotypic heterogeneity CC GPRFLN| JOURNAL Am. J. Hum. Genet. 70 (6), 1555-1563 (2002) CC GPRFLN| MEDLINE 21987645 CC GPRFLN| REMARK GeneRIF: PTPN11 mutations in Noonan syndrome: molecular spectrum, CC GPRFLN| genotype-phenotype correlation, and phenotypic heterogeneity. CC GPRFLN|REFERENCE 13 (residues 1 to 593) CC GPRFLN| AUTHORS Lacalle,R.A., Mira,E., Gomez-Mouton,C., Jimenez-Baranda,S., CC GPRFLN| Martinez-A,C. and Manes,S. CC GPRFLN| TITLE Specific SHP-2 partitioning in raft domains triggers CC GPRFLN| integrin-mediated signaling via Rho activation CC GPRFLN| JOURNAL J. Cell Biol. 157 (2), 277-289 (2002) CC GPRFLN| MEDLINE 21953171 CC GPRFLN| REMARK GeneRIF: Specific SHP-2 partitioning in raft domains triggers CC GPRFLN| integrin-mediated signaling via Rho activation CC GPRFLN|REFERENCE 14 (residues 1 to 593) CC GPRFLN| AUTHORS Ekman,S., Kallin,A., Engstrom,U., Heldin,C.H. and Ronnstrand,L. CC GPRFLN| TITLE SHP-2 is involved in heterodimer specific loss of phosphorylation CC GPRFLN| of Tyr771 in the PDGF beta-receptor CC GPRFLN| JOURNAL Oncogene 21 (12), 1870-1875 (2002) CC GPRFLN| MEDLINE 21906255 CC GPRFLN| REMARK GeneRIF: SHP-2 modulates phosphorylation of PDGF receptors, thereby CC GPRFLN| controls RasGTP recruitment and Ras/MAP kinase signaling in the CC GPRFLN| heterodimeric configuration of the PDGF receptors CC GPRFLN|REFERENCE 15 (residues 1 to 593) CC GPRFLN| AUTHORS Higashi,H., Tsutsumi,R., Muto,S., Sugiyama,T., Azuma,T., Asaka,M. CC GPRFLN| and Hatakeyama,M. CC GPRFLN| TITLE SHP-2 tyrosine phosphatase as an intracellular target of CC GPRFLN| Helicobacter pylori CagA protein CC GPRFLN| JOURNAL Science 295 (5555), 683-686 (2002) CC GPRFLN| MEDLINE 21669283 CC GPRFLN| REMARK GeneRIF: upon translocation, CagA perturbs cellular functions by CC GPRFLN| deregulating SHP-2 CC GPRFLN|REFERENCE 16 (residues 1 to 593) CC GPRFLN| AUTHORS Fukunaga,K., Noguchi,T., Takeda,H., Matozaki,T., Hayashi,Y., CC GPRFLN| Itoh,H. and Kasuga,M. CC GPRFLN| TITLE Requirement for protein-tyrosine phosphatase SHP-2 in CC GPRFLN| insulin-induced activation of c-Jun NH(2)-terminal kinase CC GPRFLN| JOURNAL J. Biol. Chem. 275 (7), 5208-5213 (2000) CC GPRFLN| MEDLINE 20138272 CC GPRFLN|REFERENCE 17 (residues 1 to 593) CC GPRFLN| AUTHORS Yu,C.L., Jin,Y.J. and Burakoff,S.J. CC GPRFLN| TITLE Cytosolic tyrosine dephosphorylation of STAT5. Potential role of CC GPRFLN| SHP-2 in STAT5 regulation CC GPRFLN| JOURNAL J. Biol. Chem. 275 (1), 599-604 (2000) CC GPRFLN| MEDLINE 20085083 CC GPRFLN|REFERENCE 18 (residues 1 to 593) CC GPRFLN| AUTHORS Li,C. and Friedman,J.M. CC GPRFLN| TITLE Leptin receptor activation of SH2 domain containing protein CC GPRFLN| tyrosine phosphatase 2 modulates Ob receptor signal transduction CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (17), 9677-9682 (1999) CC GPRFLN| MEDLINE 99380578 CC GPRFLN|REFERENCE 19 (residues 1 to 593) CC GPRFLN| AUTHORS Manes,S., Mira,E., Gomez-Mouton,C., Zhao,Z.J., Lacalle,R.A. and CC GPRFLN| Martinez-A,C. CC GPRFLN| TITLE Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion CC GPRFLN| kinase in regulation of cell motility CC GPRFLN| JOURNAL Mol. Cell. Biol. 19 (4), 3125-3135 (1999) CC GPRFLN| MEDLINE 99182500 CC GPRFLN|REFERENCE 20 (residues 1 to 593) CC GPRFLN| AUTHORS Takada,T., Matozaki,T., Takeda,H., Fukunaga,K., Noguchi,T., CC GPRFLN| Fujioka,Y., Okazaki,I., Tsuda,M., Yamao,T., Ochi,F. and Kasuga,M. CC GPRFLN| TITLE Roles of the complex formation of SHPS-1 with SHP-2 in CC GPRFLN| insulin-stimulated mitogen-activated protein kinase activation CC GPRFLN| JOURNAL J. Biol. Chem. 273 (15), 9234-9242 (1998) CC GPRFLN| MEDLINE 98204923 CC GPRFLN|REFERENCE 21 (residues 1 to 593) CC GPRFLN| AUTHORS Jamieson,C.R., van der Burgt,I., Brady,A.F., van Reen,M., CC GPRFLN| Elsawi,M.M., Hol,F., Jeffery,S., Patton,M.A. and Mariman,E. CC GPRFLN| TITLE Mapping a gene for Noonan syndrome to the long arm of chromosome 12 CC GPRFLN| JOURNAL Nat. Genet. 8 (4), 357-360 (1994) CC GPRFLN| MEDLINE 95201801 CC GPRFLN|REFERENCE 22 (residues 1 to 593) CC GPRFLN| AUTHORS Isobe,M., Hinoda,Y., Imai,K. and Adachi,M. CC GPRFLN| TITLE Chromosomal localization of an SH2 containing tyrosine phosphatase CC GPRFLN| (SH-PTP3) gene to chromosome 12q24.1 CC GPRFLN| JOURNAL Oncogene 9 (6), 1751-1753 (1994) CC GPRFLN| MEDLINE 94239755 CC GPRFLN|REFERENCE 23 (residues 1 to 593) CC GPRFLN| AUTHORS Bastien,L., Ramachandran,C., Liu,S. and Adam,M. CC GPRFLN| TITLE Cloning, expression and mutational analysis of SH-PTP2, human CC GPRFLN| protein-tyrosine phosphatase CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 196 (1), 124-133 (1993) CC GPRFLN| MEDLINE 94029983 CC GPRFLN|REFERENCE 24 (residues 1 to 593) CC GPRFLN| AUTHORS Ahmad,S., Banville,D., Zhao,Z., Fischer,E.H. and Shen,S.H. CC GPRFLN| TITLE A widely expressed human protein-tyrosine phosphatase containing CC GPRFLN| src homology 2 domains CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (6), 2197-2201 (1993) CC GPRFLN| MEDLINE 93211929 CC GPRFLN|REFERENCE 25 (residues 1 to 593) CC GPRFLN| AUTHORS Vogel,W., Lammers,R., Huang,J. and Ullrich,A. CC GPRFLN| TITLE Activation of a phosphotyrosine phosphatase by tyrosine CC GPRFLN| phosphorylation CC GPRFLN| JOURNAL Science 259 (5101), 1611-1614 (1993) CC GPRFLN| MEDLINE 93206095 CC GPRFLN|REFERENCE 26 (residues 1 to 593) CC GPRFLN| AUTHORS Adachi,M., Sekiya,M., Miyachi,T., Matsuno,K., Hinoda,Y., Imai,K. CC GPRFLN| and Yachi,A. CC GPRFLN| TITLE Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 CC GPRFLN| with sequence similarity to the src-homology region 2 CC GPRFLN| JOURNAL FEBS Lett. 314 (3), 335-339 (1992) CC GPRFLN| MEDLINE 93106179 CC GPRFLN|REFERENCE 27 (residues 1 to 593) CC GPRFLN| AUTHORS Freeman,R.M. Jr., Plutzky,J. and Neel,B.G. CC GPRFLN| TITLE Identification of a human src homology 2-containing CC GPRFLN| protein-tyrosine-phosphatase: a putative homolog of Drosophila CC GPRFLN| corkscrew CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (23), 11239-11243 (1992) CC GPRFLN| MEDLINE 93087502 CC GPRFLN|REFERENCE 28 (residues 1 to 593) CC GPRFLN| AUTHORS Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., CC GPRFLN| Imai,K. and Yachi,A. CC GPRFLN| TITLE Protein-tyrosine phosphatase expression in pre-B cell NALM-6 CC GPRFLN| JOURNAL Cancer Res. 52 (3), 737-740 (1992) CC GPRFLN| MEDLINE 92119637 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 593 VNTIFKEY:269 FT PROTEIN 1 593 protein-tyrosine phosphatase 2C; Noonan syndrome 1; protein tyrosine phosphatase, non-receptor type 11 FT VNTIFKEY:270 FT DOMAIN 6 81 SH2 FT VNTIFKEY:1026; VNTINAME:SH2_1 FT DOMAIN 112 197 SH2 FT VNTIFKEY:1026; VNTINAME:SH2_2 FT REGION 246 523 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 593 AA; MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 120 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD 180 VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360 ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 420 RTWPDHGVPS DPGGVLDFLE EVHHKQESIM DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 480 EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKRKRKGH 540 EYTNIKYSLA DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQK SFR 593 // ID hSTEP\(NP_116170)\PTPN5 STANDARD;PRT; 565 AA. AC NP_116170; DT 17-MAY-2003 DE hypothetical protein FLJ14427 [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC PREDICTED REFSEQ: The mRNA record is supported by experimental CC evidence; however, the coding sequence is predicted. The reference CC sequence was derived from AK090923.1. CC On Aug 5, 2002 this sequence version replaced gi:14249442. CC GPRFLN|REFERENCE 1 CC GPRFLN| AUTHORS Ninomiya,K., Wagatsuma,M., Kanda,K., Kondo,H., Yokoi,T., CC GPRFLN| Kodaira,H., Furuya,T., Takahashi,M., Kikkawa,E., Omura,Y., Abe,K., CC GPRFLN| Kamihara,K., Katsuta,N., Sato,K., Tanikawa,M., Yamazaki,M., CC GPRFLN| Sugiyama,T., Irie,R., Otsuki,T., Sato,H., Wakamatsu,A., Ishii,S., CC GPRFLN| Yamamoto,J., Isono,Y., Kawai-Hio,Y., Saito,K., Nishikawa,T., CC GPRFLN| Kimura,K., Yamashita,H., Matsuo,K., Nakamura,Y., Sekine,M., CC GPRFLN| Kikuchi,H., Murakawa,K., Kanehori,K., Takahashi-Fujii,A., CC GPRFLN| Oshima,A., Sugiyama,A., Kawakami,B., Suzuki,Y., Sugano,S., CC GPRFLN| Nagahari,K., Masuho,Y., Nagai,K. and Isogai,T. CC GPRFLN| TITLE NEDO human cDNA sequencing project CC GPRFLN| JOURNAL Unpublished CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 565 cloning vector: pME18SFL3 FT VNTIFKEY:269 FT PROTEIN 1 565 VNTIFKEY:270 FT REGION 299 555 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 565 AA; MNYEGARSER ENHAADDSEG GALDMCCSER LPGLPQPIVM EALDEAEGLQ DSQREMPPPP 60 PPSPPSDPAQ KPPPRGAGSH SLTVRSSLCL FAASQFLLAC GVLRFSGYGH IWSQNATNLV 120 SSLLTLLKQL EPTAWLDSGT WGVPSLLLVF LSVGLVLVTT LVWHLLRTPA EPPTPLPPED 180 RRQSVSRQPS FTYSEWMEEK IEDDFLDLDP VPETPVFDCV MDIKPEADPT SLTVKSMGLQ 240 ERRGSNVSLT LDMCTPGCNE EGFGYLMSPR EESAREYLLS ASRVLQAEEL HEKALDPFLL 300 QAEFFEIPMN FVDPKEYDIP GLVRKNRYKT ILPNPHSRVC LTSPDPDDPL SSYINANYIR 360 GYGGEEKVYI ATQGPIVSTV ADFWRMVWQE HTPIIVMITN IEEMNEKCTE YWPEEQVAYD 420 GVEITVQKVI HTEDYRLRLI SLKSGTEERG LKHYWFTSWP DQKTPDRAPP LLHLVREVEE 480 AAQQEGPHCA PIIVHCSAGI GRTGCFIATS ICCQQLRQEG VVDILKTTCQ LRQDRGGMIQ 540 TCEQYQFVHH VMSLYEKQLS HQSPE 565 // ID hTCPTP\(NP_002819)\PTPN2 STANDARD;PRT; 415 AA. AC NP_002819; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 2 isoform 1; T-cell protein tyrosine phosphatase [Homo sapiens]. OS Homo sapiens. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. CC REVIEWED REFSEQ: This record has been curated by NCBI staff. The CC reference sequence was derived from M25393.1, AW592324.1 and CC BG699440.1. CC CC Summary: The protein encoded by this gene is a member of the CC protein tyrosine phosphatase (PTP) family. Members of the PTP CC family share a highly conserved catalytic motif, which is essential CC for the catalytic activity. PTPs are known to be signaling CC molecules that regulate a variety of cellular processes including CC cell growth, differentiation, mitotic cycle, and oncogenic CC transformation. Epidermal growth factor receptor and the adaptor CC protein Shc were reported to be substrates of this PTP, which CC suggested the roles in growth factor mediated cell signaling. Three CC alternatively spliced variants of this gene, which encode isoforms CC differing at their extreme C-termini, have been described. The CC different C-termini are thought to determine the substrate CC specificity, as well as the cellular localization of the isoforms. CC Two highly related but distinctly processed pseudogenes that CC localize to distinct chromosomes have been reported. CC CC Transcript Variant: This variant (1) contains a different 3' CC region, and encodes the longest isoform (1), as compared to variant CC 2 and 3. CC GPRFLN|REFERENCE 1 (residues 1 to 415) CC GPRFLN| AUTHORS Gupta,S., Radha,V., Sudhakar,Ch. and Swarup,G. CC GPRFLN| TITLE A nuclear protein tyrosine phosphatase activates p53 and induces CC GPRFLN| caspase-1-dependent apoptosis CC GPRFLN| JOURNAL FEBS Lett. 532 (1-2), 61-66 (2002) CC GPRFLN| MEDLINE 22347239 CC GPRFLN| REMARK GeneRIF: TCPTP activates p53 and induces caspase-1-dependent CC GPRFLN| apoptosis in a human tumor cell line. CC GPRFLN|REFERENCE 2 (residues 1 to 415) CC GPRFLN| AUTHORS Yamamoto,T., Sekine,Y., Kashima,K., Kubota,A., Sato,N., Aoki,N. and CC GPRFLN| Matsuda,T. CC GPRFLN| TITLE The nuclear isoform of protein-tyrosine phosphatase TC-PTP CC GPRFLN| regulates interleukin-6-mediated signaling pathway through STAT3 CC GPRFLN| dephosphorylation CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 297 (4), 811-817 (2002) CC GPRFLN| MEDLINE 22246068 CC GPRFLN| REMARK GeneRIF: regulates interleukin-6-mediated signaling pathway through CC GPRFLN| STAT3 dephosphorylation CC GPRFLN|REFERENCE 3 (residues 1 to 415) CC GPRFLN| AUTHORS Zhu,W., Mustelin,T. and David,M. CC GPRFLN| TITLE Arginine methylation of STAT1 regulates its dephosphorylation by T CC GPRFLN| cell protein tyrosine phosphatase CC GPRFLN| JOURNAL J. Biol. Chem. 277 (39), 35787-35790 (2002) CC GPRFLN| MEDLINE 22229439 CC GPRFLN| REMARK GeneRIF: TcPTP phosphorylation is regulated by STAT1 CC GPRFLN|REFERENCE 4 (residues 1 to 415) CC GPRFLN| AUTHORS ten Hoeve,J., de Jesus Ibarra-Sanchez,M., Fu,Y., Zhu,W., CC GPRFLN| Tremblay,M., David,M. and Shuai,K. CC GPRFLN| TITLE Identification of a nuclear Stat1 protein tyrosine phosphatase CC GPRFLN| JOURNAL Mol. Cell. Biol. 22 (16), 5662-5668 (2002) CC GPRFLN| MEDLINE 22133581 CC GPRFLN| REMARK GeneRIF: Results identify TC45 as a protein tyrosine phosphatase CC GPRFLN| responsible for the dephosphorylation of Stat1 in the nucleus. CC GPRFLN|REFERENCE 5 (residues 1 to 415) CC GPRFLN| AUTHORS Tiganis,T., Kemp,B.E. and Tonks,N.K. CC GPRFLN| TITLE The protein-tyrosine phosphatase TCPTP regulates epidermal growth CC GPRFLN| factor receptor-mediated and phosphatidylinositol CC GPRFLN| 3-kinase-dependent signaling CC GPRFLN| JOURNAL J. Biol. Chem. 274 (39), 27768-27775 (1999) CC GPRFLN| MEDLINE 99419063 CC GPRFLN|REFERENCE 6 (residues 1 to 415) CC GPRFLN| AUTHORS Tiganis,T., Bennett,A.M., Ravichandran,K.S. and Tonks,N.K. CC GPRFLN| TITLE Epidermal growth factor receptor and the adaptor protein p52Shc are CC GPRFLN| specific substrates of T-cell protein tyrosine phosphatase CC GPRFLN| JOURNAL Mol. Cell. Biol. 18 (3), 1622-1634 (1998) CC GPRFLN| MEDLINE 98147803 CC GPRFLN|REFERENCE 7 (residues 1 to 415) CC GPRFLN| AUTHORS Johnson,C.V., Cool,D.E., Glaccum,M.B., Green,N., Fischer,E.H., CC GPRFLN| Bruskin,A., Hill,D.E. and Lawrence,J.B. CC GPRFLN| TITLE Isolation and mapping of human T-cell protein tyrosine phosphatase CC GPRFLN| sequences: localization of genes and pseudogenes discriminated CC GPRFLN| using fluorescence hybridization with genomic versus cDNA probes CC GPRFLN| JOURNAL Genomics 16 (3), 619-629 (1993) CC GPRFLN| MEDLINE 93315152 CC GPRFLN|REFERENCE 8 (residues 1 to 415) CC GPRFLN| AUTHORS Mosinger,B. Jr., Tillmann,U., Westphal,H. and Tremblay,M.L. CC GPRFLN| TITLE Cloning and characterization of a mouse cDNA encoding a cytoplasmic CC GPRFLN| protein-tyrosine-phosphatase CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (2), 499-503 (1992) CC GPRFLN| MEDLINE 92115688 CC GPRFLN|REFERENCE 9 (residues 1 to 415) CC GPRFLN| AUTHORS Swarup,G., Kamatkar,S., Radha,V. and Rema,V. CC GPRFLN| TITLE Molecular cloning and expression of a protein-tyrosine phosphatase CC GPRFLN| showing homology with transcription factors Fos and Jun CC GPRFLN| JOURNAL FEBS Lett. 280 (1), 65-69 (1991) CC GPRFLN| MEDLINE 91184422 CC GPRFLN|REFERENCE 10 (residues 1 to 415) CC GPRFLN| AUTHORS Cool,D.E., Tonks,N.K., Charbonneau,H., Walsh,K.A., Fischer,E.H. and CC GPRFLN| Krebs,E.G. CC GPRFLN| TITLE cDNA isolated from a human T-cell library encodes a member of the CC GPRFLN| protein-tyrosine-phosphatase family CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5257-5261 (1989) CC GPRFLN| MEDLINE 89315776 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|304502400| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 415 VNTIFKEY:269 FT PROTEIN 1 415 T-cell protein tyrosine phosphatase FT VNTIFKEY:270 FT REGION 5 277 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 415 AA; MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK 60 LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES 120 VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW 180 PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD 240 DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA 300 FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR KRIREDRKAT 360 TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV GAFVGWRLFF QQNAL 415 // ID macfaPTP\(BAB01622) STANDARD; PRT; 683 AA. AC BAB01622; DT 17-MAY-2003 DE unnamed protein product [Macaca fascicularis]. OS Macaca fascicularis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. CC URL: http://www.nih.go.jp/yoken/genebank/ CC Lib Name: macaque brain cDNA library QccE CC Lab host: TOP10 CC Vector: pME18S-FL3 (Acc.No. AB009864) CC R. Site1: DraIII (CACTGTGTG) CC R. Site2: DraIII (CACCATGTG) CC Description: 1st strand cDNA was primed with an oligo(dT) primer CC [ATGTGGCCTTTTTTTTTTTTTTTTT]; double-stranded cDNA was synthesized CC using specific 5'and 3'primers and amplified by PCR. The PCR CC product was digested with SfiI and size selection was performed to CC exclude fragments <1.5kb.The SfiI-digested PCR product was cloned CC into distinct DraIII sites of pME18S-FL3. XhoI sites just outside CC the DraIII sites can be used to isolate the cDNA insert. Libraries CC were constructed by Sugano et al.(University of Tokyo, Institute of CC Medical Science). Custom primer used for sequencing CC ( 5' end primer [CTTCTGCTCTAAAAGCTGCG]; CC 3' end primer [CGACCTGCAGCTCGAGCACA] ). CC GPRFLN|REFERENCE 1 CC GPRFLN| AUTHORS Osada,N., Hida,M., Kusuda,J., Tanuma,R., Iseki,K., Hirata,M., CC GPRFLN| Suto,Y., Hirai,M., Terao,K., Suzuki,Y., Sugano,S. and Hashimoto,K. CC GPRFLN| TITLE Assignment of 118 novel cDNAs of cynomolgus monkey brain to human CC GPRFLN| chromosomes CC GPRFLN| JOURNAL Gene 275 (1), 31-37 (2001) CC GPRFLN| MEDLINE 21458551 CC GPRFLN|REFERENCE 2 (residues 1 to 683) CC GPRFLN| AUTHORS Hashimoto,K., Osada,N., Hida,M., Kusuda,J. and Sugano,S. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (14-JUL-2000) Katsuyuki Hashimoto, National Institute of CC GPRFLN| Infectious Diseases, Division of Genetic Resources; 23-1, Toyama CC GPRFLN| 1-chome, Shinjuku-ku, Tokyo 162-8640, Japan CC GPRFLN| (E-mail:khashi@nih.go.jp, URL:http://www.nih.go.jp/yoken/genebank/, CC GPRFLN| Tel:81-3-5285-1111(ex.2120), Fax:81-3-5285-1181) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301971500| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 683 VNTIFKEY:269 FT PROTEIN 1 683 VNTIFKEY:270 SQ SEQUENCE 683 AA; MACSMACGGR ACKYENPARW SEQEQAIKGV YSSWVTDNIL AMARPSSELL EKYHIIDQFL 60 SHGIKTIINL QRPGEHASCG NPLEQESGFT YLPEAFMEAG IYFYNFGWKD YGVASLTTIL 120 DMVKVMTFAL QEGKVAIHCH AGLGRTGVLI ACYLVFATRM TADQAIIFVR AKRPNSIQTR 180 GQLLCVREFT QFLTPLRNIF SCCDPKAHAV TLAQYLIRQR HLLHGYEARL LKHVPKIIHL 240 VCKLLLDLAE NRPVMMKDES EGPGLSAEIE KTMSEMVTMQ LDKELLRNDS DVSNPPNPTA 300 VAADFDNRGM IFSNEQEFDP LWKRRNVECL QPLSHLKRRL SYSDSDLKRA ENLLEEGEPP 360 QTVPVQVLVG HNPRQQKRIS HCYIPQSSEP DLHKEALVRS TLSFWSQSKF GRLEGLKDNG 420 SPIFHGRIIP KEAQQSRAFS ADVSGPHSPG EPVSPNFANV RKDPNPTHQQ VSHCQCKTHG 480 VGSPGSVRQN SRTPQRPLDC GCSLKAQFLV EHETQDSKDL AEAASHSTLQ SELSAEARRI 540 LAAKALANLN EXVEKEELKR KKELNSRDGA WERICGERDP FILCSLMWSW VEQLKEPVIT 600 KEDVDMLVDR RADAAEALFL LEKGQHQTIL CVLHCIVNLQ TIPVDVEEAF LAHAIKAFTK 660 VNFDSENGPI VYNTLKKIFK HTR 683 // ID macfaSTEP\(BAB41172) STANDARD;PRT; 370 AA. AC BAB41172; DT 17-MAY-2003 DE hypothetical protein [Macaca fascicularis]. OS Macaca fascicularis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. CC Lab host: TOP10 CC Vector: pME18S-FL3 (Acc.No. AB009864) CC R. Site1: DraIII (CACTGTGTG) CC R. Site2: DraIII (CACCATGTG) CC Description: 1st strand cDNA was primed with an oligo(dT) primer CC [ATGTGGCCTTTTTTTTTTTTTTTTT]; double-stranded cDNA was synthesized CC using specific 5' and 3' primers and amplified by PCR. The PCR CC product was digested with SfiI and size selection was performed to CC exclude fragments <1.5kb.The SfiI-digested PCR product was cloned CC into distinct DraIII sites of pME18S-FL3. XhoI sites just outside CC the DraIII sites can be used to isolate the cDNA insert. Libraries CC were constructed by oligo-capping method CC (Sugano et al., , Institute of Medical Science, University of CC Tokyo). CC Custom primer used for sequencing CC ( 5' end primer [CTTCTGCTCTAAAAGCTGCG]; CC 3' end primer [CGACCTGCAGCTCGAGCACA] ). CC GPRFLN|REFERENCE 1 CC GPRFLN| AUTHORS Osada,N., Hida,M., Kusuda,J., Tanuma,R., Hirata,M., Hirai,M., CC GPRFLN| Terao,K., Suzuki,Y., Sugano,S. and Hashimoto,K. CC GPRFLN| TITLE Prediction of unidentified human genes on the basis of sequence CC GPRFLN| similarity to novel cDNAs from cynomolgus monkey brain CC GPRFLN| JOURNAL Online Publication CC GPRFLN| REMARK Genome Biology 2001 3(1): research0006.1-0006.5; CC GPRFLN| http://genomebiology.com/2001/3/1/research/0006/ CC GPRFLN|REFERENCE 2 (residues 1 to 370) CC GPRFLN| AUTHORS Hashimoto,K., Osada,N., Hida,M., Kusuda,J. and Sugano,S. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (17-APR-2001) Katsuyuki Hashimoto, National Institute of CC GPRFLN| Infectious Diseases, Division of Genetic Resources; 23-1, Toyama CC GPRFLN| 1-chome, Shinjuku-ku, Tokyo 162-8640, Japan CC GPRFLN| (E-mail:khashi@nih.go.jp, URL:http://www.nih.go.jp/yoken/genebank/, CC GPRFLN| Tel:81-3-5285-1111(ex.2120), Fax:81-3-5285-1181) CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301945473| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 370 VNTIFKEY:269 FT PROTEIN 1 370 VNTIFKEY:270 SQ SEQUENCE 370 AA; MGLVLVTTLV WHLLRTPPEP PTSLPPEDRR QSVSRQPSFT YSEWMEEKVE DDFLDLDPVP 60 ETPVFDCVMD IKPEADPASL TVKSMGLQER RGSNVSLTLD MCTPGCNEEG FGYLMSPREE 120 SAREYLLSAS RVLQAEELHE KALDPFLLQA EFFEIPMNFV DPKEYDIPGL VRKNRYKTIL 180 PNPHSRVCLT SPDPDDPLSS YINANYIRGY GGEEKVYIAT QGPIVSTVAD FWRMVWQEHT 240 PIIVMITNIE EMNEKCTEYW PEEQVVYDDV EITVQKVIHT EDYRLRLISL KSGTEERGLK 300 HYWFTSWPDQ KTPPPHSCTW CGRWRRQPSR RGPTVPPSSS TAVQGLGGPA ASLPPASAAS 360 SCGRRVWWTS 370 // ID macmuPTPalpha\(AAL40242) STANDARD;PRT; 135 AA. AC AAL40242; DT 17-MAY-2003 DE receptor protein tyrosine phosphatase alpha [Macaca mulatta]. OS Macaca mulatta. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 135) CC GPRFLN| AUTHORS Brown,A.E. and Ojeda,S.R. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (27-SEP-2001) Neuroscience Division, Oregon Regional CC GPRFLN| Primate Research Center, Oregon Health and Sciences University, 505 CC GPRFLN| NW 185th Ave, Beaverton, OR 97006, USA CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301970863| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 135 VNTIFKEY:269 FT PROTEIN 1 135 VNTIFKEY:270 SQ SEQUENCE 135 AA; RGEENTXYVN ASFIDGYRQK DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ 60 EKCAQYWPSD GLVSYGDITV ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV 120 GIPSDGKGMI SIIAA 135 // ID macmuPTPzeta\(AAL40258)_Fragm STANDARD;PRT; 157 AA. AC AAL40258; DT 17-MAY-2003 DE receptor-protein tyrosine phosphatase beta [Macaca mulatta]. OS Macaca mulatta. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 157) CC GPRFLN| AUTHORS Mungenast,A.E. and Ojeda,S.R. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (27-SEP-2001) Neuroscience Division, Oregon Regional CC GPRFLN| Primate Research Center, Oregon Health and Sciences University, 505 CC GPRFLN| NW 185th Ave, Beaverton, OR 97006, USA CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301971151| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 157 VNTIFKEY:269 FT PROTEIN 1 157 VNTIFKEY:270 SQ SEQUENCE 157 AA; SGACCRPLQC WSWKNRHVYC ARQYVAADST RRNCQHIWLL KHIRSQRNYL VQTEEQYVFI 60 HDTLVEAILS KETEVLDSHI HAYVNALLIP GPTGKTKLEK QFQLLSQSNI QQSDYSTALK 120 QCNREKNRTS SIIPVERSRV GISSLSGEGT DYINASY 157 // ID macneIA2beta\(O02695) STANDARD;PRT; 1013 AA. AC O02695; DT 17-MAY-2003 DE PROTEIN-TYROSINE PHOSPHATASE X PRECURSOR (R-PTP-X) (M1851). KW Hydrolase; Receptor; Glycoprotein; Signal; Transmembrane. OS Macaca nemestrina. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. CC ------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a CC collaboration between the Swiss Institute of Bioinformatics and CC the EMBL outstation - the European Bioinformatics Institute. CC The original entry is available from http://www.expasy.ch/sprot CC and http://www.ebi.ac.uk/sprot CC ------------------------------------------------------------------. CC [FUNCTION] IMPLICATED IN DEVELOPMENT OF NERVOUS SYSTEM AND CC PANCREATIC ENDOCRINE CELLS. CC [CATALYTIC ACTIVITY] PROTEIN TYROSINE PHOSPHATE + H(2)O = PROTEIN CC TYROSINE + ORTHOPHOSPHATE. CC [SUBCELLULAR LOCATION] TYPE I MEMBRANE PROTEIN (PROBABLE). CC [TISSUE SPECIFICITY] BRAIN, PROSTATE, PANCREATIC ISLETS. LOWER CC EXPRESSION IN SPINAL CORD, THYROID, ADRENAL MEDULLA AND CC GASTROINTESTINAL TRACT. CC [PTM] APPEARS TO UNDERGO MULTIPLE PROTEOLYTIC CLEAVAGE AT CC CONSECUTIVE BASIC RESIDUES (BY SIMILARITY). CC [SIMILARITY] CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN. CC GPRFLN|REFERENCE 1 (residues 1 to 1013) CC GPRFLN| AUTHORS LaGasse,J., Jelinek,L., Sexson,S., Lofton-Day,C., Breininger,J., CC GPRFLN| Sheppard,P., Kindsvogel,W. and Hagopian,W.A. CC GPRFLN| TITLE An islet-cell protein tyrosine phosphatase is a likely precursor to CC GPRFLN| the 37-kDa autoantigen in type 1 diabetes: human and macaque CC GPRFLN| sequences, tissue distribution, unique and shared epitopes, and CC GPRFLN| predictive autoantibodies CC GPRFLN| JOURNAL Mol. Med. 3 (3), 163-173 (1997) CC GPRFLN| MEDLINE 97254813 CC GPRFLN| REMARK SEQUENCE FROM N.A. CC GPRFLN| TISSUE=PANCREATIC ISLETS CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301946922| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1013 VNTIFKEY:269 FT PROTEIN 1 1013 VNTIFKEY:270 FT SIGNAL 1 19 POTENTIAL. FT VNTIFKEY:200; VNTINAME:PTPRN2 FT CHAIN 20 1013 PROTEIN-TYROSINE PHOSPHATASE X. FT VNTIFKEY:203; VNTINAME:PTPRN2 FT DOMAIN 20 613 EXTRACELLULAR (POTENTIAL). FT VNTIFKEY:1001; VNTINAME:PTPRN2 FT SITE 425 426 CLEAVAGE SITE (BY SIMILARITY). FT VNTIFKEY:221; VNTINAME:PTPRN2 FT CARBOHYD ? ? N-LINKED (GLCNAC...) (POTENTIAL). FT VNTIFKEY:238; VNTINAME:PTPRN2 FT TRANSMEM 614 634 POTENTIAL. FT VNTIFKEY:210; VNTINAME:PTPRN2 FT DOMAIN 635 1013 CYTOPLASMIC (POTENTIAL). FT VNTIFKEY:1004; VNTINAME:PTPRN2 FT DOMAIN 768 1002 PROTEIN-TYROSINE PHOSPHATASE. FT VNTIFKEY:1000; VNTINAME:PTPRN2 FT ACT_SITE ? ? POTENTIAL. FT VNTIFKEY:220; VNTINAME:PTPRN2 SQ SEQUENCE 1013 AA; MALPLLLLLL LLLPPRVLPA APSSVPHGRQ LPGRLGCLLE EGLCGASEAC VNDGVFGRCQ 60 KVPAMDFYRY EVSPVALQRL RVALQKLSGT GFTWQDDYTQ YVMDQELADL PKTYLRHPEA 120 SGPARPSKHS IGSERRYSQE GGAALAKAFR RHLPFLEALS QAPASDALAR TRMAQDRPRA 180 EGDDRFSKSI LTYVAHTSVL TYPPGPQAQL PEDLLPRTLS QLQPDELSPK VDSSVERHHL 240 MAALSAYAAQ RPPAPPGKGS LEPQYLLRAP SRMPRPLLSP AVPQKWPSPL GDPEDPPSTG 300 EGARIHTLLK DLQRQPAEAR GLSDLELDSM AELMAGLMQG MDHRGALGGP GKAALGESGE 360 QADGPKAALR GESFPDDGVQ DDDDRLYQEV HRLSATLGGL LQDHGSRLSP GALPFAKPLK 420 MERKKSERPE ASLSSEEETA GVENVKSQTY SKDLLGQQPH SEPGAGAFGE LQNQMPGPSE 480 EEQSLPAGAQ EALGDGLQLE VKPSEEEARG YIVTDRDPLR PEEGRQLVED VARLLQMPSS 540 TFADVEVLGP AVTFKVGANV QNVTTADVEK ATVDNKDKLE ETSGLKILQT GVGSKSKLKF 600 LPPQAEQEDS TKFIALTLVS LACILGVLLA SGLIYCLRHS SQHRLKEKLS GLGRDPGADA 660 TAAYQELCRQ RMATRPPDRP EGPHTSRISS VSSQFSDGPM PSPSARSSAS SWSEEPVQSN 720 MDISTGHMIL SYMEDHLKNK NRLEKEWEAL CAYQAEPNSS LVAQKEENVP KNRSLAVLTY 780 DHSRVLLKAE NSHSHSDYIN ASPIMDHDPR NPAYIATQGP LPATVADFWQ MVWESGCVVI 840 VMLTPLTENG VRQCYHYWPD EGSNLYHIYE VNLVSEHIWC EDFLVRSFYL KNLQTNETRT 900 VTQFHFLSWY DRGVPSSSRS LLDFRRKVNK CYRGRSCPII VHCSDGAGRS GTYVLIDMVL 960 NKMAKGAKEI DIAATLEHLR DQRPGMVQTK EQFEFALTAV AEEVNAILKA LPQ 1013 // ID mCD45\(NP_035340)\Ptprc STANDARD;PRT; 1152 AA. AC NP_035340; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, C [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from M14342.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1152) CC GPRFLN| AUTHORS Irles,C., Symons,A., Michel,F., Bakker,T.R., van der Merwe,P.A. and CC GPRFLN| Acuto,O. CC GPRFLN| TITLE CD45 ectodomain controls interaction with GEMs and Lck activity for CC GPRFLN| optimal TCR signaling CC GPRFLN| JOURNAL Nat. Immunol. 4 (2), 189-197 (2003) CC GPRFLN| MEDLINE 22442648 CC GPRFLN| REMARK GeneRIF: the large CD45 ectodomain is required for optimal TCR CC GPRFLN| signaling CC GPRFLN|REFERENCE 2 (residues 1 to 1152) CC GPRFLN| AUTHORS Edmonds,S.D. and Ostergaard,H.L. CC GPRFLN| TITLE Dynamic association of CD45 with detergent-insoluble microdomains CC GPRFLN| in T lymphocytes CC GPRFLN| JOURNAL J. Immunol. 169 (9), 5036-5042 (2002) CC GPRFLN| MEDLINE 22278638 CC GPRFLN| REMARK GeneRIF: CD45 is present in lipid rafts in T cells before CC GPRFLN| activation, perhaps to activate raft-associated p56(lck), allowing CC GPRFLN| membrane-proximal signaling events to proceed. CC GPRFLN|REFERENCE 3 (residues 1 to 1152) CC GPRFLN| AUTHORS Freiberg,B.A., Kupfer,H., Maslanik,W., Delli,J., Kappler,J., CC GPRFLN| Zaller,D.M. and Kupfer,A. CC GPRFLN| TITLE Staging and resetting T cell activation in SMACs CC GPRFLN| JOURNAL Nat. Immunol. 3 (10), 911-917 (2002) CC GPRFLN| MEDLINE 22239831 CC GPRFLN| REMARK GeneRIF: we studied intracellular signaling in SMACs by CC GPRFLN| three-dimensional immunofluorescence microscopic localization of CC GPRFLN| CD3, CD45, talin, phosphotyrosine, Lck and phosphorylated ZAP-70 in CC GPRFLN| T cell-APC conjugates CC GPRFLN|REFERENCE 4 (residues 1 to 1152) CC GPRFLN| AUTHORS He,X., Woodford-Thomas,T.A., Johnson,K.G., Shah,D.D. and CC GPRFLN| Thomas,M.L. CC GPRFLN| TITLE Targeting of CD45 protein tyrosine phosphatase activity to lipid CC GPRFLN| microdomains on the T cell surface inhibits TCR signaling CC GPRFLN| JOURNAL Eur. J. Immunol. 32 (9), 2578-2587 (2002) CC GPRFLN| MEDLINE 22195589 CC GPRFLN| REMARK GeneRIF: Segregation of CD45 from proximal TCR signaling components CC GPRFLN| is necessary for TCR signaling and that the targeting of CD45 PTP CC GPRFLN| activity to lipid microdomains on the T cell surface results in CC GPRFLN| decreased sensitivity of TCR-mediated signaling. CC GPRFLN|REFERENCE 5 (residues 1 to 1152) CC GPRFLN| AUTHORS Bakker,T.R., Piperi,C., Davies,E.A. and Merwe,P.A. CC GPRFLN| TITLE Comparison of CD22 binding to native CD45 and synthetic CC GPRFLN| oligosaccharide CC GPRFLN| JOURNAL Eur. J. Immunol. 32 (7), 1924-1932 (2002) CC GPRFLN| MEDLINE 22110087 CC GPRFLN| REMARK GeneRIF: CD22 binding to native CD45 CC GPRFLN|REFERENCE 6 (residues 1 to 1152) CC GPRFLN| AUTHORS Martin,P., Del Hoyo,G.M., Anjuere,F., Arias,C.F., Vargas,H.H., CC GPRFLN| Fernandez-L,A., Parrillas,V. and Ardavin,C. CC GPRFLN| TITLE Characterization of a new subpopulation of mouse CD8alpha+ B220+ CC GPRFLN| dendritic cells endowed with type 1 interferon production capacity CC GPRFLN| and tolerogenic potential CC GPRFLN| JOURNAL Blood 100 (2), 383-390 (2002) CC GPRFLN| MEDLINE 22085803 CC GPRFLN| REMARK GeneRIF: Characterization of a new subpopulation of mouse CD8alpha+ CC GPRFLN| B220+ dendritic cells endowed with type 1 interferon production CC GPRFLN| capacity and tolerogenic potential. CC GPRFLN|REFERENCE 7 (residues 1 to 1152) CC GPRFLN| AUTHORS Fortin,M., Steff,A.M., Felberg,J., Ding,I., Schraven,B., Johnson,P. CC GPRFLN| and Hugo,P. CC GPRFLN| TITLE Apoptosis mediated through CD45 is independent of its phosphatase CC GPRFLN| activity and association with leukocyte phosphatase-associated CC GPRFLN| phosphoprotein CC GPRFLN| JOURNAL J. Immunol. 168 (12), 6084-6089 (2002) CC GPRFLN| MEDLINE 22050741 CC GPRFLN| REMARK GeneRIF: The extracellular and/or the transmembrane portion of CD45 CC GPRFLN| has a major role in apoptosis signaling which is independent of its CC GPRFLN| phosphatase activity and association with leukocyte CC GPRFLN| phosphatase-associated phosphoprotein. CC GPRFLN|REFERENCE 8 (residues 1 to 1152) CC GPRFLN| AUTHORS Tchilian,E.Z. and Beverley,P.C. CC GPRFLN| TITLE CD45 in memory and disease CC GPRFLN| JOURNAL Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002) CC GPRFLN| MEDLINE 22017393 CC GPRFLN| REMARK GeneRIF: Role of high and low molecular weight isoforms of CD45 in CC GPRFLN| the function of na##ve and memory T lymphocytes. Review. CC GPRFLN|REFERENCE 9 (residues 1 to 1152) CC GPRFLN| AUTHORS Brooks,W.P. and Lynes,M.A. CC GPRFLN| TITLE Effects of hemizygous CD45 expression in the autoimmune CC GPRFLN| Fasl(gld/gld) syndrome CC GPRFLN| JOURNAL Cell. Immunol. 212 (1), 24-34 (2001) CC GPRFLN| MEDLINE 21573815 CC GPRFLN| REMARK GeneRIF: These data indicate that CD45 is essential to the CC GPRFLN| accumulation of CD4(-)/CD8(-) (DN) T cells in Fasl(gld/gld) mice CC GPRFLN|REFERENCE 10 (residues 1 to 1152) CC GPRFLN| AUTHORS Arendt,C.W. and Ostergaard,H.L. CC GPRFLN| TITLE Identification of the CD45-associated 116-kDa and 80-kDa proteins CC GPRFLN| as the alpha- and beta-subunits of alpha-glucosidase II CC GPRFLN| JOURNAL J. Biol. Chem. 272 (20), 13117-13125 (1997) CC GPRFLN| MEDLINE 97294720 CC GPRFLN|REFERENCE 11 (residues 1 to 1152) CC GPRFLN| AUTHORS Zebedee,S.L., Barritt,D.S. and Raschke,W.C. CC GPRFLN| TITLE Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles CC GPRFLN| JOURNAL Dev. Immunol. 1 (4), 243-254 (1991) CC GPRFLN| MEDLINE 92361152 CC GPRFLN|REFERENCE 12 (residues 1 to 1152) CC GPRFLN| AUTHORS Raschke,W.C. CC GPRFLN| TITLE Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within CC GPRFLN| B- and T-lymphocyte lineages CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (1), 161-165 (1987) CC GPRFLN| MEDLINE 87092355 CC GPRFLN|REFERENCE 13 (residues 1 to 1152) CC GPRFLN| AUTHORS Saga,Y., Tung,J.S., Shen,F.W. and Boyse,E.A. CC GPRFLN| TITLE Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (18), 6940-6944 (1986) CC GPRFLN| MEDLINE 86313686 CC GPRFLN|REFERENCE 14 (residues 1 to 1152) CC GPRFLN| AUTHORS Shen,F.W., Saga,Y., Litman,G., Freeman,G., Tung,J.S., Cantor,H. and CC GPRFLN| Boyse,E.A. CC GPRFLN| TITLE Cloning of Ly-5 cDNA CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (21), 7360-7363 (1985) CC GPRFLN| MEDLINE 86042665 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1152 VNTIFKEY:269 FT PROTEIN 1 1152 VNTIFKEY:270 FT REGION 500 760 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 792 1073 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 1152 AA; MGLWLKLLAF GFALLDTEVF VTGQTPTPSD GASLTTLTPS TLGLASTDPP STTIATTTKQ 60 TCAAMFGNIT VNYTYESSNQ TFKADLKDVQ NAKCGNEDCE NVLNNLEECS QIKNISVSND 120 SCAPATTIDL YVPPGTDKFS LHDCTPKEKA NTSICLEWKT KNLDFRKCNS DNISYVLHCE 180 PENNTKCIRR NTFIPERCQL DNLRAQTNYT CVAEILYRGV KLVKNVINVQ TDLGIPETPK 240 PSCGDPAARK TLVSWPEPVS KPESASKPHG YVLCYKNNSE KCKSLPNNVT SFEVESLKPY 300 KYYEVSLLAY VNGKIQRNGT AEKCNFHTKA DRPDKVNGMK TSRPTDNSIN VTCGPPYETN 360 GPKTFYILVV RSGGSFVTNT TKTNCQFYGD NLYYSTDYEF LVSFHNGVYE GDSVIRSEST 420 NFNAKALIIF LVFLIIVTSI ALLVVLYKSY DLRKKRSSNL DEQQELVERD DEKQLMDVEP 480 IHSDILLETY KRKIADEGRL FLAEFQSIPR VFSKFPIKDA RKPHNQNKNR YVDILPYDYN 540 RVELSEINGD AGSTYINASY IDGFKEPRKY IAAQGPRDET VDDFWRMIWE QKATVIVMVT 600 RCEEGNRNKC AEYWPSMEEG TRAFKDIVVT INDHKRCPDY IIQKLNVAHK KEKATGREVT 660 HIQFTSWPDH GVPEDPHLLL KLRRRVNAFS NFFSGPIVVH CSAGVGRTGT YIGIDAMLEG 720 LEAEGKVDVY GYVVKLRRQR CLMVQVEAQY ILIHQALVEY NQFGETQVNL SELHSCLHNM 780 KKRDPPSDPS PREAEYQRLP SYRSWRTQHI GNQGENKKKK RNSNVVPYDF NRVPLKHELE 840 MSKESEPESD ESSDDDSDSE ETSKYINASF VMSYWKPEMM IAAQGPLKET IGDFWQMIFQ 900 RKVKVIVMLT ELVNGDQEVC AQYWGEGKQT YGDMEVEMKD TNRASAYTLR TFELRHSKRK 960 EPRTVYQYQC TTWKGEELPA EPKDLVSMIQ DLKQKLPKAS PEGMKYHKHA SILVHCRDGS 1020 QQTGLFCALF NLLESAETED VVDVFQVVKS LRKARPGVVC SYEQYQFLYD IIASIYPAQN 1080 GQVKKTNSQD KIEFHNEVDG GKQDANCVRP DGPLNKAQED SRGVGTPEPT NSAEEPEHAA 1140 NGSASPAPTQ SS 1152 // ID mDEP1\(NP_033008)\Ptprj STANDARD;PRT; 1238 AA. AC NP_033008; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, J; colon tumor susceptibility 1 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from AY038891.1. CC GPRFLN|REFERENCE 1 (residues 1 to 1238) CC GPRFLN| AUTHORS Takahashi,T., Takahashi,K., St John,P.L., Fleming,P.A., CC GPRFLN| Tomemori,T., Watanabe,T., Abrahamson,D.R., Drake,C.J., Shirasawa,T. CC GPRFLN| and Daniel,T.O. CC GPRFLN| TITLE A mutant receptor tyrosine phosphatase, CD148, causes defects in CC GPRFLN| vascular development CC GPRFLN| JOURNAL Mol. Cell. Biol. 23 (5), 1817-1831 (2003) CC GPRFLN| MEDLINE 22477405 CC GPRFLN| REMARK GeneRIF: CD148 has a role in developmental vascular organization CC GPRFLN| and regulates endothelial proliferation and endothelium-pericyte CC GPRFLN| interactions CC GPRFLN|REFERENCE 2 (residues 1 to 1238) CC GPRFLN| AUTHORS Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C., CC GPRFLN| Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L., CC GPRFLN| Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G., CC GPRFLN| Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and CC GPRFLN| Demant,P. CC GPRFLN| TITLE Ptprj is a candidate for the mouse colon-cancer susceptibility CC GPRFLN| locus Scc1 and is frequently deleted in human cancers CC GPRFLN| JOURNAL Nat. Genet. 31 (3), 295-300 (2002) CC GPRFLN| MEDLINE 22084388 CC GPRFLN| REMARK GeneRIF: This protein is a candidate for the mouse colon cancer CC GPRFLN| susceptibility locus (Scc1). CC GPRFLN|REFERENCE 3 (residues 1 to 1238) CC GPRFLN| AUTHORS Kuramochi,S., Matsuda,S., Matsuda,Y., Saitoh,T., Ohsugi,M. and CC GPRFLN| Yamamoto,T. CC GPRFLN| TITLE Molecular cloning and characterization of Byp, a murine CC GPRFLN| receptor-type tyrosine phosphatase similar to human DEP-1 CC GPRFLN| JOURNAL FEBS Lett. 378 (1), 7-14 (1996) CC GPRFLN| MEDLINE 96140699 CC GPRFLN|REFERENCE 4 (residues 1 to 1238) CC GPRFLN| AUTHORS van Wezel,T., Ruivenkamp,C.A.L., Zanon,C., Stassen,A.P.M., CC GPRFLN| Vlcek,C., Csikos,T., Tripodis,N., Groot,P.C., Dauwerse,H., van CC GPRFLN| Ommen,G.J.B. and Demant,P. CC GPRFLN| TITLE Positional cloning identifies Ptprj as the candidate for colon CC GPRFLN| cancer susceptibility QTL Scc1 CC GPRFLN| JOURNAL Unpublished CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301885224| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1238 VNTIFKEY:269 FT PROTEIN 1 1238 colon tumor susceptibility 1 FT VNTIFKEY:270 FT DOMAIN 50 107 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 271 347 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 356 428 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 442 518 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT REGION 941 1201 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 1238 AA; MKPAARETRT PPRSPGLRWA LLPLLLLLRQ GQVLCAGAAP NPIFDIEAVV SPTSVLLTWK 60 HNDSGASECR IENKMESNLT FPVKNQTSCN ITGLSPGTSY TFSIISVTTN ETLNKTITTE 120 PWPVSDLHVT SVGVTQARLT WSNANGTASY RMLIEELTTH SSVNISGLKP GTNNTFAFPE 180 SNETQADFAV AEEVPDANGT KRIPVTNLSQ LHKNSLVSVD PPSGQDPSLT EILLTDLKPD 240 TQYNATIYSQ AANGTEGQPR NKVFKTNSTQ VSDVRAMNIS ASSMTLTWKS NYDGSRTSIV 300 YKIHVAGGTH SVNQTVNKTE AIILGLSSST LYNITVHPFL GQTEGTPGFL QVYTSPDQVS 360 DFRVTNVSTR AIGLAWRSND SKSFEIFIKQ DGGEKHRNAS TGNQSYMVED LKPGTSYHFE 420 IIPRGPDGTE GLSSTVNGST DPSAVTDIRV VNISTTEMQL EWQNTDDASG YTYHLVLESK 480 SGSIIRTNSS QKWITVGSLT PGTLYNVTIF PEVDQIQGIS NSITQYTRPS SVSHIEVNTT 540 TTTAAIRWKN EDAASASYAY SVLILKTGDG SNVTSNFTKD PSILIPELIP GVSYTVKILT 600 QVGDGTTSLV PGWNLFCTEP EPVTSFHCEV VPKEPALVLK WACPFGMYTG FELGVRSDSW 660 DNMTRLENCT SDDDTECRTE VAYLNFSTSY NISIATLSCG KMALPAQNIC TTGITDPPTP 720 DGSPNITSVS HNSVKVKFSG FEASHGPIKA YAVILTTGEA AQPSADVLKY TYEDFKRGAS 780 DTYVTYLIRI EEKGQSQGLS EVLNYEIDVG NQSTTLGYYN GRLEPLGSYR ACVAGFTNIT 840 YNLQNDGLIN GDESYVSFSP YSEAVFLPQD PGVICGAVFG CIFGALAITA VGGFIFWRKK 900 RTDAKNNEVS FSQIKPKKSK LIRVENFEAY FKKQQADSNC GFAEEYEDLK LIGISLPKYT 960 AEIAENRGKN RYNNVLPYDI SRVKLSVQTH STDDYINANY MPGYHSKKDF IATQGPLPNT 1020 LKDFWRMVWE KNVYAIVMLT KCVEQGRTKC EEYWPSKQAQ DYGDITVAMT SEVVLPEWTI 1080 RDFVVKNMQN SESHPLRQFH FTSWPDHGVP DTTDLLINFR YLVRDYMKQI PPESPILVHC 1140 SAGVGRTGTF IAIDRLIYQI ENENTVDVYG IVYDLRMHRP LMVQTEDQYV FLNQCVLDII 1200 RAQKDSKVDL IYQNTTAMTI YENLEPVSMF GKTNGYIA 1238 // ID mHDPTP\(AAH22721) STANDARD; PRT; 496 AA. AC AAH22721; DT 30-JUN-2003 DE AI462446 protein [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC Contact: MGC help desk CC Email: cgapbs-r@mail.nih.gov CC Tissue Procurement: The Cepko Laboratory CC cDNA Library Preparation: Life Technologies, Inc. CC cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) CC DNA Sequencing by: Sequencing Group at the Stanford Human Genome CC Center, Stanford University School of Medicine, Stanford, CA 94305 CC Web site: http://www-shgc.stanford.edu CC Contact: (Dickson, Mark) mcd@paxil.stanford.edu CC Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers, CC R. M. CC CC Clone distribution: MGC clone distribution information can be found CC through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov CC Series: IRAK Plate: 44 Row: e Column: 12 CC This clone was selected for full length sequencing because it CC passed the following selection criteria: Hexamer frequency ORF CC analysis. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 496) CC GPRFLN| AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., CC GPRFLN| Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., CC GPRFLN| Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., CC GPRFLN| Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., CC GPRFLN| Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., CC GPRFLN| Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., CC GPRFLN| Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., CC GPRFLN| Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., CC GPRFLN| Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., CC GPRFLN| McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., CC GPRFLN| Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., CC GPRFLN| Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., CC GPRFLN| Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., CC GPRFLN| Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., CC GPRFLN| Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., CC GPRFLN| Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., CC GPRFLN| Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., CC GPRFLN| Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CC GPRFLN| TITLE Generation and initial analysis of more than 15,000 full-length CC GPRFLN| human and mouse cDNA sequences CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) CC GPRFLN| MEDLINE 22388257 CC GPRFLN|REFERENCE 2 (residues 1 to 496) CC GPRFLN| AUTHORS Strausberg,R. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (01-FEB-2002) National Institutes of Health, Mammalian CC GPRFLN| Gene Collection (MGC), Cancer Genomics Office, National Cancer CC GPRFLN| Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, CC GPRFLN| USA CC GPRFLN| REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|306768865| CC VNTAUTHORNAME|JNA| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|UNKNOWN| FT SOURCE 1 496 Vector: pCMV-SPORT6 FT VNTIFKEY:269 FT PROTEIN 1 496 VNTIFKEY:270 SQ SEQUENCE 496 AA; LQPTKVDAAE GRRPQALRLI EQDPYEHPER LQQLQQELEA FRGQLGDAGA LDAIWRELQE 60 AQEHDARGRS IAIARCYSLK NRHQDVMPYD SNRVVLRSGK DDYINASCVE GLSPYCPPLV 120 ATQAPLPGTA ADFWLMVHEQ KVSVIVMLVS EAEMEKQKVA RYFPTERGQP MVHGALSVAL 180 SSIRTTETHV ERVLSLQFRD QSLKRSLVHL HFPTWPELGL PDSPGNLLRF IQEVHAHYLH 240 QRPLHTPIVV HCSSGVGRTG AFALLYAAVQ EVEAGNGIPE LPQLVRRMRQ QRKHMLQEKL 300 HLKFCHEALV RHVEQVLQRH GVPPPGKPVA SVNISQKNHL PQDSQDLVLG GDVPISSIQA 360 TIAKLSIRPL GGLDSPAASL PGLVEPPGLP PASLPESTPV PSSSPPPLSS PLPEAPQPEE 420 EPSVPEAPSL GPPSSSLELL ASLTPEAFSL DSSLRGKQRM SKQNFLQAHN GQGLRAAQPT 480 DDPLSLLDPL WTLNKT 496 // ID mHePTP\(NP_796055)\Ptpn7 STANDARD;PRT; 359 AA. AC NP_796055; DT 30-JUN-2003 DE RIKEN cDNA C920001D21 gene [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PREDICTED REFSEQ: The mRNA record is supported by experimental CC evidence; however, the coding sequence is predicted. The reference CC sequence was derived from AK083305.1. CC GPRFLN|REFERENCE 1 (residues 1 to 359) CC GPRFLN| AUTHORS Okazaki,Y., Furuno,M., Kasukawa,T., Adachi,J., Bono,H., Kondo,S., CC GPRFLN| Nikaido,I., Osato,N., Saito,R., Suzuki,H., Yamanaka,I., CC GPRFLN| Kiyosawa,H., Yagi,K., Tomaru,Y., Hasegawa,Y., Nogami,A., CC GPRFLN| Schonbach,C., Gojobori,T., Baldarelli,R., Hill,D.P., Bult,C., CC GPRFLN| Hume,D.A., Quackenbush,J., Schriml,L.M., Kanapin,A., Matsuda,H., CC GPRFLN| Batalov,S., Beisel,K.W., Blake,J.A., Bradt,D., Brusic,V., CC GPRFLN| Chothia,C., Corbani,L.E., Cousins,S., Dalla,E., Dragani,T.A., CC GPRFLN| Fletcher,C.F., Forrest,A., Frazer,K.S., Gaasterland,T., CC GPRFLN| Gariboldi,M., Gissi,C., Godzik,A., Gough,J., Grimmond,S., CC GPRFLN| Gustincich,S., Hirokawa,N., Jackson,I.J., Jarvis,E.D., Kanai,A., CC GPRFLN| Kawaji,H., Kawasawa,Y., Kedzierski,R.M., King,B.L., Konagaya,A., CC GPRFLN| Kurochkin,I.V., Lee,Y., Lenhard,B., Lyons,P.A., Maglott,D.R., CC GPRFLN| Maltais,L., Marchionni,L., McKenzie,L., Miki,H., Nagashima,T., CC GPRFLN| Numata,K., Okido,T., Pavan,W.J., Pertea,G., Pesole,G., CC GPRFLN| Petrovsky,N., Pillai,R., Pontius,J.U., Qi,D., Ramachandran,S., CC GPRFLN| Ravasi,T., Reed,J.C., Reed,D.J., Reid,J., Ring,B.Z., Ringwald,M., CC GPRFLN| Sandelin,A., Schneider,C., Semple,C.A., Setou,M., Shimada,K., CC GPRFLN| Sultana,R., Takenaka,Y., Taylor,M.S., Teasdale,R.D., Tomita,M., CC GPRFLN| Verardo,R., Wagner,L., Wahlestedt,C., Wang,Y., Watanabe,Y., CC GPRFLN| Wells,C., Wilming,L.G., Wynshaw-Boris,A., Yanagisawa,M., Yang,I., CC GPRFLN| Yang,L., Yuan,Z., Zavolan,M., Zhu,Y., Zimmer,A., Carninci,P., CC GPRFLN| Hayatsu,N., Hirozane-Kishikawa,T., Konno,H., Nakamura,M., CC GPRFLN| Sakazume,N., Sato,K., Shiraki,T., Waki,K., Kawai,J., Aizawa,K., CC GPRFLN| Arakawa,T., Fukuda,S., Hara,A., Hashizume,W., Imotani,K., Ishii,Y., CC GPRFLN| Itoh,M., Kagawa,I., Miyazaki,A., Sakai,K., Sasaki,D., Shibata,K., CC GPRFLN| Shinagawa,A., Yasunishi,A., Yoshino,M., Waterston,R., Lander,E.S., CC GPRFLN| Rogers,J., Birney,E. and Hayashizaki,Y. CC GPRFLN| TITLE Analysis of the mouse transcriptome based on functional annotation CC GPRFLN| of 60,770 full-length cDNAs CC GPRFLN| JOURNAL Nature 420 (6915), 563-573 (2002) CC GPRFLN| MEDLINE 22354683 CC GPRFLN|REFERENCE 2 CC GPRFLN| AUTHORS The FANTOM Consortium and the RIKEN Genome Exploration Research CC GPRFLN| Group Phase I & II Team. CC GPRFLN| TITLE Analysis of the mouse transcriptome based on functional annotation CC GPRFLN| of 60,770 full-length cDNAs CC GPRFLN| JOURNAL Nature 420, 563-573 (2002) CC GPRFLN|REFERENCE 3 CC GPRFLN| AUTHORS Kawai,J., Shinagawa,A., Shibata,K., Yoshino,M., Itoh,M., Ishii,Y., CC GPRFLN| Arakawa,T., Hara,A., Fukunishi,Y., Konno,H., Adachi,J., Fukuda,S., CC GPRFLN| Aizawa,K., Izawa,M., Nishi,K., Kiyosawa,H., Kondo,S., Yamanaka,I., CC GPRFLN| Saito,T., Okazaki,Y., Gojobori,T., Bono,H., Kasukawa,T., Saito,R., CC GPRFLN| Kadota,K., Matsuda,H., Ashburner,M., Batalov,S., Casavant,T., CC GPRFLN| Fleischmann,W., Gaasterland,T., Gissi,C., King,B., Kochiwa,H., CC GPRFLN| Kuehl,P., Lewis,S., Matsuo,Y., Nikaido,I., Pesole,G., CC GPRFLN| Quackenbush,J., Schriml,L.M., Staubli,F., Suzuki,R., Tomita,M., CC GPRFLN| Wagner,L., Washio,T., Sakai,K., Okido,T., Furuno,M., Aono,H., CC GPRFLN| Baldarelli,R., Barsh,G., Blake,J., Boffelli,D., Bojunga,N., CC GPRFLN| Carninci,P., de Bonaldo,M.F., Brownstein,M.J., Bult,C., CC GPRFLN| Fletcher,C., Fujita,M., Gariboldi,M., Gustincich,S., Hill,D., CC GPRFLN| Hofmann,M., Hume,D.A., Kamiya,M., Lee,N.H., Lyons,P., CC GPRFLN| Marchionni,L., Mashima,J., Mazzarelli,J., Mombaerts,P., Nordone,P., CC GPRFLN| Ring,B., Ringwald,M., Rodriguez,I., Sakamoto,N., Sasaki,H., CC GPRFLN| Sato,K., Schonbach,C., Seya,T., Shibata,Y., Storch,K.F., Suzuki,H., CC GPRFLN| Toyo-oka,K., Wang,K.H., Weitz,C., Whittaker,C., Wilming,L., CC GPRFLN| Wynshaw-Boris,A., Yoshida,K., Hasegawa,Y., Kawaji,H., Kohtsuki,S. CC GPRFLN| and Hayashizaki,Y. CC GPRFLN| TITLE Functional annotation of a full-length mouse cDNA collection CC GPRFLN| JOURNAL Nature 409 (6821), 685-690 (2001) CC GPRFLN| MEDLINE 21085660 CC GPRFLN|REFERENCE 4 CC GPRFLN| AUTHORS Shibata,K., Itoh,M., Aizawa,K., Nagaoka,S., Sasaki,N., Carninci,P., CC GPRFLN| Konno,H., Akiyama,J., Nishi,K., Kitsunai,T., Tashiro,H., Itoh,M., CC GPRFLN| Sumi,N., Ishii,Y., Nakamura,S., Hazama,M., Nishine,T., Harada,A., CC GPRFLN| Yamamoto,R., Matsumoto,H., Sakaguchi,S., Ikegami,T., Kashiwagi,K., CC GPRFLN| Fujiwake,S., Inoue,K. and Togawa,Y. CC GPRFLN| TITLE RIKEN integrated sequence analysis (RISA) system--384-format CC GPRFLN| sequencing pipeline with 384 multicapillary sequencer CC GPRFLN| JOURNAL Genome Res. 10 (11), 1757-1771 (2000) CC GPRFLN| MEDLINE 20530913 CC GPRFLN|REFERENCE 5 CC GPRFLN| AUTHORS Carninci,P., Shibata,Y., Hayatsu,N., Sugahara,Y., Shibata,K., CC GPRFLN| Itoh,M., Konno,H., Okazaki,Y., Muramatsu,M. and Hayashizaki,Y. CC GPRFLN| TITLE Normalization and subtraction of cap-trapper-selected cDNAs to CC GPRFLN| prepare full-length cDNA libraries for rapid discovery of new genes CC GPRFLN| JOURNAL Genome Res. 10 (10), 1617-1630 (2000) CC GPRFLN| MEDLINE 20499374 CC GPRFLN|REFERENCE 6 CC GPRFLN| AUTHORS Carninci,P. and Hayashizaki,Y. CC GPRFLN| TITLE High-efficiency full-length cDNA cloning CC GPRFLN| JOURNAL Meth. Enzymol. 303, 19-44 (1999) CC GPRFLN| MEDLINE 99279253 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|306768467| CC VNTAUTHORNAME|JNA| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|UNKNOWN| FT SOURCE 1 359 VNTIFKEY:269 FT PROTEIN 1 359 VNTIFKEY:270 FT REGION 96 349 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 359 AA; MVQACEGRSR AQLPTLSLGA DMTQPPPTKA PAKKHVRLQE RRGSSVALML DVQSLGTVEP 60 ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE FLKIPSNFVN PEDLDIPGHA 120 SKDRYKTILP NPQSRVCLGR AQSQEDSDYI NANYIRGYDG KEKVYIATQG PMPNTVADFW 180 EMVWQEDVSL IVMLTQLREG KEKCVHYWPT EEEAYGPFQI RIQDMKEHPE YTVRQLTIQH 240 QQECRSVKHI LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF 300 IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA AQLPPEPNP 359 // ID mIA2\(NP_033011)\Ptprn STANDARD;PRT; 996 AA. AC NP_033011; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, N; protein tyrosine phosphatase, receptor-type, N [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from X74438.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 996) CC GPRFLN| AUTHORS Saeki,K., Zhu,M., Kubosaki,A., Xie,J., Lan,M.S. and Notkins,A.L. CC GPRFLN| TITLE Targeted disruption of the protein tyrosine phosphatase-like CC GPRFLN| molecule IA-2 results in alterations in glucose tolerance tests and CC GPRFLN| insulin secretion CC GPRFLN| JOURNAL Diabetes 51 (6), 1842-1850 (2002) CC GPRFLN| MEDLINE 22027598 CC GPRFLN| REMARK GeneRIF: IA-2 is involved in glucose-stimulated insulin secretion CC GPRFLN|REFERENCE 2 (residues 1 to 996) CC GPRFLN| AUTHORS Kudva,Y.C., Deng,Y.J., Govindarajan,R., Abraham,R.S., CC GPRFLN| Marietta,E.V., Notkins,A.L. and David,C.S. CC GPRFLN| TITLE HLA-DQ8 transgenic and NOD mice recognize different epitopes within CC GPRFLN| the cytoplasmic region of the tyrosine phosphatase-like molecule, CC GPRFLN| IA-2 CC GPRFLN| JOURNAL Hum. Immunol. 62 (10), 1099-1105 (2001) CC GPRFLN| MEDLINE 21486216 CC GPRFLN| REMARK GeneRIF: IA-2 peptides have been identified that induce CC GPRFLN| lymphoproliferative responses in DQ8 transgenic and NOD mice and CC GPRFLN| stimulate production of Th1 and Th2 cytokines. CC GPRFLN|REFERENCE 3 (residues 1 to 996) CC GPRFLN| AUTHORS Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J., CC GPRFLN| Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M. CC GPRFLN| TITLE High-throughput sequence identification of gene coding variants CC GPRFLN| within alcohol-related QTLs CC GPRFLN| JOURNAL Mamm. Genome 12 (8), 657-663 (2001) CC GPRFLN| MEDLINE 21363810 CC GPRFLN|REFERENCE 4 (residues 1 to 996) CC GPRFLN| AUTHORS Saeki,K., Xie,J. and Notkins,A.L. CC GPRFLN| TITLE Genomic structure of mouse IA-2: comparison with its human CC GPRFLN| homologue CC GPRFLN| JOURNAL Diabetologia 43 (11), 1429-1434 (2000) CC GPRFLN| MEDLINE 21012487 CC GPRFLN|REFERENCE 5 CC GPRFLN| AUTHORS Magistrelli,G., Covini,N., Mosca,M., Lippoli,G. and Isacchi,A. CC GPRFLN| TITLE Expression of PTP35, the murine homologue of the protein tyrosine CC GPRFLN| phosphatase-related sequence IA-2, is regulated during cell growth CC GPRFLN| and stimulated by mitogens in 3T3 fibroblasts CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 217 (1), 154-161 (1995) CC GPRFLN| MEDLINE 96095652 CC GPRFLN|REFERENCE 6 (residues 1 to 996) CC GPRFLN| AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. CC GPRFLN| TITLE A novel receptor-type protein tyrosine phosphatase with a single CC GPRFLN| catalytic domain is specifically expressed in mouse brain CC GPRFLN| JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) CC GPRFLN| MEDLINE 95134232 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 996 VNTIFKEY:269 FT PROTEIN 1 996 protein tyrosine phosphatase, receptor-type, N FT VNTIFKEY:270 FT REGION 726 987 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 996 AA; MFPCARGRES SEPGRMRRPR RPGGSGGSGG SGGLRLLVCL LLLSGRPGGC SAISAHGCLF 60 DRRLCSHLEV CIQDGLFGQC QAGVGQARPL LQVTSPVLQR LQGVLRQLMS QGLSWHDDLT 120 QHVISQEMER IPRLRPPEPH PRDRSGLVPR KPGPAGELLT QGNPTGSSPA AQGFPRPAGG 180 GDGAGAGSPL SSLQAELLPP LLEHLLMPPQ PPHPALTYEP ALLQPYLFHQ FGSRDGSRGS 240 ESSSGVVGVG HLSKAEGPAL FSRSASKAIL GTHSGHSFGD LTGPSPAQLF QDSGLLYMAQ 300 ELPVPGRARA PRLPENGGNR AEDSSEGHEE EVLGGRGEKS PPQAAQPELS LQRLTAVLAG 360 YGVELRQLTP EQFSTLLTLL QLLPKGTGRN LEGAVNVGGA DVKKTIQQMQ RGDPAEALPP 420 TPSLPGYLTA SPASSEVQQV LSPGFPEPPH TPSPLGSSSV LLEKKSPLGQ SQPTVVGRPS 480 ARPSAEEYGY IVTDQKPLSL VAGVRLLEIL AEHVHMSSGS FINISVVGPA VTFRIRHNEQ 540 NLSLADVTQQ AGLVKSELEA QTGLQILQTG VGQREEAAEV LPRQAHGISP MRSVLLTLVA 600 LAGVAGLLVA LAVALCMRHH SRQRDKERLA AVGPEGAHGD TTFEYQDLCR QHMATKSLFN 660 RAEGQPEPSR VSSVSSQFSD AAQASPSSHS STPSWCEEPA QANMDISTGH MILAYMEDHL 720 RNRDRLAKEW QALCAYQAEP NTCAAAQDES NIKKNRHPDF LPYDHARIKL KVESSPSRSD 780 YINASPIIEH DPRMPAYIAT QGPLSHTIAD FWQMVWESGC TVIVMLTPLV EDGVKQCDRY 840 WPDEGSSLYH VYEVNLVSEH IWCEDFLVRS FYLKNVQTQE TRTLTQFHFL SWPAEGTPAS 900 TRPLLDFRRK VNKCYRGRSC PIIVHCSDGA GRTGTYILID MVLNRMAKGV KEIDIAATLE 960 HVRDQRPGLV RSKDQFEFAL TAVAEEVNAI LKALPQ 996 // ID mLAR\(NP_035343)\Ptprf STANDARD;PRT; 1898 AA. AC NP_035343; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, F; protein tyrosine phosphatase, receptor-type, F [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from AF300943.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1898) CC GPRFLN| AUTHORS Zeng,L., Si,X., Yu,W.P., Le,H.T., Ng,K.P., Teng,R.M., Ryan,K., CC GPRFLN| Wang,D.Z., Ponniah,S. and Pallen,C.J. CC GPRFLN| TITLE PTP alpha regulates integrin-stimulated FAK autophosphorylation and CC GPRFLN| cytoskeletal rearrangement in cell spreading and migration CC GPRFLN| JOURNAL J. Cell Biol. 160 (1), 137-146 (2003) CC GPRFLN| MEDLINE 22403956 CC GPRFLN| REMARK GeneRIF: PTP alpha is required for integrin-proximal events and CC GPRFLN| phosphorylates FAK CC GPRFLN|REFERENCE 2 (residues 1 to 1898) CC GPRFLN| AUTHORS Terszowski,G., Jankowski,A., Hendriks,W.J., Rolink,A.G. and CC GPRFLN| Kisielow,P. CC GPRFLN| TITLE Within the hemopoietic system, LAR phosphatase is a T cell CC GPRFLN| lineage-specific adhesion receptor-like protein whose phosphatase CC GPRFLN| activity appears dispensable for T cell development, repertoire CC GPRFLN| selection and function CC GPRFLN| JOURNAL Eur. J. Immunol. 31 (3), 832-840 (2001) CC GPRFLN| MEDLINE 21135493 CC GPRFLN|REFERENCE 3 (residues 1 to 1898) CC GPRFLN| AUTHORS Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T., CC GPRFLN| Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J. CC GPRFLN| TITLE The mouse gene Ptprf encoding the leukocyte common antigen-related CC GPRFLN| molecule LAR: cloning, characterization, and chromosomal CC GPRFLN| localization CC GPRFLN| JOURNAL Genomics 27 (1), 124-130 (1995) CC GPRFLN| MEDLINE 95394448 CC GPRFLN|REFERENCE 4 (residues 1 to 1898) CC GPRFLN| AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. CC GPRFLN| TITLE A novel receptor-type protein tyrosine phosphatase with a single CC GPRFLN| catalytic domain is specifically expressed in mouse brain CC GPRFLN| JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) CC GPRFLN| MEDLINE 95134232 CC GPRFLN|REFERENCE 5 (residues 1 to 1898) CC GPRFLN| AUTHORS Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W. CC GPRFLN| TITLE Identification and typing of members of the protein-tyrosine CC GPRFLN| phosphatase gene family expressed in mouse brain CC GPRFLN| JOURNAL Mol. Biol. Rep. 16 (4), 241-248 (1992) CC GPRFLN| MEDLINE 93086603 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1898 VNTIFKEY:269 FT PROTEIN 1 1898 protein tyrosine phosphatase, receptor-type, F FT VNTIFKEY:270 FT REGION 39 125 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 149 214 IGc2 FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 238 316 IG FT VNTIFKEY:266; VNTINAME:Region_3 FT DOMAIN 346 401 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 417 500 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 512 591 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 610 696 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 710 797 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT DOMAIN 812 894 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_6 FT DOMAIN 927 991 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_7 FT REGION 1342 1600 PTPc FT VNTIFKEY:266; VNTINAME:Region_4 FT REGION 1633 1890 PTPc FT VNTIFKEY:266; VNTINAME:Region_5 SQ SEQUENCE 1898 AA; MAPEPAPGRR MVPLVPALVM LGLMAGAHGD SKPVFVKVPE DQTGLSEGVA SFVCQATGEP 60 KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 120 KLSVLEEDQL PSGFPTIDMG PQLKVVEKGR TATMLCAAGG NPDPEISWFK DFLPVDPAAS 180 NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 240 QEVMPGGSVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV MRSANYTCVA 300 ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNTEPVSFY GIQYRAAGTD 360 GPFQEVDGVA STRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 420 QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP 480 GVTYSLRVLA FTAVGDGPPS PTIQVKTQQG VPARSADFQA NAESDTRIQL SWLLPPQERI 540 VKYELVYWAA EDEGQQHKVT FDPTSSYTLE DLKPDTLYRF QLAARSDLGV GVFTPTVEAX 600 TAQSTPSAPP QKVTCVSTGS TTVRVSWVPP PADSRNGIIT QYSVAYEAVD GEDRKRHVVD 660 GISREHSSWD LLGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 720 NSTAVHVSWK LPVPNKQHGQ IRGYQVTYVR LENGEPRGQP IIQDVMLAEA QETTISGLTP 780 ETTYSITVAA YTTKGDGARS KPKVVTTTGA VPGRPTMMVS TTAMHTALLQ WHPPKELPGE 840 LLGYRLQYRR ADEARPNTID FGKDDQHFTV TGLHKGATYV FRLAAKNRAG PGEEFEKEIT 900 TPEDVPSGFP QNLRVTGLTT STTELTWDPP VLAERNGXIT NYTVVYRDIN SQLELQNVTN 960 DTHLTLLGLK PDTTYDIKVR AHTSKGAGPL SPSIQSRTMP VEQVFTKNFR VAAAMKTSVL 1020 LSWEVPDSYK SAVPFKILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGSSAGGLQH 1080 LVSIRTAPDL LPQKPLPASA FIEDGRFSLS MPQVQDPSLV RWFYIVVVPI DRVGGNLLAP 1140 RWNTPEELEL DELLEAIEQG EEKQRRRRRQ AERLKPYVAA QVDVLPDTFT LGDKKSYRGF 1200 YNRPLSPDLS YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP EMLWVTGPVL 1260 AVILIILIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH 1320 PPIPITDLAD NIERLKANDG LKFSQEYESI DPGQQFTWEN SNSEVNKPKN RYADVIAYDH 1380 SRVLLTSIDG VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM 1440 TRLEEKSRVK CDQYWPVRGT ETYGLIQVTL VDTVELATYT MRTFALHKSG SSEKRELRQF 1500 QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK 1560 HEKTVDIYGH VTCMRSQRNY MVQTEDQYVF IHEALLEAAM CGHTEVLARN LYAHIQKLGQ 1620 VPPGESVTAM ELEFKLLANS KAHTSRFVSA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV 1680 EGSDYINASF LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC 1740 HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 1800 KTGEGFIDXI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ 1860 TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT 1898 // ID mMEG1\(NP_064317)\Ptpn4 STANDARD;PRT; 926 AA. AC NP_064317; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 4; testis-enriched protein tyrosine phosphatase; TEP/mPTPMEG; testis-enriched phosphatase; protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from AF106702.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 926) CC GPRFLN| AUTHORS Park,K.W., Lee,E.J., Lee,S., Lee,J.E., Choi,E., Kim,B.J., Hwang,R., CC GPRFLN| Park,K.A. and Baik,J. CC GPRFLN| TITLE Molecular cloning and characterization of a protein tyrosine CC GPRFLN| phosphatase enriched in testis, a putative murine homologue of CC GPRFLN| human PTPMEG CC GPRFLN| JOURNAL Gene 257 (1), 45-55 (2000) CC GPRFLN| MEDLINE 20510023 CC GPRFLN|REFERENCE 2 (residues 1 to 926) CC GPRFLN| AUTHORS Celler,J.W., Luo,X. and Bohmer,F.D. CC GPRFLN| TITLE Protein tyrosine phosphatase gene expression analysis in Swiss 3T3 CC GPRFLN| fibroblasts CC GPRFLN| JOURNAL Mol. Cell. Biochem. 178 (1-2), 157-162 (1998) CC GPRFLN| MEDLINE 98206672 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 926 VNTIFKEY:269 FT PROTEIN 1 926 similar to Homo sapiens megakaryocyte PTPase MEG-01; non-receptor type PTPase; contains Band 4.1-like and catalytic phosphatase domains; contains SH3 and DHR (PDZ) motifs that function as adaptor sequences; testis-enriched protein tyrosine phosphatase; TEP/mPTPMEG; testis-enriched phosphatase; protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) FT VNTIFKEY:270 FT DOMAIN 31 222 Band_41 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 517 604 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT REGION 655 913 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 926 AA; MTARFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFRVNKHDQ GQVLLDIVFK 60 HLDLTERDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YNLNFRVKFF VSDPNKLQEE 120 YTRYQYFLQI KQDILTGRLS CPCNTAALLA SFAVQSELGD YNQSENLAGY LSDYSFIPNQ 180 PQDFEKEIAK LHQQHVGLSP AEAEFNYLNA ARTLELYGVE FHYARDQSNN EILIGVMSGG 240 ILIYKNRVRM NTFLWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKTLWKA 300 CVEHHTFFRL GRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSSS 360 KPLARKLMDW EVVSRNSLSD DRLETQSLPS RSPPGTPNHR NSSFTQEATR VRPSSVGHLV 420 DHVVHMSPSE DFVSQRSPSS TQANSIVLES SPSQETPEDG QPPALPPKQS KKNSWNQIHF 480 SNSQQDLVTH TNESFDVPSS PEKSTPNGGI PHDNLVLIKM KPDENGRFGF NVKGGYDQKM 540 PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC EKHSGELVLL 600 VRPNAVYDVV EEKLESEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLAQFD 660 QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVLLKG NEDYINANYI NMEIPSSSII 720 NQYIACQGPL PHTCKDFWQM IWEQGSSMVV MLTTQVERGR VKCHQYWPEP SESSSYGCYQ 780 ATCHSEEGNP AYIFRKMTLI NQEKNESRQL TQIQYTAWPD HGVPDDSSDF LDFVCHVRDQ 840 RAGKEEPIIV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ 900 YRFVCEAILK VYEEGFVKPL TTSSNK 926 // ID mMEG2\(NP_062625)\Ptpn9 STANDARD;PRT; 593 AA. AC NP_062625; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 9; protein-tyrosine phosphatase [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from AF013490.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 593) CC GPRFLN| AUTHORS Kawai,J., Shinagawa,A., Shibata,K., Yoshino,M., Itoh,M., Ishii,Y., CC GPRFLN| Arakawa,T., Hara,A., Fukunishi,Y., Konno,H., Adachi,J., Fukuda,S., CC GPRFLN| Aizawa,K., Izawa,M., Nishi,K., Kiyosawa,H., Kondo,S., Yamanaka,I., CC GPRFLN| Saito,T., Okazaki,Y., Gojobori,T., Bono,H., Kasukawa,T., Saito,R., CC GPRFLN| Kadota,K., Matsuda,H., Ashburner,M., Batalov,S., Casavant,T., CC GPRFLN| Fleischmann,W., Gaasterland,T., Gissi,C., King,B., Kochiwa,H., CC GPRFLN| Kuehl,P., Lewis,S., Matsuo,Y., Nikaido,I., Pesole,G., CC GPRFLN| Quackenbush,J., Schriml,L.M., Staubli,F., Suzuki,R., Tomita,M., CC GPRFLN| Wagner,L., Washio,T., Sakai,K., Okido,T., Furuno,M., Aono,H., CC GPRFLN| Baldarelli,R., Barsh,G., Blake,J., Boffelli,D., Bojunga,N., CC GPRFLN| Carninci,P., de Bonaldo,M.F., Brownstein,M.J., Bult,C., CC GPRFLN| Fletcher,C., Fujita,M., Gariboldi,M., Gustincich,S., Hill,D., CC GPRFLN| Hofmann,M., Hume,D.A., Kamiya,M., Lee,N.H., Lyons,P., CC GPRFLN| Marchionni,L., Mashima,J., Mazzarelli,J., Mombaerts,P., Nordone,P., CC GPRFLN| Ring,B., Ringwald,M., Rodriguez,I., Sakamoto,N., Sasaki,H., CC GPRFLN| Sato,K., Schonbach,C., Seya,T., Shibata,Y., Storch,K.F., Suzuki,H., CC GPRFLN| Toyo-oka,K., Wang,K.H., Weitz,C., Whittaker,C., Wilming,L., CC GPRFLN| Wynshaw-Boris,A., Yoshida,K., Hasegawa,Y., Kawaji,H., Kohtsuki,S. CC GPRFLN| and Hayashizaki,Y. CC GPRFLN| TITLE Functional annotation of a full-length mouse cDNA collection CC GPRFLN| JOURNAL Nature 409 (6821), 685-690 (2001) CC GPRFLN| MEDLINE 21085660 CC GPRFLN|REFERENCE 2 (residues 1 to 593) CC GPRFLN| AUTHORS Shibata,K., Itoh,M., Aizawa,K., Nagaoka,S., Sasaki,N., Carninci,P., CC GPRFLN| Konno,H., Akiyama,J., Nishi,K., Kitsunai,T., Tashiro,H., Itoh,M., CC GPRFLN| Sumi,N., Ishii,Y., Nakamura,S., Hazama,M., Nishine,T., Harada,A., CC GPRFLN| Yamamoto,R., Matsumoto,H., Sakaguchi,S., Ikegami,T., Kashiwagi,K., CC GPRFLN| Fujiwake,S., Inoue,K. and Togawa,Y. CC GPRFLN| TITLE RIKEN integrated sequence analysis (RISA) system--384-format CC GPRFLN| sequencing pipeline with 384 multicapillary sequencer CC GPRFLN| JOURNAL Genome Res. 10 (11), 1757-1771 (2000) CC GPRFLN| MEDLINE 20530913 CC GPRFLN|REFERENCE 3 (residues 1 to 593) CC GPRFLN| AUTHORS Carninci,P., Shibata,Y., Hayatsu,N., Sugahara,Y., Shibata,K., CC GPRFLN| Itoh,M., Konno,H., Okazaki,Y., Muramatsu,M. and Hayashizaki,Y. CC GPRFLN| TITLE Normalization and subtraction of cap-trapper-selected cDNAs to CC GPRFLN| prepare full-length cDNA libraries for rapid discovery of new genes CC GPRFLN| JOURNAL Genome Res. 10 (10), 1617-1630 (2000) CC GPRFLN| MEDLINE 20499374 CC GPRFLN|REFERENCE 4 (residues 1 to 593) CC GPRFLN| AUTHORS Carninci,P. and Hayashizaki,Y. CC GPRFLN| TITLE High-efficiency full-length cDNA cloning CC GPRFLN| JOURNAL Meth. Enzymol. 303, 19-44 (1999) CC GPRFLN| MEDLINE 99279253 CC GPRFLN|REFERENCE 5 (residues 1 to 593) CC GPRFLN| AUTHORS Meng,K., Gu,M., Li,F.N., Veile,R.A., Donis-Keller,H. and CC GPRFLN| Majerus,P.W. CC GPRFLN| TITLE MPTP-MEG2 CC GPRFLN| JOURNAL Unpublished CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 593 VNTIFKEY:269 FT PROTEIN 1 593 protein-tyrosine phosphatase FT VNTIFKEY:270 FT DOMAIN 10 80 CRAL_TRIO_N FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 84 266 CRAL_TRIO FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT REGION 302 576 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 593 AA; MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR 60 AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH 120 KSAQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP 180 ARLKKVLIVR APIWFRVPYS IISLLLKDKV RERIPILTTS EVTQHLPREC LPKNLGGYVK 240 IDLATWNFQF LPQVNGHPDP FDEIILSSLP PALDWDTLHV PSPLSMTIQE LVDYVNTRQK 300 RGIYEEYEDI CLENPVGTFH RTMSPRNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA 360 SFMDGYKQKN AYNGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK 420 DSRIRFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL 480 IDFLRVVRNQ QSMAVGNMGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT 540 LNVFHTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAQKERM VPSGHSLLAM DGQ 593 // ID mPEP\(NP_033005)\Ptpn8 STANDARD;PRT; 802 AA. AC NP_033005; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 8 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from M90388.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 802) CC GPRFLN| AUTHORS Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L. CC GPRFLN| TITLE Characterization of hematopoietic intracellular protein tyrosine CC GPRFLN| phosphatases: description of a phosphatase containing an SH2 domain CC GPRFLN| and another enriched in proline-, glutamic acid-, serine-, and CC GPRFLN| threonine-rich sequences CC GPRFLN| JOURNAL Mol. Cell. Biol. 12 (5), 2396-2405 (1992) CC GPRFLN| MEDLINE 92236615 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 802 VNTIFKEY:269 FT PROTEIN 1 802 VNTIFKEY:270 FT REGION 24 291 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 553 694 Paramyxo_P FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 802 AA; MDQREILQQL LKEAQKKKLN SEEFASEFLK LKRQSTKYKA DKIYPTTVAQ RPKNIKKNRY 60 KDILPYDHSL VELSLLTSDE DSSYINASFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY 120 RILVIVMACM EFEMGKKKCE RYWAEPGETQ LQFGPFSISC EAEKKKSDYK IRTLKAKFNN 180 ETRIIYQFHY KNWPDHDVPS SIDPILQLIW DMRCYQEDDC VPICIHCSAG CGRTGVICAV 240 DYTWMLLKDG IIPKNFSVFN LIQEMRTQRP SLVQTQEQYE LVYSAVLELF KRHMDVISDN 300 HLGREIQAQC SIPEQSLTVE ADSCPLDLPK NAMRDVKTTN QHSKQGAEAE STGGSSLGLR 360 TSTMNAEEEL VLHSAKSSPS FNCLELNCGC NNKAVITRNG QARASPVVGE PLQKYQSLDF 420 GSMLFGSCPS ALPINTADRY HNSKGPVKRT KSTPFELIQQ RKTNDLAVGD GFSCLESQLH 480 EHYSLRELQV QRVAHVSSEE LNYSLPGACD ASCVPRHSPG ALRVHLYTSL AEDPYFSSSP 540 PNSADSKMSF DLPEKQDGAT SPGALLPASS TTSFFYSNPH DSLVMNTLTS FSPPLNQETA 600 VEAPSRRTDD EIPPPLPERT PESFIVVEEA GEPSPRVTES LPLVVTFGAS PECSGTSEMK 660 SHDSVGFTPS KNVKLRSPKS DRHQDGSPPP PLPERTLESF FLADEDCIQA QAVQTSSTSY 720 PETTENSTSS KQTLRTPGKS FTRSKSLKIF RNMKKSVCNS SSPSKPTERV QPKNSSSFLN 780 FGFGNRFSKP KGPRNPPSAW NM 802 // ID mPEST\(NP_035333)\Ptpn12 STANDARD;PRT; 775 AA. AC NP_035333; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 12 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from X86781.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 775) CC GPRFLN| AUTHORS Charest,A., Wagner,J., Shen,S.H. and Tremblay,M.L. CC GPRFLN| TITLE Murine protein tyrosine phosphatase-PEST, a stable cytosolic CC GPRFLN| protein tyrosine phosphatase CC GPRFLN| JOURNAL Biochem. J. 308 (Pt 2), 425-432 (1995) CC GPRFLN| MEDLINE 95289971 CC GPRFLN|REFERENCE 2 (residues 1 to 775) CC GPRFLN| AUTHORS den Hertog,J., Pals,C.E., Jonk,L.J. and Kruijer,W. CC GPRFLN| TITLE Differential expression of a novel murine non-receptor protein CC GPRFLN| tyrosine phosphatase during differentiation of P19 embryonal CC GPRFLN| carcinoma cells CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 184 (3), 1241-1249 (1992) CC GPRFLN| MEDLINE 92272714 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 775 VNTIFKEY:269 FT PROTEIN 1 775 VNTIFKEY:270 FT REGION 28 295 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 775 AA; MEQVEILRRF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT ATGEKEENVK 60 KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP KAYVATQGPF RNTVIDFWRM 120 IWEYNVVMIV MACREFEMGR KKCERYWPLY GEDPITFAPF KISCENEQAR TDYFIRTLLL 180 EFQNESRRLY QFHYVNWPDH DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA 240 ICAIDYTWNL LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL 300 YEIHGAQKIR DGNEITTGTM VSSIDSEKQD SPPPKPPRTR SCLVEGDAKE EILQPPEPHP 360 VPPILTPSPP SAFPTVTTVW QDSDRYHPKP VLHMASPEQH PADLNRSYDK SADQWGKSES 420 AIEHIDKKLE RNLSFEIKKV PLQEGPKSFD GNTLLNRGHA IKIKSASSSV VDRTSKPQEL 480 SAGALKVDDV SQNSCADCSA AHSHRAAESS EESQSNSHTP PRPDCLPLDK KGHVTWSLHG 540 PENATPVPDS PDGKSPDNHS QTLKTVSSTP NSTAEEEAHD LTEHHNSSPL LKAPLSFTNP 600 LHSDDWHSDG GSSDGAVTRN KTSISTASAT VSPASSAESA CHRRVLPMSI ARQEVAGTPH 660 SGAEKDADVS EESPPPLPER TPESFVLADM PVRPEWHELP NQEWSEQRES EGLTTSGNEK 720 HDAGGIHTEA SADSPPAFSD KKDQITKSPA EVTDIGFGNR CGKPKGPREP PSEWT 775 // ID mPTP1B\(NP_035331)\Ptpn1 STANDARD;PRT; 432 AA. AC NP_035331; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 1 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from U24700.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 432) CC GPRFLN| AUTHORS Haj,F.G., Markova,B., Klaman,L.D., Bohmer,F.D. and Neel,B.G. CC GPRFLN| TITLE Regulation of receptor tyrosine kinase signaling by protein CC GPRFLN| tyrosine phosphatase-1B CC GPRFLN| JOURNAL J. Biol. Chem. 278 (2), 739-744 (2003) CC GPRFLN| MEDLINE 22401841 CC GPRFLN| REMARK GeneRIF: Protein tyrosine phosphatase-1B regulates receptor CC GPRFLN| tyrosine kinase signaling. CC GPRFLN|REFERENCE 2 (residues 1 to 432) CC GPRFLN| AUTHORS Zinker,B.A., Rondinone,C.M., Trevillyan,J.M., Gum,R.J., CC GPRFLN| Clampit,J.E., Waring,J.F., Xie,N., Wilcox,D., Jacobson,P., CC GPRFLN| Frost,L., Kroeger,P.E., Reilly,R.M., Koterski,S., Opgenorth,T.J., CC GPRFLN| Ulrich,R.G., Crosby,S., Butler,M., Murray,S.F., McKay,R.A., CC GPRFLN| Bhanot,S., Monia,B.P. and Jirousek,M.R. CC GPRFLN| TITLE PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes CC GPRFLN| blood glucose, and improves insulin sensitivity in diabetic mice CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (17), 11357-11362 (2002) CC GPRFLN| MEDLINE 22177164 CC GPRFLN| REMARK GeneRIF: findings suggest that PTP1B modulates insulin signaling in CC GPRFLN| liver and fat, and that therapeutic modalities targeting PTP1B CC GPRFLN| inhibition may have clinical benefit in type 2 diabetes CC GPRFLN|REFERENCE 3 (residues 1 to 432) CC GPRFLN| AUTHORS Rondinone,C.M., Trevillyan,J.M., Clampit,J., Gum,R.J., Berg,C., CC GPRFLN| Kroeger,P., Frost,L., Zinker,B.A., Reilly,R., Ulrich,R., Butler,M., CC GPRFLN| Monia,B.P., Jirousek,M.R. and Waring,J.F. CC GPRFLN| TITLE Protein tyrosine phosphatase 1B reduction regulates adiposity and CC GPRFLN| expression of genes involved in lipogenesis CC GPRFLN| JOURNAL Diabetes 51 (8), 2405-2411 (2002) CC GPRFLN| MEDLINE 22139929 CC GPRFLN| REMARK GeneRIF: reduction regulates adiposity and expression of genes CC GPRFLN| involved in lipogenesis CC GPRFLN|REFERENCE 4 (residues 1 to 432) CC GPRFLN| AUTHORS Iversen,L.F., Moller,K.B., Pedersen,A.K., Peters,G.H., CC GPRFLN| Petersen,A.S., Andersen,H.S., Branner,S., Mortensen,S.B. and CC GPRFLN| Moller,N.P. CC GPRFLN| TITLE Structure determination of T cell protein-tyrosine phosphatase CC GPRFLN| JOURNAL J. Biol. Chem. 277 (22), 19982-19990 (2002) CC GPRFLN| MEDLINE 22028072 CC GPRFLN| REMARK GeneRIF: Structure determination of T cell protein-tyrosine CC GPRFLN| phosphatase CC GPRFLN|REFERENCE 5 (residues 1 to 432) CC GPRFLN| AUTHORS Cheng,A., Uetani,N., Simoncic,P.D., Chaubey,V.P., Lee-Loy,A., CC GPRFLN| McGlade,C.J., Kennedy,B.P. and Tremblay,M.L. CC GPRFLN| TITLE Attenuation of leptin action and regulation of obesity by protein CC GPRFLN| tyrosine phosphatase 1B CC GPRFLN| JOURNAL Dev. Cell 2 (4), 497-503 (2002) CC GPRFLN| MEDLINE 21966114 CC GPRFLN| REMARK GeneRIF: Attenuation of leptin action and regulation of obesity by CC GPRFLN| protein tyrosine phosphatase 1B. CC GPRFLN|REFERENCE 6 (residues 1 to 432) CC GPRFLN| AUTHORS Zabolotny,J.M., Bence-Hanulec,K.K., Stricker-Krongrad,A., Haj,F., CC GPRFLN| Wang,Y., Minokoshi,Y., Kim,Y.B., Elmquist,J.K., Tartaglia,L.A., CC GPRFLN| Kahn,B.B. and Neel,B.G. CC GPRFLN| TITLE PTP1B regulates leptin signal transduction in vivo CC GPRFLN| JOURNAL Dev. Cell 2 (4), 489-495 (2002) CC GPRFLN| MEDLINE 21966113 CC GPRFLN| REMARK GeneRIF: PTP1B regulates leptin signal transduction CC GPRFLN|REFERENCE 7 (residues 1 to 432) CC GPRFLN| AUTHORS Buckley,D.A., Cheng,A., Kiely,P.A., Tremblay,M.L. and O'Connor,R. CC GPRFLN| TITLE Regulation of insulin-like growth factor type I (IGF-I) receptor CC GPRFLN| kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and CC GPRFLN| enhanced IGF-I-mediated suppression of apoptosis and motility in CC GPRFLN| PTP-1B-deficient fibroblasts CC GPRFLN| JOURNAL Mol. Cell. Biol. 22 (7), 1998-2010 (2002) CC GPRFLN| MEDLINE 21881935 CC GPRFLN| REMARK GeneRIF: Regulation of insulin-like growth factor type I (IGF-I) CC GPRFLN| receptor kinase activity by protein tyrosine phosphatase 1B CC GPRFLN| (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and CC GPRFLN| motility in PTP-1B-deficient fibroblasts CC GPRFLN|REFERENCE 8 (residues 1 to 432) CC GPRFLN| AUTHORS Park,K.S., Kim,Y.W., Kim,C.W., Kang,D.O. and Byun,S.M. CC GPRFLN| TITLE Molecular cloning and expression of a cDNA encoding a protein CC GPRFLN| tyrosine phosphatase from mouse brain CC GPRFLN| JOURNAL Biochem. Mol. Biol. Int. 40 (5), 1025-1032 (1996) CC GPRFLN| MEDLINE 97114074 CC GPRFLN|REFERENCE 9 (residues 1 to 432) CC GPRFLN| AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. CC GPRFLN| TITLE A novel receptor-type protein tyrosine phosphatase with a single CC GPRFLN| catalytic domain is specifically expressed in mouse brain CC GPRFLN| JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) CC GPRFLN| MEDLINE 95134232 CC GPRFLN|REFERENCE 10 (residues 1 to 432) CC GPRFLN| AUTHORS Miyasaka,H. and Li,S.S. CC GPRFLN| TITLE The cDNA cloning, nucleotide sequence and expression of an CC GPRFLN| intracellular protein tyrosine phosphatase from mouse testis CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 185 (3), 818-825 (1992) CC GPRFLN| MEDLINE 92328784 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 432 VNTIFKEY:269 FT PROTEIN 1 432 VNTIFKEY:270 FT REGION 3 279 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 432 AA; MEMEKEFEEI DKAGNWAAIY QDIRHEASDF PCKVAKLPKN KNRNRYRDVS PFDHSRIKLH 60 QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRIMEKGSLK 120 CAQYWPQQEE KEMVFDDTGL KLTLISEDVK SYYTVRQLEL ENLTTKETRE ILHFHYTTWP 180 DFGVPESPAS FLNFLFKVRE SGSLSLEHGP IVVHCSAGIG RSGTFCLADT CLLLMDKRKD 240 PSSVDIKKVL LEMRRFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSREDLD 300 LPPEHVPPPP RPPKRTLEPH NGKCKELFSS HQWVSEETCG DEDSLAREEG RAQSSAMHSV 360 SSMSPDTEVR RRMVGGGLQS AQASVPTEEE LSSTEEEHKA HWPSHWKPFL VNVCMATLLA 420 TGAYLCYRVC FH 432 // ID mPTP36\(NP_033002)\Ptpn14 STANDARD;PRT; 1189 AA. AC NP_033002; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 14 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from D31842.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1189) CC GPRFLN| AUTHORS Aoyama,K., Matsuda,T. and Aoki,N. CC GPRFLN| TITLE Characterization of newly identified four isoforms for a putative CC GPRFLN| cytosolic protein tyrosine phosphatase PTP36 CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999) CC GPRFLN| MEDLINE 20068798 CC GPRFLN|REFERENCE 2 (residues 1 to 1189) CC GPRFLN| AUTHORS Sawada,M., Ogata,M., Fujino,Y. and Hamaoka,T. CC GPRFLN| TITLE cDNA cloning of a novel protein tyrosine phosphatase with homology CC GPRFLN| to cytoskeletal protein 4.1 and its expression in T-lineage cells CC GPRFLN| JOURNAL Biochem. Biophys. Res. Commun. 203 (1), 479-484 (1994) CC GPRFLN| MEDLINE 94354845 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1189 VNTIFKEY:269 FT PROTEIN 1 1189 VNTIFKEY:270 FT REGION 17 220 B41 FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 910 1184 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 1189 AA; MPFGLKLRRT RRYNVLSKNC FVARIRLLDS NVIECTLSVE STGQECLEAV AQRLELRETH 60 YFGLWFLSKS QQARWVELEK PLKKHLDKFA NEPLLFFGVM FYVPNVSRLQ QEATRYQYYL 120 QVKKDVLEGR LRCSLEQVIR LAGLAVQADF GDYNQFDSQE FLREYVLFPM DLAMEEAALE 180 ELTQKVAQEH KAHSGILPAE AELMYINEVE RLDGFGQEIF PVKDSHGNSV HLGIFFMGIF 240 VRNRVGRQAV IYRWNDIGSV THSKAAILLE LIDKEETALF HTDDIENAKY ISRLFTTRHK 300 FYKQNKICTE QSNSPPPIRR QPTWSRSSLP RQQPYILPPM HVQCSEHYSE THTSQDSIFP 360 GNEEALYCRS HNSLDLNYLN GTVTNGSVCS VHSVNSLSCS QSFIQASPVS SNLSIPGSDI 420 MRADYIPSHR HSTIIVPSYR PTPDYETVMR QMKRGLMHAD SQSRSLRNLN IINTHAYNQP 480 EELVYSQPEM RERHPYTVPY AHQGCYGHKL VSPSDQMNPQ NCAMPIKPGA SSISHTVSTP 540 ELANMQLQGA QHYSTAHMLK NYLFRPPPPY PRPRPATSTP DLASHRHKYV SGSSPDLVTR 600 KVQLSVKTFQ EDSSPVVHQS LQEVSEPLTA TKHHGGGGGT VNKRHSLEVM NSMVRGMEAM 660 TLKSLNIPMA RRNTLREQGP SEETGGHEVH GLPQYHHKKT FSDATMLIHS SESEEEEETL 720 EAAPQVPVLR EKVEYSAQLQ AALARIPNRP PPEYPGPRKS VSNGALRQDQ GTPLPAMARC 780 RVLRHGPSKA LSVSRAEQLA VNGASLGPSI SEPDLTSVKE RVKKEPVKER PVSEMFSLED 840 SIIEREMMIR NLEKQKMTGP QAQKRPLMLA ALNGLSVARV SGREDGRHDA TRVPIDERLR 900 ALKKKLEDGM VFTEYEQIPN KKANGVFSTA TLPENAERSR IREVVPYEEN RVELIPTKEN 960 NTGYINASHI KVVVGGSEWH YIATQGPLPH TCHDFWQMVW EQGVNVIAMV TAEEEGGRTK 1020 SHRYWPKLGS KHSSATYGKF KVTTKFRTDS GCYATTGLKV KHLLSGQERT VWHLQYTDWP 1080 HHGCPEDVQG FLSYLEEIQS VRRHTNSVLE GIRTRHPPIV VHCSAGVGRT GVVILSELMI 1140 YCLEHNEKVE VPTMLRFLRE QRMFMIQTIA QYKFVYQVLV QFLQNSRLI 1189 // ID mPTPalpha\(AAK56109)\Ptpra STANDARD;PRT; 793 AA. AC AAK56109; DT 27-JUN-2003 DE protein tyrosin phosphatase receptor type alpha [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC Method: conceptual translation. CC GPRFLN|REFERENCE 1 (residues 1 to 793) CC GPRFLN| AUTHORS Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J., CC GPRFLN| Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M. CC GPRFLN| TITLE High-throughput sequence identification of gene coding variants CC GPRFLN| within alcohol-related QTLs CC GPRFLN| JOURNAL Mamm. Genome 12 (8), 657-663 (2001) CC GPRFLN| MEDLINE 21363810 CC GPRFLN|REFERENCE 2 (residues 1 to 793) CC GPRFLN| AUTHORS Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J., CC GPRFLN| Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (26-DEC-2000) Pharmacology, University of Colorado Health CC GPRFLN| Sciences Center, 4200 East Ninth Ave C236, Denver, CO 80262, USA CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|306541243| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 793 VNTIFKEY:269 FT PROTEIN 1 793 VNTIFKEY:270 SQ SEQUENCE 793 AA; MDSWFILVLF GSGLIHVSAN NATTVSPSLG TTRLIKTSTT ELAKEENKTS NSTSSVISLS 60 VAPTFSPNLT LEPTYVTTVN SSHSDNGTRR AASTESGGTT ISPNGSWLIE NQFTDAITEP 120 WEGNSSTAAT TPETFPPADE TPIIAVMVAL SSLLVIVFII IVLYMLRFKK YKQAGSHSNS 180 FRLSNGRTED VEPQSVPLLA RSPSTNRKYP PLPVDKLEEE INRRMADDNK LFREEFNALP 240 ACPIQATCEA ASKEENKEKN RYVNILPYDH SRVHLTPVEG VPDSDYINAS FINGYQEKNK 300 FIAAQGPKEE TVNDFWRMIW EQNTATIVMV TNLKERKECK CAQYWPDQGC WTYGNVRVSV 360 EDVTVLVDYT VRKFCIQQVG DVTNRKPQRL ITQFHFTSWP DFGVPFTPIG MLKFLKKVKA 420 CNPQYAGAIV VHCSAGVGRT GTFVVIDAML DMMHSERKVD VYGFVSRIRA QRCQMVQTDM 480 QYVFIYQALL EHYLYGDTEL EVTSLETHLQ KIYNKIPGTS NNGLEEEFKK LTSIKIQNDK 540 MRTGNLPANM KKNRVLQIIP YEFNRVIIPV KRGEENTDYV NASFIDGYRQ KDSYIASQGP 600 LLHTIEDFWR MIWEWKSCSI VMLTELEERG QEKCAQYWPS DGLVSYGDIT VELKKEEECE 660 SYTVRDLLVT NTRENKSRQI RQFHFHGWPE VGIPSDGKGM INIIAAVQKQ QQQSGNHPIT 720 VHCSAGAGRT GTFCALSTVL ERVKAEGILD VFQTVKSLRL QRPHMVQTLE QYEFCYKVVQ 780 EYIDAFSDYA NFK 793 // ID mPTPbeta\(NP_084204)\Ptprb STANDARD;PRT; 1998 AA. AC NP_084204; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, B; vascular endothelial protein tyrosine phosphatase [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from AY077755.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1998) CC GPRFLN| AUTHORS Nawroth,R., Poell,G., Ranft,A., Kloep,S., Samulowitz,U., CC GPRFLN| Fachinger,G., Golding,M., Shima,D.T., Deutsch,U. and Vestweber,D. CC GPRFLN| TITLE VE-PTP and VE-cadherin ectodomains interact to facilitate CC GPRFLN| regulation of phosphorylation and cell contacts CC GPRFLN| JOURNAL EMBO J. 21 (18), 4885-4895 (2002) CC GPRFLN| MEDLINE 22220060 CC GPRFLN| REMARK GeneRIF: Data show that vascular endothelial protein tyrosine CC GPRFLN| phosphatase (VE-PTP) is a transmembrane binding partner of CC GPRFLN| VE-cadherin that reduces the tyrosine phosphorylation of CC GPRFLN| VE-cadherin and cell layer permeability. CC GPRFLN|REFERENCE 2 (residues 1 to 1998) CC GPRFLN| AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. CC GPRFLN| TITLE A novel receptor-type protein tyrosine phosphatase with a single CC GPRFLN| catalytic domain is specifically expressed in mouse brain CC GPRFLN| JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) CC GPRFLN| MEDLINE 95134232 CC GPRFLN|REFERENCE 3 (residues 1 to 1998) CC GPRFLN| AUTHORS Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W. CC GPRFLN| TITLE Identification and typing of members of the protein-tyrosine CC GPRFLN| phosphatase gene family expressed in mouse brain CC GPRFLN| JOURNAL Mol. Biol. Rep. 16 (4), 241-248 (1992) CC GPRFLN| MEDLINE 93086603 CC GPRFLN|REFERENCE 4 (residues 1 to 1998) CC GPRFLN| AUTHORS Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R., CC GPRFLN| Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H. CC GPRFLN| TITLE Cloning, expression and chromosomal localization of a new putative CC GPRFLN| receptor-like protein tyrosine phosphatase CC GPRFLN| JOURNAL FEBS Lett. 290 (1-2), 123-130 (1991) CC GPRFLN| MEDLINE 92008644 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1998 VNTIFKEY:269 FT PROTEIN 1 1998 vascular endothelial protein tyrosine phosphatase FT VNTIFKEY:270 FT DOMAIN 126 195 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 293 371 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 394 455 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 473 548 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 659 723 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT DOMAIN 735 812 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_6 FT DOMAIN 823 895 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_7 FT DOMAIN 911 982 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_8 FT DOMAIN 1009 1078 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_9 FT DOMAIN 1089 1161 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_10 FT DOMAIN 1187 1249 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_11 FT DOMAIN 1265 1345 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_12 FT DOMAIN 1360 1436 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_13 FT REGION 1703 1966 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 1998 AA; MLRHGALTAL WITLSVVQTG VAEQVKCNFT LLESRVSSLS ASIQWRTFAS PCNFSLIYSS 60 DTSGPMWCHP IRIDNFTYGC NPKDLQAGTV YNFRIVSLDG EESTLVLQTD PLPPARFEVN 120 REKTASTTLQ VRWTPSSGKV SWYEVQLFDH NNQKIQEVQV QESTTWSQYT FLNLTEGNSY 180 KVAITAVSGE KRSFPVYING STVPSPVKDL GISPNPNSLL ISWSRGSGNV EQYRLVLMDK 240 GAIVQDTNVD RRDTSYAFHE LTPGHLYNLT IVTMASGLQN SRWKLVRTAP MEVSNLKVTN 300 DGRLTSLNVK WQKPPGDVDS YSITLSHQGT IKESKTLAPP VTETQFKDLV PGRLYQVTIS 360 CISGELSAEK SAAGRTVPEK VRNLVSYNEI WMKSFTVNWT PPAGDWEHYR IVLFNESLVL 420 LNTTVGKEET HYALDGLELI PGRQYEIEVI VESGNLRNSE RCQGRTVPLA VLQLRVKHAN 480 ETSLGITWRA PLGEWEKYII SLMDRELLVI HKSLSKDAKE FTFTDLMPGR NYKATVTSMS 540 GDLKQSSSIK GRTVPAQVTD LHVNNQGMTS SLFTNWTKAL GDVEFYQVLL IHENVVVKNE 600 SVSSDTSRYS FRALKPGSLY SVVVTTVSGG ISSRQVVAEG RTVPSSVSGV TVNNSGRNDY 660 LSVSWLPAPG EVDHYVVSLS HEGKVDQFLI IAKSVSECSF SSLTPGRLYN VTVTTKSGNY 720 ASHSFTEERT VPDKVQGISV SNSARSDYLK VSWVHATGDF DHYEVTIKNR ESFIQTKTIP 780 KSENECEFIE LVPGRLYSVT VSTKSGQYEA SEQGTGRTIP EPVKDLTLLN RSTEDLHVTW 840 SRANGDVDQY EVQLLFNDMK VFPHIHLVNT ATEYKFTALT PGRHYKILVL TISGDVQQSA 900 FIEGLPVPST VKNIHISANG ATDRLMVTWS PGGGDVDSYV VSAFRQDEKV DSQTIPKHAS 960 EHTFHRLEAG AKYRIAIVSV SGSLRNQIDA LGQTVPASVQ GVVAANAYSS NSLTVSWQKA 1020 LGVAERYDIL LLNENGLLLS NVSEPATARQ HKFEDLTPGK KYKMQILTVS GGLFSKESQA 1080 EGRTVPAAVT NLRITENSSR YLSFGWTASE GELSWYNIFL YNPDRTLQER AQVDPLVQSF 1140 SFQNLLQGRM YKMVIVTHSG ELSNESFIFG RTVPAAVNHL KGSHRNTTDS LWFSWSPASG 1200 DFDFYELILY NPNGTKKENW KEKDVTEWRF QGLVPGRKYT LYVVTHSGDL SNKVTGEGRT 1260 APSPPSLLSF ADVANTSLAI TWKGPPDWTD YNDFELQWFP GDALTIFNPY SSRKSEGRIV 1320 YGLHPGRSYQ FSVKTVSGDS WKTYSKPISG SVRTKPDKIQ NLHCRPQNST AIACSWIPPD 1380 SDFDGYSIEC RKMDTQEIEF SRKLEKEKSL LNIMMLVPHK RYLVSIKVQS AGMTSEVVED 1440 STITMIDRPP QPPPHIRVNE KDVLISKSSI NFTVNCSWFS DTNGAVKYFA VVVREADSMD 1500 ELKPEQQHPL PSYLEYRHNA SIRVYQTNYF ASKCAESPDS SSKSFNIKLG AEMDSLGGKC 1560 DPSQQKFCDG PLKPHTAYRI SIRAFTQLFD EDLKEFTKPL YSDTFFSMPI TTESEPLFGV 1620 IEGVSAGLFL IGMLVALVAF FICRQKASHS RERPSARLSI RRDRPLSVHL NLGQKGNRKT 1680 SCPIKINQFE GHFMKLQADS NYLLSKEYED LKDVGRSQSC DIALLPENRG KNRYNNILPY 1740 DASRVKLSNV DDDPCSDYIN ASYIPGNNFR REYIATQGPL PGTKDDFWKM AWEQNVHNIV 1800 MVTQCVEKGR VKCDHYWPAD QDPLYYGDLI LQMVSESVLP EWTIREFKIC SEEQLDAHRL 1860 IRHFHYTVWP DHGVPETTQS LIQFVRTVRD YINRSPGAGP TVVHCSAGVG RTGTFVALDR 1920 ILQQLDSKDS VDIYGAVHDL RLHRVHMVQT ECQYVYLHQC VRDVLRAKKL RNEQENPLFP 1980 IYENVNPEYH RDAIYSRH 1998 // ID mPTPBL\(NP_035334)\Ptpn13 STANDARD;PRT; 2460 AA. AC NP_035334; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 13 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from Z32740.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 2460) CC GPRFLN| AUTHORS Palmer,A., Zimmer,M., Erdmann,K.S., Eulenburg,V., Porthin,A., CC GPRFLN| Heumann,R., Deutsch,U. and Klein,R. CC GPRFLN| TITLE EphrinB phosphorylation and reverse signaling: regulation by Src CC GPRFLN| kinases and PTP-BL phosphatase CC GPRFLN| JOURNAL Mol. Cell 9 (4), 725-737 (2002) CC GPRFLN| MEDLINE 21980164 CC GPRFLN| REMARK GeneRIF: With delayed kinetics, ephrinB ligands recruit the CC GPRFLN| cytoplasmic PDZ domain containing protein tyrosine phosphatase CC GPRFLN| PTP-BL and are dephosphorylated. CC GPRFLN|REFERENCE 2 (residues 1 to 2460) CC GPRFLN| AUTHORS Walma,T., Spronk,C.A., Tessari,M., Aelen,J., Schepens,J., CC GPRFLN| Hendriks,W. and Vuister,G.W. CC GPRFLN| TITLE Structure, dynamics and binding characteristics of the second PDZ CC GPRFLN| domain of PTP-BL CC GPRFLN| JOURNAL J. Mol. Biol. 316 (5), 1101-1110 (2002) CC GPRFLN| MEDLINE 21881810 CC GPRFLN| REMARK GeneRIF: Structure, dynamics and binding characteristics of the CC GPRFLN| second PDZ domain of PTP-BL CC GPRFLN|REFERENCE 3 (residues 1 to 2460) CC GPRFLN| AUTHORS Hendriks,W., Schepens,J., Bachner,D., Rijss,J., Zeeuwen,P., CC GPRFLN| Zechner,U., Hameister,H. and Wieringa,B. CC GPRFLN| TITLE Molecular cloning of a mouse epithelial protein-tyrosine CC GPRFLN| phosphatase with similarities to submembranous proteins CC GPRFLN| JOURNAL J. Cell. Biochem. 59 (4), 418-430 (1995) CC GPRFLN| MEDLINE 96340953 CC GPRFLN|REFERENCE 4 (residues 1 to 2460) CC GPRFLN| AUTHORS Chida,D., Kume,T., Mukouyama,Y., Tabata,S., Nomura,N., Thomas,M.L., CC GPRFLN| Watanabe,T. and Oishi,M. CC GPRFLN| TITLE Characterization of a protein tyrosine phosphatase (RIP) expressed CC GPRFLN| at a very early stage of differentiation in both mouse CC GPRFLN| erythroleukemia and embryonal carcinoma cells CC GPRFLN| JOURNAL FEBS Lett. 358 (3), 233-239 (1995) CC GPRFLN| MEDLINE 95145716 CC GPRFLN|REFERENCE 5 (residues 1 to 2460) CC GPRFLN| AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. CC GPRFLN| TITLE A novel receptor-type protein tyrosine phosphatase with a single CC GPRFLN| catalytic domain is specifically expressed in mouse brain CC GPRFLN| JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) CC GPRFLN| MEDLINE 95134232 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 2460 VNTIFKEY:269 FT PROTEIN 1 2460 VNTIFKEY:270 FT REGION 565 774 B41 FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 1081 1170 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 1355 1441 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 1487 1577 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 1763 1842 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT DOMAIN 1858 1941 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_5 FT REGION 2180 2434 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 2460 AA; MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQEVFRRVS IADPAALGFI ISPWSLLLLP 60 SGSVSFTDEN VSNQDLRAST APEVLQSHSL TSLADVEKIH IYSLGMTLYW GADHEVPQSQ 120 PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSNVK QLVKLVLGNI 180 SGTDPLSRSS EQKPDRSQAI RDRLRGKGLP TGRSSTSDAL DTHEAPLSQQ TFVNKGLSKS 240 MGFLSIRDTR DEEDYLKDTP SDNNSRHEDS ETFSSPYQFK TSTPQMDALS KKKTWASSMD 300 LLCAANRDIS GETGRYQRCD PKTVTGRTSI TPRKKEGRYS DGSIALDIFG PQKVEPVIHT 360 RELPTSTAVS SALDRIRERQ QKLQVLREAM NVEEPVRRYK TYHSDIFSIS SESPSVISSE 420 SDFRQVRKSE ASKRFESSSG LPGVDETGQT RPSRQYETSL EGNLINQDIM LRRQEEEMMQ 480 LQARMALRQS RLSLYPGDTV KASMLDISRD PLREMALETA MTQRKLRNFF GPEFVKMTVE 540 PFVSLDLPRS ILSQTKKGKS EDQRRKVNIR LLSGQRLELT CDTKTICKDV FDMVVAHIGL 600 VEHHLFALAT RKENEYFFVD PDLKLTKVAP EGWKEEPKRK GKAAVDFTLF FRIKFFMDDV 660 SLIQHDLTCH QYYLQLRKDL LDERVHCDDE AALLLASLAL QAEYGDYQPE VHGVSYFRLE 720 HYLPARVMEK LDVSYIKEEL PKLHNTYAGA SEKETELEFL KVCQRLTEYG VHFHRVHPEK 780 KSQTGILLGV CSKGVLVFEV HNGVRALVLR FPWRETKKIS FSKKKITLQN TSDGIKHAFQ 840 TDSSKACQYL LHLCSSQHKF QLQMRARQSN QDAQDIERAS FRSLNLQAES VRGFNMGRAI 900 STGSLASSTI NKLAVRPLSV QAEILKRLSS SEWSLYQPLQ NSSKEKTDKA SWEEKPRGMS 960 KSYHDLSQAS LCPHRKQVIN MEALPQAFAE LVGKPLYPMA RSDTESLAGL PKLDNSKSVA 1020 SLNRSPERRN HESDSSTEDP GQAYVVGMSL PSSGKSSSQV PFKDNDTLHK RWSIVSSPER 1080 EITLVNLKKD PKHGLGFQII GGEKMGRLDL GVFISAVTPG GPADLDGCLK PGDRLISVNS 1140 VSLEGVSHHA AVDILQNAPE DVTLVISQPK EKPSKVPSTP VHFANGMKSY TKKPAYMQDS 1200 AMDPSEDQPW PRGTLRHIPE SPFGLSGGLR EGSLSSQDSR TESASLSQSQ VNGFFASHLG 1260 DRGWQEPQHS SPSPSVTTKV NEKTFSDSNR SKAKRRGISD LIEHLDCADS DKDDSTYTSS 1320 QDHQTSKQEP SSSLSTSNKT SFPTSSASPP KPGDTFEVEL AKTDGSLGIS VTGGVNTSVR 1380 HGGIYVKAII PKGAAESDGR IHKGDRVLAV NGVSLEGATH KQAVETLRNT GQVVHLLLEK 1440 GQVPTSRERD PAGPQSPPPD QDAQRQAPEK VAKKHPMSKT TALLLKIIFE VKLFKNSSGL 1500 GFSFSREDNL IPEQINGSIV RVKKLFPGQP AAESGKIDVG DVILKVNGAP LKGLSQQDVI 1560 SALRGTAPEV SLLLCRPAPG VLPEIDTTFL NPLYSPANSF LNSSKETSQP SSSVEQGASS 1620 DDNGVSGKTK NHCRAPSRRE SYSDHSESGE DDSVRAPAKM PNVTRVAAFP HEAPRSQEES 1680 ICAMFYLPRK IPGKLESESS HPPPLDVSPG QTCQPPAECA PSDATGKHFT HLASQLSKEE 1740 NITTLKNDLG NHLEDSELEV ELLITLVKSE KGSLGFTVTK GSQSIGCYVH DVIQDPAKGD 1800 GRLKAGDRLI KVNDTDVTNM THTDAVNLLR AAPKTVRLVL GRILELPRMP VFPHLLPDIT 1860 VTCHGEELGF PLSGGQGSPH GVVYISDINP RSAAAVDGSL QLLDIIHYVN GVSTQGMTLE 1920 DANRALDLSL PSVVLKVTRD GCPVVPTTRA AISAPRFTKA NGLTSMEPSG QPALMPKNSF 1980 SKVNGEGVHE AVCPAGEGSS SQMKESAGLT ETKESNSRDD DIYDDPQEAE VIQSLLDVVD 2040 EEAQNLLNQR HATRRACSPD PLRTNGEAPE EGDTDYDGSP LPEDVPESVS SGEGKVDLAS 2100 LTAASQEEKP IEEDATQESR NSTTETTDGE DSSKDPPFLT NEELAALPVV RVPPSGKYTG 2160 TQLQATIRTL QGLLDQGIPS KELENLQELK PLDQCLIGQT KENRRKNRYK NILPYDTTRV 2220 PLGDEGGYIN ASFIRIPVGT QEFVYIACQG PLPTTVGDFW QMVWEQNSTV IAMMTQEVEG 2280 EKIKCQRYWP SILGTTTMAN ERLRLALLRM QQLKGFIVRV MALEDIQTGE VRHISHLNFT 2340 AWPDHDTPSQ PDDLLTFISY MRHIRRSGPV ITHCSAGIGR SGTLICIDVV LGLISQDLEF 2400 DISDLVRCMR LQRHGMVQTE GQYVFCYQVI LYVLTHLQAE EQKAQQGSHS DAEQPPKAPP 2460 // ID mPTPdelta\(D54689)\Ptprd STANDARD;PRT; 1691 AA. AC D54689; DT 17-MAY-2003 DE protein-tyrosine-phosphatase (EC 3.1.3.48), receptor type delta, splice form D precursor - mouse. KW alternative splicing; glycoprotein; phosphoprotein; phosphoric monoester hydrolase; transmembrane protein; tyrosine-specific phosphatase. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC GPRFLN|REFERENCE 1 (residues 1 to 1691) CC GPRFLN| AUTHORS Mizuno,K., Hasegawa,K., Katagiri,T., Ogimoto,M., Ichikawa,T. and CC GPRFLN| Yakura,H. CC GPRFLN| TITLE MPTP delta, a putative murine homolog of HPTP delta, is expressed CC GPRFLN| in specialized regions of the brain and in the B-cell lineage CC GPRFLN| JOURNAL Mol. Cell. Biol. 13 (9), 5513-5523 (1993) CC GPRFLN| MEDLINE 93360986 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301885396| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1691 VNTIFKEY:269 FT PROTEIN 1 1691 MPTP delta type D FT VNTIFKEY:270 FT DOMAIN 42 95 immunoglobulin homology #label IMM3 FT VNTIFKEY:1000; VNTINAME:IMM3 FT DOMAIN 114 196 fibronectin type III repeat homology #label FN3A FT VNTIFKEY:1018; VNTINAME:FN3A FT DOMAIN 1075 1691 leukocyte common antigen cytosolic domain homology #label LAC FT VNTIFKEY:1000; VNTINAME:LAC FT ACT_SITE ? ? Cys (phosphocysteine intermediate) FT VNTIFKEY:220; VNTINAME:Active_Site_1 FT BINDING ? ? substrate phosphate (Arg) FT VNTIFKEY:1007; VNTINAME:Binding_1 FT DOMAIN 1449 1671 protein-tyrosine-phosphatase homology #label PTP2 FT VNTIFKEY:1000; VNTINAME:PTP2 FT ACT_SITE ? ? Cys (phosphocysteine intermediate) FT VNTIFKEY:220; VNTINAME:Active_Site_2 FT BINDING ? ? substrate phosphate (Arg) FT VNTIFKEY:1007; VNTINAME:Binding_2 SQ SEQUENCE 1691 AA; MCLTSCFILA SHMLSCDLVF VPVRRVPPRF SIPPTNHEIM PGGSVNITCV AVGSPMPYVK 60 WMLGAEDLTP EDDMPIGRNV LELNDVRQSA NYTCVAMSTL GVIEAIAQIT VKALPKPPGT 120 PVVTESTATS ITLTWDSGNP GPVSYYIIQH KPKNSEEPYK EIDGIATTRY SVAGLSPYSD 180 YEFRVVAVNN IGRGPASEPV LTQTSEQTPS SAPRDVQARM LSSTTILVQW KEPEEPNGQI 240 QGYRVYYTMD PTQHVNNWMK HNVADSQITT IGNLVPQKTY SVKVLAFTSI GDGPLSSDIQ 300 VITQTGVPGQ PLNFKAEPES ETSILLSWTP PRSDTIASYE LVDRDGDQGE EQRITIEPGT 360 SYRLQGLKPN SLYYFRLSAT SPQGLGASTA EISARTMQKP SAPPQDISCT SPSSTSILVS 420 WQPPPVEKQN GIITEYSLKY AAVDGEDYKP HEIIGNSSDT TKYLLEQLEK WTEYRITVTA 480 HTDVGPWPES LSVLIRTDED VPSGPPRKVE VEAVNATAVK VSWRSPVPNK QHGQIRGYQV 540 HYVKMENGEP KSAMLKDVML ADAQDMIISG LQPETSYSLT VTAYTTKGDG ARSKPKLVST 600 TGSVPGKPRL VINHTQMNTA LIQWHPPVDT FGLQGYRLKF GRKDMEPLTT LEFSEKEDHF 660 TATDIHKGAS YVFRLSARNK VGFGEEMVKE ISVPEEIPTG FPQNLHSEGT TSTSVQLSWQ 720 PPVLAERNGV ITKYTLLYRD INVPLLPMEH LIVPADTSMT LTGLKSDTTY DVKVRAHTSK 780 RRGPYSPSVQ FRTLPVDQSM FAKNFHVKAV MKTSVLLSWE IPENYNPAIL SKFFMMMDGK 840 MVEEVDGRAT QKLIVNLKPE KSYSFVLTNR GNSAGGLQHR VTAKTAPDVL RTKPAFIGKT 900 NLDGMITVQL PDVPANENIK GYYIIIVPLK KSRGKFIKPW ESPDEMELDE LLKEISRKRR 960 SIRYGREVEL KPYIAAHFDV LPTEFTLGDD KHYGGFTNKQ LQSGQEYVFF VLAVMDHAES 1020 KMYATSPYSD PVVSMDLDPQ PITDEEEGLI WVVGPVLAVV FIICIVIAIL LYKRKRAESE 1080 SRKSSLPNSK EVPSHHPTDP VELRRLNFQT PGMASHPPIP ILELADHIER LKANDNLKFS 1140 QEYESIDPGQ QFTWEHSNLE VNKPKNRYAN VIAYDHSRVL LSAIEGIPGS DYVNANYIDG 1200 YRKQNAYIAT QGSLPETFGD FWRMIWEQEA TVVMMTKLEE RSRVKCDQYW PSRGTETHGL 1260 VQVTLLDTVE LTYCVRTFAL YNNGSSEKRK VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT 1320 CNPPDAGPMV VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED 1380 QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR LASSKAHTSR 1440 FISANLPCNK FKNRLVNIMP YESGRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP 1500 LAETTEDFWR MLWEHNSTIV VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP 1560 QYILREFKVT DARDQSRTVR QFQFTDWPEQ GVPKSGEGFI DFIGQVHKTK EQFGQDGPIS 1620 VHCSAGVGRT GVFITLSIVL ERMRYEGVVD IFQTVKMLRT QRPAMVQTED QYQFCYRAAL 1680 EYLGSFDHYA T 1691 // ID mPTPepsilon\(NP_035342)\Ptpre STANDARD;PRT; 699 AA. AC NP_035342; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, E [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from U62387.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 699) CC GPRFLN| AUTHORS Schmidt,A., Rutledge,S.J., Endo,N., Opas,E.E., Tanaka,H., CC GPRFLN| Wesolowski,G., Leu,C.T., Huang,Z., Ramachandaran,C., Rodan,S.B. and CC GPRFLN| Rodan,G.A. CC GPRFLN| TITLE Protein-tyrosine phosphatase activity regulates osteoclast CC GPRFLN| formation and function: inhibition by alendronate CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (7), 3068-3073 (1996) CC GPRFLN| MEDLINE 96181534 CC GPRFLN|REFERENCE 2 (residues 1 to 699) CC GPRFLN| AUTHORS Elson,A. and Leder,P. CC GPRFLN| TITLE Identification of a cytoplasmic, phorbol ester-inducible isoform of CC GPRFLN| protein tyrosine phosphatase epsilon CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12235-12239 (1995) CC GPRFLN| MEDLINE 96109240 CC GPRFLN|REFERENCE 3 (residues 1 to 699) CC GPRFLN| AUTHORS Elson,A. and Leder,P. CC GPRFLN| TITLE Protein-tyrosine phosphatase epsilon. An isoform specifically CC GPRFLN| expressed in mouse mammary tumors initiated by v-Ha-ras OR neu CC GPRFLN| JOURNAL J. Biol. Chem. 270 (44), 26116-26122 (1995) CC GPRFLN| MEDLINE 96064677 CC GPRFLN|REFERENCE 4 (residues 1 to 699) CC GPRFLN| AUTHORS Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B. CC GPRFLN| TITLE A novel receptor-type protein tyrosine phosphatase with a single CC GPRFLN| catalytic domain is specifically expressed in mouse brain CC GPRFLN| JOURNAL Biochem. J. 305 (Pt 2), 499-504 (1995) CC GPRFLN| MEDLINE 95134232 CC GPRFLN|REFERENCE 5 (residues 1 to 699) CC GPRFLN| AUTHORS Schepens,J., Zeeuwen,P., Wieringa,B. and Hendriks,W. CC GPRFLN| TITLE Identification and typing of members of the protein-tyrosine CC GPRFLN| phosphatase gene family expressed in mouse brain CC GPRFLN| JOURNAL Mol. Biol. Rep. 16 (4), 241-248 (1992) CC GPRFLN| MEDLINE 93086603 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 699 VNTIFKEY:269 FT PROTEIN 1 699 VNTIFKEY:270 FT REGION 134 395 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 424 689 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 699 AA; MEPFCPLLLA SFSLSLARAG QGNDTTPTES NWTSTTAGPP DPGASQPLLT WLLLPLLLLL 60 FLLAAYFFRF RKQRKAVVSS NDKKMPNGIL EEQEQQRVML LSRSPSGPKK FFPIPVEHLE 120 EEIRVRSADD CKRFREEFNS LPSGHIQGTF ELANKEENRE KNRYPNILPN DHCRVILSQV 180 DGIPCSDYIN ASYIDGYKEK NKFIAAQGPK QETVNDFWRM VWEQRSATIV MLTNLKERKE 240 EKCYQYWPDQ GCWTYGNIRV CVEDCVVLVD YTIRKFCIHP QLPDSCKAPR LVSQLHFTSW 300 PDFGVPFTPI GMLKFLKKVK TLNPSHAGPI VVHCSAGVGR TGTFIVIDAM MDMIHSEQKV 360 DVFEFVSRIR NQRPQMVQTD VQYTFIYQAL LEYYLYGDTE LDVSSLERHL QTLHSTATHF 420 DKIGLEEEFR KLTNVRIMKE NMRTGNLPAN MKKARVIQII PYDFNRVILS MKRGQEFTDY 480 INASFIDGYR QKDYFMATQG PLAHTGEDFW RMVWEWKSHT IVMLTEVQER EQDKCYQYWP 540 TEGSVTHGDI TIEIKSDTLS EAISVRDFLV TFKQPLARQE EQVRMVRQFH FHGWPEVGIP 600 AEGKGMIDLI AAVQKQQQQT GNHPITVHCS AGAGRTGTFI ALSNILERVK AEGLLDVFQA 660 VKSLRLQRPH MVQTLEQYEF CYKVVQDFID IFSDYANFK 699 // ID mPTPESP\(NP_031981)\Ptprv STANDARD;PRT; 1705 AA. AC NP_031981; DT 17-MAY-2003 DE embryonic stem cell phosphatase; protein tyrosine phosphatase, receptor type, W [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from U36488.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1705) CC GPRFLN| AUTHORS Morrison,D.F. and Mauro,L.J. CC GPRFLN| TITLE Structural characterization and chromosomal localization of the CC GPRFLN| mouse cDNA and gene encoding the bone tyrosine phosphatase, CC GPRFLN| mOST-PTP CC GPRFLN| JOURNAL Gene 257 (2), 195-208 (2000) CC GPRFLN| MEDLINE 20534790 CC GPRFLN|REFERENCE 2 (residues 1 to 1705) CC GPRFLN| AUTHORS Lee,K., Nichols,J. and Smith,A. CC GPRFLN| TITLE Identification of a developmentally regulated protein tyrosine CC GPRFLN| phosphatase in embryonic stem cells that is a marker of CC GPRFLN| pluripotential epiblast and early mesoderm CC GPRFLN| JOURNAL Mech. Dev. 59 (2), 153-164 (1996) CC GPRFLN| MEDLINE 97109513 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1705 VNTIFKEY:269 FT PROTEIN 1 1705 protein tyrosine phosphatase, receptor type, W FT VNTIFKEY:270 FT PROTEIN 1 1705 putative; protein tyrosine phosphatase, receptor type, W FT VNTIFKEY:270 FT DOMAIN 473 551 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 656 730 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT REGION 1150 1411 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 FT REGION 1486 1697 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 SQ SEQUENCE 1705 AA; MRPLILLAAL LWLQDSLAQE DVCSSLDGSP DRQGGGPPLS VSVTSRGRPT SLFLSWVAAE 60 PGGFDYALCL RAMNLSGFPE GQQLQAHTNE SSFEFHGLVP GSRYQLELTV LRPCWQNVTI 120 TLTARTAPTV VRGLQLHSTG SPASLEASWS DASGDQDSYQ LLLYHPESHT LACNVSVSPD 180 TLSYNFGDLL PGSQYVLEVI TWAGSLHAKT SILQWTEPVP PDHLRVRALG TSSLQAFWNS 240 SEGATWFHLI LTDLLEGTNL TKVVRQGIST HTFLRLSPGT PYQLKICAAA GPHQIWGPNA 300 TEWTYPSYPS DLVLTPLWNE LWASWKAGQG ARDGYVLKLS GPVENTTTLG PEECNAVFPG 360 PLPPGHYTLG LRVLAGPYDA WVEGSIWLAE SAARPMEVPG ARLWLEGLEA TKQPGRRALL 420 YSVDAPGLLG NISVSSGATH VTFCGLVPGA HYRVDIASSM GDITQSLTGY TSPLPPQSLE 480 IISRNSPSDL TIGWAPAPGQ MEGYKVTWHQ DGSQRSPGDL VDLGPDISSL TLKSLVPGSC 540 YTVSAWAWSG NLSSDSQKIH SCTRPAPPTN LSLGFAHQPA TLRASWCHPP GGRDAFQLRL 600 YRLRPLTLES EKILSQEAQN FSWAQLPAGY EFQVQLSTLW GSEESGSANT TGWTPPSAPT 660 LVNVTSEAPT QLHVSWVHAA GDRSSYQVTL YQESTRTATS IVGPKADSTS FWGLTPGTKY 720 KVEAISWAGP LYTAAANVSA WTYPLTPNEL LASMQAGSAV VNLAWPSGPL GRGTCHAQLS 780 DAGHLSWEQP LSLGQDLLML RNLIPGHTVS LSVKCRAGPL QASTHPLVLS VEPGPVEDVF 840 CQPEATYLSL NWTMPTGDVA VCLVEVEQLV PGGSAHFVFQ VNTSEDALLL PNLTPTTSYR 900 LSLTVLGGNR QWSRAVTLVC TTSAEVWHPP ELAEAPQVEL GTGMGVTVTR GMFGKDDGQI 960 QWYGIIATIN MTLAQPSQEA INHTWYDHYY RGHDSYLALL FPNPFYPEPW AVPRSWTVPV 1020 GTEDCDNTQE ICNGHLKPGF QYRFSIAAFS RLSSPETILA FSAFSEPQAS ISLVAMPLTV 1080 MMGTVVGCII IVCAVLCLLC RRGLKGPRSE KNGFSQELMP YNLWRTHRPI PSHSFRQSYE 1140 AKSARAHQAF FQEFEELKEV GKDQPRLEAE HPANITKNRY PHVLPYDHSR VRLTQLSGEP 1200 HSDYINANFI PGYSHPQEII ATQGPLKKTV EDFWRLVWEQ QVHVIIMLTV GMENGRVLCE 1260 HYWPVNSTPV THGHITTHLL AEESEDEWTR REFQLQHGAE QKQRRVKQLQ FTTWPDHSVP 1320 EAPSSLLAFV ELVQEEVKAT QGKGPILVHC SAGVGRTGTF VALLPAVRQL EEEQVVDVFN 1380 TVYILRLHRP LMIQTLSQYI FLHSCLLNKI LEGPSDASDS GPIPVMNFAQ ACAKRAANAN 1440 AGFLKEYRLL KQAIKDETGS LLPSPDYNQN SIASCHHSQE QLALVEESPA DNMLAASLFP 1500 GGPSGRDHVV LTGSAGPKEL WEMVWEHGAY VLVSLGLPDT KEKPQDIWPM EMQPIVTDMV 1560 TVHRVAESNT AGWPSTLIRV IHGDSGTERQ VQCLQFPHCE TGSELPANTL LTFLDAVGQC 1620 CSRGNSKKPG TLLSHSSKVT NQLSTFLAME QLLQQAGTER TVDVFSVALK QTQACAVKTP 1680 TLEQYIYLYN CLNSALRNRL PRARK 1705 // ID mPTPgamma\(NP_033007)\Ptprg STANDARD;PRT; 1442 AA. AC NP_033007; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, G [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from L09562.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1442) CC GPRFLN| AUTHORS Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D., CC GPRFLN| D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al. CC GPRFLN| TITLE Identification of a carbonic anhydrase-like domain in the CC GPRFLN| extracellular region of RPTP gamma defines a new subfamily of CC GPRFLN| receptor tyrosine phosphatases CC GPRFLN| JOURNAL Mol. Cell. Biol. 13 (3), 1497-1506 (1993) CC GPRFLN| MEDLINE 93180796 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1442 VNTIFKEY:269 FT PROTEIN 1 1442 VNTIFKEY:270 FT SIGNAL 1 19 VNTIFKEY:200; VNTINAME:Signal_1 FT REGION 60 320 carb_anhydrase FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 348 426 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 844 1118 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1147 1409 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1442 AA; MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGTLQE SRQDSSVQIR RRKASGDPYW 60 AYSGAYGPEH WVTSSVSCGG SHQSPIDILD HHARVGDEYQ ELQLDGFDNE SSNKTWMKNT 120 GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSVNGRRF PVEMQIFFYN 180 PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFILRD 240 LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300 YLRNNFRPQQ ALNDRVVSKS AVRDAWNHDL ADFLDNPLGT EASKVCSSPP IHMKVQPLNQ 360 TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 420 FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 480 TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 540 ASAASKQAGR TVLATTEALA SPGPDVHSAP SKDSEGTEEG EKEEKSESED GEREHEEEEK 600 DSEKKEKSEA THTAAESDRT APAPTPSSPH RTAAEGGHQT IPGRRQDHSA PATDQPGHVA 660 PDLDPLVDTA TQVPPTATEE HYSGSDPRRP EMPSKKPMSR GDRFSEDSKF ITVNPAEKNT 720 SGMLSRPSPG RMEWIIPLIV VSALTFVCLV LLIAVLVYWR GCNKIKSKGF PRRSREVPSS 780 GERGEKGSRK CFQTAHFYVE DSSSPRVVPN ESVPIIPIPD DMEAIPVKQF GKHIGELYSN 840 SQHGFSEDFE EVQRCTADMN ITAEHSNHPD NKHKNRYINI LAYDHSRVKL RPLPGKDSKH 900 SDYINANYVD GYNKAKAYIA TQGPLKSTFE DFWRMIWEQN TGIIIMITNL VEKGRRKCDQ 960 YWPTENTEEY GNIIVTLKST KVHACYTVRR LSVRNTKVKK GQKGNPKGRQ NERTVIQYHY 1020 TQWPDMGVPE YALPVLTFVR RSSAARMPDM GPVLVHCSAG VGRTGTYIVI DSMLQQIKDK 1080 STVNVLGFLK HIRTQRNYLV QTEEQYIFIH DALLEAILGK ETAVSSSQLH SYVNSILIPG 1140 VGGKTRLEKQ FKLITQCNAK YVECFSAQKE CNKEKNRNSS VVPAERARVG LAPLPGMKGT 1200 DYINASYIMG YYRSNEFIIT QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW 1260 PSREESMNCE AFTVTLISKD RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD 1320 APISSTFELI NVIKEEALTR DGPTIVHDEY GAVSAGMLCA LTTLSQQLEN ENAVDVFQVA 1380 KMINLMRPGV FTDIEQYQFV YKAMLSLIST KENGNGPMTG DKNGAVLTAE ESDPAESMES 1440 LV 1442 // ID mPTPH1\(XP_143789)\Ptpn3 STANDARD;PRT; 1028 AA. AC XP_143789; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 3 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC GENOME ANNOTATION REFSEQ: This model reference sequence was CC predicted from NCBI contig NW_000208 by automated computational CC analysis using gene prediction method: GenomeScan, supported by EST CC evidence. CC Also see: CC Documentation of NCBI's Annotation Process CC CC GPRFLN|REFERENCE 1 (residues 1 to 1028) CC GPRFLN| AUTHORS NCBI Annotation Project. CC GPRFLN| TITLE Direct Submission CC GPRFLN| JOURNAL Submitted (15-MAY-2002) National Center for Biotechnology CC GPRFLN| Information, NIH, Bethesda, MD 20894, USA CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|301883538| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1028 VNTIFKEY:269 FT PROTEIN 1 1028 VNTIFKEY:270 FT REGION 104 335 B41 FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 107 335 Band_41 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT DOMAIN 629 695 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 653 698 PDZ FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT REGION 764 1018 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 785 1014 Y_phosphatase FT VNTIFKEY:266; VNTINAME:Region_3 FT REGION 875 1011 DSPc FT VNTIFKEY:266; VNTINAME:Region_4 FT REGION 915 1014 PTPc_motif FT VNTIFKEY:266; VNTINAME:Region_5 FT REGION 918 968 DSPc FT VNTIFKEY:266; VNTINAME:Region_6 SQ SEQUENCE 1028 AA; MVNKPRDPPP QPGIQGIFHP AQETPTGIPG LQRTVGWEYE VKQLFSGKLA RKYIPDSSDI 60 FIEKGMVEVV GYSAAVMTSR LRALGGRINN TRTSELPKEK TRSEVICSIR FLDGLVQTFK 120 VNKQDLGQSL LDMAYGHLGV TEKEYFGLQH GDDPVDSPRW LEASKPLRKQ LKGEYALASL 180 GRWVYGKLSS PYGGLKVAGK PNLFLKNVVG GFPCTLHFRV RYFIPDPNTL QQEQTRHLYF 240 LQLKMDVCEG RLTCPLNSAV VLASYAVQSH FGDFNSSIHH PGYLADSQFI PDQNDDFLSK 300 VESLHEQHSG LKQSEAESCY INIARTLDFY GVELHGGRDL HNLDLMIGIA SAGIAVYRKY 360 ICTSFYPWKK FFIHQRQKQE EKIVAVRSSD PVAISAESRE HIVAFNMLNY RSCKNLWKSC 420 VEHHSFFQAK KLLPQEKNVL SQYWTLGSRN PKKSVNNQYC KKVIGGMVWN PVMRRSLSVE 480 RLETKSLPSR SPPITPNWRS PRLRHEIRKP RHSSADNLAN EMTYITETED VFYTYKGPLS 540 PKDSDSEVSQ NHSPHRESLS ENNPAQSCLT QKSSSSVSPS SNAPGSCSPD GVDQRFLEDY 600 HKVTKGGFVE DASQYYCDKS DDGDGYLVLI RITPDEEGRF GFNLKADTCM PKLNEGDQIV 660 LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRKGKA TFVGHEGLVP ARAVRSLAEI 720 RSEDELSQLF PEAMFPACPE GGDSLEGSME LLKKGLESGT VLIQFEQLYR KKPGLAVSFA 780 KLPQNLDKNR YKDVLPYDTT RVLLQGNEDY INASYVNMEM PAANLVNKYI ATQGPLPNTC 840 AQFWQVVWDQ KLSLVVMLTT LTERGRTKCH QYWPDPPDIM DHGIFHIQCQ TEDCTIAYVS 900 REMLVTNTET GEEHTVTHLQ YVAWPDHGVP DDSSDFLEFV KYVRSLRVDG EPALVHCSAG 960 IGRTGVLVTM ETAMCLIERN LPVYPLDIVR KMRDQRAMMV QTSSQYKFVC EAILRVYEEG 1020 LVQRLDPS 1028 // ID mPTPK1\(NP_035336)\Ptpn18 STANDARD;PRT; 452 AA. AC NP_035336; DT 17-MAY-2003 DE protein tyrosine phosphatase, non-receptor type 18 [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from U52523.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 452) CC GPRFLN| AUTHORS Dosil,M., Leibman,N. and Lemischka,I.R. CC GPRFLN| TITLE Cloning and characterization of fetal liver phosphatase 1, a CC GPRFLN| nuclear protein tyrosine phosphatase isolated from hematopoietic CC GPRFLN| stem cells CC GPRFLN| JOURNAL Blood 88 (12), 4510-4525 (1996) CC GPRFLN| MEDLINE 97131769 CC GPRFLN|REFERENCE 2 (residues 1 to 452) CC GPRFLN| AUTHORS Huang,K., Sommers,C.L., Grinberg,A., Kozak,C.A. and Love,P.E. CC GPRFLN| TITLE Cloning and characterization of PTP-K1, a novel nonreceptor protein CC GPRFLN| tyrosine phosphatase highly expressed in bone marrow CC GPRFLN| JOURNAL Oncogene 13 (7), 1567-1573 (1996) CC GPRFLN| MEDLINE 97030045 CC GPRFLN|REFERENCE 3 (residues 1 to 452) CC GPRFLN| AUTHORS Cheng,J., Daimaru,L., Fennie,C. and Lasky,L.A. CC GPRFLN| TITLE A novel protein tyrosine phosphatase expressed in CC GPRFLN| lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells CC GPRFLN| JOURNAL Blood 88 (4), 1156-1167 (1996) CC GPRFLN| MEDLINE 96329547 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 452 VNTIFKEY:269 FT PROTEIN 1 452 VNTIFKEY:270 FT REGION 26 293 PTPc FT VNTIFKEY:266; VNTINAME:Region_1 SQ SEQUENCE 452 AA; MSRHTDLVRS LLEQLEARDY REGAILAREF SDIKARSVAW KSEGVCSTKA GSRLGNTNKN 60 RYKDVVAYDE TRVILSLLQE EGHGDYINAN FIRGIDGSQA YIATQGPLPH TLLDFWRLVW 120 EFGVKVILMA CQETENGRRK CERYWAREQE PLKAGPFCIT LTKETTLNAD ITLRTLQVTF 180 QKEFRSVHQL QYMSWPDHGV PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC 240 AVDYVRQLLL TQTIPPNFSL FQVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQDTS 300 PHYQNLKENC APICKEAFSL RTSSALPATS RPPGGVLRSI SVPAPPTLPM ADTYAVVQKR 360 GLRRHRAGPR APTSTDTPIY SQVAPRAQRP VAHTEDAQGT TALRRVPADQ NSSGPDAYEE 420 VTDGAQTGGL GFNLRIGRPK GPRDPPAEWT RV 452 // ID mPTPkappa\(NP_033009)\Ptprk STANDARD;PRT; 1457 AA. AC NP_033009; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, K [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from L10106.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1457) CC GPRFLN| AUTHORS Jiang,Y.P., Wang,H., D'Eustachio,P., Musacchio,J.M., CC GPRFLN| Schlessinger,J. and Sap,J. CC GPRFLN| TITLE Cloning and characterization of R-PTP-kappa, a new member of the CC GPRFLN| receptor protein tyrosine phosphatase family with a proteolytically CC GPRFLN| cleaved cellular adhesion molecule-like extracellular region CC GPRFLN| JOURNAL Mol. Cell. Biol. 13 (5), 2942-2951 (1993) CC GPRFLN| MEDLINE 93233655 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1457 VNTIFKEY:269 FT PROTEIN 1 1457 VNTIFKEY:270 FT SIGNAL 1 4 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 5 1457 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 31 193 MAM FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 201 288 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 291 362 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 489 582 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT REGION 898 1161 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1191 1455 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1457 AA; MDVAAAALPA FVALWLLYPW PLLGSALGQF SAGGCTFDDG PGACDYHQDL YDDFEWVHVS 60 AQEPHYLPPE MPQGSYMVVD SSNHDPGEKA RLQLPTMKEN DTHCIDFSYL LYSQKGLNPG 120 TLNILVRVNK GPLANPIWNV TGFTGRDWLR AELAVSTFWP NEYQVIFEAE VSGGRSGYIA 180 IDDIQVLSYP CDKSPHFLRL GDVEVNAGQN ATFQCIATGR DAVHNKLWLQ RRNGEDIPVA 240 QTKNINHRRF AASFRLQEVT KTDQDLYRCV TQSERGSGVS NFAQLIVREP PRPIAPPQLL 300 GVGPTYLLIQ LNANSIIGDG PIILKEVEYR MTSGSWTETH AVNAPTYKLW HLDPDTEYEI 360 RVLLTRPGEG GTGLPGPPLI TRTKCAEPMR TPKTLKIAEI QARRIAVDWE SLGYNITRCH 420 TFNVTICYHY FRGHNESRAD CLDMDPKAPQ HVVNHLPPYT NVSLKMILTN PEGRKESEET 480 IIQTDEDVPG PVPVKSLQGT SFENKIFLNW KEPLEPNGII TQYEVSYSSI RSFDPAVPVA 540 GPPQTVSNLW NSTHHVFMHL HPGTTYQFFI RASTVKGFGP ATAINVTTNI SAPSLPDYEG 600 VDASLNETAT TITVLLRPAQ AKGAPISAYQ IVVEQLHPHR TKREAGAMEC YQVPVTYQNA 660 LSGGAPYYFA AELPPGNLPE PAPFTVGDNR TYKGFWNPPL APRKGYNIYF QAMSSVEKET 720 KTQCVRIATK AAATEEPEVI PDPAKQTDRV VKIAGISAGI LVFILLLLVV IVIVKKSKLA 780 KKRKDAMGNT RQEMTHMVNA MDRSYADQST LHAEDPLSLT FMDQHNFSPR LPNDPLVPTA 840 VLDENHSATA ESSRLLDVPR YLCEGTESPY QTGQLHPAIR VADLLQHINL MKTSDSYGFK 900 EEYESFFEGQ SASWDVAKKD QNRAKNRYGN IIAYDHSRVI LQPVEDDPSS DYINANYIDI 960 WLYRDGYQRP SHYIATQGPV HETVYDFWRM VWQEQSACIV MVTNLVEVGR VKCYKYWPDD 1020 TEVYGDFKVT CVEMEPLAEY VVRTFTLERR GYNEIREVKQ FHFTGWPDHG VPYHATGLLS 1080 FIRRVKLSNP PSAGPIVVHC SAGAGRTGCY IVIDIMLDMA EREGVVDIYN CVKALRSRRI 1140 NMVQTEEQYI FIHDAILEAC LCGETAIPVC EFKAAYFDMI RIDSQTNSSH LKDEFQTLNS 1200 VTPRLQAEDC SIACLPRNHD KNRFMDMLPP DRCLPFLITI DGESSNYINA ALMDSYRQPA 1260 AFIVTQYPLP NTVKDFWRLV YDYGCTSIVM LNEVDLSQGC PQYWPEEGML RYGPIQVECM 1320 SCSMDCDVIN RIFRICNLTR PQEGYLMVQQ FQYLGWASHR EVPGSKRSFL KLILQVEKWQ 1380 EECEEGEGRT IIHCLNGGGR SGMFCAIGIV VEMVKRQNVV DVFHAVKTLR NSKPNMVEAP 1440 EQYRFCYDVA LEYLESS 1457 // ID mPTPlamda\(NP_035344)\Ptprl STANDARD;PRT; 1436 AA. AC NP_035344; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, L [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from U55057.1. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1436) CC GPRFLN| AUTHORS Yoneya,T., Yamada,Y., Kakeda,M., Osawa,M., Arai,E., Hayashi,K., CC GPRFLN| Nishi,N., Inoue,H. and Nishikawa,M. CC GPRFLN| TITLE Molecular cloning of a novel receptor-type protein tyrosine CC GPRFLN| phosphatase from murine fetal liver CC GPRFLN| JOURNAL Gene 194 (2), 241-247 (1997) CC GPRFLN| MEDLINE 97417493 CC GPRFLN|REFERENCE 2 (residues 1 to 1436) CC GPRFLN| AUTHORS Cheng,J., Armanini,M., Phillips,H., Dowbenko,D., Daimaru,L. and CC GPRFLN| Lasky,L.A. CC GPRFLN| TITLE A novel protein tyrosine phosphatase related to the homotypically CC GPRFLN| adhering Kappa and Mu receptors CC GPRFLN| JOURNAL Unpublished CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1436 VNTIFKEY:269 FT PROTEIN 1 1436 VNTIFKEY:270 FT DOMAIN 22 188 MAM FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 196 283 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 286 357 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 494 578 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT REGION 883 1136 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1165 1431 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1436 AA; MARAQALVLA LTFQFCAPET ETPAAGCTFE EASDPVVPCE FSQAQYDDFQ WEQVRIHPGT 60 RTPEDLPHGA YLMVNASQHT PGQRAHIIFQ TLSENDTHCV QFSYFLYSRD GHSPGTLGVY 120 VRVNGGPLGS AVWNMTGSHG RQWHQAELAV STFWPNEFQV LFEALISPDH KGYIGLDDIL 180 LFSYPCAKAP HFSRLGDVEV NAGQNASFQC MAAGRAAEAE HFFLQRQSGV LVPAAGVRHI 240 SHRRFLATFP LASVGRSEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT 300 YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVNLQ TYKLWHLDPD TEYEISVLLT 360 RPGDGGTGRP GPPLISRTKC AEPTRAPKGL AFAEIQARQL TLQWEPLGYN VTRCHTYAVS 420 LCYRYTLGGS HNQTIRECVK MERGASRYTI KNLLPFRNIH VRLILTNPEG RKEGKEVTFQ 480 TDEDVPGGIA AESLTFTPLE DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR 540 RTISKLRNET YHVFSNLHPG TTYLFSVRAR TSKGFGQAAL TEITTNISAP SFDYADMPSP 600 LGESENTITV LLRPAQGRGA PISVYQVVVE EERPRRLRRE PGAQDCFSVP LTFETALARG 660 LVHYFGAELA ASSLLEAMPF TVGDNQTYRG FWNPPLEPRK AYLIYFQAAS HLKGETRLNC 720 IRIARKAACK ESKRPLEVSQ RSEEMGLILG ICAGGLAVLI LLLGAIIVII RKGKPVNMTK 780 ATVNYRQEKT HMMSAVDRSF TDQSTLQEDE RLGLSFMDAP GYSPRGDQRS GGVTEASSLL 840 GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES FFEGWDATKK 900 KDKLKGGRQE PVSAYDRHHV KLHPMLADPD ADYISANYID GYHRSNHFIA TQGPKPEMIY 960 DFWRMVWQEQ CASIVMITKL VEVGRVKCSR YWPEDSDMYG DIKITLVKTE TLAEYVVRTF 1020 ALERRGYSAR HEVRQFHFTA WPEHGVPYHA TGLLAFIRRV KASTPPDAGP IVIHCSAGTG 1080 RTGCYIVLDV MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA ILEACLCGET 1140 TIPVNEFRAT YREMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL PRNRDKNRSM 1200 DVLPPDRCLP FLISSDGDPN NYINAALTDS YTRSAAFIVT LHPLQSTTPD FWRLVYDYGC 1260 TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY GLMEVEFVSG TANEDLVSRV FRVQNSSRLQ 1320 EGHLLVRHFQ FLRWSAYRDT PDSRKAFLHL LAEVDKWQAE SGDGRTVVHC LNGGGRSGTF 1380 CACATVLEMI RCHSLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL EALELR 1436 // ID mPTPmu\(NP_033010)\Ptprm STANDARD;PRT; 1452 AA. AC NP_033010; DT 17-MAY-2003 DE protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor-type, M [Mus musculus]. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC PROVISIONAL REFSEQ: This record has not yet been subject to final CC NCBI review. The reference sequence was derived from X58287.1. CC CC GPRFLN|REFERENCE 1 CC GPRFLN| AUTHORS Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R., CC GPRFLN| Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H. CC GPRFLN| TITLE Cloning, expression and chromosomal localization of a new putative CC GPRFLN| receptor-like protein tyrosine phosphatase CC GPRFLN| JOURNAL FEBS Lett. 290 (1-2), 123-130 (1991) CC GPRFLN| MEDLINE 92008644 CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC VNTOAUTHORTEL|(301)496-2475| CC VNTOAUTHORFAX|(301)480-9241| CC VNTOAUTHOREML|info@ncbi.nlm.nih.gov| CC VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/| CC VNTOAUTHORAD1|National Center for Biotechnology Information| CC VNTOAUTHORAD2|National Library of Medicine| CC VNTOAUTHORAD3|Building 38A, Room 8N805| CC VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.| FT SOURCE 1 1452 VNTIFKEY:269 FT PROTEIN 1 1452 protein tyrosine phosphatase, receptor-type, M FT VNTIFKEY:270 FT SIGNAL 1 20 VNTIFKEY:200; VNTINAME:Signal_1 FT CHAIN 21 1452 VNTIFKEY:203; VNTINAME:Chain_1 FT DOMAIN 23 182 MAM FT VNTIFKEY:1000; VNTINAME:Dom_Misc_1 FT REGION 192 279 IG FT VNTIFKEY:266; VNTINAME:Region_1 FT DOMAIN 282 361 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_2 FT DOMAIN 383 467 FN3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_3 FT DOMAIN 499 574 fn3 FT VNTIFKEY:1000; VNTINAME:Dom_Misc_4 FT REGION 899 1156 PTPc FT VNTIFKEY:266; VNTINAME:Region_2 FT REGION 1185 1449 PTPc FT VNTIFKEY:266; VNTINAME:Region_3 SQ SEQUENCE 1452 AA; MRTLGTCLVT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ ADEDDFNWEQ VNTLTKPTSD 60 PWMPSGSFML VNTSGKPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNAA PGLLNVYVKV 120 NNGPLGNPIW NISGDPTRTW HRAELAISTF WPNFYQVIFE VVTSGHQGYL AIDEVKVLGH 180 PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR 240 FIASFNVVNT TKRDAGKYRC MICTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI 300 QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE 360 GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW EPFGYNVTRC HSYNLTVHYG 420 YQVGGQEQVR EEVSWDTDNS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELTVQTDED 480 LPGAVPTESI QGSAFEEKIF LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS 540 KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YEFETPLNQT 600 DNTVTVMLKP AQSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ NASILNSQYY 660 FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPHKSYRI YYQAASRANG ETKIDCVRVA 720 TKGAVTPKPV PEPEKQTDHT VKIAGVIAGI LLFVIIFLGV VLVMKKRKLA KKRKETMSST 780 RQEMTVMVNS MDKSYAEQGT NCDEAFSFMG THNLNGRSVS SPSSFTMKTN TLSTSVPNSY 840 YPDETHTMAS DTSSLAQPHT YKKREAADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900 KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQMLEGDNN SDYINGNYID 960 GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL VEVGRVKCCK YWPDDTEIYK 1020 DIKVTLIDTE LLAEYVIRTF AVEKRGIHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV 1080 KSKSPPNAGP LVVHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT 1140 EEQYVFIHDA ILEACLCGDT SIPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200 RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT 1260 QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE 1320 EDIISRIFRI YNASRPQDGH RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG 1380 GEGPTVVHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF 1440 CYEVALEYLN SG 1452 // ID mPTPNP\(P80560)\Ptprn2 STANDARD;PRT; 1001 AA. AC P80560; DT 17-MAY-2003 DE Protein-tyrosine phosphatase X precursor (R-PTP-X) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP). KW Hydrolase; Receptor; Glycoprotein; Signal; Transmembrane; Alternative splicing. OS Mus musculus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. CC ------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a CC collaboration between the Swiss Institute of Bioinformatics and CC the EMBL outstation - the European Bioinformatics Institute. CC The original entry is available from http://www.expasy.ch/sprot CC and http://www.ebi.ac.uk/sprot CC ------------------------------------------------------------------. CC [FUNCTION] IMPLICATED IN DEVELOPMENT OF NERVOUS SYSTEM AND CC PANCREATIC ENDOCRINE CELLS. CC [CATALYTIC ACTIVITY] Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC [SUBCELLULAR LOCATION] Type I membrane protein (Probable). CC [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named CC isoforms=2; Comment=Additional isoforms seem to exist; Name=1; CC Synonyms=Type 1-PTP-NP; IsoId=P80560-1; Sequence=Displayed; Name=2; CC Synonyms=Type 2-PTP-NP; IsoId=P80560-2; Sequence=Not described. CC [TISSUE SPECIFICITY] PANCREAS AND BRAIN. CC [DEVELOPMENTAL STAGE] EXPRESSED IN EARLY STAGES OF PANCREATIC CC DEVELOPMENT. FIRST EXPRESSED IN DAY 8.5 EMBRYOS (E8.5) IN THE CC DORSAL PART OF THE MIDGUT ENDODERM AND BY E9.5, IN THE PANCREATIC CC RUDIMENT SPECIFICALLY IN EARLY ENDOCRINE PROGENITOR CELLS. AT LATER CC STAGES EXPRESSED IN INSULIN- OR GLUCAGON-PRODUCING CELLS. DURING CC NEURAL DEVELOPMENT, THE TYPE 2 PTP-NP IS EXPRESSED IN EARLY STAGES CC OF NEUROGENESIS, AND THE TYPE 1 WEAKLY IN THE LATER STAGES. CC [PTM] APPEARS TO UNDERGO MULTIPLE PROTEOLYTIC CLEAVAGE AT CC CONSECUTIVE BASIC RESIDUES (BY SIMILARITY). CC [DISEASE] AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES MELLITUS CC (IDDD). CC [SIMILARITY] Contains 1 protein-tyrosine phosphatase domain. CC CC GPRFLN|REFERENCE 1 (residues 1 to 1001) CC GPRFLN| AUTHORS Chiang,M.K. and Flanagan,J.G. CC GPRFLN| TITLE PTP-NP, a new member of the receptor protein tyrosine phosphatase CC GPRFLN| family, implicated in development of nervous system and pancreatic CC GPRFLN| endocrine cells CC GPRFLN| JOURNAL Development 122 (7), 2239-2250 (1996) CC GPRFLN| MEDLINE 96281667 CC GPRFLN| REMARK SEQUENCE FROM N.A. CC GPRFLN| STRAIN=ICR; TISSUE=Brain CC GPRFLN|REFERENCE 2 (residues 1 to 1001) CC GPRFLN| AUTHORS Lu,J., Li,Q., Xie,H., Chen,Z.J., Borovitskaya,A.E., Maclaren,N.K., CC GPRFLN| Notkins,A.L. and Lan,M.S. CC GPRFLN| TITLE Identification of a second transmembrane protein tyrosine CC GPRFLN| phosphatase, IA-2beta, as an autoantigen in insulin-dependent CC GPRFLN| diabetes mellitus: precursor of the 37-kDa tryptic fragment CC GPRFLN| JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (6), 2307-2311 (1996) CC GPRFLN| MEDLINE 96197307 CC GPRFLN| REMARK SEQUENCE OF 282-1001 FROM N.A. CC GPRFLN| TISSUE=Neonatal brain CC This file is created by Vector NTI suite CC ORIGDB|GenPept CC VNTDATE|0| CC VNTAUTHORNAME|Jannik N Andersen| CC VNTAUTHOREML|jannik@noergaardandersen.com| CC VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp| CC VNTOAUTHORNAME|NCBI Entrez| CC