ID   hBDP1_D1\(NP_055184)\PTPN18 STANDARD;PRT;   288 AA.
AC   NP_055184;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 18; brain-derived phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X79568.1 and BI261717.1.
CC   On Jan 25, 2002 this sequence version replaced gi:7657484.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains a PEST motif, which
CC   often serves as a protein-protein interaction domain, and may be
CC   related to protein intracellular half-live. This gene was found to
CC   be expressed in brain, colon tissues, and several different
CC   tumor-derived cell lines. The bilogical function of this PTP has
CC   not yet been determined.
CC   GPRFLN|REFERENCE   1  (residues 1 to 460)
CC   GPRFLN|  AUTHORS   Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and
CC   GPRFLN|            Ullrich,A.
CC   GPRFLN|  TITLE     Characterization of the PEST family protein tyrosine phosphatase
CC   GPRFLN|            BDP1
CC   GPRFLN|  JOURNAL   Oncogene 13 (10), 2275-2279 (1996)
CC   GPRFLN|  MEDLINE   97108674
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    288       VNTIFKEY:269
FT   PROTEIN       1    288       brain-derived phosphatase
FT                                VNTIFKEY:270
FT   REGION       21    287       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   288 AA;
     DSARSFLERL EARGGREGAV LAGEFSDIQA CSAAWKADGV CSTVAGSRPE NVRKNRYKDV        60
     LPYDQTRVIL SLLQEEGHSD YINGNFIRGV DGSLAYIATQ GPLPHTLLDF WRLVWEFGVK       120
     VILMACREIE NGRKRCERYW AQEQEPLQTG LFCITLIKEK WLNEDIMLRT LKVTFQKESR       180
     SVYQLQYMSW PDRGVPSSPD HMLAMVEEAR RLQGSGPEPL CVHCSAGCGR TGVLCTVDYV       240
     RQLLLTQMIP PDFSLFDVVL KMRKQRPAAV QTEEQYRFLY HTVAQMFC                    288
//
ID   hCD45_D1\(NP_002829)\PTPRC STANDARD;PRT;   279 AA.
AC   NP_002829;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, C isoform 1 precursor; protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00638.1 and Y00062.1.
CC   On Feb 8, 2002 this sequence version replaced gi:4506307.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus belongs to receptor
CC   type PTP. This gene is specifically expressed in hematopoietic
CC   cells. This PTP has been shown to be an essential regulator of T-
CC   and B-cell antigen receptor signaling. It functions through either
CC   direct interaction with components of the antigen receptor
CC   complexes, or by activating various Src family kinases required for
CC   the antigen receptor signaling. This PTP also suppresses JAK
CC   kinases, and thus functions as a regulator of cytokine receptor
CC   signaling. Four alternatively spliced transcripts variants of this
CC   gene, which encode distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Baldwin,T.A. and Ostergaard,H.L.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase CD45 reaches the cell surface via
CC   GPRFLN|            golgi-dependent and -independent pathways
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (52), 50333-50340 (2002)
CC   GPRFLN|  MEDLINE   22384317
CC   GPRFLN|  REMARK    GeneRIF: reaches the cell surface via Golgi-dependent and
CC   GPRFLN|            -independent pathways
CC   GPRFLN|REFERENCE   2  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Harashima,A., Suzuki,M., Okochi,A., Yamamoto,M., Matsuo,Y.,
CC   GPRFLN|            Motoda,R., Yoshioka,T. and Orita,K.
CC   GPRFLN|  TITLE     CD45 tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn
CC   GPRFLN|  JOURNAL   Blood 100 (13), 4440-4445 (2002)
CC   GPRFLN|  MEDLINE   22340750
CC   GPRFLN|  REMARK    GeneRIF: CD45 may play a pivotal role in erythropoiesis. CD45
CC   GPRFLN|            tyrosine phosphatase inhibits erythroid differentiation of
CC   GPRFLN|            umbilical cord blood CD34+ cells associated with selective
CC   GPRFLN|            inactivation of Lyn.
CC   GPRFLN|REFERENCE   3  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   4  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pradhan,D. and Morrow,J.
CC   GPRFLN|  TITLE     The spectrin-ankyrin skeleton controls CD45 surface display and
CC   GPRFLN|            interleukin-2 production
CC   GPRFLN|  JOURNAL   Immunity 17 (3), 303-315 (2002)
CC   GPRFLN|  MEDLINE   22241694
CC   GPRFLN|  REMARK    GeneRIF: The spectrin-ankyrin skeleton controls CD45 surface
CC   GPRFLN|            display and interleukin-2 production.
CC   GPRFLN|REFERENCE   5  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ballerini,C., Rosati,E., Salvetti,M., Ristori,G., Cannoni,S.,
CC   GPRFLN|            Biagioli,T., Massacesi,L., Sorbi,S. and Vergelli,M.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor-type C exon 4 gene mutation
CC   GPRFLN|            distribution in an Italian multiple sclerosis population
CC   GPRFLN|  JOURNAL   Neurosci. Lett. 328 (3), 325-327 (2002)
CC   GPRFLN|  MEDLINE   22142931
CC   GPRFLN|  REMARK    GeneRIF: Role of the C-->G mutation in position 77 of exon 4 of the
CC   GPRFLN|            protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding
CC   GPRFLN|            for the CD45 molecule, for the development of multiple sclerosis
CC   GPRFLN|            (MS) in Italy.
CC   GPRFLN|REFERENCE   6  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yamada,T., Zhu,D., Saxon,A. and Zhang,K.
CC   GPRFLN|  TITLE     CD45 controls interleukin-4-mediated IgE class switch recombination
CC   GPRFLN|            in human B cells through its function as a Janus kinase phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (32), 28830-28835 (2002)
CC   GPRFLN|  MEDLINE   22151051
CC   GPRFLN|  REMARK    GeneRIF: CD45 controls interleukin-4-mediated IgE class switch
CC   GPRFLN|            recombination in human B cells
CC   GPRFLN|REFERENCE   7  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Yu,C., Yu,H.S., Sun,K.H., Hsieh,S.C. and Tsai,C.Y.
CC   GPRFLN|  TITLE     Anti-CD45 isoform antibodies enhance phagocytosis and gene
CC   GPRFLN|            expression of IL-8 and TNF-alpha in human neutrophils by
CC   GPRFLN|            differential suppression on protein tyrosine phosphorylation and
CC   GPRFLN|            p56lck tyrosine kinase
CC   GPRFLN|  JOURNAL   Clin. Exp. Immunol. 129 (1), 78-85 (2002)
CC   GPRFLN|  MEDLINE   22095000
CC   GPRFLN|  REMARK    GeneRIF: Biological functions of membrane expressed CD45 isoforms
CC   GPRFLN|            on PMNs were studied. Cross-linking of CD45 isoforms by specific
CC   GPRFLN|            MAbs stimulated different PMN activities by differential
CC   GPRFLN|            suppression on protein tyrosine phosphorylation and p56lck.
CC   GPRFLN|REFERENCE   8  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Jacobsen,M., Hoffmann,S., Cepok,S., Stei,S., Ziegler,A., Sommer,N.
CC   GPRFLN|            and Hemmer,B.
CC   GPRFLN|  TITLE     A novel mutation in PTPRC interferes with splicing and alters the
CC   GPRFLN|            structure of the human CD45 molecule
CC   GPRFLN|  JOURNAL   Immunogenetics 54 (3), 158-163 (2002)
CC   GPRFLN|  MEDLINE   22067726
CC   GPRFLN|  REMARK    GeneRIF: a mutation in PTPRC interferes with splicing and alters
CC   GPRFLN|            the structure of the CD45 molecule
CC   GPRFLN|REFERENCE   9  (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z. and Beverley,P.C.
CC   GPRFLN|  TITLE     CD45 in memory and disease
CC   GPRFLN|  JOURNAL   Arch. Immunol. Ther. Exp. (Warsz.) 50 (2), 85-93 (2002)
CC   GPRFLN|  MEDLINE   22017393
CC   GPRFLN|  REMARK    GeneRIF: Role of high and low molecular weight isoforms of CD45 in
CC   GPRFLN|            the function of na##ve and memory T lymphocytes. Review.
CC   GPRFLN|REFERENCE   10 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fajka-Boja,R., Szemes,M., Ion,G., Legradi,A., Caron,M. and
CC   GPRFLN|            Monostori,E.
CC   GPRFLN|  TITLE     Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not
CC   GPRFLN|            mediate its apoptotic signal in T cell lines
CC   GPRFLN|  JOURNAL   Immunol. Lett. 82 (1-2), 149-154 (2002)
CC   GPRFLN|  MEDLINE   22003829
CC   GPRFLN|  REMARK    GeneRIF: Receptor tyrosine phosphatase, CD45 binds galectin-1 but
CC   GPRFLN|            does not mediate its apoptotic signal in Jurkat cells
CC   GPRFLN|REFERENCE   11 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Fukuhara,K., Okumura,M., Shiono,H., Inoue,M., Kadota,Y., Miyoshi,S.
CC   GPRFLN|            and Matsuda,H.
CC   GPRFLN|  TITLE     A study on CD45 isoform expression during T-cell development and
CC   GPRFLN|            selection events in the human thymus
CC   GPRFLN|  JOURNAL   Hum. Immunol. 63 (5), 394-404 (2002)
CC   GPRFLN|  MEDLINE   21972715
CC   GPRFLN|  REMARK    GeneRIF: analysis of CD45 isoform expression during T-cell
CC   GPRFLN|            development and selection in the human thymus
CC   GPRFLN|REFERENCE   12 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wu,L., Fu,J. and Shen,S.H.
CC   GPRFLN|  TITLE     SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 22 (8), 2673-2686 (2002)
CC   GPRFLN|  MEDLINE   21907230
CC   GPRFLN|  REMARK    GeneRIF: SKAP55 coupled with CD45 positively regulates T-cell
CC   GPRFLN|            receptor-mediated gene transcription.
CC   GPRFLN|REFERENCE   13 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ishikawa,H., Tsuyama,N., Abroun,S., Liu,S., Li,F.J., Taniguchi,O.
CC   GPRFLN|            and Kawano,M.M.
CC   GPRFLN|  TITLE     Requirements of src family kinase activity associated with CD45 for
CC   GPRFLN|            myeloma cell proliferation by interleukin-6
CC   GPRFLN|  JOURNAL   Blood 99 (6), 2172-2178 (2002)
CC   GPRFLN|  MEDLINE   21866149
CC   GPRFLN|  REMARK    GeneRIF: Requirements of src family kinase activity associated with
CC   GPRFLN|            CD45 for myeloma cell proliferation by interleukin-6
CC   GPRFLN|REFERENCE   14 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Tchilian,E.Z., Dawes,R., Ramaley,P.A., Whitworth,J.A.,
CC   GPRFLN|            Yuldasheva,N., Wells,R.S., Watera,C., French,N., Gilks,C.F.,
CC   GPRFLN|            Kunachiwa,W., Ruzibakiev,R., Leetrakool,N., Carrington,C.V.,
CC   GPRFLN|            Ramdath,D.D., Gotch,F., Stephens,H.A., Hill,A.V. and Beverley,P.C.
CC   GPRFLN|  TITLE     A CD45 polymorphism associated with abnormal splicing is absent in
CC   GPRFLN|            African populations
CC   GPRFLN|  JOURNAL   Immunogenetics 53 (10-11), 980-983 (2002)
CC   GPRFLN|  MEDLINE   21850514
CC   GPRFLN|  REMARK    GeneRIF: we examined the frequency of the C77G allele in African
CC   GPRFLN|            and Asian populations from countries with high or low prevalence of
CC   GPRFLN|            HIV infection; Here we report that the variant CD45 C77G allele is
CC   GPRFLN|            absent in African populations
CC   GPRFLN|REFERENCE   15 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Wood,J.P., Bieda,K., Segni,M., Herwig,J., Krause,M., Usadel,K.H.
CC   GPRFLN|            and Badenhoop,K.
CC   GPRFLN|  TITLE     CD45 exon 4 point mutation does not confer susceptibility to type 1
CC   GPRFLN|            diabetes mellitus or Graves' disease
CC   GPRFLN|  JOURNAL   Eur. J. Immunogenet. 29 (1), 73-74 (2002)
CC   GPRFLN|  MEDLINE   21830605
CC   GPRFLN|  REMARK    GeneRIF: CD45 variant (C77G, exon 4) does not confer susceptibility
CC   GPRFLN|            to either IDDM or Graves' disease
CC   GPRFLN|REFERENCE   16 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Moro,H., Iwai,K., Mori,N., Watanabe,M., Fukushi,M., Oie,M.,
CC   GPRFLN|            Arai,M., Tanaka,Y., Miyawaki,T., Gejyo,F., Arakawa,M. and Fujii,M.
CC   GPRFLN|  TITLE     Interleukin-2-dependent but not independent T-cell lines infected
CC   GPRFLN|            with human T-cell leukemia virus type 1 selectively express CD45RO,
CC   GPRFLN|            a marker for persistent infection in vivo
CC   GPRFLN|  JOURNAL   Virus Genes 23 (3), 263-271 (2001)
CC   GPRFLN|  MEDLINE   21636965
CC   GPRFLN|  REMARK    GeneRIF: role of CD45RO in the persistent HTLV-1 infection in vivo
CC   GPRFLN|REFERENCE   17 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Irie-Sasaki,J., Sasaki,T., Matsumoto,W., Opavsky,A., Cheng,M.,
CC   GPRFLN|            Welstead,G., Griffiths,E., Krawczyk,C., Richardson,C.D., Aitken,K.,
CC   GPRFLN|            Iscove,N., Koretzky,G., Johnson,P., Liu,P., Rothstein,D.M. and
CC   GPRFLN|            Penninger,J.M.
CC   GPRFLN|  TITLE     CD45 is a JAK phosphatase and negatively regulates cytokine
CC   GPRFLN|            receptor signalling
CC   GPRFLN|  JOURNAL   Nature 409 (6818), 349-354 (2001)
CC   GPRFLN|  MEDLINE   21069057
CC   GPRFLN|REFERENCE   18 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Goff,L.K., van Soest,S., Timon,M., Tchilian,E. and Beverley,P.C.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on
CC   GPRFLN|            human chromosome band 1q31-->q32 localizes with marker D1S413(1) on
CC   GPRFLN|            a 610-kb yeast artificial chromosome
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 223-224 (1999)
CC   GPRFLN|  MEDLINE   20169194
CC   GPRFLN|REFERENCE   19 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Petricoin,E.F. III, Ito,S., Williams,B.L., Audet,S., Stancato,L.F.,
CC   GPRFLN|            Gamero,A., Clouse,K., Grimley,P., Weiss,A., Beeler,J.,
CC   GPRFLN|            Finbloom,D.S., Shores,E.W., Abraham,R. and Larner,A.C.
CC   GPRFLN|  TITLE     Antiproliferative action of interferon-alpha requires components of
CC   GPRFLN|            T-cell-receptor signalling
CC   GPRFLN|  JOURNAL   Nature 390 (6660), 629-632 (1997)
CC   GPRFLN|  MEDLINE   98065953
CC   GPRFLN|REFERENCE   20 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   21 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.
CC   GPRFLN|  TITLE     Association of CD2 and CD45 on human T lymphocytes
CC   GPRFLN|  JOURNAL   Nature 345 (6270), 71-74 (1990)
CC   GPRFLN|  MEDLINE   90231464
CC   GPRFLN|REFERENCE   22 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Pingel,J.T. and Thomas,M.L.
CC   GPRFLN|  TITLE     Evidence that the leukocyte-common antigen is required for
CC   GPRFLN|            antigen-induced T lymphocyte proliferation
CC   GPRFLN|  JOURNAL   Cell 58 (6), 1055-1065 (1989)
CC   GPRFLN|  MEDLINE   89376557
CC   GPRFLN|REFERENCE   23 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Charbonneau,H., Tonks,N.K., Walsh,K.A. and Fischer,E.H.
CC   GPRFLN|  TITLE     The leukocyte common antigen (CD45): a putative receptor-linked
CC   GPRFLN|            protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7182-7186 (1988)
CC   GPRFLN|  MEDLINE   89017162
CC   GPRFLN|REFERENCE   24 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Streuli,M., Hall,L.R., Saga,Y., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     Differential usage of three exons generates at least five different
CC   GPRFLN|            mRNAs encoding human leukocyte common antigens
CC   GPRFLN|  JOURNAL   J. Exp. Med. 166 (5), 1548-1566 (1987)
CC   GPRFLN|  MEDLINE   88061067
CC   GPRFLN|REFERENCE   25 (residues 1 to 1304)
CC   GPRFLN|  AUTHORS   Ralph,S.J., Thomas,M.L., Morton,C.C. and Trowbridge,I.S.
CC   GPRFLN|  TITLE     Structural variants of human T200 glycoprotein (leukocyte-common
CC   GPRFLN|            antigen)
CC   GPRFLN|  JOURNAL   EMBO J. 6 (5), 1251-1257 (1987)
CC   GPRFLN|  MEDLINE   87275816
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       protein tyrosine phosphatase, receptor type, c polypeptide; leukocyte-common antigen; T200 glycoprotein; human homolog of severe combined immunodeficiency due to PTPRC deficiency; SCID due to PTPRC deficiency; CD45 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   279 AA;
     DILLETYKRK IADEGRLFLA EFQSIPRVFS KFPIKEARKP FNQNKNRYVD ILPYDYNRVE        60
     LSEINGDAGS NYINASYIDG FKEPRKYIAA QGPRDETVDD FWRMIWEQKA TVIVMVTRCE       120
     EGNRNKCAEY WPSMEEGTRA FGDVVVKINQ HKRCPDYIIQ KLNIVNKKEK ATGREVTHIQ       180
     FTSWPDHGVP EDPHLLLKLR RRVNAFSNFF SGPIVVHCSA GVGRTGTYIG IDAMLEGLEA       240
     ENKVDVYGYV VKLRRQRCLM VQVEAQYILI HQALVEYNQ                              279
//
ID   hDEP1_D1\(NP_002834)\PTPRJ STANDARD;PRT;   277 AA.
AC   NP_002834;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, J precursor; protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U10886.1.
CC   On Feb 22, 2002 this sequence version replaced gi:4506315.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region containing five fibronectin type III repeats, a single
CC   transmembrane region, and a single intracytoplasmic catalytic
CC   domain, and thus represents a receptor-type PTP. This PTP is
CC   present in all hematopoietic lineages, and was shown to negatively
CC   regulate T cell receptor signaling possibly through interfering
CC   with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and
CC   Linker for Activation of T Cells (LAT). This PTP was also found to
CC   dephosphorylate PDGF beta receptor, and may be involved in
CC   UV-induced signal transduction.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
CC   GPRFLN|            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
CC   GPRFLN|            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
CC   GPRFLN|            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
CC   GPRFLN|            Demant,P.
CC   GPRFLN|  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
CC   GPRFLN|            locus Scc1 and is frequently deleted in human cancers
CC   GPRFLN|  JOURNAL   Nat. Genet. 31 (3), 295-300 (2002)
CC   GPRFLN|  MEDLINE   22084388
CC   GPRFLN|  REMARK    GeneRIF: This protein is frequently deleted in human breast
CC   GPRFLN|            cancers.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase CD148-mediated inhibition of T-cell
CC   GPRFLN|            receptor signal transduction is associated with reduced LAT and
CC   GPRFLN|            phospholipase Cgamma1 phosphorylation
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 21 (7), 2393-2403 (2001)
CC   GPRFLN|  MEDLINE   21160271
CC   GPRFLN|REFERENCE   3  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S.,
CC   GPRFLN|            Jandt,E., Vilella,R., Bohmer,F. and Ostman,A.
CC   GPRFLN|  TITLE     Site-selective dephosphorylation of the platelet-derived growth
CC   GPRFLN|            factor beta-receptor by the receptor-like protein-tyrosine
CC   GPRFLN|            phosphatase DEP-1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (21), 16219-16226 (2000)
CC   GPRFLN|  MEDLINE   20283660
CC   GPRFLN|REFERENCE   4  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Gross,S., Knebel,A., Tenev,T., Neininger,A., Gaestel,M.,
CC   GPRFLN|            Herrlich,P. and Bohmer,F.D.
CC   GPRFLN|  TITLE     Inactivation of protein-tyrosine phosphatases as mechanism of
CC   GPRFLN|            UV-induced signal transduction
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (37), 26378-26386 (1999)
CC   GPRFLN|  MEDLINE   99403084
CC   GPRFLN|REFERENCE   5  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Tangye,S.G., Phillips,J.H., Lanier,L.L., de Vries,J.E. and
CC   GPRFLN|            Aversa,G.
CC   GPRFLN|  TITLE     CD148: a receptor-type protein tyrosine phosphatase involved in the
CC   GPRFLN|            regulation of human T cell activation
CC   GPRFLN|  JOURNAL   J. Immunol. 161 (7), 3249-3255 (1998)
CC   GPRFLN|  MEDLINE   98430639
CC   GPRFLN|REFERENCE   6  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E.,
CC   GPRFLN|            Thomas,A.P., Vilella,R., Vives,J. and Gaya,A.
CC   GPRFLN|  TITLE     CD148 is a membrane protein tyrosine phosphatase present in all
CC   GPRFLN|            hematopoietic lineages and is involved in signal transduction on
CC   GPRFLN|            lymphocytes
CC   GPRFLN|  JOURNAL   Blood 91 (8), 2800-2809 (1998)
CC   GPRFLN|  MEDLINE   98200586
CC   GPRFLN|REFERENCE   7  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Honda,H., Inazawa,J., Nishida,J., Yazaki,Y. and Hirai,H.
CC   GPRFLN|  TITLE     Molecular cloning, characterization, and chromosomal localization
CC   GPRFLN|            of a novel protein-tyrosine phosphatase, HPTP eta
CC   GPRFLN|  JOURNAL   Blood 84 (12), 4186-4194 (1994)
CC   GPRFLN|  MEDLINE   95086212
CC   GPRFLN|REFERENCE   8  (residues 1 to 1337)
CC   GPRFLN|  AUTHORS   Ostman,A., Yang,Q. and Tonks,N.K.
CC   GPRFLN|  TITLE     Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase,
CC   GPRFLN|            is enhanced with increasing cell density
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (21), 9680-9684 (1994)
CC   GPRFLN|  MEDLINE   95024024
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    277       VNTIFKEY:269
FT   PROTEIN       1    277       protein tyrosine phosphatase, receptor type, J polypeptide; human density enhanced phosphatase-1; CD148 antigen
FT                                VNTIFKEY:270
FT   CHAIN         1    277       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   277 AA;
     ENFEAYFKKQ QADSNCGFAE EYEDLKLVGI SQPKYAAELA ENRGKNRYNN VLPYDISRVK        60
     LSVQTHSTDD YINANYMPGY HSKKDFIATQ GPLPNTLKDF WRMVWEKNVY AIIMLTKCVE       120
     QGRTKCEEYW PSKQAQDYGD ITVAMTSEIV LPEWTIRDFT VKNIQTSESH PLRQFHFTSW       180
     PDHGVPDTTD LLINFRYLVR DYMKQSPPES PILVHCSAGV GRTGTFIAID RLIYQIENEN       240
     TVDVYGIVYD LRMHRPLMVQ TEDQYVFLNQ CVLDIVR                                277
//
ID   hGLEPP1_D1\(NP_109592)\PTPRO STANDARD;PRT;   277 AA.
AC   NP_109592;
DT   27-JUN-2003
DE   receptor-type protein tyrosine phosphatase O isoform a precursor; glomerular epithelial protein-1; protein tyrosine phosphatase PTP-U2; phosphotyrosine phosphatase U2; PTPase U2; PTPROt [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Z48541.1 and U20489.1.
CC   
CC   Summary: This gene encodes a receptor-type protein tyrosine
CC   phosphatase containing a single intracellular catalytic domain with
CC   a characteristic signature motif. The gene product, which has a
CC   transmembrane domain, is an integral membrane protein. Several
CC   alternatively spliced transcript variants, some of which encode
CC   different isoforms of the protein, have been described. These
CC   variants exhibit tissue-specific expression.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (a) known to date. The encoded protein has a large extracellular
CC   domain containing 8 repeats of a fibronectin type III-like motif.
CC   This variant is expressed in the glomerulus of kidney and in brain.
CC   In kidney, it may play a role in regulating glomerular epithelial
CC   cell (podocyte) structure and/or function.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J.
CC   GPRFLN|            and Shipp,M.A.
CC   GPRFLN|  TITLE     PTPROt: an alternatively spliced and developmentally regulated
CC   GPRFLN|            B-lymphoid phosphatase that promotes G0/G1 arrest
CC   GPRFLN|  JOURNAL   Blood 94 (7), 2403-2413 (1999)
CC   GPRFLN|  MEDLINE   99428326
CC   GPRFLN|REFERENCE   2  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Seimiya,H., Sawabe,T., Inazawa,J. and Tsuruo,T.
CC   GPRFLN|  TITLE     Cloning, expression and chromosomal localization of a novel gene
CC   GPRFLN|            for protein tyrosine phosphatase (PTP-U2) induced by various
CC   GPRFLN|            differentiation-inducing agents
CC   GPRFLN|  JOURNAL   Oncogene 10 (9), 1731-1738 (1995)
CC   GPRFLN|  MEDLINE   95273089
CC   GPRFLN|REFERENCE   3  (residues 1 to 1216)
CC   GPRFLN|  AUTHORS   Wiggins,R.C., Wiggins,J.E., Goyal,M., Wharram,B.L. and Thomas,P.E.
CC   GPRFLN|  TITLE     Molecular cloning of cDNAs encoding human GLEPP1, a membrane
CC   GPRFLN|            protein tyrosine phosphatase: characterization of the GLEPP1
CC   GPRFLN|            protein distribution in human kidney and assignment of the GLEPP1
CC   GPRFLN|            gene to human chromosome 12p12-p13
CC   GPRFLN|  JOURNAL   Genomics 27 (1), 174-181 (1995)
CC   GPRFLN|  MEDLINE   95394455
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   REGION       17    272       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
FT   DOMAIN      214    224       VNTIFKEY:1000; VNTINAME:Dom_Misc_3
SQ   SEQUENCE   277 AA;
     DDFDAYIKDM AKDSDYKFSL QFEELKLIGL DIPHFAADLP LNRCKNRYTN ILPYDFSRVR        60
     LVSMNEEEGA DYINANYIPG YNSPQEYIAT QGPLPETRND FWKMVLQQKS QIIVMLTQCN       120
     EKRRVKCDHY WPFTEEPIAY GDITVEMISE EEQDDWACRH FRINYADEMQ DVMHFNYTAW       180
     PDHGVPTANA AESILQFVHM VRQQATKSKG PMIIHCSAGV GRTGTFIALD RLLQHIRDHE       240
     FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWM                                277
//
ID   hHDPTP_D1\(NP_056281)\PTPN23 STANDARD;PRT;   286 AA.
AC   NP_056281;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 23; His-domain protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   PREDICTED REFSEQ: The mRNA record is supported by experimental
CC   evidence; however, the coding sequence is predicted. The reference
CC   sequence was derived from AF290614.1.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1636)
CC   GPRFLN|  AUTHORS   Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Lu,C., Wang,M. and He,F.
CC   GPRFLN|  TITLE     Cloning, chromosomal assignment and tissue expression of a novel
CC   GPRFLN|            human protein tyrosine phosphatase (PTP-TD14) gene
CC   GPRFLN|  JOURNAL   I Chuan 23 (6), 1-9 (2001)
CC   GPRFLN|REFERENCE   2  (residues 1 to 1636)
CC   GPRFLN|  AUTHORS   Toyooka,S., Ouchida,M., Jitsumori,Y., Tsukuda,K., Sakai,A.,
CC   GPRFLN|            Nakamura,A., Shimizu,N. and Shimizu,K.
CC   GPRFLN|  TITLE     HD-PTP: A novel protein tyrosine phosphatase gene on human
CC   GPRFLN|            chromosome 3p21.3
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 278 (3), 671-678 (2000)
CC   GPRFLN|  MEDLINE   20549011
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    286       VNTIFKEY:269
FT   PROTEIN       1    286       His-domain protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       23    286       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   286 AA;
     ERLRQLQQEL EAFRGQLGDV GALDTVWREL QDAQEHDARG RSIAIARCYS LKNRHQDVMP        60
     YDSNRVVLRS GKDDYINASC VEGLSPYCPP LVATQAPLPG TAADFWLMVH EQKVSVIVML       120
     VSEAEMEKQK VARYFPTERG QPMVHGALSL ALSSVRSTET HVERVLSLQF RDQSLKRSLV       180
     HLHFPTWPEL GLPDSPSNLL RFIQEVHAHY LHQRPLHTPI IVHCSSGVGR TGAFALLYAA       240
     VQEVEAGNGI PELPQLVRRM RQQRKHMLQE KLHLRFCYEA VVRHVE                      286
//
ID   hHePTP_D1\(NP_002823)\PTPN7 STANDARD;PRT;   273 AA.
AC   NP_002823;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 7 isoform 1; protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from BC001746.1, BG340453.1,
CC   D11327.1 and M64322.1.
CC   On Jan 25, 2002 this sequence version replaced gi:4506299.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This gene is preferentially expressed in
CC   a variety of hematopoietic cells, and is an early response gene in
CC   lymphokine stimulated cells. The noncatalytic N-terminus of this
CC   PTP can interact with MAP kinases and suppress the MAP kinase
CC   activities. This PTP was shown to be involved in the regulation of
CC   T cell antigen receptor (TCR) signaling, which was thought to
CC   function through dephosphorylating the molecules related to MAP
CC   kinase pathway. Three alternatively spliced transcript variants of
CC   this gene, which encode two distinct isoforms, are reported.
CC   
CC   Transcript Variant: This variant (1) contains a different 5'
CC   region, which includes a part of the coding sequence when compared
CC   to variant 2. It thus encodes a protein that has a shorter
CC   N-terminus, as compared to isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Oh-hora,M., Ogata,M., Mori,Y., Adachi,M., Imai,K., Kosugi,A. and
CC   GPRFLN|            Hamaoka,T.
CC   GPRFLN|  TITLE     Direct suppression of TCR-mediated activation of extracellular
CC   GPRFLN|            signal-regulated kinase by leukocyte protein tyrosine phosphatase,
CC   GPRFLN|            a tyrosine-specific phosphatase
CC   GPRFLN|  JOURNAL   J. Immunol. 163 (3), 1282-1288 (1999)
CC   GPRFLN|  MEDLINE   99343735
CC   GPRFLN|REFERENCE   2  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Saxena,M., Williams,S., Brockdorff,J., Gilman,J. and Mustelin,T.
CC   GPRFLN|  TITLE     Inhibition of T cell signaling by mitogen-activated protein
CC   GPRFLN|            kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (17), 11693-11700 (1999)
CC   GPRFLN|  MEDLINE   99223488
CC   GPRFLN|REFERENCE   3  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Saxena,M., Williams,S., Gilman,J. and Mustelin,T.
CC   GPRFLN|  TITLE     Negative regulation of T cell antigen receptor signal transduction
CC   GPRFLN|            by hematopoietic tyrosine phosphatase (HePTP)
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (25), 15340-15344 (1998)
CC   GPRFLN|  MEDLINE   98288260
CC   GPRFLN|REFERENCE   4  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Swieter,M., Berenstein,E.H., Swaim,W.D. and Siraganian,R.P.
CC   GPRFLN|  TITLE     Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells
CC   GPRFLN|            induces tyrosine phosphorylation of the cytosolic protein-tyrosine
CC   GPRFLN|            phosphatase HePTP
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (37), 21902-21906 (1995)
CC   GPRFLN|  MEDLINE   95394959
CC   GPRFLN|REFERENCE   5  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Isobe,M., Kumura,Y., Ogita,Z., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Molecular cloning and chromosomal mapping of a human
CC   GPRFLN|            protein-tyrosine phosphatase LC-PTP
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 186 (3), 1607-1615 (1992)
CC   GPRFLN|  MEDLINE   92378634
CC   GPRFLN|REFERENCE   6  (residues 1 to 360)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
CC   GPRFLN|  JOURNAL   Cancer Res. 52 (3), 737-740 (1992)
CC   GPRFLN|  MEDLINE   92119637
CC   GPRFLN|REFERENCE   7  (sites)
CC   GPRFLN|  AUTHORS   Zanke,B., Suzuki,H., Kishihara,K., Mizzen,L., Minden,M., Pawson,A.
CC   GPRFLN|            and Mak,T.W.
CC   GPRFLN|  TITLE     Cloning and expression of an inducible lymphoid-specific, protein
CC   GPRFLN|            tyrosine phosphatase (HePTPase)
CC   GPRFLN|  JOURNAL   Eur. J. Immunol. 22 (1), 235-239 (1992)
CC   GPRFLN|  MEDLINE   92111631
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    273       VNTIFKEY:269
FT   PROTEIN       1    273       protein-tyrosine phoshatase, nonreceptor-type, stress induced; hematopoietic protein-tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       17    271       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   273 AA;
     HPLTRWALQR QPPSPKQLEE EFLKIPSNFV SPEDLDIPGH ASKDRYKTIL PNPQSRVCLG        60
     RAQSQEDGDY INANYIRGYD GKEKVYIATQ GPMPNTVSDF WEMVWQEEVS LIVMLTQLRE       120
     GKEKCVHYWP TEEETYGPFQ IRIQDMKECP EYTVRQLTIQ YQEERRSVKH ILFSAWPDHQ       180
     TPESAGPLLR LVAEVEESPE TAAHPGPIVV HCSAGIGRTG CFIATRIGCQ QLKARGEVDI       240
     LGIVCQLRLD RGGMIQTAEQ YQFLHHTLAL YAG                                    273
//
ID   hIA2_D1\(NP_002837)\PTPRN STANDARD;PRT;   279 AA.
AC   NP_002837;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, N precursor; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L18983.1, AF042285.4 and
CC   BC007713.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single catalytic
CC   domain, and thus represents a receptor-type PTP. This PTP was found
CC   to be an autoantigen that is reactive with insulin-dependent
CC   diabetes mellitus (IDDM) patient sera, and thus may be a potential
CC   target of autoimmunity in diabetes mellitus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Sanjeevi,C.B., Das,A.K. and Shtauvere-Brameus,A.
CC   GPRFLN|  TITLE     BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune
CC   GPRFLN|            diabetes in southern India
CC   GPRFLN|  JOURNAL   Ann. N. Y. Acad. Sci. 958, 293-296 (2002)
CC   GPRFLN|  MEDLINE   22015049
CC   GPRFLN|  REMARK    GeneRIF: BCG vaccination and GAD65 and IA-2 autoantibodies in
CC   GPRFLN|            autoimmune diabetes in southern India.
CC   GPRFLN|REFERENCE   2  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Kawasaki,E., Yamaguchi,H., Hattori,H., Egashira,T. and Eguchi,K.
CC   GPRFLN|  TITLE     Autoantibodies to IA-2 in type 1 diabetes: measurements with a new
CC   GPRFLN|            enzyme-linked immunosorbent assay
CC   GPRFLN|  JOURNAL   Ann. N. Y. Acad. Sci. 958, 241-246 (2002)
CC   GPRFLN|  MEDLINE   22015037
CC   GPRFLN|  REMARK    GeneRIF: Autoantibodies to IA-2 in type 1 diabetes: measurements
CC   GPRFLN|            with a new enzyme-linked immunosorbent assay.
CC   GPRFLN|REFERENCE   3  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Miao,D., Yu,L., Tiberti,C., Cuthbertson,D.D., Rewers,M., di
CC   GPRFLN|            Mario,U., Eisenbarth,G.S. and Dotta,F.
CC   GPRFLN|  TITLE     ICA512(IA-2) epitope specific assays distinguish transient from
CC   GPRFLN|            diabetes associated autoantibodies
CC   GPRFLN|  JOURNAL   J. Autoimmun. 18 (2), 191-196 (2002)
CC   GPRFLN|  MEDLINE   21906940
CC   GPRFLN|  REMARK    GeneRIF: ICA512(IA-2) epitope specific assays distinguish transient
CC   GPRFLN|            from diabetes associated autoantibodies.
CC   GPRFLN|REFERENCE   4  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Mikulecky,M. and Michalkova,D.
CC   GPRFLN|  TITLE     Secular and seasonal cycling of IA2-ab autoantibody in Slovak
CC   GPRFLN|            diabetic children
CC   GPRFLN|  JOURNAL   Biomed. Pharmacother. 55 Suppl 1, 106S-109S (2001)
CC   GPRFLN|  MEDLINE   21630621
CC   GPRFLN|REFERENCE   5  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cloning and characterization of islet cell antigen-related
CC   GPRFLN|            protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and
CC   GPRFLN|            autoantigen in insulin-dependent diabetes
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (40), 24817-24823 (1996)
CC   GPRFLN|  MEDLINE   96394649
CC   GPRFLN|REFERENCE   6  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   van den Maagdenberg,A.M., Olde Weghuis,D., Rijss,J., van de
CC   GPRFLN|            Wetering,R.A., Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.
CC   GPRFLN|  TITLE     Assignment of the human gene for receptor-type protein tyrosine
CC   GPRFLN|            phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and
CC   GPRFLN|            identification of an intragenic genetic marker
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 145-148 (1996)
CC   GPRFLN|  MEDLINE   96244610
CC   GPRFLN|REFERENCE   7  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Lan,M.S., Lu,J., Goto,Y. and Notkins,A.L.
CC   GPRFLN|  TITLE     Molecular cloning and identification of a receptor-type protein
CC   GPRFLN|            tyrosine phosphatase, IA-2, from human insulinoma
CC   GPRFLN|  JOURNAL   DNA Cell Biol. 13 (5), 505-514 (1994)
CC   GPRFLN|  MEDLINE   94296553
CC   GPRFLN|REFERENCE   8  (residues 1 to 979)
CC   GPRFLN|  AUTHORS   Rabin,D.U., Pleasic,S.M., Shapiro,J.A., Yoo-Warren,H., Oles,J.,
CC   GPRFLN|            Hicks,J.M., Goldstein,D.E. and Rae,P.M.
CC   GPRFLN|  TITLE     Islet cell antigen 512 is a diabetes-specific islet autoantigen
CC   GPRFLN|            related to protein tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Immunol. 152 (6), 3183-3188 (1994)
CC   GPRFLN|  MEDLINE   94194080
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N precursor
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    278       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     HMILAYMEDH LRNRDRLAKE WQALCAYQAE PNTCATAQGE GNIKKNRHPD FLPYDHARIK        60
     LKVESSPSRS DYINASPIIE HDPRMPAYIA TQGPLSHTIA DFWQMVWESG CTVIVMLTPL       120
     VEDGVKQCDR YWPDEGASLY HVYEVNLVSE HIWCEDFLVR SFYLKNVQTQ ETRTLTQFHF       180
     LSWPAEGTPA STRPLLDFRR KVNKCYRGRS CPIIVHCSDG AGRTGTYILI DMVLNRMAKG       240
     VKEIDIAATL EHVRDQRPGL VRSKDQFEFA LTAVAEEVN                              279
//
ID   hIA2beta_D1\(NP_002838)\PTPRN2 STANDARD;PRT;   279 AA.
AC   NP_002838;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor; protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U66702.1 and AF007555.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single intracellular
CC   catalytic domain, and thus represents a receptor-type PTP. The
CC   catalytic domain of this PTP is most closely related to
CC   PTPRN/IA-2beta. This PTP and PTPRN are both found to be major
CC   autoantigens associated with insulin-dependent diabetes mellitus.
CC   Three alternatively spliced transcript variants of this gene, which
CC   encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   van den Maagdenberg,A.M., Schepens,J.T., Schepens,M.T., Pepers,B.,
CC   GPRFLN|            Wieringa,B., van Kessel,A.G. and Hendriks,W.J.
CC   GPRFLN|  TITLE     Assignment of Ptprn2, the gene encoding receptor-type protein
CC   GPRFLN|            tyrosine phosphatase IA-2beta, a major autoantigen in
CC   GPRFLN|            insulin-dependent diabetes mellitus, to mouse chromosome region 12F
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 82 (3-4), 153-155 (1998)
CC   GPRFLN|  MEDLINE   99077744
CC   GPRFLN|REFERENCE   2  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Schmidli,R.S., Colman,P.G., Cui,L., Yu,W.P., Kewming,K.,
CC   GPRFLN|            Jankulovski,C., Harrison,L.C., Pallen,C.J. and DeAizpurua,H.J.
CC   GPRFLN|  TITLE     Antibodies to the protein tyrosine phosphatases IAR and IA-2 are
CC   GPRFLN|            associated with progression to insulin-dependent diabetes (IDDM) in
CC   GPRFLN|            first-degree relatives at-risk for IDDM
CC   GPRFLN|  JOURNAL   Autoimmunity 28 (1), 15-23 (1998)
CC   GPRFLN|  MEDLINE   98425805
CC   GPRFLN|REFERENCE   3  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Li,Q., Borovitskaya,A.E., DeSilva,M.G., Wasserfall,C.,
CC   GPRFLN|            Maclaren,N.K., Notkins,A.L. and Lan,M.S.
CC   GPRFLN|  TITLE     Autoantigens in insulin-dependent diabetes mellitus: molecular
CC   GPRFLN|            cloning and characterization of human IA-2 beta
CC   GPRFLN|  JOURNAL   Proc. Assoc. Am. Physicians 109 (4), 429-439 (1997)
CC   GPRFLN|  MEDLINE   97364262
CC   GPRFLN|REFERENCE   4  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Smith,P.D., Barker,K.T., Wang,J., Lu,Y.J., Shipley,J. and
CC   GPRFLN|            Crompton,M.R.
CC   GPRFLN|  TITLE     ICAAR, a novel member of a new family of transmembrane, tyrosine
CC   GPRFLN|            phosphatase-like proteins
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 229 (2), 402-411 (1996)
CC   GPRFLN|  MEDLINE   97127415
CC   GPRFLN|REFERENCE   5  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Kawasaki,E., Hutton,J.C. and Eisenbarth,G.S.
CC   GPRFLN|  TITLE     Molecular cloning and characterization of the human transmembrane
CC   GPRFLN|            protein tyrosine phosphatase homologue, phogrin, an autoantigen of
CC   GPRFLN|            type 1 diabetes
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 227 (2), 440-447 (1996)
CC   GPRFLN|  MEDLINE   97032784
CC   GPRFLN|REFERENCE   6  (residues 1 to 1015)
CC   GPRFLN|  AUTHORS   Cui,L., Yu,W.P., DeAizpurua,H.J., Schmidli,R.S. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cloning and characterization of islet cell antigen-related
CC   GPRFLN|            protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and
CC   GPRFLN|            autoantigen in insulin-dependent diabetes
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (40), 24817-24823 (1996)
CC   GPRFLN|  MEDLINE   96394649
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       protein tyrosine phosphatase receptor pi; phogrin; tyrosine phosphatase IA-2 beta; IAR/receptor-like protein-tyrosine phosphatase
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    278       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     HMILSYMEDH LKNKNRLEKE WEALCAYQAE PNSSFVAQRE ENVPKNRSLA VLTYDHSRVL        60
     LKAENSHSHS DYINASPIMD HDPRNPAYIA TQGPLPATVA DFWQMVWESG CVVIVMLTPL       120
     AENGVRQCYH YWPDEGSNLY HIYEVNLVSE HIWCEDFLVR SFYLKNLQTN ETRTVTQFHF       180
     LSWYDRGVPS SSRSLLDFRR KVNKCYRGRS CPIIVHCSDG AGRSGTYVLI DMVLNKMAKG       240
     AKEIDIAATL EHLRDQRPGM VQTKEQFEFA LTAVAEEVN                              279
//
ID   hLAR_D1\(NP_002831)\PTPRF STANDARD;PRT;   275 AA.
AC   NP_002831;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, F isoform 1 precursor; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from Y00815.1 and BI711143.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. The extracellular region contains three Ig-like
CC   domains, and nine non-Ig like domains similar to that of
CC   neural-cell adhesion molecule. This PTP was shown to function in
CC   the regulation of epithelial cell-cell contacts at adherents
CC   junctions, as well as in the control of beta-catenin signaling. An
CC   increased expression level of this protein was found in the
CC   insulin-responsive tissue of obese, insulin-resistant individuals,
CC   and may contribute to the pathogenesis of insulin resistance. Two
CC   alternatively spliced transcript variants of this gene, which
CC   encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (1) contains an extra internal
CC   fragment within the coding region when compared to variant 2. It
CC   thus encodes a protein that has a 9 aa internal fragment absent in
CC   isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Symons,J.R., LeVea,C.M. and Mooney,R.A.
CC   GPRFLN|  TITLE     Expression of the leucocyte common antigen-related (LAR) tyrosine
CC   GPRFLN|            phosphatase is regulated by cell density through functional
CC   GPRFLN|            E-cadherin complexes
CC   GPRFLN|  JOURNAL   Biochem. J. 365 (Pt 2), 513-519 (2002)
CC   GPRFLN|  MEDLINE   22090243
CC   GPRFLN|  REMARK    GeneRIF: regulation of expression by cell density through
CC   GPRFLN|            functional E-cadherin complexes
CC   GPRFLN|REFERENCE   3  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Zabolotny,J.M., Kim,Y.B., Peroni,O.D., Kim,J.K., Pani,M.A.,
CC   GPRFLN|            Boss,O., Klaman,L.D., Kamatkar,S., Shulman,G.I., Kahn,B.B. and
CC   GPRFLN|            Neel,B.G.
CC   GPRFLN|  TITLE     Overexpression of the LAR (leukocyte antigen-related)
CC   GPRFLN|            protein-tyrosine phosphatase in muscle causes insulin resistance
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (9), 5187-5192 (2001)
CC   GPRFLN|  MEDLINE   21221100
CC   GPRFLN|REFERENCE   4  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Muller,T., Choidas,A., Reichmann,E. and Ullrich,A.
CC   GPRFLN|  TITLE     Phosphorylation and free pool of beta-catenin are regulated by
CC   GPRFLN|            tyrosine kinases and tyrosine phosphatases during epithelial cell
CC   GPRFLN|            migration
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (15), 10173-10183 (1999)
CC   GPRFLN|  MEDLINE   99214576
CC   GPRFLN|REFERENCE   5  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Ahmad,F. and Goldstein,B.J.
CC   GPRFLN|  TITLE     Functional association between the insulin receptor and the
CC   GPRFLN|            transmembrane protein-tyrosine phosphatase LAR in intact cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (1), 448-457 (1997)
CC   GPRFLN|  MEDLINE   97150746
CC   GPRFLN|REFERENCE   6  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Harder,K.W., Saw,J., Miki,N. and Jirik,F.
CC   GPRFLN|  TITLE     Coexisting amplifications of the chromosome 1p32 genes (PTPRF and
CC   GPRFLN|            MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a
CC   GPRFLN|            small cell lung cancer line
CC   GPRFLN|  JOURNAL   Genomics 27 (3), 552-553 (1995)
CC   GPRFLN|  MEDLINE   96047346
CC   GPRFLN|REFERENCE   7  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Schaapveld,R.Q., van den Maagdenberg,A.M., Schepens,J.T.,
CC   GPRFLN|            Weghuis,D.O., Geurts van Kessel,A., Wieringa,B. and Hendriks,W.J.
CC   GPRFLN|  TITLE     The mouse gene Ptprf encoding the leukocyte common antigen-related
CC   GPRFLN|            molecule LAR: cloning, characterization, and chromosomal
CC   GPRFLN|            localization
CC   GPRFLN|  JOURNAL   Genomics 27 (1), 124-130 (1995)
CC   GPRFLN|  MEDLINE   95394448
CC   GPRFLN|REFERENCE   8  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   O'Grady,P., Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Genomic organization of the human LAR protein tyrosine phosphatase
CC   GPRFLN|            gene and alternative splicing in the extracellular fibronectin
CC   GPRFLN|            type-III domains
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (40), 25193-25199 (1994)
CC   GPRFLN|  MEDLINE   95014301
CC   GPRFLN|REFERENCE   9  (residues 1 to 1897)
CC   GPRFLN|  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
CC   GPRFLN|  TITLE     A new member of the immunoglobulin superfamily that has a
CC   GPRFLN|            cytoplasmic region homologous to the leukocyte common antigen
CC   GPRFLN|  JOURNAL   J. Exp. Med. 168 (5), 1523-1530 (1988)
CC   GPRFLN|  MEDLINE   89035978
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog
FT                                VNTIFKEY:270
FT   CHAIN         1    275       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    272       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_4
SQ   SEQUENCE   275 AA;
     TDLADNIERL KANDGLKFSQ EYESIDPGQQ FTWENSNLEV NKPKNRYANV IAYDHSRVIL        60
     TSIDGVPGSD YINANYIDGY RKQNAYIATQ GPLPETMGDF WRMVWEQRTA TVVMMTRLEE       120
     KSRVKCDQYW PARGTETCGL IQVTLLDTVE LATYTVRTFA LHKSGSSEKR ELRQFQFMAW       180
     PDHGVPEYPT PILAFLRRVK ACNPLDAGPM VVHCSAGVGR TGCFIVIDAM LERMKHEKTV       240
     DIYGHVTCMR SQRNYMVQTE DQYVFIHEAL LEAAT                                  275
//
ID   hLyPTP_D1\(NP_057051)\PTPN22 STANDARD;PRT;   287 AA.
AC   NP_057051;
DT   30-JUN-2003
DE   lymphoid-specific protein tyrosine phosphatase isoform 1; lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from AF077031.1 and AF001846.1.
CC   
CC   Summary: This gene encodes a protein tyrosine phosphatase which is
CC   expressed primarily in lymphoid tissues. This enzyme associates
CC   with the molecular adapter protein CBL and may be involved in
CC   regulating CBL function in the T-cell receptor signaling pathway.
CC   Alternative splicing of this gene results in two transcript
CC   variants encoding distinct isoforms.
CC   
CC   Transcript Variant: This variant (1) encodes the longer isoform (1)
CC   which is 116 aa longer than isoform 2 and has a distinct
CC   C-terminus.
CC   GPRFLN|REFERENCE   1  (residues 1 to 807)
CC   GPRFLN|  AUTHORS   Hill,R.J., Zozulya,S., Lu,Y.L., Ward,K., Gishizky,M. and Jallal,B.
CC   GPRFLN|  TITLE     The lymphoid protein tyrosine phosphatase Lyp interacts with the
CC   GPRFLN|            adaptor molecule Grb2 and functions as a negative regulator of
CC   GPRFLN|            T-cell activation
CC   GPRFLN|  JOURNAL   Exp. Hematol. 30 (3), 237-244 (2002)
CC   GPRFLN|  MEDLINE   21876996
CC   GPRFLN|  REMARK    GeneRIF: data demonstrate a novel interaction between Lyp and the
CC   GPRFLN|            adaptor Grb2 and are consistent with a negative regulatory role for
CC   GPRFLN|            Lyp in T-cell signaling.
CC   GPRFLN|REFERENCE   2  (residues 1 to 807)
CC   GPRFLN|  AUTHORS   Cohen,S., Dadi,H., Shaoul,E., Sharfe,N. and Roifman,C.M.
CC   GPRFLN|  TITLE     Cloning and characterization of a lymphoid-specific, inducible
CC   GPRFLN|            human protein tyrosine phosphatase, Lyp
CC   GPRFLN|  JOURNAL   Blood 93 (6), 2013-2024 (1999)
CC   GPRFLN|  MEDLINE   99168989
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    287       VNTIFKEY:269
FT   PROTEIN       1    287       lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase homolog
FT                                VNTIFKEY:270
FT   REGION       20    287       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   287 AA;
     EILQKFLDEA QSKKITKEEF ANEFLKLKRQ STKYKADKTY PTTVAEKPKN IKKNRYKDIL        60
     PYDYSRVELS LITSDEDSSY INANFIKGVY GPKAYIATQG PLSTTLLDFW RMIWEYSVLI       120
     IGMACMEYEM GKKKCERYWA EPVEMQLEFG PFSVSCEAEK RKSDYIIRTL KVKFNSETRT       180
     IYQFHYKNWP DHDVPSSIDP ILELIWDVRC YQEDDSVPIC IHCSAGCGRT GVICAIDYTW       240
     MLLKDGIIPE NFSVFSLIRE MRTQRPSLVQ TQEQYELVYN AVLELFK                     287
//
ID   hMEG1_D1\(NP_002821)\PTPN4 STANDARD;PRT;   277 AA.
AC   NP_002821;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 4; megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M68941.1 and BC010674.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This protein contains a C-terminal PTP
CC   domain and an N-terminal domain homologous to the band 4.1
CC   superfamily of cytoskeletal-associated proteins. This PTP has been
CC   shown to interact with glutamate receptor delta 2 and epsilon
CC   subunits, and is thought to play a role in signalling downstream of
CC   the glutamate receptors through tyrosine dephosphorylation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Hironaka,K., Umemori,H., Tezuka,T., Mishina,M. and Yamamoto,T.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase PTPMEG interacts with glutamate
CC   GPRFLN|            receptor delta 2 and epsilon subunits
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (21), 16167-16173 (2000)
CC   GPRFLN|  MEDLINE   20283654
CC   GPRFLN|REFERENCE   2  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Gu,M., Meng,K. and Majerus,P.W.
CC   GPRFLN|  TITLE     The effect of overexpression of the protein tyrosine phosphatase
CC   GPRFLN|            PTPMEG on cell growth and on colony formation in soft agar in COS-7
CC   GPRFLN|            cells
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (23), 12980-12985 (1996)
CC   GPRFLN|  MEDLINE   97075104
CC   GPRFLN|REFERENCE   3  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Gu,M. and Majerus,P.W.
CC   GPRFLN|  TITLE     The properties of the protein tyrosine phosphatase PTPMEG
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (44), 27751-27759 (1996)
CC   GPRFLN|  MEDLINE   97066967
CC   GPRFLN|REFERENCE   4  (residues 1 to 926)
CC   GPRFLN|  AUTHORS   Gu,M.X., York,J.D., Warshawsky,I. and Majerus,P.W.
CC   GPRFLN|  TITLE     Identification, cloning, and expression of a cytosolic
CC   GPRFLN|            megakaryocyte protein-tyrosine-phosphatase with sequence homology
CC   GPRFLN|            to cytoskeletal protein 4.1
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (13), 5867-5871 (1991)
CC   GPRFLN|  MEDLINE   91288564
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    277       VNTIFKEY:269
FT   PROTEIN       1    277       megakaryocyte phosphatase; PTPase-MEG1; protein tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       19    277       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   277 AA;
     HSLRESMIQL AEGLITGTVL TQFDQLYRKK PGMTMSCAKL PQNISKNRYR DISPYDATRV        60
     ILKGNEDYIN ANYINMEIPS SSIINQYIAC QGPLPHTCTD FWQMTWEQGS SMVVMLTTQV       120
     ERGRVKCHQY WPEPTGSSSY GCYQVTCHSE EGNTAYIFRK MTLFNQEKNE SRPLTQIQYI       180
     AWPDHGVPDD SSDFLDFVCH VRNKRAGKEE PVVVHCSAGI GRTGVLITME TAMCLIECNQ       240
     PVYPLDIVRT MRDQRAMMIQ TPSQYRFVCE AILKVYE                                277
//
ID   hMEG2_D1\(NP_002824)\PTPN9 STANDARD;PRT;   291 AA.
AC   NP_002824;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 9; protein-tyrosine phosphatase MEG2; PTPase-MEG2 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M83738.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an N-terminal domain
CC   that shares a significant similarity with yeast SEC14, which is a
CC   protein that has phosphatidylinositol transfer activity and is
CC   required for protein secretion through the Golgi complex in yeast.
CC   This PTP was found to be activated by polyphosphoinositide, and is
CC   thought to be involved in signaling events regulating phagocytosis.
CC   GPRFLN|REFERENCE   1  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Qi,Y., Zhao,R., Cao,H., Sui,X., Krantz,S.B. and Zhao,Z.J.
CC   GPRFLN|  TITLE     Purification and characterization of protein tyrosine phosphatase
CC   GPRFLN|            PTP-MEG2
CC   GPRFLN|  JOURNAL   J. Cell. Biochem. 86 (1), 79-89 (2002)
CC   GPRFLN|  MEDLINE   22106294
CC   GPRFLN|  REMARK    GeneRIF: Purification and characterization of protein tyrosine
CC   GPRFLN|            phosphatase PTP-MEG2
CC   GPRFLN|REFERENCE   2  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Kruger,J.M., Fukushima,T., Cherepanov,V., Borregaard,N., Loeve,C.,
CC   GPRFLN|            Shek,C., Sharma,K., Tanswell,A.K., Chow,C.W. and Downey,G.P.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase MEG2 is expressed by human
CC   GPRFLN|            neutrophils. Localization to the phagosome and activation by
CC   GPRFLN|            polyphosphoinositides
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (4), 2620-2628 (2002)
CC   GPRFLN|  MEDLINE   21659736
CC   GPRFLN|REFERENCE   3  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Gu,M., Warshawsky,I. and Majerus,P.W.
CC   GPRFLN|  TITLE     Cloning and expression of a cytosolic megakaryocyte
CC   GPRFLN|            protein-tyrosine-phosphatase with sequence homology to
CC   GPRFLN|            retinaldehyde-binding protein and yeast SEC14p
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2980-2984 (1992)
CC   GPRFLN|  MEDLINE   92212952
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    291       VNTIFKEY:269
FT   PROTEIN       1    291       protein-tyrosine phosphatase MEG2; PTPase-MEG2
FT                                VNTIFKEY:270
FT   REGION       17    291       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   291 AA;
     MTIQELVDYV NARQKQGIYE EYEDIRRENP VGTFHCSMSP GNLEKNRYGD VPCLDQTRVK        60
     LTKRSGHTQT DYINASFMDG YKQKNAYIGT QGPLENTYRD FWLMVWEQKV LVIVMTTRFE       120
     EGGRRKCGQY WPLEKDSRIR FGFLTVTNLG VENMNHYKKT TLEIHNTEER QKRQVTHFQF       180
     LSWPDYGVPS SAASLIDFLR VVRNQQSLAV SNMGARSKGQ CPEPPIVVHC SAGIGRTGTF       240
     CSLDICLAQL EELGTLNVFQ TVSRMRTQRA FSIQTPEQYY FCYKAILEFA E                291
//
ID   hPCPTP1_D1\(NP_002840)\PTPRR STANDARD;PRT;   275 AA.
AC   NP_002840;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, R isoform 1 precursor; protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from D64053.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single intracellular
CC   catalytic domains, and thus represents a receptor-type PTP. The
CC   similar gene predominately expressed in mouse brain was found to
CC   associate with, and thus regulate the activity and cellular
CC   localization of MAP kinases. The rat counterpart of this gene was
CC   reported to be regulated by the nerve growth factor, which
CC   suggested the function of this gene in neuronal growth and
CC   differentiation.
CC   
CC   Transcript Variant: This variant (1) contains a different 5' end
CC   region when compared to variant 2. It thus encodes a protein that
CC   has a longer N-terminus, as compared to isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Blanco-Aparicio,C., Torres,J. and Pulido,R.
CC   GPRFLN|  TITLE     A novel regulatory mechanism of MAP kinases activation and nuclear
CC   GPRFLN|            translocation mediated by PKA and the PTP-SL tyrosine phosphatase
CC   GPRFLN|  JOURNAL   J. Cell Biol. 147 (6), 1129-1136 (1999)
CC   GPRFLN|  MEDLINE   20069779
CC   GPRFLN|REFERENCE   2  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H.
CC   GPRFLN|  TITLE     Cloning and expression of PCPTP1 encoding protein tyrosine
CC   GPRFLN|            phosphatase
CC   GPRFLN|  JOURNAL   Gene 162 (2), 279-284 (1995)
CC   GPRFLN|  MEDLINE   96032358
CC   GPRFLN|  REMARK    founctional study of the rat homolog
CC   GPRFLN|REFERENCE   3  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Ogata,M., Sawada,M., Fujino,Y. and Hamaoka,T.
CC   GPRFLN|  TITLE     cDNA cloning and characterization of a novel receptor-type protein
CC   GPRFLN|            tyrosine phosphatase expressed predominantly in the brain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (5), 2337-2343 (1995)
CC   GPRFLN|  MEDLINE   95138207
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   4  (residues 1 to 657)
CC   GPRFLN|  AUTHORS   Sharma,E. and Lombroso,P.J.
CC   GPRFLN|  TITLE     A neuronal protein tyrosine phosphatase induced by nerve growth
CC   GPRFLN|            factor
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (1), 49-53 (1995)
CC   GPRFLN|  MEDLINE   95113874
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       protein tyrosine phosphatase, receptor type, Q; protein-tyrosine phosphatase NC-PTPCOM1; protein tyrosine phosphatase Cr1PTPase precursor; Ch-1 PTPase
FT                                VNTIFKEY:270
FT   CHAIN         1    275       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       18    273       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   275 AA;
     SRILTRSQLR DVVASSHLLQ SEFMEIPMNF VDPKEIDIPR HGTKNRYKTI LPNPLSRVCL        60
     RPKNVTDSLS TYINANYIRG YSGKEKAFIA TQGPMINTVD DFWQMVWQED SPVIVMITKL       120
     KEKNEKCVLY WPEKRGIYGK VEVLVISVNE CDNYTIRNLV LKQGSHTQHV KHYWYTSWPD       180
     HKTPDSAQPL LQLMLDVEED RLASQGRGPV VVHCSAGIGR TGCFIATSIG CQQLKEEGVV       240
     DALSIVCQLR MDRGGMVQTS EQYEFVHHAL CLYES                                  275
//
ID   hPEST_D1\(NP_002826)\PTPN12 STANDARD;PRT;   288 AA.
AC   NP_002826;
DT   3-JUL-2003
DE   protein tyrosine phosphatase, non-receptor type 12; protein-tyrosine phosphatase G1 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M93425.1.
CC   On Jan 25, 2002 this sequence version replaced gi:4506287.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains a C-terminal PEST
CC   motif, which serves as a protein-protein interaction domain, and
CC   may be related to protein intracellular half-life. This PTP was
CC   found to bind and dephosphorylate the product of oncogene c-ABL,
CC   thus may play a role in oncogenesis. This PTP was shown to interact
CC   with, and dephosphorylate, various of cytoskeleton and cell
CC   adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and
CC   paxillin, which suggested its regulatory roles in controlling cell
CC   shape and mobility.
CC   GPRFLN|REFERENCE   1  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Lyons,P.D., Dunty,J.M., Schaefer,E.M. and Schaller,M.D.
CC   GPRFLN|  TITLE     Inhibition of the catalytic activity of cell adhesion kinase beta
CC   GPRFLN|            by protein-tyrosine phosphatase-PEST-mediated dephosphorylation
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (26), 24422-24431 (2001)
CC   GPRFLN|  MEDLINE   21316574
CC   GPRFLN|REFERENCE   2  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Cong,F., Spencer,S., Cote,J.F., Wu,Y., Tremblay,M.L., Lasky,L.A.
CC   GPRFLN|            and Goff,S.P.
CC   GPRFLN|  TITLE     Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine
CC   GPRFLN|            phosphatase to the c-Abl kinase to mediate Abl dephosphorylation
CC   GPRFLN|  JOURNAL   Mol. Cell 6 (6), 1413-1423 (2000)
CC   GPRFLN|  MEDLINE   21111050
CC   GPRFLN|REFERENCE   3  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Shen,Y., Lyons,P., Cooley,M., Davidson,D., Veillette,A., Salgia,R.,
CC   GPRFLN|            Griffin,J.D. and Schaller,M.D.
CC   GPRFLN|  TITLE     The noncatalytic domain of protein-tyrosine phosphatase-PEST
CC   GPRFLN|            targets paxillin for dephosphorylation in vivo
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (2), 1405-1413 (2000)
CC   GPRFLN|  MEDLINE   20092920
CC   GPRFLN|REFERENCE   4  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Nishiya,N., Iwabuchi,Y., Shibanuma,M., Cote,J.F., Tremblay,M.L. and
CC   GPRFLN|            Nose,K.
CC   GPRFLN|  TITLE     Hic-5, a paxillin homologue, binds to the protein-tyrosine
CC   GPRFLN|            phosphatase PEST (PTP-PEST) through its LIM 3 domain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (14), 9847-9853 (1999)
CC   GPRFLN|  MEDLINE   99194842
CC   GPRFLN|REFERENCE   5  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Garton,A.J. and Tonks,N.K.
CC   GPRFLN|  TITLE     Regulation of fibroblast motility by the protein tyrosine
CC   GPRFLN|            phosphatase PTP-PEST
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (6), 3811-3818 (1999)
CC   GPRFLN|  MEDLINE   99121127
CC   GPRFLN|REFERENCE   6  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Adachi,M., Ariyama,T., Inazawa,J.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Chromosomal localization of the protein tyrosine phosphatase G1
CC   GPRFLN|            gene and characterization of the aberrant transcripts in human
CC   GPRFLN|            colon cancer cells
CC   GPRFLN|  JOURNAL   FEBS Lett. 339 (3), 222-228 (1994)
CC   GPRFLN|  MEDLINE   94156037
CC   GPRFLN|REFERENCE   7  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Yang,Q., Co,D., Sommercorn,J. and Tonks,N.K.
CC   GPRFLN|  TITLE     Cloning and expression of PTP-PEST. A novel, human,
CC   GPRFLN|            nontransmembrane protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 268 (9), 6622-6628 (1993)
CC   GPRFLN|  MEDLINE   93203262
CC   GPRFLN|REFERENCE   8  (residues 1 to 780)
CC   GPRFLN|  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Arimura,Y., Toyota,M., Sekiya,M.,
CC   GPRFLN|            Adachi,M., Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Cloning and characterization of a human cDNA encoding a novel
CC   GPRFLN|            putative cytoplasmic protein-tyrosine-phosphatase
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 189 (2), 1223-1230 (1992)
CC   GPRFLN|  MEDLINE   93112015
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    288       VNTIFKEY:269
FT   PROTEIN       1    288       protein-tyrosine phosphatase G1
FT                                VNTIFKEY:270
FT   REGION       21    288       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   288 AA;
     RKFIQRVQAM KSPDHNGEDN FARDFMRLRR LSTKYRTEKI YPTATGEKEE NVKKNRYKDI        60
     LPFDHSRVKL TLKTPSQDSD YINANFIKGV YGPKAYVATQ GPLANTVIDF WRMIWEYNVV       120
     IIVMACREFE MGRKKCERYW PLYGEDPITF APFKISCEDE QARTDYFIRT LLLEFQNESR       180
     RLYQFHYVNW PDHDVPSSFD SILDMISLMR KYQEHEDVPI CIHCSAGCGR TGAICAIDYT       240
     WNLLKAGKIP EEFNVFNLIQ EMRTQRHSAV QTKEQYELVH RAIAQLFE                    288
//
ID   hPTP1B_D1\(NP_002818)\PTPN1 STANDARD;PRT;   279 AA.
AC   NP_002818;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 1; non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M33689.1 and AU117677.1.
CC   
CC   Summary: The protein encoded by this gene is the founding member of
CC   the protein tyrosine phosphatase (PTP) family, which was isolated
CC   and identified based on its enzymatic activity and amino acid
CC   sequence. PTPs catalyze the hydrolysis of the phosphate monoesters
CC   specifically on tyrosine residues. Members of the PTP family share
CC   a highly conserved catalytic motif, which is essential for the
CC   catalytic activity. PTPs are known to be signaling molecules that
CC   regulate a variety of cellular processes including cell growth,
CC   differentiation, mitotic cycle, and oncogenic transformation. This
CC   PTP has been shown to act as a negative regulator of insulin
CC   signaling by dephosphorylating the phosphotryosine residues of
CC   insulin receptor kinase. This PTP was also reported to
CC   dephosphorylate epidermal growth factor receptor kinase, as well as
CC   JAK2 and TYK2 kinases, which implicated the role of this PTP in
CC   cell growth control, and cell response to interferon stimulation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Li,S. and Whorton,A.R.
CC   GPRFLN|  TITLE     Regulation of protein tyrosine phosphatase 1B in intact cells by
CC   GPRFLN|            S-nitrosothiols
CC   GPRFLN|  JOURNAL   Arch. Biochem. Biophys. 410 (2), 269-279 (2003)
CC   GPRFLN|  MEDLINE   22461115
CC   GPRFLN|  REMARK    GeneRIF: PTP1B inhibition by S-nitrosylation is caused by formation
CC   GPRFLN|            of a mixed disulfide
CC   GPRFLN|REFERENCE   2  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Fukada,T. and Tonks,N.K.
CC   GPRFLN|  TITLE     Identification of YB-1 as a regulator of PTP1B expression:
CC   GPRFLN|            implications for regulation of insulin and cytokine signaling
CC   GPRFLN|  JOURNAL   EMBO J. 22 (3), 479-493 (2003)
CC   GPRFLN|  MEDLINE   22441887
CC   GPRFLN|  REMARK    GeneRIF: Data show that Y box-binding protein-1 (YB-1) is a
CC   GPRFLN|            regulator of protein tyrosine phosphatase 1B (PTP1B) expression,
CC   GPRFLN|            and highlight PTP1B as a critical regulator of insulin- and
CC   GPRFLN|            cytokine-mediated signal transduction.
CC   GPRFLN|REFERENCE   3  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Yigzaw,Y., Poppleton,H.M., Sreejayan,N., Hassid,A. and Patel,T.B.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory
CC   GPRFLN|            actions of Sprouty
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 278 (1), 284-288 (2003)
CC   GPRFLN|  MEDLINE   22393490
CC   GPRFLN|  REMARK    GeneRIF: Data show that an increase in soluble protein-tyrosine
CC   GPRFLN|            phosphatase 1B activity contributes to the anti-migratory, but not
CC   GPRFLN|            anti-mitogenic, actions of human Sprouty 2.
CC   GPRFLN|REFERENCE   4  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Di Paola,R., Frittitta,L., Miscio,G., Bozzali,M., Baratta,R.,
CC   GPRFLN|            Centra,M., Spampinato,D., Santagati,M.G., Ercolino,T.,
CC   GPRFLN|            Cisternino,C., Soccio,T., Mastroianno,S., Tassi,V., Almgren,P.,
CC   GPRFLN|            Pizzuti,A., Vigneri,R. and Trischitta,V.
CC   GPRFLN|  TITLE     A variation in 3' UTR of hPTP1B increases specific gene expression
CC   GPRFLN|            and associates with insulin resistance
CC   GPRFLN|  JOURNAL   Am. J. Hum. Genet. 70 (3), 806-812 (2002)
CC   GPRFLN|  MEDLINE   21832513
CC   GPRFLN|  REMARK    GeneRIF: variation in 3' UTR of hPTP1B increases specific gene
CC   GPRFLN|            expression and associates with insulin resistance
CC   GPRFLN|REFERENCE   5  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Myers,M.P., Andersen,J.N., Cheng,A., Tremblay,M.L., Horvath,C.M.,
CC   GPRFLN|            Parisien,J.P., Salmeen,A., Barford,D. and Tonks,N.K.
CC   GPRFLN|  TITLE     TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (51), 47771-47774 (2001)
CC   GPRFLN|  MEDLINE   21611285
CC   GPRFLN|REFERENCE   6  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Wang,J., Cheung,A.T., Kolls,J.K., Starks,W.W.,
CC   GPRFLN|            Martinez-Hernandez,A., Dietzen,D. and Bryer-Ash,M.
CC   GPRFLN|  TITLE     Effects of adenovirus-mediated liver-selective overexpression of
CC   GPRFLN|            protein tyrosine phosphatase-1b on insulin sensitivity in vivo
CC   GPRFLN|  JOURNAL   Diabetes Obes Metab 3 (5), 367-380 (2001)
CC   GPRFLN|  MEDLINE   21560532
CC   GPRFLN|  REMARK    GeneRIF: Moderate overabundance of PTP-1B in liver tissue does not
CC   GPRFLN|            alter insulin action on glucose metabolism, and the site of action
CC   GPRFLN|            of PTP-1B is presumably at insulin-responsive target tissue or
CC   GPRFLN|            tissues other than the liver.
CC   GPRFLN|REFERENCE   7  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Dadke,S., Kusari,A. and Kusari,J.
CC   GPRFLN|  TITLE     Phosphorylation and activation of protein tyrosine phosphatase
CC   GPRFLN|            (PTP) 1B by insulin receptor
CC   GPRFLN|  JOURNAL   Mol. Cell. Biochem. 221 (1-2), 147-154 (2001)
CC   GPRFLN|  MEDLINE   21396990
CC   GPRFLN|REFERENCE   8  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Egawa,K., Maegawa,H., Shimizu,S., Morino,K., Nishio,Y.,
CC   GPRFLN|            Bryer-Ash,M., Cheung,A.T., Kolls,J.K., Kikkawa,R. and Kashiwagi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase-1B negatively regulates insulin
CC   GPRFLN|            signaling in l6 myocytes and Fao hepatoma cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (13), 10207-10211 (2001)
CC   GPRFLN|  MEDLINE   21167830
CC   GPRFLN|REFERENCE   9  (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Salmeen,A., Andersen,J.N., Myers,M.P., Tonks,N.K. and Barford,D.
CC   GPRFLN|  TITLE     Molecular basis for the dephosphorylation of the activation segment
CC   GPRFLN|            of the insulin receptor by protein tyrosine phosphatase 1B
CC   GPRFLN|  JOURNAL   Mol. Cell 6 (6), 1401-1412 (2000)
CC   GPRFLN|  MEDLINE   21111049
CC   GPRFLN|REFERENCE   10 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S.,
CC   GPRFLN|            Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P.
CC   GPRFLN|  TITLE     Residue 259 is a key determinant of substrate specificity of
CC   GPRFLN|            protein-tyrosine phosphatases 1B and alpha
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (24), 18201-18209 (2000)
CC   GPRFLN|  MEDLINE   20309769
CC   GPRFLN|REFERENCE   11 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Ahmad,F., Li,P.M., Meyerovitch,J. and Goldstein,B.J.
CC   GPRFLN|  TITLE     Osmotic loading of neutralizing antibodies demonstrates a role for
CC   GPRFLN|            protein-tyrosine phosphatase 1B in negative regulation of the
CC   GPRFLN|            insulin action pathway
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (35), 20503-20508 (1995)
CC   GPRFLN|  MEDLINE   95386495
CC   GPRFLN|REFERENCE   12 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Milarski,K.L., Zhu,G., Pearl,C.G., McNamara,D.J., Dobrusin,E.M.,
CC   GPRFLN|            MacLean,D., Thieme-Sefler,A., Zhang,Z.Y., Sawyer,T., Decker,S.J. et
CC   GPRFLN|            al.
CC   GPRFLN|  TITLE     Sequence specificity in recognition of the epidermal growth factor
CC   GPRFLN|            receptor by protein tyrosine phosphatase 1B
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 268 (31), 23634-23639 (1993)
CC   GPRFLN|  MEDLINE   94043167
CC   GPRFLN|REFERENCE   13 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Brown-Shimer,S., Johnson,K.A., Lawrence,J.B., Johnson,C.,
CC   GPRFLN|            Bruskin,A., Green,N.R. and Hill,D.E.
CC   GPRFLN|  TITLE     Molecular cloning and chromosome mapping of the human gene encoding
CC   GPRFLN|            protein phosphotyrosyl phosphatase 1B
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5148-5152 (1990)
CC   GPRFLN|  MEDLINE   90311360
CC   GPRFLN|REFERENCE   14 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Chernoff,J., Schievella,A.R., Jost,C.A., Erikson,R.L. and Neel,B.G.
CC   GPRFLN|  TITLE     Cloning of a cDNA for a major human protein-tyrosine-phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (7), 2735-2739 (1990)
CC   GPRFLN|  MEDLINE   90207272
CC   GPRFLN|REFERENCE   15 (residues 1 to 435)
CC   GPRFLN|  AUTHORS   Charbonneau,H., Tonks,N.K., Kumar,S., Diltz,C.D., Harrylock,M.,
CC   GPRFLN|            Cool,D.E., Krebs,E.G., Fischer,E.H. and Walsh,K.A.
CC   GPRFLN|  TITLE     Human placenta protein-tyrosine-phosphatase: amino acid sequence
CC   GPRFLN|            and relationship to a family of receptor-like proteins
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5252-5256 (1989)
CC   GPRFLN|  MEDLINE   89315775
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       non-receptor tyrosine phophatase 1; protein tyrosine phophatase 1B; protein tyrosine phophatase, placental
FT                                VNTIFKEY:270
FT   REGION        3    279       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH        60
     QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK       120
     CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP       180
     DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD       240
     PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAK                              279
//
ID   hPTPalpha_D1\(NP_002827)\PTPRA STANDARD;PRT;   280 AA.
AC   NP_002827;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, A isoform 1 precursor; protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M34668.1 and AI284972.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. This PTP has been shown to dephosphorylate and
CC   activate Src family tyrosine kinases, and is implicated in the
CC   regulation of integrin signaling, cell adhesion and proliferation.
CC   Three alternatively spliced variants of this gene, which encode two
CC   distinct isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) contains a unique 5' UTR
CC   region when compared to other variants. The genomic exons forming
CC   the 5' end region of this transcript are also used to form an
CC   internal coding region in the transcripts of VPS16, a distinct gene
CC   located at the locus immediately upstream of this gene on
CC   chromosome 20. This variant encodes the longest isoform (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Mustelin,T. and Hunter,T.
CC   GPRFLN|  TITLE     Meeting at mitosis: cell cycle-specific regulation of c-Src by
CC   GPRFLN|            RPTPalpha
CC   GPRFLN|  JOURNAL   Sci STKE 2002 (115), PE3 (2002)
CC   GPRFLN|  MEDLINE   21655780
CC   GPRFLN|  REMARK    GeneRIF: In entering mitosis the cell cycle-specific regulation of
CC   GPRFLN|            c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527
CC   GPRFLN|            that activates c-Src in a reaction catalyzed by the transmembrane
CC   GPRFLN|            receptor-like protein tyrosine phosphatase RPTPalpha.
CC   GPRFLN|REFERENCE   3  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Ardini,E., Agresti,R., Tagliabue,E., Greco,M., Aiello,P.,
CC   GPRFLN|            Yang,L.T., Menard,S. and Sap,J.
CC   GPRFLN|  TITLE     Expression of protein tyrosine phosphatase alpha (RPTPalpha) in
CC   GPRFLN|            human breast cancer correlates with low tumor grade, and inhibits
CC   GPRFLN|            tumor cell growth in vitro and in vivo
CC   GPRFLN|  JOURNAL   Oncogene 19 (43), 4979-4987 (2000)
CC   GPRFLN|  MEDLINE   20499263
CC   GPRFLN|REFERENCE   4  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Peters,G.H., Iversen,L.F., Branner,S., Andersen,H.S.,
CC   GPRFLN|            Mortensen,S.B., Olsen,O.H., Moller,K.B. and Moller,N.P.
CC   GPRFLN|  TITLE     Residue 259 is a key determinant of substrate specificity of
CC   GPRFLN|            protein-tyrosine phosphatases 1B and alpha
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (24), 18201-18209 (2000)
CC   GPRFLN|  MEDLINE   20309769
CC   GPRFLN|REFERENCE   5  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Harder,K.W., Moller,N.P., Peacock,J.W. and Jirik,F.R.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase alpha regulates Src family kinases and
CC   GPRFLN|            alters cell-substratum adhesion
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (48), 31890-31900 (1998)
CC   GPRFLN|  MEDLINE   99041953
CC   GPRFLN|REFERENCE   6  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Zheng,X.M., Wang,Y. and Pallen,C.J.
CC   GPRFLN|  TITLE     Cell transformation and activation of pp60c-src by overexpression
CC   GPRFLN|            of a protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Nature 359 (6393), 336-339 (1992)
CC   GPRFLN|  MEDLINE   93024881
CC   GPRFLN|REFERENCE   7  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Rao,V.V., Loffler,C., Sap,J., Schlessinger,J. and Hansmann,I.
CC   GPRFLN|  TITLE     The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is
CC   GPRFLN|            assigned to human chromosome 20p12-pter by in situ hybridization
CC   GPRFLN|            (ISH and FISH)
CC   GPRFLN|  JOURNAL   Genomics 13 (3), 906-907 (1992)
CC   GPRFLN|  MEDLINE   92347910
CC   GPRFLN|REFERENCE   8  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Ohagi,S., Nishi,M. and Steiner,D.F.
CC   GPRFLN|  TITLE     Sequence of a cDNA encoding human LRP (leukocyte common
CC   GPRFLN|            antigen-related peptide)
CC   GPRFLN|  JOURNAL   Nucleic Acids Res. 18 (23), 7159 (1990)
CC   GPRFLN|  MEDLINE   91088320
CC   GPRFLN|REFERENCE   9  (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Jirik,F.R., Janzen,N.M., Melhado,I.G. and Harder,K.W.
CC   GPRFLN|  TITLE     Cloning and chromosomal assignment of a widely expressed human
CC   GPRFLN|            receptor-like protein-tyrosine phosphatase
CC   GPRFLN|  JOURNAL   FEBS Lett. 273 (1-2), 239-242 (1990)
CC   GPRFLN|  MEDLINE   91032191
CC   GPRFLN|REFERENCE   10 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   GPRFLN|REFERENCE   11 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   GPRFLN|REFERENCE   12 (residues 1 to 802)
CC   GPRFLN|  AUTHORS   Sap,J., D'Eustachio,P., Givol,D. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning and expression of a widely expressed receptor tyrosine
CC   GPRFLN|            phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6112-6116 (1990)
CC   GPRFLN|  MEDLINE   90349565
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    280       VNTIFKEY:269
FT   PROTEIN       1    280       protein tyrosine phosphatase, receptor type, alpha polypeptide; PTPase-alpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); tyrosine phosphatase alpha; PTPLCA-related phosphatase
FT                                VNTIFKEY:270
FT   CHAIN         1    280       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    280       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   280 AA;
     DKLEEEINRR MADDNKLFRE EFNALPACPI QATCEAASKE ENKEKNRYVN ILPYDHSRVH        60
     LTPVEGVPDS DYINASFING YQEKNKFIAA QGPKEETVND FWRMIWEQNT ATIVMVTNLK       120
     ERKECKCAQY WPDQGCWTYG NIRVSVEDVT VLVDYTVRKF CIQQVGDMTN RKPQRLITQF       180
     HFTSWPDFGV PFTPIGMLKF LKKVKACNPQ YAGAIVVHCS AGVGRTGTFV VIDAMLDMMH       240
     TERKVDVYGF VSRIRAQRCQ MVQTDMQYVF IYQALLEHYL                             280
//
ID   hPTPBAS_D1\(NP_006255)\PTPN13 STANDARD;PRT;   275 AA.
AC   NP_006255;
DT   30-JUN-2003
DE   protein tyrosine phosphatase, non-receptor type 13 isoform 2; protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from D21210.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP is a large protein that
CC   possesses a PTP domain at C-terminus, and multiple noncatalytic
CC   domains, which include a domain with similarity to band 4.1
CC   superfamily of cytoskeletal-associated proteins, a region
CC   consisting of five PDZ domains, and a leucine zipper motif. This
CC   PTP was found to interact with, and dephosphorylate Fas receptor,
CC   as well as IkappaBalpha through the PDZ domains, which suggested
CC   its role in Fas mediated programmed cell death. This PTP was also
CC   shown to interact with GTPase-activating protein, and thus may
CC   function as a regulator of Rho signaling pathway. Four
CC   alternatively spliced transcript variants, which encode distinct
CC   proteins, have been reported.
CC   
CC   Transcript Variant: This variant (2) lacks an internal fragment
CC   within the coding region when compared to variant 4. The
CC   translation remains in frame, and the encoded protein lacks
CC   internal 19 aa, as compared to isoform 4.
CC   GPRFLN|REFERENCE   1  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Yoshida,S., Harada,H., Nagai,H., Fukino,K., Teramoto,A. and Emi,M.
CC   GPRFLN|  TITLE     Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1)
CC   GPRFLN|            and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and
CC   GPRFLN|            seven polymorphisms of the FAP-1 gene
CC   GPRFLN|  JOURNAL   J. Hum. Genet. 47 (11), 614-619 (2002)
CC   GPRFLN|  MEDLINE   22323362
CC   GPRFLN|  REMARK    GeneRIF: Shares a promoter region with the tightly linked gene
CC   GPRFLN|            encoding stress-activated protein kinase JNK3.
CC   GPRFLN|REFERENCE   2  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Bompard,G., Puech,C., Prebois,C., Vignon,F. and Freiss,G.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in
CC   GPRFLN|            human breast cancer cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47861-47869 (2002)
CC   GPRFLN|  MEDLINE   22344658
CC   GPRFLN|  REMARK    GeneRIF: PTPL1/FAP-1 has a key role in the apoptotic process in
CC   GPRFLN|            human breast cancer cells independent of Fas but associated with an
CC   GPRFLN|            early inhibition of the insulin receptor
CC   GPRFLN|            substrate-1/phosphatidylinositol 3-kinase pathway
CC   GPRFLN|REFERENCE   3  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Kozlov,G., Banville,D., Gehring,K. and Ekiel,I.
CC   GPRFLN|  TITLE     Solution structure of the PDZ2 domain from cytosolic human
CC   GPRFLN|            phosphatase hPTP1E complexed with a peptide reveals contribution of
CC   GPRFLN|            the beta2-beta3 loop to PDZ domain-ligand interactions
CC   GPRFLN|  JOURNAL   J. Mol. Biol. 320 (4), 813-820 (2002)
CC   GPRFLN|  MEDLINE   22090786
CC   GPRFLN|  REMARK    GeneRIF: PDZ2 domain from cytosolic human phosphatase hPTP1E
CC   GPRFLN|            complexed with peptide, RA-GEF-2, reveals contribution of the
CC   GPRFLN|            beta2-beta3 loop to PDZ domain-ligand interactions
CC   GPRFLN|REFERENCE   4  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Walma,T., Spronk,C.A., Tessari,M., Aelen,J., Schepens,J.,
CC   GPRFLN|            Hendriks,W. and Vuister,G.W.
CC   GPRFLN|  TITLE     Structure, dynamics and binding characteristics of the second PDZ
CC   GPRFLN|            domain of PTP-BL
CC   GPRFLN|  JOURNAL   J. Mol. Biol. 316 (5), 1101-1110 (2002)
CC   GPRFLN|  MEDLINE   21881810
CC   GPRFLN|  REMARK    GeneRIF: Structure, dynamics and binding characteristics of the
CC   GPRFLN|            second PDZ domain of PTP-BL
CC   GPRFLN|REFERENCE   5  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Marin,L., Minguela,A., Moya-Quiles,M.R., Torio,A., Muro,M.,
CC   GPRFLN|            Garcia-Alonso,A.M., Sanchez-Bueno,F., Bru,M., Parrilla,P. and
CC   GPRFLN|            Alvarez-Lopez,M.R.
CC   GPRFLN|  TITLE     Expression of CD95 and apoptosis induction in peripheral blood
CC   GPRFLN|            cells from liver graft recipients
CC   GPRFLN|  JOURNAL   Transplant. Proc. 34 (1), 280-282 (2002)
CC   GPRFLN|  MEDLINE   21957524
CC   GPRFLN|  REMARK    GeneRIF: expression and apoptosis induction in peripheral blood
CC   GPRFLN|            cells from liver graft
CC   GPRFLN|REFERENCE   6  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Nakai,Y., Irie,S. and Sato,T.A.
CC   GPRFLN|  TITLE     Identification of IkappaBalpha as a substrate of Fas-associated
CC   GPRFLN|            phosphatase-1
CC   GPRFLN|  JOURNAL   Eur. J. Biochem. 267 (24), 7170-7175 (2000)
CC   GPRFLN|  MEDLINE   20558254
CC   GPRFLN|REFERENCE   7  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Irie,S., Hachiya,T., Rabizadeh,S., Maruyama,W., Mukai,J., Li,Y.,
CC   GPRFLN|            Reed,J.C., Bredesen,D.E. and Sato,T.A.
CC   GPRFLN|  TITLE     Functional interaction of Fas-associated phosphatase-1 (FAP-1) with
CC   GPRFLN|            p75(NTR) and their effect on NF-kappaB activation
CC   GPRFLN|  JOURNAL   FEBS Lett. 460 (2), 191-198 (1999)
CC   GPRFLN|  MEDLINE   20012928
CC   GPRFLN|REFERENCE   8  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Maekawa,K., Imagawa,N., Naito,A., Harada,S., Yoshie,O. and
CC   GPRFLN|            Takagi,S.
CC   GPRFLN|  TITLE     Association of protein-tyrosine phosphatase PTP-BAS with the
CC   GPRFLN|            transcription-factor-inhibitory protein IkappaBalpha through
CC   GPRFLN|            interaction between the PDZ1 domain and ankyrin repeats
CC   GPRFLN|  JOURNAL   Biochem. J. 337 (Pt 2), 179-184 (1999)
CC   GPRFLN|  MEDLINE   99102074
CC   GPRFLN|REFERENCE   9  (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Saras,J., Franzen,P., Aspenstrom,P., Hellman,U., Gonez,L.J. and
CC   GPRFLN|            Heldin,C.H.
CC   GPRFLN|  TITLE     A novel GTPase-activating protein for Rho interacts with a PDZ
CC   GPRFLN|            domain of the protein-tyrosine phosphatase PTPL1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (39), 24333-24338 (1997)
CC   GPRFLN|  MEDLINE   97450957
CC   GPRFLN|REFERENCE   10 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Saras,J., Engstrom,U., Gonez,L.J. and Heldin,C.H.
CC   GPRFLN|  TITLE     Characterization of the interactions between PDZ domains of the
CC   GPRFLN|            protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail
CC   GPRFLN|            of Fas
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (34), 20979-20981 (1997)
CC   GPRFLN|  MEDLINE   97407871
CC   GPRFLN|REFERENCE   11 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Yanagisawa,J., Takahashi,M., Kanki,H., Yano-Yanagisawa,H.,
CC   GPRFLN|            Tazunoki,T., Sawa,E., Nishitoba,T., Kamishohara,M., Kobayashi,E.,
CC   GPRFLN|            Kataoka,S. and Sato,T.
CC   GPRFLN|  TITLE     The molecular interaction of Fas and FAP-1. A tripeptide blocker of
CC   GPRFLN|            human Fas interaction with FAP-1 promotes Fas-induced apoptosis
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (13), 8539-8545 (1997)
CC   GPRFLN|  MEDLINE   97236811
CC   GPRFLN|REFERENCE   12 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Inazawa,J., Ariyama,T., Abe,T., Druck,T., Ohta,M., Huebner,K.,
CC   GPRFLN|            Yanagisawa,J., Reed,J.C. and Sato,T.
CC   GPRFLN|  TITLE     PTPN13, a fas-associated protein tyrosine phosphatase, is located
CC   GPRFLN|            on the long arm of chromosome 4 at band q21.3
CC   GPRFLN|  JOURNAL   Genomics 31 (2), 240-242 (1996)
CC   GPRFLN|  MEDLINE   96422192
CC   GPRFLN|REFERENCE   13 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Sato,T., Irie,S., Kitada,S. and Reed,J.C.
CC   GPRFLN|  TITLE     FAP-1: a protein tyrosine phosphatase that associates with Fas
CC   GPRFLN|  JOURNAL   Science 268 (5209), 411-415 (1995)
CC   GPRFLN|  MEDLINE   95232528
CC   GPRFLN|REFERENCE   14 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Saras,J., Claesson-Welsh,L., Heldin,C.H. and Gonez,L.J.
CC   GPRFLN|  TITLE     Cloning and characterization of PTPL1, a protein tyrosine
CC   GPRFLN|            phosphatase with similarities to cytoskeletal-associated proteins
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (39), 24082-24089 (1994)
CC   GPRFLN|  MEDLINE   95014139
CC   GPRFLN|REFERENCE   15 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Banville,D., Ahmad,S., Stocco,R. and Shen,S.H.
CC   GPRFLN|  TITLE     A novel protein-tyrosine phosphatase with homology to both the
CC   GPRFLN|            cytoskeletal proteins of the band 4.1 family and
CC   GPRFLN|            junction-associated guanylate kinases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (35), 22320-22327 (1994)
CC   GPRFLN|  MEDLINE   94350988
CC   GPRFLN|REFERENCE   16 (residues 1 to 2466)
CC   GPRFLN|  AUTHORS   Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S.
CC   GPRFLN|  TITLE     Molecular cloning of a novel protein-tyrosine phosphatase
CC   GPRFLN|            containing a membrane-binding domain and GLGF repeats
CC   GPRFLN|  JOURNAL   FEBS Lett. 337 (2), 200-206 (1994)
CC   GPRFLN|  MEDLINE   94116679
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|JNA|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        4    275       VNTIFKEY:269
FT   PROTEIN       4    275       protein tyrosine phosphatase, nonreceptor type 13; protein tyrosine phosphatase 1E; Fas-associated phosphatase-1; protein-tyrosine phosphatase 1, Fas-associated; protein-tyrosine phophatase PTPL1; APO-1/CD95 (Fas)-associated phosphatase
FT                                VNTIFKEY:270
FT   REGION       20    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   275 AA;
     ANLKSVIRVL RGLLDQGIPS KELENLQELK PLDQCLIGQT KENRRKNRYK NILPYDATRV        60
     PLGDEGGYIN ASFIKIPVGK EEFVYIACQG PLPTTVGDFW QMIWEQKSTV IAMMTQEVEG       120
     EKIKCQRYWP NILGKTTMVS NRLRLALVRM QQLKGFVVRA MTLEDIQTRE VRHISHLNFT       180
     AWPDHDTPSQ PDDLLTFISY MRHIHRSGPI ITHCSAGIGR SGTLICIDVV LGLISQDLDF       240
     DISDLVRCMR LQRHGMVQTE DQYIFCYQVI LYVLT                                  275
//
ID   hPTPbeta_D1\(NP_002828)\PTPRB STANDARD;PRT;   280 AA.
AC   NP_002828;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, B precursor; protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X54131.1 and BE042873.1.
CC   On Feb 4, 2002 this sequence version replaced gi:4506305.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   domain, a single transmembrane segment and one intracytoplasmic
CC   catalytic domain, thus belongs to receptor type PTP. The
CC   extracellular region of this PTP is composed of multiple
CC   fibronectin type_III repeats, which was shown to interact with
CC   neuronal receptor and cell adhesion molecules, such as contactin
CC   and tenascin C. This protein was also found to interact with sodium
CC   channels, and thus may regulate sodium channels by altering
CC   tyrosine phosphorylation status. The functions of the interaction
CC   partners of this protein implicate the roles of this PTP in cell
CC   adhesion, neurite growth, and neuronal differentiation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Adamsky,K., Schilling,J., Garwood,J., Faissner,A. and Peles,E.
CC   GPRFLN|  TITLE     Glial tumor cell adhesion is mediated by binding of the FNIII
CC   GPRFLN|            domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to
CC   GPRFLN|            tenascin C
CC   GPRFLN|  JOURNAL   Oncogene 20 (5), 609-618 (2001)
CC   GPRFLN|  MEDLINE   21214455
CC   GPRFLN|REFERENCE   2  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Ratcliffe,C.F., Qu,Y., McCormick,K.A., Tibbs,V.C., Dixon,J.E.,
CC   GPRFLN|            Scheuer,T. and Catterall,W.A.
CC   GPRFLN|  TITLE     A sodium channel signaling complex: modulation by associated
CC   GPRFLN|            receptor protein tyrosine phosphatase beta
CC   GPRFLN|  JOURNAL   Nat. Neurosci. 3 (5), 437-444 (2000)
CC   GPRFLN|  MEDLINE   20233995
CC   GPRFLN|REFERENCE   3  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Sakurai,T., Lustig,M., Nativ,M., Hemperly,J.J., Schlessinger,J.,
CC   GPRFLN|            Peles,E. and Grumet,M.
CC   GPRFLN|  TITLE     Induction of neurite outgrowth through contactin and Nr-CAM by
CC   GPRFLN|            extracellular regions of glial receptor tyrosine phosphatase beta
CC   GPRFLN|  JOURNAL   J. Cell Biol. 136 (4), 907-918 (1997)
CC   GPRFLN|  MEDLINE   97201469
CC   GPRFLN|REFERENCE   4  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Peles,E., Nativ,M., Campbell,P.L., Sakurai,T., Martinez,R., Lev,S.,
CC   GPRFLN|            Clary,D.O., Schilling,J., Barnea,G., Plowman,G.D. et al.
CC   GPRFLN|  TITLE     The carbonic anhydrase domain of receptor tyrosine phosphatase beta
CC   GPRFLN|            is a functional ligand for the axonal cell recognition molecule
CC   GPRFLN|            contactin
CC   GPRFLN|  JOURNAL   Cell 82 (2), 251-260 (1995)
CC   GPRFLN|  MEDLINE   95354206
CC   GPRFLN|REFERENCE   5  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Harder,K.W., Anderson,L.L., Duncan,A.M. and Jirik,F.R.
CC   GPRFLN|  TITLE     The gene for receptor-like protein tyrosine phosphatase (PTPRB) is
CC   GPRFLN|            assigned to chromosome 12q15-->q21
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 61 (4), 269-270 (1992)
CC   GPRFLN|  MEDLINE   93137605
CC   GPRFLN|REFERENCE   6  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   GPRFLN|REFERENCE   7  (residues 1 to 1997)
CC   GPRFLN|  AUTHORS   Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
CC   GPRFLN|            Ricca,G., Jaye,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Cloning of three human tyrosine phosphatases reveals a multigene
CC   GPRFLN|            family of receptor-linked protein-tyrosine-phosphatases expressed
CC   GPRFLN|            in brain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
CC   GPRFLN|  MEDLINE   90384936
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    280       VNTIFKEY:269
FT   PROTEIN       1    280       protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase beta
FT                                VNTIFKEY:270
FT   CHAIN         1    280       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    280       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   280 AA;
     NQFEGHFMKL QADSNYLLSK EYEELKDVGR NQSCDIALLP ENRGKNRYNN ILPYDATRVK        60
     LSNVDDDPCS DYINASYIPG NNFRREYIVT QGPLPGTKDD FWKMVWEQNV HNIVMVTQCV       120
     EKGRVKCDHY WPADQDSLYY GDLILQMLSE SVLPEWTIRE FKICGEEQLD AHRLIRHFHY       180
     TVWPDHGVPE TTQSLIQFVR TVRDYINRSP GAGPTVVHCS AGVGRTGTFI ALDRILQQLD       240
     SKDSVDIYGA VHDLRLHRVH MVQTECQYVY LHQCVRDVLR                             280
//
ID   hPTPD1_D1\(NP_008970)\PTPN21 STANDARD;PRT;   292 AA.
AC   NP_008970;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 21; protein tyrosine phosphatase D1 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X79510.1 and AI800682.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an N-terminal domain,
CC   similar to cytoskeletal- associated proteins including band 4.1,
CC   ezrin, merlin, and radixin. This PTP was shown to specially
CC   interact with BMX/ETK, a member of Tec tyrosine kinase family
CC   characterized by a multimodular structures including PH, SH3, and
CC   SH2 domains. The interaction of this PTP with BMX kinase was found
CC   to increase the activation of STAT3, but not STAT2 kinase. Studies
CC   of the similar gene in mice suggested the possible roles of this
CC   PTP in liver regeneration and spermatogenesis.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Jui,H.Y., Tseng,R.J., Wen,X., Fang,H.I., Huang,L.M., Chen,K.Y.,
CC   GPRFLN|            Kung,H.J., Ann,D.K. and Shih,H.M.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase D1, a potential regulator and effector
CC   GPRFLN|            for Tec family kinases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (52), 41124-41132 (2000)
CC   GPRFLN|  MEDLINE   20576274
CC   GPRFLN|REFERENCE   2  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Tokuchi,H., Higashitsuji,H., Nishiyama,H., Nonoguchi,K., Nagao,T.,
CC   GPRFLN|            Xue,J.H., Itoh,K., Ogawa,O. and Fujita,J.
CC   GPRFLN|  TITLE     Expression of protein tyrosine phosphatase PTP-RL10 and its isoform
CC   GPRFLN|            in the mouse testis
CC   GPRFLN|  JOURNAL   Int J Urol 6 (11), 572-577 (1999)
CC   GPRFLN|  MEDLINE   20049818
CC   GPRFLN|REFERENCE   3  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Higashitsuji,H., Arii,S., Furutani,M., Imamura,M., Kaneko,Y.,
CC   GPRFLN|            Takenawa,J., Nakayama,H. and Fujita,J.
CC   GPRFLN|  TITLE     Enhanced expression of multiple protein tyrosine phosphatases in
CC   GPRFLN|            the regenerating mouse liver: isolation of PTP-RL10, a novel
CC   GPRFLN|            cytoplasmic-type phosphatase with sequence homology to cytoskeletal
CC   GPRFLN|            protein 4.1
CC   GPRFLN|  JOURNAL   Oncogene 10 (2), 407-414 (1995)
CC   GPRFLN|  MEDLINE   95140431
CC   GPRFLN|REFERENCE   4  (residues 1 to 1174)
CC   GPRFLN|  AUTHORS   Moller,N.P., Moller,K.B., Lammers,R., Kharitonenkov,A., Sures,I.
CC   GPRFLN|            and Ullrich,A.
CC   GPRFLN|  TITLE     Src kinase associates with a member of a distinct subfamily of
CC   GPRFLN|            protein-tyrosine phosphatases containing an ezrin-like domain
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (16), 7477-7481 (1994)
CC   GPRFLN|  MEDLINE   94329538
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    292       VNTIFKEY:269
FT   PROTEIN       1    292       protein tyrosine phosphatase D1
FT                                VNTIFKEY:270
FT   REGION       18    292       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   292 AA;
     ATNDERCKIL EQRLEQGMVF TEYERILKKR LVDGECSTAR LPENAERNRF QDVLPYDDAR        60
     VELVPTKENN TGYINASHIK VSVSGIEWDY IATQGPLQNT CQDFWQMVWE QGIAIIAMVT       120
     AEEEGGREKS FRYWPRLGSR HNTVTYGRFK ITTRFRTDSG CYATTGLKMK HLLTGQERTV       180
     WHLQYTDWPE HGCPEDLKGF LSYLEEIQSV RRHTNSTSDP QSPNPPLLVH CSAGVGRTGV       240
     VILSEIMIAC LEHNEVLDIP RVLDMLRQQR MMLVQTLCQY TFVYRVLIQF LK               292
//
ID   hPTPD2_D1\(NP_005392)\PTPN14 STANDARD;PRT;   292 AA.
AC   NP_005392;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 14; cytoskeletal-associated protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X82676.1 and BC017300.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an N-terminal
CC   noncatalytic domain similar to that of band 4.1 superfamily
CC   cytoskeleton-associated proteins, which suggested the membrane or
CC   cytoskeleton localization of this protein. The specific function of
CC   this PTP has not yet been determined.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y.
CC   GPRFLN|  TITLE     Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to
CC   GPRFLN|            the nucleus is associated with induction of cell proliferation
CC   GPRFLN|  JOURNAL   J. Cell. Sci. 113 (Pt 17), 3117-3123 (2000)
CC   GPRFLN|  MEDLINE   20394014
CC   GPRFLN|REFERENCE   2  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Aoyama,K., Matsuda,T. and Aoki,N.
CC   GPRFLN|  TITLE     Characterization of newly identified four isoforms for a putative
CC   GPRFLN|            cytosolic protein tyrosine phosphatase PTP36
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999)
CC   GPRFLN|  MEDLINE   20068798
CC   GPRFLN|REFERENCE   3  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A.,
CC   GPRFLN|            Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T.
CC   GPRFLN|  TITLE     Regulation of phosphorylation level and distribution of PTP36, a
CC   GPRFLN|            putative protein tyrosine phosphatase, by cell-substrate adhesion
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (29), 20717-20724 (1999)
CC   GPRFLN|  MEDLINE   99329094
CC   GPRFLN|REFERENCE   4  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A.,
CC   GPRFLN|            Miyake,K. and Hamaoka,T.
CC   GPRFLN|  TITLE     Effects of overexpression of PTP36, a putative protein tyrosine
CC   GPRFLN|            phosphatase, on cell adhesion, cell growth, and cytoskeletons in
CC   GPRFLN|            HeLa cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (18), 12905-12909 (1999)
CC   GPRFLN|  MEDLINE   99230323
CC   GPRFLN|REFERENCE   5  (residues 1 to 1187)
CC   GPRFLN|  AUTHORS   Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V.
CC   GPRFLN|            and Crompton,M.R.
CC   GPRFLN|  TITLE     Pez: a novel human cDNA encoding protein tyrosine phosphatase- and
CC   GPRFLN|            ezrin-like domains
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 209 (3), 959-965 (1995)
CC   GPRFLN|  MEDLINE   95251727
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    292       VNTIFKEY:269
FT   PROTEIN       1    292       cytoskeletal-associated protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       18    292       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   292 AA;
     VPMDERFRTL KKKLEEGMVF TEYEQIPKKK ANGIFSTAAL PENAERSRIR EVVPYEENRV        60
     ELIPTKENNT GYINASHIKV VVGGAEWHYI ATQGPLPHTC HDFWQMVWEQ GVNVIAMVTA       120
     EEEGGRTKSH RYWPKLGSKH SSATYGKFKV TTKFRTDSVC YATTGLKVKH LLSGQERTVW       180
     HLQYTDWPDH GCPEDVQGFL SYLEEIQSVR RHTNSMLEGT KNRHPPIVVH CSAGVGRTGV       240
     LILSELMIYC LEHNEKVEVP MMLRLLREQR MFMIQTIAQY KFVYQVLIQF LQ               292
//
ID   hPTPdelta\_D1\(NP_002830)\PTPRD STANDARD;PRT;   275 AA.
AC   NP_002830;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, D isoform 1 precursor; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L38929.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   region, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, thus represents a receptor-type
CC   PTP. The extracellular region of this protein is composed of three
CC   Ig-like and eight fibronectin type III-like domains. Studies of the
CC   similar genes in chick and fly suggest the role of this PTP is in
CC   promoting neurite growth, and regulating neurons axon guidance.
CC   Multiple tissue specific alternatively spliced transcript variants
CC   of this gene have been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
CC   GPRFLN|  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
CC   GPRFLN|            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
CC   GPRFLN|            PTP sigma isoforms are expressed in a tissue-specific manner and
CC   GPRFLN|            associate with the LAR-interacting protein LIP.1
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
CC   GPRFLN|  MEDLINE   96102179
CC   GPRFLN|REFERENCE   3  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M.
CC   GPRFLN|  TITLE     Molecular characterization of the human transmembrane
CC   GPRFLN|            protein-tyrosine phosphatase delta. Evidence for tissue-specific
CC   GPRFLN|            expression of alternative human transmembrane protein-tyrosine
CC   GPRFLN|            phosphatase delta isoforms
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (12), 6722-6728 (1995)
CC   GPRFLN|  MEDLINE   95204468
CC   GPRFLN|REFERENCE   4  (residues 1 to 1912)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase delta
FT                                VNTIFKEY:270
FT   CHAIN         1    275       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_4
SQ   SEQUENCE   275 AA;
     LELADHIERL KANDNLKFSQ EYESIDPGQQ FTWEHSNLEV NKPKNRYANV IAYDHSRVLL        60
     SAIEGIPGSD YVNANYIDGY RKQNAYIATQ GSLPETFGDF WRMIWEQRSA TVVMMTKLEE       120
     RSRVKCDQYW PSRGTETHGL VQVTLLDTVE LATYCVRTFA LYKNGSSEKR EVRQFQFTAW       180
     PDHGVPEHPT PFLAFLRRVK TCNPPDAGPM VVHCSAGVGR TGCFIVIDAM LERIKHEKTV       240
     DIYGHVTLMR AQRNYMVQTE DQYIFIHDAL LEAVT                                  275
//
ID   hPTPepsilon_D1\(NP_006495)\PTPRE STANDARD;PRT;   279 AA.
AC   NP_006495;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, E isoform 1 precursor; protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X54134.1, AJ315969.1 and
CC   BI559814.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. Two alternatively spliced transcript
CC   variants of this gene have been reported, one of which encodes a
CC   receptor-type PTP that possesses a short extracellular domain, a
CC   single transmembrane region, and two tandem intracytoplasmic
CC   catalytic domains; Another one encodes a PTP that contains a
CC   distinct hydrophilic N-terminus, and thus represents a
CC   nonreceptor-type isoform of this PTP. Studies of the similar gene
CC   in mice suggested the regulatory roles of this PTP in RAS related
CC   signal transduction pathways, cytokines induced SATA signaling, as
CC   well as the activation of voltage-gated K+ channels.
CC   
CC   Transcript Variant: This variant (1) contains a different 5' end
CC   region that includes a part of the coding region, when compared to
CC   variant 2. It thus encodes a protein that has a distinct
CC   N-terminus, as compared to isoform 2. The encoded protein is a
CC   receptor type isoform of this PTP.
CC   GPRFLN|REFERENCE   1  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Wabakken,T., Hauge,H., Funderud,S. and Aasheim,H.C.
CC   GPRFLN|  TITLE     Characterization, expression and functional aspects of a novel
CC   GPRFLN|            protein tyrosine phosphatase epsilon isoform
CC   GPRFLN|  JOURNAL   Scand. J. Immunol. 56 (3), 276-285 (2002)
CC   GPRFLN|  MEDLINE   22181756
CC   GPRFLN|  REMARK    GeneRIF: Characterization, expression and functional aspects of an
CC   GPRFLN|            alternative spliced isoform of protein tyrosine phosphatase epsilon
CC   GPRFLN|REFERENCE   3  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Wabakken,T., Hauge,H., Finne,E.F., Wiedlocha,A. and Aasheim,H.
CC   GPRFLN|  TITLE     Expression of human protein tyrosine phosphatase epsilon in
CC   GPRFLN|            leucocytes: a potential ERK pathway-regulating phosphatase
CC   GPRFLN|  JOURNAL   Scand. J. Immunol. 56 (2), 195-203 (2002)
CC   GPRFLN|  MEDLINE   22118122
CC   GPRFLN|  REMARK    GeneRIF: Transfection of cells with different PTPepsilon constructs
CC   GPRFLN|            and activator protein-1 reporter gene indicates that the catalytic
CC   GPRFLN|            activity of PTPepsilon is involved in the regulation of the
CC   GPRFLN|            mitogen-activated protein kinase cascade.
CC   GPRFLN|REFERENCE   4  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Tanuma,N., Nakamura,K., Shima,H. and Kikuchi,K.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT
CC   GPRFLN|            signaling and differentiation induced by interleukin-6 and leukemia
CC   GPRFLN|            inhibitory factor in M1 leukemia cells
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (36), 28216-28221 (2000)
CC   GPRFLN|  MEDLINE   20428741
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   5  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Peretz,A., Gil-Henn,H., Sobko,A., Shinder,V., Attali,B. and
CC   GPRFLN|            Elson,A.
CC   GPRFLN|  TITLE     Hypomyelination and increased activity of voltage-gated K(+)
CC   GPRFLN|            channels in mice lacking protein tyrosine phosphatase epsilon
CC   GPRFLN|  JOURNAL   EMBO J. 19 (15), 4036-4045 (2000)
CC   GPRFLN|  MEDLINE   20380937
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   6  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Toledano-Katchalski,H. and Elson,A.
CC   GPRFLN|  TITLE     The transmembranal and cytoplasmic forms of protein tyrosine
CC   GPRFLN|            phosphatase epsilon physically associate with the adaptor molecule
CC   GPRFLN|            Grb2
CC   GPRFLN|  JOURNAL   Oncogene 18 (36), 5024-5031 (1999)
CC   GPRFLN|  MEDLINE   99422037
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   7  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Elson,A. and Leder,P.
CC   GPRFLN|  TITLE     Identification of a cytoplasmic, phorbol ester-inducible isoform of
CC   GPRFLN|            protein tyrosine phosphatase epsilon
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12235-12239 (1995)
CC   GPRFLN|  MEDLINE   96109240
CC   GPRFLN|REFERENCE   8  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   van den Maagdenberg,A.M., van den Hurk,H.H., Weghuis,D.,
CC   GPRFLN|            Wieringa,B., Geurts van Kessel,A. and Hendriks,W.J.
CC   GPRFLN|  TITLE     Assignment of the human protein tyrosine phosphatase epsilon
CC   GPRFLN|            (PTPRE) gene to chromosome 10q26 by fluorescence in situ
CC   GPRFLN|            hybridization
CC   GPRFLN|  JOURNAL   Genomics 30 (1), 128-129 (1995)
CC   GPRFLN|  MEDLINE   96129319
CC   GPRFLN|REFERENCE   9  (residues 1 to 700)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       protein tyrosine phosphatase, receptor type, epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide; protein tyrosine phosphatase epsilon
FT                                VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    279       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     EHLEEEIRIR SADDCKQFRE EFNSLPSGHI QGTFELANKE ENREKNRYPN ILPNDHSRVI        60
     LSQLDGIPCS DYINASYIDG YKEKNKFIAA QGPKQETVND FWRMVWEQKS ATIVMLTNLK       120
     ERKEEKCHQY WPDQGCWTYG NIRVCVEDCV VLVDYTIRKF CIQPQLPDGC KAPRLVSQLH       180
     FTSWPDFGVP FTPIGMLKFL KKVKTLNPVH AGPIVVHCSA GVGRTGTFIV IDAMMAMMHA       240
     EQKVDVFEFV SRIRNQRPQM VQTDMQYTFI YQALLEYYL                              279
//
ID   hPTPgamma_D1\(NP_002832)\PTPRG STANDARD;PRT;   291 AA.
AC   NP_002832;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, G precursor; protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L09247.1, AI872451.1 and
CC   U46089.1.
CC   On Feb 22, 2002 this sequence version replaced gi:11386169.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. The extracellular region of this PTP contains a
CC   carbonic anhydrase-like (CAH) domain, which is also found in the
CC   extracellular region of PTPRBETA/ZETA. This gene is located in a
CC   chromosomal region that is frequently deleted in renal cell
CC   carcinoma and lung carcinoma, thus is thought to be a candidate
CC   tumor suppressor gene.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Liu,S., Sugimoto,Y., Kulp,S.K., Jiang,J., Chang,H.L., Park,K.Y.,
CC   GPRFLN|            Kashida,Y. and Lin,Y.C.
CC   GPRFLN|  TITLE     Estrogenic down-regulation of protein tyrosine phosphatase gamma
CC   GPRFLN|            (PTP gamma) in human breast is associated with estrogen receptor
CC   GPRFLN|            alpha
CC   GPRFLN|  JOURNAL   Anticancer Res. 22 (6C), 3917-3923 (2002)
CC   GPRFLN|  MEDLINE   22441179
CC   GPRFLN|  REMARK    GeneRIF: Estrogenic down-regulation of protein tyrosine phosphatase
CC   GPRFLN|            gamma (PTP gamma) in human breast is associated with estrogen
CC   GPRFLN|            receptor alpha.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Liu,S., Kulp,S.K., Sugimoto,Y., Jiang,J., Chang,H.L. and Lin,Y.C.
CC   GPRFLN|  TITLE     Involvement of breast epithelial-stromal interactions in the
CC   GPRFLN|            regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA
CC   GPRFLN|            expression by estrogenically active agents
CC   GPRFLN|  JOURNAL   Breast Cancer Res. Treat. 71 (1), 21-35 (2002)
CC   GPRFLN|  MEDLINE   21848634
CC   GPRFLN|  REMARK    GeneRIF: both estradiol-17beta and zeranol regulate PTPgamma
CC   GPRFLN|            expression in human breast; epithelial-stromal cell interaction is
CC   GPRFLN|            important in regulation of PTPgamma expression by estrogenically
CC   GPRFLN|            active agents
CC   GPRFLN|REFERENCE   3  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Kastury,K., Ohta,M., Lasota,J., Moir,D., Dorman,T., LaForgia,S.,
CC   GPRFLN|            Druck,T. and Huebner,K.
CC   GPRFLN|  TITLE     Structure of the human receptor tyrosine phosphatase gamma gene
CC   GPRFLN|            (PTPRG) and relation to the familial RCC t(3;8) chromosome
CC   GPRFLN|            translocation
CC   GPRFLN|  JOURNAL   Genomics 32 (2), 225-235 (1996)
CC   GPRFLN|  MEDLINE   96429999
CC   GPRFLN|REFERENCE   4  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Barnea,G., Silvennoinen,O., Shaanan,B., Honegger,A.M., Canoll,P.D.,
CC   GPRFLN|            D'Eustachio,P., Morse,B., Levy,J.B., Laforgia,S., Huebner,K. et al.
CC   GPRFLN|  TITLE     Identification of a carbonic anhydrase-like domain in the
CC   GPRFLN|            extracellular region of RPTP gamma defines a new subfamily of
CC   GPRFLN|            receptor tyrosine phosphatases
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 13 (3), 1497-1506 (1993)
CC   GPRFLN|  MEDLINE   93180796
CC   GPRFLN|REFERENCE   5  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   LaForgia,S., Morse,B., Levy,J., Barnea,G., Cannizzaro,L.A., Li,F.,
CC   GPRFLN|            Nowell,P.C., Boghosian-Sell,L., Glick,J., Weston,A. et al.
CC   GPRFLN|  TITLE     Receptor protein-tyrosine phosphatase gamma is a candidate tumor
CC   GPRFLN|            suppressor gene at human chromosome region 3p21
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (11), 5036-5040 (1991)
CC   GPRFLN|  MEDLINE   91271326
CC   GPRFLN|REFERENCE   6  (residues 1 to 1445)
CC   GPRFLN|  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
CC   GPRFLN|  TITLE     Structural diversity and evolution of human receptor-like protein
CC   GPRFLN|            tyrosine phosphatases
CC   GPRFLN|  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
CC   GPRFLN|  MEDLINE   91006018
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    291       VNTIFKEY:269
FT   PROTEIN       1    291       protein tyrosine phosphatase, receptor type, gamma polypeptide; protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor tyrosine phosphatase gamma
FT                                VNTIFKEY:270
FT   CHAIN         1    291       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    291       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   291 AA;
     KQFVKHIGEL YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR        60
     VKLRPLPGKD SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI       120
     TNLVEKGRRK CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK VKKGQKGNPK       180
     GRQNERVVIQ YHYTQWPDMG VPEYALPVLT FVRRSSAARM PETGPVLVHC SAGVGRTGTY       240
     IVIDSMLQQI KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI L                291
//
ID   hPTPH1_D1\(NP_002820)\PTPN3 STANDARD;PRT;   276 AA.
AC   NP_002820;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 3; protein tyrosin phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M64572.1 and W15441.1.
CC   On Jan 10, 2002 this sequence version replaced gi:4506293.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This protein contains a C-terminal PTP
CC   domain and an N-terminal domain homologous to the band 4.1
CC   superfamily of cytoskeletal-associated proteins. P97, a cell cycle
CC   regulator involved in a variety of membrane related functions, has
CC   been shown to be a substrate of this PTP. This PTP was also found
CC   to interact with, and be regulated by adaptor protein 14-3-3 beta.
CC   GPRFLN|REFERENCE   1  (residues 1 to 913)
CC   GPRFLN|  AUTHORS   Zheng,Y., Schlondorff,J. and Blobel,C.P.
CC   GPRFLN|  TITLE     Evidence for regulation of the tumor necrosis factor
CC   GPRFLN|            alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (45), 42463-42470 (2002)
CC   GPRFLN|  MEDLINE   22301977
CC   GPRFLN|  REMARK    GeneRIF: regulates TACE (tnf-alpha convertase}
CC   GPRFLN|REFERENCE   2  (residues 1 to 913)
CC   GPRFLN|  AUTHORS   Zhang,S.H., Liu,J., Kobayashi,R. and Tonks,N.K.
CC   GPRFLN|  TITLE     Identification of the cell cycle regulator VCP (p97/CDC48) as a
CC   GPRFLN|            substrate of the band 4.1-related protein-tyrosine phosphatase
CC   GPRFLN|            PTPH1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (25), 17806-17812 (1999)
CC   GPRFLN|  MEDLINE   99292748
CC   GPRFLN|REFERENCE   3  (residues 1 to 913)
CC   GPRFLN|  AUTHORS   Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and
CC   GPRFLN|            Tonks,N.K.
CC   GPRFLN|  TITLE     Serine phosphorylation-dependent association of the band
CC   GPRFLN|            4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta
CC   GPRFLN|            protein
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 272 (43), 27281-27287 (1997)
CC   GPRFLN|  MEDLINE   98001710
CC   GPRFLN|REFERENCE   4  (residues 1 to 913)
CC   GPRFLN|  AUTHORS   Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and
CC   GPRFLN|            Yachi,A.
CC   GPRFLN|  TITLE     Expression of cytoskeletal-associated protein tyrosine phosphatase
CC   GPRFLN|            PTPH1 mRNA in human hepatocellular carcinoma
CC   GPRFLN|  JOURNAL   J. Gastroenterol. 29 (6), 727-732 (1994)
CC   GPRFLN|  MEDLINE   95179278
CC   GPRFLN|REFERENCE   5  (residues 1 to 913)
CC   GPRFLN|  AUTHORS   Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M.,
CC   GPRFLN|            Ariyama,T., Inazawa,J., Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Expression and chromosomal assignment of PTPH1 gene encoding a
CC   GPRFLN|            cytosolic protein tyrosine phosphatase homologous to
CC   GPRFLN|            cytoskeletal-associated proteins
CC   GPRFLN|  JOURNAL   Int. J. Cancer 55 (6), 947-951 (1993)
CC   GPRFLN|  MEDLINE   94075060
CC   GPRFLN|REFERENCE   6  (residues 1 to 913)
CC   GPRFLN|  AUTHORS   Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M.,
CC   GPRFLN|            Adachi,M., Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     cDNA cloning of new protein tyrosine phosphatases in the human
CC   GPRFLN|            colon
CC   GPRFLN|  JOURNAL   Tumour Biol. 13 (3), 180-186 (1992)
CC   GPRFLN|  MEDLINE   92327504
CC   GPRFLN|REFERENCE   7  (residues 1 to 913)
CC   GPRFLN|  AUTHORS   Yang,Q. and Tonks,N.K.
CC   GPRFLN|  TITLE     Isolation of a cDNA clone encoding a human protein-tyrosine
CC   GPRFLN|            phosphatase with homology to the cytoskeletal-associated proteins
CC   GPRFLN|            band 4.1, ezrin, and talin
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (14), 5949-5953 (1991)
CC   GPRFLN|  MEDLINE   91296738
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    276       VNTIFKEY:269
FT   PROTEIN       1    276       protein tyrosin phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION       22    276       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   276 AA;
     DTLEGSMAQL KKGLESGTVL IQFEQLYRKK PGLAITFAKL PQNLDKNRYK DVLPYDTTRV        60
     LLQGNEDYIN ASYVNMEIPA ANLVNKYIAT QGPLPHTCAQ FWQVVWDQKL SLIVMLTTLT       120
     ERGRTKCHQY WPDPPDVMNH GGFHIQCQSE DCTIAYVSRE MLVTNTQTGE EHTVTHLQYV       180
     AWPDHGVPDD SSDFLEFVNY VRSLRVDSEP LLVHCSAGIG RTGVLVTMET AMCLTERNLP       240
     IYPLDIVRKM RDQRAMMVQT SSQYKFVCEA ILRVYE                                 276
//
ID   hPTPkappa_D1\(NP_002835)\PTPRK STANDARD;PRT;   274 AA.
AC   NP_002835;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, K precursor; protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from L77886.1 and BI755683.1.
CC   On Feb 22, 2002 this sequence version replaced gi:4506317.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem catalytic
CC   domains, and thus represents a receptor-type PTP. The extracellular
CC   region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like
CC   domain and four fibronectin type III-like repeats. This PTP was
CC   shown to mediate homophilic intercellular interaction, possibly
CC   through the interaction with beta- and gamma-catenin at adherens
CC   junctions. Expression of this gene was found to be stimulated by
CC   TGF-beta 1, which may be important for the inhibition of
CC   keratinocyte proliferation.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Yang,Y., Gil,M.C., Choi,E.Y., Park,S.H., Pyun,K.H. and Ha,H.
CC   GPRFLN|  TITLE     Molecular cloning and chromosomal localization of a human gene
CC   GPRFLN|            homologous to the murine R-PTP-kappa, a receptor-type protein
CC   GPRFLN|            tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Gene 186 (1), 77-82 (1997)
CC   GPRFLN|  MEDLINE   97199372
CC   GPRFLN|REFERENCE   2  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Yang,Y., Gil,M., Byun,S.M., Choi,I., Pyun,K.H. and Ha,H.
CC   GPRFLN|  TITLE     Transforming growth factor-beta1 inhibits human keratinocyte
CC   GPRFLN|            proliferation by upregulation of a receptor-type tyrosine
CC   GPRFLN|            phosphatase R-PTP-kappa gene expression
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 228 (3), 807-812 (1996)
CC   GPRFLN|  MEDLINE   97096334
CC   GPRFLN|REFERENCE   3  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Fuchs,M., Muller,T., Lerch,M.M. and Ullrich,A.
CC   GPRFLN|  TITLE     Association of human protein-tyrosine phosphatase kappa with
CC   GPRFLN|            members of the armadillo family
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 271 (28), 16712-16719 (1996)
CC   GPRFLN|  MEDLINE   96279245
CC   GPRFLN|REFERENCE   4  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Zondag,G.C., Koningstein,G.M., Jiang,Y.P., Sap,J., Moolenaar,W.H.
CC   GPRFLN|            and Gebbink,M.F.
CC   GPRFLN|  TITLE     Homophilic interactions mediated by receptor tyrosine phosphatases
CC   GPRFLN|            mu and kappa. A critical role for the novel extracellular MAM
CC   GPRFLN|            domain
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 270 (24), 14247-14250 (1995)
CC   GPRFLN|  MEDLINE   95301498
CC   GPRFLN|REFERENCE   5  (residues 1 to 1440)
CC   GPRFLN|  AUTHORS   Sap,J., Jiang,Y.P., Friedlander,D., Grumet,M. and Schlessinger,J.
CC   GPRFLN|  TITLE     Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic
CC   GPRFLN|            binding
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 14 (1), 1-9 (1994)
CC   GPRFLN|  MEDLINE   94088505
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    274       VNTIFKEY:269
FT   PROTEIN       1    274       protein-tyrosine phosphatase, receptor type, kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa precursor
FT                                VNTIFKEY:270
FT   CHAIN         1    274       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   274 AA;
     ADLLQHINLM KTSDSYGFKE EYESFFEGQS ASWDVAKKDQ NRAKNRYGNI IAYDHSRVIL        60
     QPVEDDPSSD YINANYIDGY QRPSHYIATQ GPVHETVYDF WRMIWQEQSA CIVMVTNLVE       120
     VGRVKCYKYW PDDTEVYGDF KVTCVEMEPL AEYVVRTFTL ERRGYNEIRE VKQFHFTGWP       180
     DHGVPYHATG LLSFIRRVKL SNPPSAGPIV VHCSAGAGRT GCYIVIDIML DMAEREGVVD       240
     IYNCVKALRS RRINMVQTEE QYIFIHDAIL EACL                                   274
//
ID   hPTPlamda_D1\(NP_005695)\PTPRU STANDARD;PRT;   270 AA.
AC   NP_005695;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, U isoform 3 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X97198.1 and X95712.1.
CC   On Mar 26, 2002 this sequence version replaced gi:5032003.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem intracellular
CC   catalytic domains, and thus represents a receptor-type PTP. The
CC   extracellular region contains a meprin-A5 antigen-PTP (MAM) domain,
CC   Ig-like and fibronectin type III-like repeats. This PTP was thought
CC   to play roles in cell-cell recognition and adhesion. Studies of the
CC   similar gene in mice suggested the role of this PTP in early neural
CC   development. The expression of this gene was reported to be
CC   regulated by phorbol myristate acetate (PMA) or calcium ionophore
CC   in Jurkat T lymphoma cells. Three alternatively spliced transcript
CC   variants, which encode distinct proteins, have been reported.
CC   
CC   Transcript Variant: This variant (3) encodes the longest isoform
CC   (3).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Yan,H.X., He,Y.Q., Dong,H., Zhang,P., Zeng,J.Z., Cao,H.F., Wu,M.C.
CC   GPRFLN|            and Wang,H.Y.
CC   GPRFLN|  TITLE     Physical and functional interaction between receptor-like protein
CC   GPRFLN|            tyrosine phosphatase PCP-2 and beta-catenin
CC   GPRFLN|  JOURNAL   Biochemistry 41 (52), 15854-15860 (2002)
CC   GPRFLN|  MEDLINE   22389441
CC   GPRFLN|  REMARK    GeneRIF: Expressed in a cell density-dependent fashion, PCP-2
CC   GPRFLN|            interacts directly with its substrate beta-catenin, independent of
CC   GPRFLN|            the tyrosine phosphorylation state of beta-catenin.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Wang,B., Kishihara,K., Zhang,D., Sakamoto,T. and Nomoto,K.
CC   GPRFLN|  TITLE     Transcriptional regulation of a receptor protein tyrosine
CC   GPRFLN|            phosphatase gene hPTP-J by PKC-mediated signaling pathways in
CC   GPRFLN|            Jurkat and Molt-4 T lymphoma cells
CC   GPRFLN|  JOURNAL   Biochim. Biophys. Acta 1450 (3), 331-340 (1999)
CC   GPRFLN|  MEDLINE   99326162
CC   GPRFLN|REFERENCE   3  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S.,
CC   GPRFLN|            White,R.A., Painter,C., Steinberger,A.A. and Avraham,H.
CC   GPRFLN|  TITLE     Characterization and chromosomal localization of PTPRO, a novel
CC   GPRFLN|            receptor protein tyrosine phosphatase, expressed in hematopoietic
CC   GPRFLN|            stem cells
CC   GPRFLN|  JOURNAL   Gene 204 (1-2), 5-16 (1997)
CC   GPRFLN|  MEDLINE   98094249
CC   GPRFLN|REFERENCE   4  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K.
CC   GPRFLN|  TITLE     Molecular cloning and characterization of a novel human receptor
CC   GPRFLN|            protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene
CC   GPRFLN|            expression by PMA and calcium ionophore in Jurkat T lymphoma cells
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 231 (1), 77-81 (1997)
CC   GPRFLN|  MEDLINE   97223402
CC   GPRFLN|REFERENCE   5  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Crossland,S., Smith,P.D. and Crompton,M.R.
CC   GPRFLN|  TITLE     Molecular cloning and characterization of PTP pi, a novel
CC   GPRFLN|            receptor-like protein-tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Biochem. J. 319 (Pt 1), 249-254 (1996)
CC   GPRFLN|  MEDLINE   97024447
CC   GPRFLN|REFERENCE   6  (residues 1 to 1446)
CC   GPRFLN|  AUTHORS   Wang,H., Lian,Z., Lerch,M.M., Chen,Z., Xie,W. and Ullrich,A.
CC   GPRFLN|  TITLE     Characterization of PCP-2, a novel receptor protein tyrosine
CC   GPRFLN|            phosphatase of the MAM domain family
CC   GPRFLN|  JOURNAL   Oncogene 12 (12), 2555-2562 (1996)
CC   GPRFLN|  MEDLINE   96293401
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    270       VNTIFKEY:269
FT   PROTEIN       1    270       protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron
FT                                VNTIFKEY:270
FT   CHAIN         1    270       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    270       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   270 AA;
     ADLLQHINQM KTAEGYGFKQ EYESFFEGWD ATKKKDKVKG SRQEPMPAYD RHRVKLHPML        60
     GDPNADYINA NYIDGYHRSN HFIATQGPKP EMVYDFWRMV WQEHCSSIVM ITKLVEVGRV       120
     KCSRYWPEDS DTYGDIKIML VKTETLAEYV VRTFALERRG YSARHEVRQF HFTAWPEHGV       180
     PYHATGLLAF IRRVKASTPP DAGPIVIHCS AGTGRTGCYI VLDVMLDMAE CEGVVDIYNC       240
     VKTLCSRRVN MIQTEEQYIF IHDAILEACL                                        270
//
ID   hPTPmu_D1\(NP_002836)\PTPRM STANDARD;PRT;   274 AA.
AC   NP_002836;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, M precursor; protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from X58288.1 and AA281524.1.
CC   On Feb 22, 2002 this sequence version replaced gi:4506319.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem catalytic
CC   domains, and thus represents a receptor-type PTP. The extracellular
CC   region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like
CC   domain and four fibronectin type III-like repeats. This PTP has
CC   been shown to mediate cell-cell aggregation through the interaction
CC   with another molecule of this PTP on an adjacent cell. This PTP can
CC   interact with scaffolding protein RACK1/GNB2L1, which may be
CC   necessary for the downstream signaling in response to cell-cell
CC   adhesion.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Mourton,T., Hellberg,C.B., Burden-Gulley,S.M., Hinman,J., Rhee,A.
CC   GPRFLN|            and Brady-Kalnay,S.M.
CC   GPRFLN|  TITLE     The PTPmu protein-tyrosine phosphatase binds and recruits the
CC   GPRFLN|            scaffolding protein RACK1 to cell-cell contacts
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 276 (18), 14896-14901 (2001)
CC   GPRFLN|  MEDLINE   21226727
CC   GPRFLN|REFERENCE   3  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Feiken,E., van Etten,I., Gebbink,M.F., Moolenaar,W.H. and
CC   GPRFLN|            Zondag,G.C.
CC   GPRFLN|  TITLE     Intramolecular interactions between the juxtamembrane domain and
CC   GPRFLN|            phosphatase domains of receptor protein-tyrosine phosphatase
CC   GPRFLN|            RPTPmu. Regulation of catalytic activity
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (20), 15350-15356 (2000)
CC   GPRFLN|  MEDLINE   20270248
CC   GPRFLN|REFERENCE   4  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Brady-Kalnay,S.M. and Tonks,N.K.
CC   GPRFLN|  TITLE     Identification of the homophilic binding site of the receptor
CC   GPRFLN|            protein tyrosine phosphatase PTP mu
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (45), 28472-28477 (1994)
CC   GPRFLN|  MEDLINE   95050637
CC   GPRFLN|REFERENCE   5  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Suijkerbuijk,R.F., Gebbink,M.F., Moolenaar,W.H. and Geurts van
CC   GPRFLN|            Kessel,A.
CC   GPRFLN|  TITLE     Fine mapping of the human receptor-like protein tyrosine
CC   GPRFLN|            phosphatase gene (PTPRM) to 18p11.2 by fluorescence in situ
CC   GPRFLN|            hybridization
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 64 (3-4), 245-246 (1993)
CC   GPRFLN|  MEDLINE   94007972
CC   GPRFLN|REFERENCE   6  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Brady-Kalnay,S.M., Flint,A.J. and Tonks,N.K.
CC   GPRFLN|  TITLE     Homophilic binding of PTP mu, a receptor-type protein tyrosine
CC   GPRFLN|            phosphatase, can mediate cell-cell aggregation
CC   GPRFLN|  JOURNAL   J. Cell Biol. 122 (4), 961-972 (1993)
CC   GPRFLN|  MEDLINE   93352709
CC   GPRFLN|REFERENCE   7  (residues 1 to 1452)
CC   GPRFLN|  AUTHORS   Gebbink,M.F., van Etten,I., Hateboer,G., Suijkerbuijk,R.,
CC   GPRFLN|            Beijersbergen,R.L., Geurts van Kessel,A. and Moolenaar,W.H.
CC   GPRFLN|  TITLE     Cloning, expression and chromosomal localization of a new putative
CC   GPRFLN|            receptor-like protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   FEBS Lett. 290 (1-2), 123-130 (1991)
CC   GPRFLN|  MEDLINE   92008644
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    274       VNTIFKEY:269
FT   PROTEIN       1    274       protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase mu precursor
FT                                VNTIFKEY:270
FT   CHAIN         1    274       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   274 AA;
     ADLLQHITQM KCAEGYGFKE EYESFFEGQS APWDSAKKDE NRMKNRYGNI IAYDHSRVRL        60
     QTIEGDTNSD YINGNYIDGY HRPNHYIATQ GPMQETIYDF WRMVWHENTA SIIMVTNLVE       120
     VGRVKCCKYW PDDTEIYKDI KVTLIETELL AEYVIRTFAV EKRGVHEIRE IRQFHFTGWP       180
     DHGVPYHATG LLGFVRQVKS KSPPSAGPLV VHCSAGAGRT GCFIVIDIML DMAEREGVVD       240
     IYNCVRELRS RRVNMVQTEE QYVFIHDAIL EACL                                   274
//
ID   hPTPrho_D1\(NP_573400)\PTPRT STANDARD;PRT;   274 AA.
AC   NP_573400;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, T isoform 1 precursor; receptor protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from AF043644.4 and R50970.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and two tandem intracellular
CC   catalytic domains, and thus represents a receptor-type PTP. The
CC   extracellular region contains a meprin-A5 antigen-PTP (MAM) domain,
CC   Ig-like and fibronectin type III-like repeats. The protein domain
CC   structure and the expression pattern of the mouse counterpart of
CC   this PTP suggest its roles in both signal transduction and cellular
CC   adhesion in the central nervous system. Two alternatively spliced
CC   transcript variants of this gene, which encode distinct proteins,
CC   have been reported.
CC   
CC   Transcript Variant: This variant (1) contains an additional
CC   fragment within the coding region when compared to variant 2, and
CC   thus encodes a protein that contains an extra internal segment, as
CC   compared to isoform 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   Besco,J.A., Frostholm,A., Popesco,M.C., Burghes,A.H. and Rotter,A.
CC   GPRFLN|  TITLE     Genomic organization and alternative splicing of the human and
CC   GPRFLN|            mouse RPTPrho genes
CC   GPRFLN|  JOURNAL   BMC Genomics 2 (1), 1 (2001)
CC   GPRFLN|REFERENCE   2  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   McAndrew,P.E., Frostholm,A., White,R.A., Rotter,A. and Burghes,A.H.
CC   GPRFLN|  TITLE     Identification and characterization of RPTP rho, a novel RPTP
CC   GPRFLN|            mu/kappa-like receptor protein tyrosine phosphatase whose
CC   GPRFLN|            expression is restricted to the central nervous system
CC   GPRFLN|  JOURNAL   Brain Res. Mol. Brain Res. 56 (1-2), 9-21 (1998)
CC   GPRFLN|  MEDLINE   98267260
CC   GPRFLN|REFERENCE   3  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   McAndrew,P.E., Frostholm,A., Evans,J.E., Zdilar,D., Goldowitz,D.,
CC   GPRFLN|            Chiu,I.M., Burghes,A.H. and Rotter,A.
CC   GPRFLN|  TITLE     Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic
CC   GPRFLN|            fibroblast growth factor (FGF-1) transcripts delineate a
CC   GPRFLN|            rostrocaudal boundary in the granule cell layer of the murine
CC   GPRFLN|            cerebellar cortex
CC   GPRFLN|  JOURNAL   J. Comp. Neurol. 391 (4), 444-455 (1998)
CC   GPRFLN|  MEDLINE   98146229
CC   GPRFLN|REFERENCE   4  (residues 1 to 1463)
CC   GPRFLN|  AUTHORS   Hillier,L.D., Lennon,G., Becker,M., Bonaldo,M.F., Chiapelli,B.,
CC   GPRFLN|            Chissoe,S., Dietrich,N., DuBuque,T., Favello,A., Gish,W.,
CC   GPRFLN|            Hawkins,M., Hultman,M., Kucaba,T., Lacy,M., Le,M., Le,N.,
CC   GPRFLN|            Mardis,E., Moore,B., Morris,M., Parsons,J., Prange,C., Rifkin,L.,
CC   GPRFLN|            Rohlfing,T., Schellenberg,K., Marra,M. et al.
CC   GPRFLN|  TITLE     Generation and analysis of 280,000 human expressed sequence tags
CC   GPRFLN|  JOURNAL   Genome Res. 6 (9), 807-828 (1996)
CC   GPRFLN|  MEDLINE   97044478
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    274       VNTIFKEY:269
FT   PROTEIN       1    274       receptor protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   CHAIN         1    274       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   274 AA;
     ADLLQHITQM KRGQGYGFKE EYEALPEGQT ASWDTAKEDE NRNKNRYGNI ISYDHSRVRL        60
     LVLDGDPHSD YINANYIDGY HRPRHYIATQ GPMQETVKDF WRMIWQENSA SIVMVTNLVE       120
     VGRVKCVRYW PDDTEVYGDI KVTLIETEPL AEYVIRTFTV QKKGYHEIRE LRLFHFTSWP       180
     DHGVPCYATG LLGFVRQVKF LNPPEAGPIV VHCSAGAGRT GCFIAIDTML DMAENEGVVD       240
     IFNCVRELRA QRVNLVQTEE QYVFVHDAIL EACL                                   274
//
ID   hPTPS31_D1\(AR073855)\PTPGMC1 STANDARD;PRT;   276 AA.
DT   17-MAY-2003
DE   Translation of a fragment of delete.
KW   TRANSLATED.
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
SQ   SEQUENCE   276 AA;
     KSFLQHVEEL CTNNNLKFQE EFSELPKFLQ DLSSTDADLP WNRAKNRFPN IKPYNNNRVK        60
     LIADASVPGS DYINASYISG YLCPNEFIAT QGPLPGTVGD FWRMVWETRA KTLVMLTQCF       120
     EKGRIRCHQY WPEDNKPVTV FGDIVITKLM EDVQIDWTIR DLKIERHGDC MTVRQCNFTA       180
     WPEHGVPENS APLIHFVKLV RASRAHDTTP MIVHCSAGVG RTGVFIALDH LTQHINDHDF       240
     VDIYGLVAEL RSERMCMVQN LAQYIFLHQC ILDLLS                                 276
//
ID   hPTPsigma_D1\(NP_002841)\PTPRS STANDARD;PRT;   275 AA.
AC   NP_002841;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, sigma isoform 1 precursor; protein tyrosine phosphatase PTPsigma [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from U35234.1 and BI461316.1.
CC   On Mar 26, 2002 this sequence version replaced gi:4506327.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains an extracellular
CC   region, a single transmembrane segment and two tandem
CC   intracytoplasmic catalytic domains, and thus represents a
CC   receptor-type PTP. The extracellular region of this protein is
CC   composed of multiple Ig-like and fibronectin type III-like domains.
CC   Studies of the similar gene in mice suggested that this PTP may be
CC   involved in cell-cell interaction, primary axonogenesis, and axon
CC   guidance during embryogenesis. This PTP has been also implicated in
CC   the molecular control of adult nerve repair. Four alternatively
CC   spliced transcript variants, which encode distinct proteins, have
CC   been reported.
CC   
CC   Transcript Variant: This variant (1) encodes the longest isoform
CC   (1).
CC   GPRFLN|REFERENCE   1  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
CC   GPRFLN|  TITLE     Intra- and intermolecular interactions between intracellular
CC   GPRFLN|            domains of receptor protein-tyrosine phosphatases
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
CC   GPRFLN|  MEDLINE   22344739
CC   GPRFLN|  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
CC   GPRFLN|            a common but specific mechanism that is likely to be regulated-
CC   GPRFLN|            domain2s and the wedge structures are crucial determinants of
CC   GPRFLN|            binding specificity, thus regulating cross-talk between RPTPs
CC   GPRFLN|REFERENCE   2  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Wallace,M.J., Batt,J., Fladd,C.A., Henderson,J.T., Skarnes,W. and
CC   GPRFLN|            Rotin,D.
CC   GPRFLN|  TITLE     Neuronal defects and posterior pituitary hypoplasia in mice lacking
CC   GPRFLN|            the receptor tyrosine phosphatase PTPsigma
CC   GPRFLN|  JOURNAL   Nat. Genet. 21 (3), 334-338 (1999)
CC   GPRFLN|  MEDLINE   99178277
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   3  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Elchebly,M., Wagner,J., Kennedy,T.E., Lanctot,C., Michaliszyn,E.,
CC   GPRFLN|            Itie,A., Drouin,J. and Tremblay,M.L.
CC   GPRFLN|  TITLE     Neuroendocrine dysplasia in mice lacking protein tyrosine
CC   GPRFLN|            phosphatase sigma
CC   GPRFLN|  JOURNAL   Nat. Genet. 21 (3), 330-333 (1999)
CC   GPRFLN|  MEDLINE   99178276
CC   GPRFLN|  REMARK    functional study of the mouse homolog
CC   GPRFLN|REFERENCE   4  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Haworth,K., Shu,K.K., Stokes,A., Morris,R. and Stoker,A.
CC   GPRFLN|  TITLE     The expression of receptor tyrosine phosphatases is responsive to
CC   GPRFLN|            sciatic nerve crush
CC   GPRFLN|  JOURNAL   Mol. Cell. Neurosci. 12 (3), 93-104 (1998)
CC   GPRFLN|  MEDLINE   99009170
CC   GPRFLN|  REMARK    functional study of the rat homolog
CC   GPRFLN|REFERENCE   5  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Wagner,J., Gordon,L.A., Heng,H.H., Tremblay,M.L. and Olsen,A.S.
CC   GPRFLN|  TITLE     Physical mapping of receptor type protein tyrosine phosphatase
CC   GPRFLN|            sigma (PTPRS) to human chromosome 19p13.3
CC   GPRFLN|  JOURNAL   Genomics 38 (1), 76-78 (1996)
CC   GPRFLN|  MEDLINE   97124849
CC   GPRFLN|REFERENCE   6  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Endo,N., Rutledge,S.J., Opas,E.E., Vogel,R., Rodan,G.A. and
CC   GPRFLN|            Schmidt,A.
CC   GPRFLN|  TITLE     Human protein tyrosine phosphatase-sigma: alternative splicing and
CC   GPRFLN|            inhibition by bisphosphonates
CC   GPRFLN|  JOURNAL   J. Bone Miner. Res. 11 (4), 535-543 (1996)
CC   GPRFLN|  MEDLINE   96255038
CC   GPRFLN|REFERENCE   7  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
CC   GPRFLN|  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
CC   GPRFLN|            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
CC   GPRFLN|            PTP sigma isoforms are expressed in a tissue-specific manner and
CC   GPRFLN|            associate with the LAR-interacting protein LIP.1
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
CC   GPRFLN|  MEDLINE   96102179
CC   GPRFLN|REFERENCE   8  (residues 1 to 1948)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
CC   GPRFLN|  JOURNAL   Cancer Res. 52 (3), 737-740 (1992)
CC   GPRFLN|  MEDLINE   92119637
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       protein tyrosine phosphatase PTPsigma
FT                                VNTIFKEY:270
FT   CHAIN         1    275       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_4
SQ   SEQUENCE   275 AA;
     ADMAEHTERL KANDSLKLSQ EYESIDPGQQ FTWEHSNLEV NKPKNRYANV IAYDHSRVIL        60
     QPIEGIMGSD YINANYVDGY RRQNAYIATQ GPLPETFGDF WRMVWEQRSA TIVMMTRLEE       120
     KSRIKCDQYW PNRGTETYGF IQVTLLDTIE LATFCVRTFS LHKNGSSEKR EVRQFQFTAW       180
     PDHGVPEYPT PFLAFLRRVK TCNPPDAGPI VVHCSAGVGR TGCFIVIDAM LERIKPEKTV       240
     DVYGHVTLMR SQRNYMVQTE DQYSFIHEAL LEAVG                                  275
//
ID   hPTPTyp_D1\(AL050040)\PTPN20 STANDARD;PRT;   274 AA.
DT   17-MAY-2003
DE   Translation of a fragment of hPTPTyp (AL050040).
KW   TRANSLATED.
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
SQ   SEQUENCE   274 AA;
     TAIKDCLKIL EEKTAAYDIM QEFMALELKN LPGEFYSGNQ PSNREKNRYR DILPYDSTRV        60
     PLGKSKDYIN ASYIRIVNCG EEYFYIATQG PLLSTIDDFW QMVLENNSNV IAMITREMEG       120
     GIIKCYHYWP ISLKKPLELK HFRVFLENYQ ILQYFIIRMF QVVEKSTGTS HSVKQLQFTK       180
     WPDHGTPASA DSFIKYIRYA RKSHLTGPMV VHCSAGIGRT GVFLCVDVVF CAIVKDCSFN       240
     IMDIVAQMRE QRSGMVQTKE QYHFCYDIVL EVLR                                   274
//
ID   hPTPzeta_D1\(NP_002842)\PTPRZ1 STANDARD;PRT;   293 AA.
AC   NP_002842;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   PROVISIONAL REFSEQ: This record has not yet been subject to final
CC   NCBI review. The reference sequence was derived from M93426.1.
CC   GPRFLN|REFERENCE   1  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Harroch,S., Furtado,G.C., Brueck,W., Rosenbluth,J., Lafaille,J.,
CC   GPRFLN|            Chao,M., Buxbaum,J.D. and Schlessinger,J.
CC   GPRFLN|  TITLE     A critical role for the protein tyrosine phosphatase receptor type
CC   GPRFLN|            Z in functional recovery from demyelinating lesions
CC   GPRFLN|  JOURNAL   Nat. Genet. 32 (3), 411-414 (2002)
CC   GPRFLN|  MEDLINE   22297719
CC   GPRFLN|  REMARK    GeneRIF: PTPRZ1 has a role in oligodendrocyte survival and in
CC   GPRFLN|            recovery from demyelinating disease
CC   GPRFLN|REFERENCE   2  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Thomaidou,D., Coquillat,D., Meintanis,S., Noda,M., Rougon,G. and
CC   GPRFLN|            Matsas,R.
CC   GPRFLN|  TITLE     Soluble forms of NCAM and F3 neuronal cell adhesion molecules
CC   GPRFLN|            promote Schwann cell migration: identification of protein tyrosine
CC   GPRFLN|            phosphatases zeta/beta as the putative F3 receptors on Schwann
CC   GPRFLN|            cells
CC   GPRFLN|  JOURNAL   J. Neurochem. 78 (4), 767-778 (2001)
CC   GPRFLN|  MEDLINE   21412137
CC   GPRFLN|REFERENCE   3  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Kawachi,H., Fujikawa,A., Maeda,N. and Noda,M.
CC   GPRFLN|  TITLE     Identification of GIT1/Cat-1 as a substrate molecule of protein
CC   GPRFLN|            tyrosine phosphatase zeta /beta by the yeast substrate-trapping
CC   GPRFLN|            system
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (12), 6593-6598 (2001)
CC   GPRFLN|  MEDLINE   21287250
CC   GPRFLN|REFERENCE   4  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Meng,K., Rodriguez-Pena,A., Dimitrov,T., Chen,W., Yamin,M., Noda,M.
CC   GPRFLN|            and Deuel,T.F.
CC   GPRFLN|  TITLE     Pleiotrophin signals increased tyrosine phosphorylation of beta
CC   GPRFLN|            beta-catenin through inactivation of the intrinsic catalytic
CC   GPRFLN|            activity of the receptor-type protein tyrosine phosphatase
CC   GPRFLN|            beta/zeta
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (6), 2603-2608 (2000)
CC   GPRFLN|  MEDLINE   20183934
CC   GPRFLN|REFERENCE   5  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Kawachi,H., Tamura,H., Watakabe,I., Shintani,T., Maeda,N. and
CC   GPRFLN|            Noda,M.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase zeta/RPTPbeta interacts with
CC   GPRFLN|            PSD-95/SAP90 family
CC   GPRFLN|  JOURNAL   Brain Res. Mol. Brain Res. 72 (1), 47-54 (1999)
CC   GPRFLN|  MEDLINE   99453345
CC   GPRFLN|REFERENCE   6  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Onyango,P., Lubyova,B., Gardellin,P., Kurzbauer,R. and Weith,A.
CC   GPRFLN|  TITLE     Molecular cloning and expression analysis of five novel genes in
CC   GPRFLN|            chromosome 1p36
CC   GPRFLN|  JOURNAL   Genomics 50 (2), 187-198 (1998)
CC   GPRFLN|  MEDLINE   98317532
CC   GPRFLN|REFERENCE   7  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Ariyama,T., Hasegawa,K., Inazawa,J., Mizuno,K., Ogimoto,M.,
CC   GPRFLN|            Katagiri,T. and Yakura,H.
CC   GPRFLN|  TITLE     Assignment of the human protein tyrosine phosphatase,
CC   GPRFLN|            receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 70 (1-2), 52-54 (1995)
CC   GPRFLN|  MEDLINE   95254878
CC   GPRFLN|REFERENCE   8  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Levy,J.B., Canoll,P.D., Silvennoinen,O., Barnea,G., Morse,B.,
CC   GPRFLN|            Honegger,A.M., Huang,J.T., Cannizzaro,L.A., Park,S.H., Druck,T. et
CC   GPRFLN|            al.
CC   GPRFLN|  TITLE     The cloning of a receptor-type protein tyrosine phosphatase
CC   GPRFLN|            expressed in the central nervous system
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 268 (14), 10573-10581 (1993)
CC   GPRFLN|  MEDLINE   93252948
CC   GPRFLN|REFERENCE   9  (residues 1 to 2314)
CC   GPRFLN|  AUTHORS   Krueger,N.X. and Saito,H.
CC   GPRFLN|  TITLE     A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is
CC   GPRFLN|            expressed in brain and has an N-terminal receptor domain homologous
CC   GPRFLN|            to carbonic anhydrases
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7417-7421 (1992)
CC   GPRFLN|  MEDLINE   92366472
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    293       VNTIFKEY:269
FT   PROTEIN       1    293       protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; receptor-type tyrosine phosphatase beta/zeta
FT                                VNTIFKEY:270
FT   REGION       15    293       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_2
SQ   SEQUENCE   293 AA;
     KHFPKHVADL HASSGFTEEF ETLKEFYQEV QSCTVDLGIT ADSSNHPDNK HKNRYINIVA        60
     YDHSRVKLAQ LAEKDGKLTD YINANYVDGY NRPKAYIAAQ GPLKSTAEDF WRMIWEHNVE       120
     VIVMITNLVE KGRRKCDQYW PADGSEEYGN FLVTQKSVQV LAYYTVRNFT LRNTKIKKGS       180
     QKGRPSGRVV TQYHYTQWPD MGVPEYSLPV LTFVRKAAYA KRHAVGPVVV HCSAGVGRTG       240
     TYIVLDSMLQ QIQHEGTVNI FGFLKHIRSQ RNYLVQTEEQ YVFIHDTLVE AIL              293
//
ID   hSAP1_D1\(NP_002833)\PTPRH STANDARD;PRT;   279 AA.
AC   NP_002833;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, receptor type, H precursor [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from D15049.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP possesses an extracellular
CC   region, a single transmembrane region, and a single
CC   intracytoplasmic catalytic domain, and thus represents a
CC   receptor-type PTP. The extracellular region contains eight
CC   fibronectin type III-like repeats and multiple N-glycosylation
CC   sites. The gene was shown to be expressed primarily in brain and
CC   liver, and at a lower level in heart and stomach. It was also found
CC   to be expressed in several cancer cell lines, but not in the
CC   corresponding normal tissues.
CC   GPRFLN|REFERENCE   1  (residues 1 to 1118)
CC   GPRFLN|  AUTHORS   Takada,T., Noguchi,T., Inagaki,K., Hosooka,T., Fukunaga,K.,
CC   GPRFLN|            Yamao,T., Ogawa,W., Matozaki,T. and Kasuga,M.
CC   GPRFLN|  TITLE     Induction of apoptosis by stomach cancer-associated
CC   GPRFLN|            protein-tyrosine phosphatase-1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (37), 34359-34366 (2002)
CC   GPRFLN|  MEDLINE   22206505
CC   GPRFLN|  REMARK    GeneRIF: SAP-1 induces apoptotic cell death by inhibition of cell
CC   GPRFLN|            survival signaling mediated by PI 3-kinase, Akt, and ILK and
CC   GPRFLN|            activation of a caspase-dependent proapoptotic pathway.
CC   GPRFLN|REFERENCE   2  (residues 1 to 1118)
CC   GPRFLN|  AUTHORS   Marneros,A.G., Mehenni,H., Reichenberger,E., Antonarakis,S.E.,
CC   GPRFLN|            Krieg,T. and Olsen,B.R.
CC   GPRFLN|  TITLE     Gene for the human transmembrane-type protein tyrosine phosphatase
CC   GPRFLN|            H (PTPRH): genomic structure, fine-mapping and its exclusion as a
CC   GPRFLN|            candidate for Peutz-Jeghers syndrome
CC   GPRFLN|  JOURNAL   Cytogenet. Cell Genet. 92 (3-4), 213-216 (2001)
CC   GPRFLN|  MEDLINE   21328879
CC   GPRFLN|REFERENCE   3  (residues 1 to 1118)
CC   GPRFLN|  AUTHORS   Matozaki,T., Suzuki,T., Uchida,T., Inazawa,J., Ariyama,T.,
CC   GPRFLN|            Matsuda,K., Horita,K., Noguchi,H., Mizuno,H., Sakamoto,C. et al.
CC   GPRFLN|  TITLE     Molecular cloning of a human transmembrane-type protein tyrosine
CC   GPRFLN|            phosphatase and its expression in gastrointestinal cancers
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 269 (3), 2075-2081 (1994)
CC   GPRFLN|  MEDLINE   94124561
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    279       VNTIFKEY:269
FT   PROTEIN       1    279       VNTIFKEY:270
FT   CHAIN         1    279       VNTIFKEY:203; VNTINAME:Chain_1
FT   REGION       17    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   279 AA;
     EDFADHVRKN ERDSNCGFAD EYQQLSLVGH SQSQMVASAS ENNAKNRYRN VLPYDWSRVP        60
     LKPIHEEPGS DYINASFMPG LWSPQEFIAT QGPLPQTVGD FWRLVWEQQS HTLVMLTNCM       120
     EAGRVKCEHY WPLDSQPCTH GHLRVTLVGE EVMENWTVRE LLLLQVEEQK TLSVRQFHYQ       180
     AWPDHGVPSS PDTLLAFWRM LRQWLDQTME GGPPIVHCSA GVGRTGTLIA LDVLLRQLQS       240
     EGLLGPFSFV RKMRESRPLM VQTEAQYVFL HQCICGSSN                              279
//
ID   hSHP1_D1\(NP_002822)\PTPN6 STANDARD;PRT;   297 AA.
AC   NP_002822;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 6 isoform 1; protein-tyrosine phosphatase 1C; hematopoietic cell phophatase; hematopoietic cell protein-tyrosine phosphatase; 70 kda SHP-1L protein [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M77273.1, BC002523.1 and
CC   U15536.1.
CC   On Jan 10, 2002 this sequence version replaced gi:4506297.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. N-terminal part of this PTP contains two
CC   tandem Src homolog (SH2) domains, which act as protein
CC   phospho-tyrosine binding domains, and mediate the interaction of
CC   this PTP with its substrates. This PTP is expressed primarily in
CC   hematopoietic cells, and functions as an important regulator of
CC   multiple signaling pathways in hematopoietic cells. This PTP has
CC   been shown to interact with, and dephosphorylate a wide spectrum of
CC   phospho-proteins involved in hematopoietic cell signaling. Three
CC   alternatively spliced variants of this gene, which encode distinct
CC   isoforms, have been reported.
CC   
CC   Transcript Variant: This variant (1) lacks an internal fragment
CC   within the coding region, which leads to a translation frame change
CC   when compared to variant 3. It encodes a protein that has an
CC   identical N-terminus and a different C-terminus, as compared to
CC   isoform 3.
CC   GPRFLN|REFERENCE   1  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Hanson,E.M., Dickensheets,H., Qu,C.K., Donnelly,R.P. and
CC   GPRFLN|            Keegan,A.D.
CC   GPRFLN|  TITLE     Regulation of the dephosphorylation of Stat6. Participation of
CC   GPRFLN|            Tyr-713 in the interleukin-4 receptor alpha, the tyrosine
CC   GPRFLN|            phosphatase SHP-1, and the proteasome
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 278 (6), 3903-3911 (2003)
CC   GPRFLN|  MEDLINE   22450671
CC   GPRFLN|  REMARK    GeneRIF: participation in regulation of Stat6 dephosphorylation
CC   GPRFLN|REFERENCE   2  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Oka,T., Ouchida,M., Koyama,M., Ogama,Y., Takada,S., Nakatani,Y.,
CC   GPRFLN|            Tanaka,T., Yoshino,T., Hayashi,K., Ohara,N., Kondo,E.,
CC   GPRFLN|            Takahashi,K., Tsuchiyama,J., Tanimoto,M., Shimizu,K. and Akagi,T.
CC   GPRFLN|  TITLE     Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant
CC   GPRFLN|            methylation in leukemias/lymphomas
CC   GPRFLN|  JOURNAL   Cancer Res. 62 (22), 6390-6394 (2002)
CC   GPRFLN|  MEDLINE   22325693
CC   GPRFLN|  REMARK    GeneRIF: Functional loss of SHP1 is associated with the
CC   GPRFLN|            pathogenesis of leukemias/lymphomas.
CC   GPRFLN|REFERENCE   3  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Leon,F., Cespon,C., Franco,A., Lombardia,M., Roldan,E.,
CC   GPRFLN|            Escribano,L., Harto,A., Gonzalez-Porque,P. and Roy,G.
CC   GPRFLN|  TITLE     SHP-1 expression in peripheral T cells from patients with Sezary
CC   GPRFLN|            syndrome and in the T cell line HUT-78: implications in
CC   GPRFLN|            JAK3-mediated signaling
CC   GPRFLN|  JOURNAL   Leukemia 16 (8), 1470-1477 (2002)
CC   GPRFLN|  MEDLINE   22140504
CC   GPRFLN|  REMARK    GeneRIF: In the T cell line HUT-78, JAK3 was found to be highly
CC   GPRFLN|            phosphorylated. These results suggest that SHP-1 might be involved
CC   GPRFLN|            in maintaining the IL-2R/JAK3 signaling pathway under control and
CC   GPRFLN|            point towards a role of SHP-1 in the pathogenesis of the disease.
CC   GPRFLN|REFERENCE   4  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Nikolova,M., Musette,P., Bagot,M., Boumsell,L. and Bensussan,A.
CC   GPRFLN|  TITLE     Engagement of ILT2/CD85j in Sezary syndrome cells inhibits their
CC   GPRFLN|            CD3/TCR signaling
CC   GPRFLN|  JOURNAL   Blood 100 (3), 1019-1025 (2002)
CC   GPRFLN|  MEDLINE   22122461
CC   GPRFLN|  REMARK    GeneRIF: ILT2 triggering on cutaneous T-cell lymphoma (CTCL) cells
CC   GPRFLN|            leads to the recruitment of SHP-1 and to the specific inhibition of
CC   GPRFLN|            CTCL malignant cell proliferation in S##zary syndrome induced by
CC   GPRFLN|            CD3/T-cell receptor. (TCR) stimulation.
CC   GPRFLN|REFERENCE   5  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and
CC   GPRFLN|            Varki,A.
CC   GPRFLN|  TITLE     Cloning and characterization of human Siglec-11. A recently evolved
CC   GPRFLN|            signaling that can interact with SHP-1 and SHP-2 and is expressed
CC   GPRFLN|            by tissue macrophages, including brain microglia
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (27), 24466-24474 (2002)
CC   GPRFLN|  MEDLINE   22086217
CC   GPRFLN|  REMARK    GeneRIF: interacts with siglec-11
CC   GPRFLN|REFERENCE   6  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Vyas,Y.M., Maniar,H. and Dupont,B.
CC   GPRFLN|  TITLE     Cutting edge: differential segregation of the SRC homology
CC   GPRFLN|            2-containing protein tyrosine phosphatase-1 within the early NK
CC   GPRFLN|            cell immune synapse distinguishes noncytolytic from cytolytic
CC   GPRFLN|            interactions
CC   GPRFLN|  JOURNAL   J. Immunol. 168 (7), 3150-3154 (2002)
CC   GPRFLN|  MEDLINE   21904490
CC   GPRFLN|  REMARK    GeneRIF: SHP-1 is recruited to the NK cell immune synapse within 1
CC   GPRFLN|            min in both cytolytic and noncytolytic conjugates, allowing clear
CC   GPRFLN|            distinction between noncytolytic and cytolytic interactions at this
CC   GPRFLN|            early time.
CC   GPRFLN|REFERENCE   7  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Kurita-Taniguchi,M., Hazeki,K., Murabayashi,N., Fukui,A., Tsuji,S.,
CC   GPRFLN|            Matsumoto,M., Toyoshima,K. and Seya,T.
CC   GPRFLN|  TITLE     Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and
CC   GPRFLN|            protein tyrosine phosphatase SHP-1 in human macrophages through
CC   GPRFLN|            differentiation by GM-CSF
CC   GPRFLN|  JOURNAL   Mol. Immunol. 38 (9), 689-700 (2002)
CC   GPRFLN|  MEDLINE   21848359
CC   GPRFLN|  REMARK    GeneRIF: peripheral blood monocytes treated for 5--8 days with
CC   GPRFLN|            GM-CSF (i.e. mature Mphi) acquired the capacity to assemble
CC   GPRFLN|            tyrosine phosphatase SHP-1 with CD9, alpha3-beta1 integrin and
CC   GPRFLN|            their CD46.
CC   GPRFLN|REFERENCE   8  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Blasioli,J. and Goodnow,C.C.
CC   GPRFLN|  TITLE     Lyn/CD22/SHP-1 and their importance in autoimmunity
CC   GPRFLN|  JOURNAL   Curr. Dir. Autoimmun. 5, 151-160 (2002)
CC   GPRFLN|  MEDLINE   21685428
CC   GPRFLN|  REMARK    GeneRIF: The Lyn/CD22/SHP-1 pathway is important in autoimmunity.
CC   GPRFLN|            Naive and tolerant B-cells differ in their calcium signaling in
CC   GPRFLN|            response to antigenic stimulation.
CC   GPRFLN|REFERENCE   9  (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Jin,Y.J., Yu,C.L. and Burakoff,S.J.
CC   GPRFLN|  TITLE     Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal
CC   GPRFLN|            structure and catalytic activity
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (40), 28301-28307 (1999)
CC   GPRFLN|  MEDLINE   99428497
CC   GPRFLN|REFERENCE   10 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Bousquet,C., Delesque,N., Lopez,F., Saint-Laurent,N., Esteve,J.P.,
CC   GPRFLN|            Bedecs,K., Buscail,L., Vaysse,N. and Susini,C.
CC   GPRFLN|  TITLE     sst2 somatostatin receptor mediates negative regulation of insulin
CC   GPRFLN|            receptor signaling through the tyrosine phosphatase SHP-1
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (12), 7099-7106 (1998)
CC   GPRFLN|  MEDLINE   98175983
CC   GPRFLN|REFERENCE   11 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Blery,M., Kubagawa,H., Chen,C.C., Vely,F., Cooper,M.D. and
CC   GPRFLN|            Vivier,E.
CC   GPRFLN|  TITLE     The paired Ig-like receptor PIR-B is an inhibitory receptor that
CC   GPRFLN|            recruits the protein-tyrosine phosphatase SHP-1
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (5), 2446-2451 (1998)
CC   GPRFLN|  MEDLINE   98151532
CC   GPRFLN|REFERENCE   12 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Ono,M., Okada,H., Bolland,S., Yanagi,S., Kurosaki,T. and
CC   GPRFLN|            Ravetch,J.V.
CC   GPRFLN|  TITLE     Deletion of SHIP or SHP-1 reveals two distinct pathways for
CC   GPRFLN|            inhibitory signaling
CC   GPRFLN|  JOURNAL   Cell 90 (2), 293-301 (1997)
CC   GPRFLN|  MEDLINE   97386454
CC   GPRFLN|REFERENCE   13 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Li,R.Y., Gaits,F., Ragab,A., Ragab-Thomas,J.M. and Chap,H.
CC   GPRFLN|  TITLE     Tyrosine phosphorylation of an SH2-containing protein tyrosine
CC   GPRFLN|            phosphatase is coupled to platelet thrombin receptor via a
CC   GPRFLN|            pertussis toxin-sensitive heterotrimeric G-protein
CC   GPRFLN|  JOURNAL   EMBO J. 14 (11), 2519-2526 (1995)
CC   GPRFLN|  MEDLINE   95300784
CC   GPRFLN|REFERENCE   14 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Banville,D., Stocco,R. and Shen,S.H.
CC   GPRFLN|  TITLE     Human protein tyrosine phosphatase 1C (PTPN6) gene structure:
CC   GPRFLN|            alternate promoter usage and exon skipping generate multiple
CC   GPRFLN|            transcripts
CC   GPRFLN|  JOURNAL   Genomics 27 (1), 165-173 (1995)
CC   GPRFLN|  MEDLINE   95394454
CC   GPRFLN|REFERENCE   15 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Plutzky,J., Neel,B.G., Rosenberg,R.D., Eddy,R.L., Byers,M.G.,
CC   GPRFLN|            Jani-Sait,S. and Shows,T.B.
CC   GPRFLN|  TITLE     Chromosomal localization of an SH2-containing tyrosine phosphatase
CC   GPRFLN|            (PTPN6)
CC   GPRFLN|  JOURNAL   Genomics 13 (3), 869-872 (1992)
CC   GPRFLN|  MEDLINE   92347896
CC   GPRFLN|REFERENCE   16 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Plutzky,J., Neel,B.G. and Rosenberg,R.D.
CC   GPRFLN|  TITLE     Isolation of a src homology 2-containing tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (3), 1123-1127 (1992)
CC   GPRFLN|  MEDLINE   92141214
CC   GPRFLN|REFERENCE   17 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Yi,T.L., Cleveland,J.L. and Ihle,J.N.
CC   GPRFLN|  TITLE     Protein tyrosine phosphatase containing SH2 domains:
CC   GPRFLN|            characterization, preferential expression in hematopoietic cells,
CC   GPRFLN|            and localization to human chromosome 12p12-p13
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 12 (2), 836-846 (1992)
CC   GPRFLN|  MEDLINE   92123209
CC   GPRFLN|REFERENCE   18 (residues 1 to 595)
CC   GPRFLN|  AUTHORS   Shen,S.H., Bastien,L., Posner,B.I. and Chretien,P.
CC   GPRFLN|  TITLE     A protein-tyrosine phosphatase with sequence similarity to the SH2
CC   GPRFLN|            domain of the protein-tyrosine kinases
CC   GPRFLN|  JOURNAL   Nature 352 (6337), 736-739 (1991)
CC   GPRFLN|  MEDLINE   91343005
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    297       VNTIFKEY:269
FT   PROTEIN       1    297       protein-tyrosine phosphatase 1C; hematopoietic cell phophatase; hematopoietic cell protein-tyrosine phosphatase; 70 kda SHP-1L protein
FT                                VNTIFKEY:270
FT   REGION       23    297       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   297 AA;
     ADIENRVLEL NKKQESEDTA KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KGKNRYKNIL        60
     PFDHSRVILQ GRDSNIPGSD YINANYIKNQ LLGPDENAKT YIASQGCLEA TVNDFWQMAW       120
     QENSRVIVMT TREVEKGRNK CVPYWPEVGM QRAYGPYSVT NCGEHDTTEY KLRTLQVSPL       180
     DNGDLIREIW HYQYLSWPDH GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT       240
     GTIIVIDMLM ENISTKGLDC DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIE          297
//
ID   hSHP2_D1\(NP_002825)\PTPN11 STANDARD;PRT;   300 AA.
AC   NP_002825;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 11 isoform 1; protein-tyrosine phosphatase 2C; Noonan syndrome 1; protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from D13540.1 and BF515187.1.
CC   On Jan 25, 2002 this sequence version replaced gi:13430846.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. PTPs are known to be
CC   signaling molecules that regulate a variety of cellular processes
CC   including cell growth, differentiation, mitotic cycle, and
CC   oncogenic transformation. This PTP contains two tandem Src
CC   homology-2 domains, which function as phospho-tyrosine binding
CC   domains and mediate the interaction of this PTP with its
CC   substrates. This PTP is widely expressed in most tissues and plays
CC   a regulatory role in various cell signaling events that are
CC   important for a diversity of cell functions, such as mitogenic
CC   activation, metabolic control, transcription regulation, and cell
CC   migration. Two alternatively spliced transcript variants of this
CC   gene, which encode distinct isoforms, have been described.
CC   
CC   Transcript Variant: This variant (1) contains a different 3' end
CC   region, and encodes a longer isoform (1), as compared to variant 2.
CC   GPRFLN|REFERENCE   1  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Yamazaki,S., Yamakawa,A., Ito,Y., Ohtani,M., Higashi,H.,
CC   GPRFLN|            Hatakeyama,M. and Azuma,T.
CC   GPRFLN|  TITLE     The CagA protein of Helicobacter pylori is translocated into
CC   GPRFLN|            epithelial cells and binds to SHP-2 in human gastric mucosa
CC   GPRFLN|  JOURNAL   J. Infect. Dis. 187 (2), 334-337 (2003)
CC   GPRFLN|  MEDLINE   22439942
CC   GPRFLN|  REMARK    GeneRIF: The CagA protein of Helicobacter pylori is translocated
CC   GPRFLN|            into epithelial cells and binds to SHP-2 in human gastric mucosa
CC   GPRFLN|REFERENCE   2  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Lehmann,U., Schmitz,J., Weissenbach,M., Sobota,R.M., Hortner,M.,
CC   GPRFLN|            Friederichs,K., Behrmann,I., Tsiaris,W., Sasaki,A.,
CC   GPRFLN|            Schneider-Mergener,J., Yoshimura,A., Neel,B.G., Heinrich,P.C. and
CC   GPRFLN|            Schaper,F.
CC   GPRFLN|  TITLE     SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of
CC   GPRFLN|            interleukin-6 signaling through gp130
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 278 (1), 661-671 (2003)
CC   GPRFLN|  MEDLINE   22393451
CC   GPRFLN|  REMARK    GeneRIF: These data suggest, that there are two, largely distinct
CC   GPRFLN|            modes of negative regulation of gp130 activity, despite the fact
CC   GPRFLN|            that both SOCS3 and SHP2 are recruited to the same site within
CC   GPRFLN|            gp130.
CC   GPRFLN|REFERENCE   3  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Wu,T.R., Hong,Y.K., Wang,X.D., Ling,M.Y., Dragoi,A.M., Chung,A.S.,
CC   GPRFLN|            Campbell,A.G., Han,Z.Y., Feng,G.S. and Chin,Y.E.
CC   GPRFLN|  TITLE     SHP-2 is a dual-specificity phosphatase involved in Stat1
CC   GPRFLN|            dephosphorylation at both tyrosine and serine residues in nuclei
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (49), 47572-47580 (2002)
CC   GPRFLN|  MEDLINE   22344627
CC   GPRFLN|  REMARK    GeneRIF: SHP-2 is a dual-specificity protein phosphatase involved
CC   GPRFLN|            in Stat1 dephosphorylation at both tyrosine and serine residues and
CC   GPRFLN|            plays an important role in modulating STAT function in gene
CC   GPRFLN|            regulation
CC   GPRFLN|REFERENCE   4  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Maile,L.A. and Clemmons,D.R.
CC   GPRFLN|  TITLE     The alphaVbeta3 integrin regulates insulin-like growth factor I
CC   GPRFLN|            (IGF-I) receptor phosphorylation by altering the rate of
CC   GPRFLN|            recruitment of the Src-homology 2-containing phosphotyrosine
CC   GPRFLN|            phosphatase-2 to the activated IGF-I receptor
CC   GPRFLN|  JOURNAL   Endocrinology 143 (11), 4259-4264 (2002)
CC   GPRFLN|  MEDLINE   22286240
CC   GPRFLN|  REMARK    GeneRIF: activation state of alphaVbeta3 integrin is an important
CC   GPRFLN|            regulator of the duration of insulin-like growth factor I receptor
CC   GPRFLN|            phosphorylation and this regulation is mediated through changes in
CC   GPRFLN|            the subcellular localization of SHP-2
CC   GPRFLN|REFERENCE   5  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Ion,A., Tartaglia,M., Song,X., Kalidas,K., van der Burgt,I.,
CC   GPRFLN|            Shaw,A.C., Ming,J.E., Zampino,G., Zackai,E.H., Dean,J.C., Somer,M.,
CC   GPRFLN|            Parenti,G., Crosby,A.H., Patton,M.A., Gelb,B.D. and Jeffery,S.
CC   GPRFLN|  TITLE     Absence of PTPN11 mutations in 28 cases of cardiofaciocutaneous
CC   GPRFLN|            (CFC) syndrome
CC   GPRFLN|  JOURNAL   Hum. Genet. 111 (4-5), 421-427 (2002)
CC   GPRFLN|  MEDLINE   22271640
CC   GPRFLN|  REMARK    GeneRIF: absence of mutation in cases of cardiofaciocutaneous
CC   GPRFLN|            syndrome
CC   GPRFLN|REFERENCE   6  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Cai,T., Nishida,K., Hirano,T. and Khavari,P.A.
CC   GPRFLN|  TITLE     Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and
CC   GPRFLN|            differentiation
CC   GPRFLN|  JOURNAL   J. Cell Biol. 159 (1), 103-112 (2002)
CC   GPRFLN|  MEDLINE   22267353
CC   GPRFLN|  REMARK    GeneRIF: Results indicate that Gab1 and SHP-2 promote the
CC   GPRFLN|            undifferentiated epidermal cell state by facilitating Ras/MAPK
CC   GPRFLN|            signaling.
CC   GPRFLN|REFERENCE   7  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Maheshwari,M., Belmont,J., Fernbach,S., Ho,T., Molinari,L.,
CC   GPRFLN|            Yakub,I., Yu,F., Combes,A., Towbin,J., Craigen,W.J. and Gibbs,R.
CC   GPRFLN|  TITLE     PTPN11 mutations in Noonan syndrome type I: detection of recurrent
CC   GPRFLN|            mutations in exons 3 and 13
CC   GPRFLN|  JOURNAL   Hum. Mutat. 20 (4), 298-304 (2002)
CC   GPRFLN|  MEDLINE   22236043
CC   GPRFLN|  REMARK    GeneRIF: Mutations in PTPN11/SHP2 underlie a common form of Noonan
CC   GPRFLN|            syndrome and confirm that the disease exhibits both allelic and
CC   GPRFLN|            locus heterogeneity.
CC   GPRFLN|REFERENCE   8  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Legius,E., Schrander-Stumpel,C., Schollen,E.,
CC   GPRFLN|            Pulles-Heintzberger,C., Gewillig,M. and Fryns,J.P.
CC   GPRFLN|  TITLE     PTPN11 mutations in LEOPARD syndrome
CC   GPRFLN|  JOURNAL   J. Med. Genet. 39 (8), 571-574 (2002)
CC   GPRFLN|  MEDLINE   22151430
CC   GPRFLN|  REMARK    GeneRIF: Some PTPN11 mutations (e.g., Y279C) are associated with
CC   GPRFLN|            both the Noonan syndrome phenotype and with skin pigmentation
CC   GPRFLN|            anomalies, such as multiple lentigines or caf## au lait spots
CC   GPRFLN|            (LEOPARD syndrome).
CC   GPRFLN|REFERENCE   9  (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Kosaki,K., Suzuki,T., Muroya,K., Hasegawa,T., Sato,S., Matsuo,N.,
CC   GPRFLN|            Kosaki,R., Nagai,T., Hasegawa,Y. and Ogata,T.
CC   GPRFLN|  TITLE     PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11)
CC   GPRFLN|            mutations in seven Japanese patients with Noonan syndrome
CC   GPRFLN|  JOURNAL   J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002)
CC   GPRFLN|  MEDLINE   22151235
CC   GPRFLN|  REMARK    GeneRIF: PTPN11 mutations are responsible for Noonan syndrome in a
CC   GPRFLN|            substantial fraction of patients and that relatively infrequent
CC   GPRFLN|            features of Noonan syndrome, such as sensory deafness and bleeding
CC   GPRFLN|            diathesis, can also result from mutations of PTPN11.
CC   GPRFLN|REFERENCE   10 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and
CC   GPRFLN|            Varki,A.
CC   GPRFLN|  TITLE     Cloning and characterization of human Siglec-11. A recently evolved
CC   GPRFLN|            signaling that can interact with SHP-1 and SHP-2 and is expressed
CC   GPRFLN|            by tissue macrophages, including brain microglia
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (27), 24466-24474 (2002)
CC   GPRFLN|  MEDLINE   22086217
CC   GPRFLN|  REMARK    GeneRIF: interacts with siglec-11
CC   GPRFLN|REFERENCE   11 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Bordin,L., Brunati,A.M., Donella-Deana,A., Baggio,B., Toninello,A.
CC   GPRFLN|            and Clari,G.
CC   GPRFLN|  TITLE     Band 3 is an anchor protein and a target for SHP-2 tyrosine
CC   GPRFLN|            phosphatase in human erythrocytes
CC   GPRFLN|  JOURNAL   Blood 100 (1), 276-282 (2002)
CC   GPRFLN|  MEDLINE   22065093
CC   GPRFLN|  REMARK    GeneRIF: Band 3 is an anchor protein for and a target for SHP-2
CC   GPRFLN|            tyrosine phosphatase in human erythrocytes.
CC   GPRFLN|REFERENCE   12 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Tartaglia,M., Kalidas,K., Shaw,A., Song,X., Musat,D.L., van der
CC   GPRFLN|            Burgt,I., Brunner,H.G., Bertola,D.R., Crosby,A., Ion,A.,
CC   GPRFLN|            Kucherlapati,R.S., Jeffery,S., Patton,M.A. and Gelb,B.D.
CC   GPRFLN|  TITLE     PTPN11 mutations in Noonan syndrome: molecular spectrum,
CC   GPRFLN|            genotype-phenotype correlation, and phenotypic heterogeneity
CC   GPRFLN|  JOURNAL   Am. J. Hum. Genet. 70 (6), 1555-1563 (2002)
CC   GPRFLN|  MEDLINE   21987645
CC   GPRFLN|  REMARK    GeneRIF: PTPN11 mutations in Noonan syndrome: molecular spectrum,
CC   GPRFLN|            genotype-phenotype correlation, and phenotypic heterogeneity.
CC   GPRFLN|REFERENCE   13 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Lacalle,R.A., Mira,E., Gomez-Mouton,C., Jimenez-Baranda,S.,
CC   GPRFLN|            Martinez-A,C. and Manes,S.
CC   GPRFLN|  TITLE     Specific SHP-2 partitioning in raft domains triggers
CC   GPRFLN|            integrin-mediated signaling via Rho activation
CC   GPRFLN|  JOURNAL   J. Cell Biol. 157 (2), 277-289 (2002)
CC   GPRFLN|  MEDLINE   21953171
CC   GPRFLN|  REMARK    GeneRIF: Specific SHP-2 partitioning in raft domains triggers
CC   GPRFLN|            integrin-mediated signaling via Rho activation
CC   GPRFLN|REFERENCE   14 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Ekman,S., Kallin,A., Engstrom,U., Heldin,C.H. and Ronnstrand,L.
CC   GPRFLN|  TITLE     SHP-2 is involved in heterodimer specific loss of phosphorylation
CC   GPRFLN|            of Tyr771 in the PDGF beta-receptor
CC   GPRFLN|  JOURNAL   Oncogene 21 (12), 1870-1875 (2002)
CC   GPRFLN|  MEDLINE   21906255
CC   GPRFLN|  REMARK    GeneRIF: SHP-2 modulates phosphorylation of PDGF receptors, thereby
CC   GPRFLN|            controls RasGTP recruitment and Ras/MAP kinase signaling in the
CC   GPRFLN|            heterodimeric configuration of the PDGF receptors
CC   GPRFLN|REFERENCE   15 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Higashi,H., Tsutsumi,R., Muto,S., Sugiyama,T., Azuma,T., Asaka,M.
CC   GPRFLN|            and Hatakeyama,M.
CC   GPRFLN|  TITLE     SHP-2 tyrosine phosphatase as an intracellular target of
CC   GPRFLN|            Helicobacter pylori CagA protein
CC   GPRFLN|  JOURNAL   Science 295 (5555), 683-686 (2002)
CC   GPRFLN|  MEDLINE   21669283
CC   GPRFLN|  REMARK    GeneRIF: upon translocation, CagA perturbs cellular functions by
CC   GPRFLN|            deregulating SHP-2
CC   GPRFLN|REFERENCE   16 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Fukunaga,K., Noguchi,T., Takeda,H., Matozaki,T., Hayashi,Y.,
CC   GPRFLN|            Itoh,H. and Kasuga,M.
CC   GPRFLN|  TITLE     Requirement for protein-tyrosine phosphatase SHP-2 in
CC   GPRFLN|            insulin-induced activation of c-Jun NH(2)-terminal kinase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (7), 5208-5213 (2000)
CC   GPRFLN|  MEDLINE   20138272
CC   GPRFLN|REFERENCE   17 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Yu,C.L., Jin,Y.J. and Burakoff,S.J.
CC   GPRFLN|  TITLE     Cytosolic tyrosine dephosphorylation of STAT5. Potential role of
CC   GPRFLN|            SHP-2 in STAT5 regulation
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 275 (1), 599-604 (2000)
CC   GPRFLN|  MEDLINE   20085083
CC   GPRFLN|REFERENCE   18 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Li,C. and Friedman,J.M.
CC   GPRFLN|  TITLE     Leptin receptor activation of SH2 domain containing protein
CC   GPRFLN|            tyrosine phosphatase 2 modulates Ob receptor signal transduction
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (17), 9677-9682 (1999)
CC   GPRFLN|  MEDLINE   99380578
CC   GPRFLN|REFERENCE   19 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Manes,S., Mira,E., Gomez-Mouton,C., Zhao,Z.J., Lacalle,R.A. and
CC   GPRFLN|            Martinez-A,C.
CC   GPRFLN|  TITLE     Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion
CC   GPRFLN|            kinase in regulation of cell motility
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 19 (4), 3125-3135 (1999)
CC   GPRFLN|  MEDLINE   99182500
CC   GPRFLN|REFERENCE   20 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Takada,T., Matozaki,T., Takeda,H., Fukunaga,K., Noguchi,T.,
CC   GPRFLN|            Fujioka,Y., Okazaki,I., Tsuda,M., Yamao,T., Ochi,F. and Kasuga,M.
CC   GPRFLN|  TITLE     Roles of the complex formation of SHPS-1 with SHP-2 in
CC   GPRFLN|            insulin-stimulated mitogen-activated protein kinase activation
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 273 (15), 9234-9242 (1998)
CC   GPRFLN|  MEDLINE   98204923
CC   GPRFLN|REFERENCE   21 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Jamieson,C.R., van der Burgt,I., Brady,A.F., van Reen,M.,
CC   GPRFLN|            Elsawi,M.M., Hol,F., Jeffery,S., Patton,M.A. and Mariman,E.
CC   GPRFLN|  TITLE     Mapping a gene for Noonan syndrome to the long arm of chromosome 12
CC   GPRFLN|  JOURNAL   Nat. Genet. 8 (4), 357-360 (1994)
CC   GPRFLN|  MEDLINE   95201801
CC   GPRFLN|REFERENCE   22 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Isobe,M., Hinoda,Y., Imai,K. and Adachi,M.
CC   GPRFLN|  TITLE     Chromosomal localization of an SH2 containing tyrosine phosphatase
CC   GPRFLN|            (SH-PTP3) gene to chromosome 12q24.1
CC   GPRFLN|  JOURNAL   Oncogene 9 (6), 1751-1753 (1994)
CC   GPRFLN|  MEDLINE   94239755
CC   GPRFLN|REFERENCE   23 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Bastien,L., Ramachandran,C., Liu,S. and Adam,M.
CC   GPRFLN|  TITLE     Cloning, expression and mutational analysis of SH-PTP2, human
CC   GPRFLN|            protein-tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 196 (1), 124-133 (1993)
CC   GPRFLN|  MEDLINE   94029983
CC   GPRFLN|REFERENCE   24 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Ahmad,S., Banville,D., Zhao,Z., Fischer,E.H. and Shen,S.H.
CC   GPRFLN|  TITLE     A widely expressed human protein-tyrosine phosphatase containing
CC   GPRFLN|            src homology 2 domains
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 90 (6), 2197-2201 (1993)
CC   GPRFLN|  MEDLINE   93211929
CC   GPRFLN|REFERENCE   25 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Vogel,W., Lammers,R., Huang,J. and Ullrich,A.
CC   GPRFLN|  TITLE     Activation of a phosphotyrosine phosphatase by tyrosine
CC   GPRFLN|            phosphorylation
CC   GPRFLN|  JOURNAL   Science 259 (5101), 1611-1614 (1993)
CC   GPRFLN|  MEDLINE   93206095
CC   GPRFLN|REFERENCE   26 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Miyachi,T., Matsuno,K., Hinoda,Y., Imai,K.
CC   GPRFLN|            and Yachi,A.
CC   GPRFLN|  TITLE     Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3
CC   GPRFLN|            with sequence similarity to the src-homology region 2
CC   GPRFLN|  JOURNAL   FEBS Lett. 314 (3), 335-339 (1992)
CC   GPRFLN|  MEDLINE   93106179
CC   GPRFLN|REFERENCE   27 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Freeman,R.M. Jr., Plutzky,J. and Neel,B.G.
CC   GPRFLN|  TITLE     Identification of a human src homology 2-containing
CC   GPRFLN|            protein-tyrosine-phosphatase: a putative homolog of Drosophila
CC   GPRFLN|            corkscrew
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (23), 11239-11243 (1992)
CC   GPRFLN|  MEDLINE   93087502
CC   GPRFLN|REFERENCE   28 (residues 1 to 593)
CC   GPRFLN|  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
CC   GPRFLN|            Imai,K. and Yachi,A.
CC   GPRFLN|  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
CC   GPRFLN|  JOURNAL   Cancer Res. 52 (3), 737-740 (1992)
CC   GPRFLN|  MEDLINE   92119637
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    300       VNTIFKEY:269
FT   PROTEIN       1    300       protein-tyrosine phosphatase 2C; Noonan syndrome 1; protein tyrosine phosphatase, non-receptor type 11
FT                                VNTIFKEY:270
FT   REGION       23    300       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   300 AA;
     AEIESRVREL SKLAETTDKV KQGFWEEFET LQQQECKLLY SRKEGQRQEN KNKNRYKNIL        60
     PFDHTRVVLH DGDPNEPVSD YINANIIMPE FETKCNNSKP KKSYIATQGC LQNTVNDFWR       120
     MVFQENSRVI VMTTKEVERG KSKCVKYWPD EYALKEYGVM RVRNVKESAA HDYTLRELKL       180
     SKVGQGNTER TVWQYHFRTW PDHGVPSDPG GVLDFLEEVH HKQESIMDAG PVVVHCSAGI       240
     GRTGTFIVID ILIDIIREKG VDCDIDVPKT IQMVRSQRSG MVQTEAQYRF IYMAVQHYIE       300
//
ID   hSTEP_D1\(NP_116170)\PTPN5 STANDARD;PRT;   276 AA.
AC   NP_116170;
DT   17-MAY-2003
DE   hypothetical protein FLJ14427 [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   PREDICTED REFSEQ: The mRNA record is supported by experimental
CC   evidence; however, the coding sequence is predicted. The reference
CC   sequence was derived from AK090923.1.
CC   On Aug 5, 2002 this sequence version replaced gi:14249442.
CC   GPRFLN|REFERENCE   1
CC   GPRFLN|  AUTHORS   Ninomiya,K., Wagatsuma,M., Kanda,K., Kondo,H., Yokoi,T.,
CC   GPRFLN|            Kodaira,H., Furuya,T., Takahashi,M., Kikkawa,E., Omura,Y., Abe,K.,
CC   GPRFLN|            Kamihara,K., Katsuta,N., Sato,K., Tanikawa,M., Yamazaki,M.,
CC   GPRFLN|            Sugiyama,T., Irie,R., Otsuki,T., Sato,H., Wakamatsu,A., Ishii,S.,
CC   GPRFLN|            Yamamoto,J., Isono,Y., Kawai-Hio,Y., Saito,K., Nishikawa,T.,
CC   GPRFLN|            Kimura,K., Yamashita,H., Matsuo,K., Nakamura,Y., Sekine,M.,
CC   GPRFLN|            Kikuchi,H., Murakawa,K., Kanehori,K., Takahashi-Fujii,A.,
CC   GPRFLN|            Oshima,A., Sugiyama,A., Kawakami,B., Suzuki,Y., Sugano,S.,
CC   GPRFLN|            Nagahari,K., Masuho,Y., Nagai,K. and Isogai,T.
CC   GPRFLN|  TITLE     NEDO human cDNA sequencing project
CC   GPRFLN|  JOURNAL   Unpublished
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    276       cloning vector: pME18SFL3
FT                                VNTIFKEY:269
FT   PROTEIN       1    276       VNTIFKEY:270
FT   REGION       18    274       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   276 AA;
     SRVLQAEELH EKALDPFLLQ AEFFEIPMNF VDPKEYDIPG LVRKNRYKTI LPNPHSRVCL        60
     TSPDPDDPLS SYINANYIRG YGGEEKVYIA TQGPIVSTVA DFWRMVWQEH TPIIVMITNI       120
     EEMNEKCTEY WPEEQVAYDG VEITVQKVIH TEDYRLRLIS LKSGTEERGL KHYWFTSWPD       180
     QKTPDRAPPL LHLVREVEEA AQQEGPHCAP IIVHCSAGIG RTGCFIATSI CCQQLRQEGV       240
     VDILKTTCQL RQDRGGMIQT CEQYQFVHHV MSLYEK                                 276
//
ID   hTCPTP_D1\(NP_002819)\PTPN2 STANDARD;PRT;   275 AA.
AC   NP_002819;
DT   17-MAY-2003
DE   protein tyrosine phosphatase, non-receptor type 2 isoform 1; T-cell protein tyrosine phosphatase [Homo sapiens].
OS   Homo sapiens.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
CC   REVIEWED REFSEQ: This record has been curated by NCBI staff. The
CC   reference sequence was derived from M25393.1, AW592324.1 and
CC   BG699440.1.
CC   
CC   Summary: The protein encoded by this gene is a member of the
CC   protein tyrosine phosphatase (PTP) family. Members of the PTP
CC   family share a highly conserved catalytic motif, which is essential
CC   for the catalytic activity. PTPs are known to be signaling
CC   molecules that regulate a variety of cellular processes including
CC   cell growth, differentiation, mitotic cycle, and oncogenic
CC   transformation. Epidermal growth factor receptor and the adaptor
CC   protein Shc were reported to be substrates of this PTP, which
CC   suggested the roles in growth factor mediated cell signaling. Three
CC   alternatively spliced variants of this gene, which encode isoforms
CC   differing at their extreme C-termini, have been described. The
CC   different C-termini are thought to determine the substrate
CC   specificity, as well as the cellular localization of the isoforms.
CC   Two highly related but distinctly processed pseudogenes that
CC   localize to distinct chromosomes have been reported.
CC   
CC   Transcript Variant: This variant (1) contains a different 3'
CC   region, and encodes the longest isoform (1), as compared to variant
CC   2 and 3.
CC   GPRFLN|REFERENCE   1  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Gupta,S., Radha,V., Sudhakar,Ch. and Swarup,G.
CC   GPRFLN|  TITLE     A nuclear protein tyrosine phosphatase activates p53 and induces
CC   GPRFLN|            caspase-1-dependent apoptosis
CC   GPRFLN|  JOURNAL   FEBS Lett. 532 (1-2), 61-66 (2002)
CC   GPRFLN|  MEDLINE   22347239
CC   GPRFLN|  REMARK    GeneRIF: TCPTP activates p53 and induces caspase-1-dependent
CC   GPRFLN|            apoptosis in a human tumor cell line.
CC   GPRFLN|REFERENCE   2  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Yamamoto,T., Sekine,Y., Kashima,K., Kubota,A., Sato,N., Aoki,N. and
CC   GPRFLN|            Matsuda,T.
CC   GPRFLN|  TITLE     The nuclear isoform of protein-tyrosine phosphatase TC-PTP
CC   GPRFLN|            regulates interleukin-6-mediated signaling pathway through STAT3
CC   GPRFLN|            dephosphorylation
CC   GPRFLN|  JOURNAL   Biochem. Biophys. Res. Commun. 297 (4), 811-817 (2002)
CC   GPRFLN|  MEDLINE   22246068
CC   GPRFLN|  REMARK    GeneRIF: regulates interleukin-6-mediated signaling pathway through
CC   GPRFLN|            STAT3 dephosphorylation
CC   GPRFLN|REFERENCE   3  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Zhu,W., Mustelin,T. and David,M.
CC   GPRFLN|  TITLE     Arginine methylation of STAT1 regulates its dephosphorylation by T
CC   GPRFLN|            cell protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 277 (39), 35787-35790 (2002)
CC   GPRFLN|  MEDLINE   22229439
CC   GPRFLN|  REMARK    GeneRIF: TcPTP phosphorylation is regulated by STAT1
CC   GPRFLN|REFERENCE   4  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   ten Hoeve,J., de Jesus Ibarra-Sanchez,M., Fu,Y., Zhu,W.,
CC   GPRFLN|            Tremblay,M., David,M. and Shuai,K.
CC   GPRFLN|  TITLE     Identification of a nuclear Stat1 protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 22 (16), 5662-5668 (2002)
CC   GPRFLN|  MEDLINE   22133581
CC   GPRFLN|  REMARK    GeneRIF: Results identify TC45 as a protein tyrosine phosphatase
CC   GPRFLN|            responsible for the dephosphorylation of Stat1 in the nucleus.
CC   GPRFLN|REFERENCE   5  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Tiganis,T., Kemp,B.E. and Tonks,N.K.
CC   GPRFLN|  TITLE     The protein-tyrosine phosphatase TCPTP regulates epidermal growth
CC   GPRFLN|            factor receptor-mediated and phosphatidylinositol
CC   GPRFLN|            3-kinase-dependent signaling
CC   GPRFLN|  JOURNAL   J. Biol. Chem. 274 (39), 27768-27775 (1999)
CC   GPRFLN|  MEDLINE   99419063
CC   GPRFLN|REFERENCE   6  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Tiganis,T., Bennett,A.M., Ravichandran,K.S. and Tonks,N.K.
CC   GPRFLN|  TITLE     Epidermal growth factor receptor and the adaptor protein p52Shc are
CC   GPRFLN|            specific substrates of T-cell protein tyrosine phosphatase
CC   GPRFLN|  JOURNAL   Mol. Cell. Biol. 18 (3), 1622-1634 (1998)
CC   GPRFLN|  MEDLINE   98147803
CC   GPRFLN|REFERENCE   7  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Johnson,C.V., Cool,D.E., Glaccum,M.B., Green,N., Fischer,E.H.,
CC   GPRFLN|            Bruskin,A., Hill,D.E. and Lawrence,J.B.
CC   GPRFLN|  TITLE     Isolation and mapping of human T-cell protein tyrosine phosphatase
CC   GPRFLN|            sequences: localization of genes and pseudogenes discriminated
CC   GPRFLN|            using fluorescence hybridization with genomic versus cDNA probes
CC   GPRFLN|  JOURNAL   Genomics 16 (3), 619-629 (1993)
CC   GPRFLN|  MEDLINE   93315152
CC   GPRFLN|REFERENCE   8  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Mosinger,B. Jr., Tillmann,U., Westphal,H. and Tremblay,M.L.
CC   GPRFLN|  TITLE     Cloning and characterization of a mouse cDNA encoding a cytoplasmic
CC   GPRFLN|            protein-tyrosine-phosphatase
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (2), 499-503 (1992)
CC   GPRFLN|  MEDLINE   92115688
CC   GPRFLN|REFERENCE   9  (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Swarup,G., Kamatkar,S., Radha,V. and Rema,V.
CC   GPRFLN|  TITLE     Molecular cloning and expression of a protein-tyrosine phosphatase
CC   GPRFLN|            showing homology with transcription factors Fos and Jun
CC   GPRFLN|  JOURNAL   FEBS Lett. 280 (1), 65-69 (1991)
CC   GPRFLN|  MEDLINE   91184422
CC   GPRFLN|REFERENCE   10 (residues 1 to 415)
CC   GPRFLN|  AUTHORS   Cool,D.E., Tonks,N.K., Charbonneau,H., Walsh,K.A., Fischer,E.H. and
CC   GPRFLN|            Krebs,E.G.
CC   GPRFLN|  TITLE     cDNA isolated from a human T-cell library encodes a member of the
CC   GPRFLN|            protein-tyrosine-phosphatase family
CC   GPRFLN|  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (14), 5257-5261 (1989)
CC   GPRFLN|  MEDLINE   89315776
CC   This file is created by Vector NTI suite
CC   ORIGDB|GenPept
CC   VNTDATE|302014800|

CC   VNTAUTHORNAME|Jannik N Andersen|
CC   VNTAUTHOREML|jannik@noergaardandersen.com|
CC   VNTAUTHORWWW|http://ptp.cshl.edu & http://science.novonordisk.com/ptp|
CC   VNTOAUTHORNAME|NCBI Entrez|
CC   VNTOAUTHORTEL|(301)496-2475|
CC   VNTOAUTHORFAX|(301)480-9241|
CC   VNTOAUTHOREML|info@ncbi.nlm.nih.gov|
CC   VNTOAUTHORWWW|http://www3.ncbi.nlm.nih.gov/Entrez/|
CC   VNTOAUTHORAD1|National Center for Biotechnology Information|
CC   VNTOAUTHORAD2|National Library of Medicine|
CC   VNTOAUTHORAD3|Building 38A, Room 8N805|
CC   VNTOAUTHORAD4|Bethesda, MD 20894, U.S.A.|
FT   SOURCE        1    275       VNTIFKEY:269
FT   PROTEIN       1    275       T-cell protein tyrosine phosphatase
FT                                VNTIFKEY:270
FT   REGION        3    275       PTPc
FT                                VNTIFKEY:266; VNTINAME:Region_1
SQ   SEQUENCE   275 AA;
     TTIEREFEEL DTQRRWQPLY LEIRNESHDY PHRVAKFPEN RNRNRYRDVS PYDHSRVKLQ        60
     NAENDYINAS LVDIEEAQRS YILTQGPLPN TCCHFWLMVW QQKTKAVVML NRIVEKESVK       120
     CAQYWPTDDQ EMLFKETGFS VKLLSEDVKS YYTVHLLQLE NINSGETRTI SHFHYTTWPD       180
     FGVPESPASF LNFLFKVRES GSLNPDHGPA VIHCSAGIGR SGTFSLVDTC LVLMEKGDDI       240
     NIKQVLLNMR KYRMGLIQTP DQLRFSYMAI IEGAK                                  275
//